{"id":"https://openalex.org/W2148106535","doi":"https://doi.org/10.4049/jimmunol.175.3.1643","title":"TLR-4 Regulates CD8+ T Cell Trapping in the Liver","display_name":"TLR-4 Regulates CD8+ T Cell Trapping in the Liver","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W2148106535","doi":"https://doi.org/10.4049/jimmunol.175.3.1643","mag":"2148106535","pmid":"https://pubmed.ncbi.nlm.nih.gov/16034104"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.175.3.1643","doi":"https://doi.org/10.4049/jimmunol.175.3.1643","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.175.3.1643","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058628173","display_name":"Beena John","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beena John","raw_affiliation_strings":["David H. Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David H. Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018427690","display_name":"Ian Nicholas Crispe","orcid":"https://orcid.org/0000-0003-2375-5863","observed_orcids":["https://orcid.org/0000-0003-2375-5863"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Nicholas Crispe","raw_affiliation_strings":["David H. Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David H. Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642","institution_ids":["https://openalex.org/I28792581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28792581"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.1282,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.87370372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"175","issue":"3","first_page":"1643","last_page":"1650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.984000027179718},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.6840000152587891},{"id":"https://openalex.org/keywords/t-cell-adhesion","display_name":"T cell adhesion","score":0.8360000252723694},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/commensal-bacteria","display_name":"commensal bacteria","score":0.9359999895095825},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.5680000185966492},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.5590000152587891},{"id":"https://openalex.org/keywords/systemic-immune-response","display_name":"systemic immune response","score":0.6840000152587891},{"id":"https://openalex.org/keywords/t-cell-distribution","display_name":"T cell distribution","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6318073272705078},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6301400661468506},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5702329277992249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5696927309036255},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5696408152580261},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5265745520591736},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5128557682037354},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.45214375853538513},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.44279909133911133},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.41135770082473755},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39824944734573364},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23042234778404236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.057248055934906006}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008806","descriptor_name":"Mice, Inbred AKR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018089","descriptor_name":"Superantigens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.175.3.1643","doi":"https://doi.org/10.4049/jimmunol.175.3.1643","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.175.3.1643","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:16034104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16034104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7542521092","display_name":"PERIPHERAL T CELL DELETION IN LIVER","funder_award_id":"R01AI037554","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W119361745","https://openalex.org/W196899815","https://openalex.org/W1483162601","https://openalex.org/W1498929362","https://openalex.org/W1535223882","https://openalex.org/W1573433003","https://openalex.org/W1588051227","https://openalex.org/W1920318310","https://openalex.org/W1950136813","https://openalex.org/W1963588999","https://openalex.org/W1970853163","https://openalex.org/W1972486471","https://openalex.org/W2007498454","https://openalex.org/W2014591244","https://openalex.org/W2018485256","https://openalex.org/W2051368119","https://openalex.org/W2055791442","https://openalex.org/W2062632117","https://openalex.org/W2069668308","https://openalex.org/W2072679758","https://openalex.org/W2083089709","https://openalex.org/W2089004438","https://openalex.org/W2090640877","https://openalex.org/W2094133741","https://openalex.org/W2101363646","https://openalex.org/W2116690744","https://openalex.org/W2129319296","https://openalex.org/W2134862628","https://openalex.org/W2135322609","https://openalex.org/W2137590150","https://openalex.org/W2143274206","https://openalex.org/W2152027636","https://openalex.org/W2474206148"],"related_works":["https://openalex.org/W2166977320","https://openalex.org/W1573433003","https://openalex.org/W1963958238","https://openalex.org/W1588051227","https://openalex.org/W2124778856","https://openalex.org/W1906591077","https://openalex.org/W2016578959","https://openalex.org/W2132663389","https://openalex.org/W2412285629","https://openalex.org/W2045061633"],"abstract_inverted_index":{"Mammalian":[0],"TLRs":[1],"are":[2],"understood":[3],"primarily":[4],"as":[5],"an":[6,122],"activating":[7],"system":[8],"for":[9,51,67],"innate":[10],"and":[11,23,53,119,137],"adaptive":[12],"immunity,":[13],"but":[14,64],"have":[15],"also":[16,35],"been":[17],"implicated":[18],"in":[19,24,38,89,110,134,140,145,157],"sensing":[20],"cellular":[21],"damage":[22],"promoting":[25],"intestinal":[26],"integrity.":[27],"In":[28,71,101],"this":[29,68,72],"study":[30,73],"we":[31,74],"show":[32],"that":[33,78],"TLR-4":[34,94,151,181],"controls":[36],"the":[37,65,76,79,90,102,106,126,135,141,146,158,161,175],"vivo":[39],"distribution":[40],"of":[41,55,104,128,148,160,177],"activated":[42,56,97,115,129,165],"CD8+":[43,57,116,130,166],"T":[44,58,98,117,131,167],"cells.":[45,168],"The":[46],"liver":[47,107,136,162],"is":[48,69],"a":[49,154,171],"site":[50],"trapping":[52],"apoptosis":[54],"cells":[59,132],"during":[60],"systemic":[61],"immune":[62,178],"responses,":[63],"reason":[66],"unknown.":[70],"tested":[75],"hypothesis":[77],"liver's":[80],"constant":[81],"exposure":[82],"to":[83,95,113,163],"endotoxin,":[84],"derived":[85],"from":[86],"commensal":[87],"bacteria":[88],"gut,":[91],"acts":[92],"via":[93],"promote":[96],"cell":[99],"adhesion.":[100],"absence":[103,147],"TLR-4,":[105],"was":[108,121],"compromised":[109],"its":[111],"ability":[112,159],"sequester":[114],"cells,":[118],"there":[120],"inverse":[123],"correlation":[124],"between":[125],"frequency":[127,139],"trapped":[133],"their":[138],"circulating":[142],"pool.":[143],"Thus,":[144],"any":[149],"inflammation,":[150],"ligands":[152],"play":[153],"significant":[155],"role":[156],"trap":[164],"This":[169],"provides":[170],"new":[172],"perspective":[173],"on":[174],"regulation":[176],"responses":[179],"by":[180],"under":[182],"basal":[183],"conditions.":[184]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}