{"id":"https://openalex.org/W2148089677","doi":"https://doi.org/10.1371/journal.pone.0089135","title":"Twisted Gastrulation, a BMP Antagonist, Exacerbates Podocyte Injury","display_name":"Twisted Gastrulation, a BMP Antagonist, Exacerbates Podocyte Injury","publication_year":2014,"publication_date":"2014-02-25","ids":{"openalex":"https://openalex.org/W2148089677","doi":"https://doi.org/10.1371/journal.pone.0089135","mag":"2148089677","pmid":"https://pubmed.ncbi.nlm.nih.gov/24586548","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3934867"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0089135","doi":"https://doi.org/10.1371/journal.pone.0089135","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0089135","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089135&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089135&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111679972","display_name":"Sachiko Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sachiko Yamada","raw_affiliation_strings":["Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029660419","display_name":"Jin Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jin Nakamura","raw_affiliation_strings":["Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112282225","display_name":"Misako Asada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misako Asada","raw_affiliation_strings":["Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masayuki Takase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Takase","raw_affiliation_strings":["Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034452500","display_name":"Taiji Matsusaka","orcid":"https://orcid.org/0000-0001-9466-4585","observed_orcids":["https://orcid.org/0000-0001-9466-4585"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiji Matsusaka","raw_affiliation_strings":["Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111892104","display_name":"Taku Iguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taku Iguchi","raw_affiliation_strings":["TMK Project, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TMK Project, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019602773","display_name":"Ryo Yamada","orcid":"https://orcid.org/0000-0002-1587-630X","observed_orcids":["https://orcid.org/0000-0002-1587-630X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Yamada","raw_affiliation_strings":["Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060867222","display_name":"Mari Tanaka","orcid":"https://orcid.org/0000-0003-2187-1406","observed_orcids":["https://orcid.org/0000-0003-2187-1406","https://orcid.org/0000-0002-4162-4034"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mari Tanaka","raw_affiliation_strings":["Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069142861","display_name":"Atsuko Y. Higashi","orcid":"https://orcid.org/0009-0005-3300-0597","observed_orcids":["https://orcid.org/0009-0005-3300-0597"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuko Y. Higashi","raw_affiliation_strings":["Deaprtment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deaprtment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021348767","display_name":"Tomohiko Okuda","orcid":"https://orcid.org/0000-0001-8040-7131","observed_orcids":["https://orcid.org/0000-0001-8040-7131"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiko Okuda","raw_affiliation_strings":["Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072008904","display_name":"Nariaki Asada","orcid":"https://orcid.org/0000-0002-5659-2944","observed_orcids":["https://orcid.org/0000-0002-5659-2944"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nariaki Asada","raw_affiliation_strings":["Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110394383","display_name":"Atsushi Fukatsu","orcid":"https://orcid.org/0000-0001-8141-1984","observed_orcids":["https://orcid.org/0000-0001-8141-1984"]},"institutions":[{"id":"https://openalex.org/I4405254549","display_name":"Yachiyo Hospital","ror":"https://ror.org/01yen8f82","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405254549"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Fukatsu","raw_affiliation_strings":["Yachiyo Hospital, Anjyo, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yachiyo Hospital, Anjyo, Aichi, Japan","institution_ids":["https://openalex.org/I4405254549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103066571","display_name":"Hiroshi Kawachi","orcid":"https://orcid.org/0000-0003-0823-1981","observed_orcids":["https://orcid.org/0000-0003-0823-1981"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kawachi","raw_affiliation_strings":["Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009448621","display_name":"Daniel Graf","orcid":"https://orcid.org/0000-0003-1163-8117","observed_orcids":["https://orcid.org/0000-0003-1163-8117"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel Graf","raw_affiliation_strings":["Institute of Oral Biology, Faculty of Medicine, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oral Biology, Faculty of Medicine, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033364831","display_name":"Eri Muso","orcid":"https://orcid.org/0000-0002-1150-7419","observed_orcids":["https://orcid.org/0000-0002-1150-7419"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Muso","raw_affiliation_strings":["Department of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109115866","display_name":"Toru Kita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161700","display_name":"Kobe City Medical Center General Hospital","ror":"https://ror.org/04j4nak57","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161700","https://openalex.org/I4405284131"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Kita","raw_affiliation_strings":["Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan","institution_ids":["https://openalex.org/I4210161700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100668637","display_name":"Takeshi Kimura","orcid":"https://orcid.org/0000-0002-5665-4076","observed_orcids":["https://orcid.org/0000-0002-5665-4076"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Kimura","raw_affiliation_strings":["Deaprtment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deaprtment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056573254","display_name":"Ira H Pastan","orcid":"https://orcid.org/0000-0002-9223-0270","observed_orcids":["https://orcid.org/0000-0002-9223-0270"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira Pastan","raw_affiliation_strings":["Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002782925","display_name":"Aris N. Economides","orcid":"https://orcid.org/0000-0002-6508-8942","observed_orcids":["https://orcid.org/0000-0002-6508-8942"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aris N. Economides","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, New York, United States of America","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053240410","display_name":"Motoko Yanagita","orcid":"https://orcid.org/0000-0002-0339-9008","observed_orcids":["https://orcid.org/0000-0002-0339-9008"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Motoko Yanagita","raw_affiliation_strings":["Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5053240410"],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.6369,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.88804815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"2","first_page":"e89135","last_page":"e89135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-7","display_name":"BMP-7","score":0.8080000281333923},{"id":"https://openalex.org/keywords/bone-morphogenetic-protein-antagonist","display_name":"bone morphogenetic protein antagonist","score":0.8169999718666077},{"id":"https://openalex.org/keywords/podocyte-injury","display_name":"podocyte injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.9309999942779541},{"id":"https://openalex.org/keywords/podocyte-differentiation","display_name":"podocyte differentiation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/podocyte-proliferation","display_name":"podocyte proliferation","score":0.996999979019165},{"id":"https://openalex.org/keywords/parietal-epithelial-cells","display_name":"parietal epithelial cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hypoalbuminemia","display_name":"hypoalbuminemia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.9658369421958923},{"id":"https://openalex.org/C2910727860","wikidata":"https://www.wikidata.org/wiki/Q21174993","display_name":"Synaptopodin","level":5,"score":0.6422473192214966},{"id":"https://openalex.org/C2781156571","wikidata":"https://www.wikidata.org/wiki/Q614409","display_name":"Podocalyxin","level":5,"score":0.6158331036567688},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.5173525214195251},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5041977167129517},{"id":"https://openalex.org/C125349252","wikidata":"https://www.wikidata.org/wiki/Q14903102","display_name":"Bone morphogenetic protein 7","level":4,"score":0.4835759997367859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42201119661331177},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.4134323000907898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39084678888320923},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38179969787597656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2631341218948364},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.24204444885253906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05609786510467529},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050199","descriptor_name":"Podocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0089135","doi":"https://doi.org/10.1371/journal.pone.0089135","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0089135","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089135&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2925909","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3934867","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3934867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3934867","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24586548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24586548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2cbb3391f30847d5a744d0fe8de15080","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2cbb3391f30847d5a744d0fe8de15080","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 2, p e89135 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/944189","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Twisted_Gastrulation_a_BMP_Antagonist_Exacerbates_Podocyte_Injury_/944189","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/242348","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2433/242348","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoral thesis"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0089135","doi":"https://doi.org/10.1371/journal.pone.0089135","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0089135","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089135&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2867137895","display_name":"BMP\u30b7\u30b0\u30ca\u30eb\u304c\u5236\u5fa1\u3059\u308b\u5e79\u7d30\u80de\u306b\u3088\u308b\u814e\u81d3\u306e\u767a\u751f\u30fb\u518d\u751f\u30fb\u764c\u9032\u5c55\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e","funder_award_id":"21200080","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4955223053","display_name":"Mechanisms of progression of chronic kidney disease","funder_award_id":"22249033","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7379416431","display_name":"Common pathogenesis of nephrotic syndrome and vascular diseases in other organs","funder_award_id":"23390224","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148089677.pdf","grobid_xml":"https://content.openalex.org/works/W2148089677.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1495619257","https://openalex.org/W1514989738","https://openalex.org/W1534052611","https://openalex.org/W1541748202","https://openalex.org/W1649327708","https://openalex.org/W1906672622","https://openalex.org/W1923939500","https://openalex.org/W1964399247","https://openalex.org/W1966022628","https://openalex.org/W1967471692","https://openalex.org/W1984706329","https://openalex.org/W1987379081","https://openalex.org/W1992139297","https://openalex.org/W1993228795","https://openalex.org/W1993345123","https://openalex.org/W1998740840","https://openalex.org/W2000300682","https://openalex.org/W2006819017","https://openalex.org/W2009131231","https://openalex.org/W2016465321","https://openalex.org/W2018509996","https://openalex.org/W2031800834","https://openalex.org/W2034893253","https://openalex.org/W2047642636","https://openalex.org/W2051175427","https://openalex.org/W2051281330","https://openalex.org/W2061980453","https://openalex.org/W2076381257","https://openalex.org/W2076872741","https://openalex.org/W2077012158","https://openalex.org/W2089883882","https://openalex.org/W2100829428","https://openalex.org/W2100990796","https://openalex.org/W2114245705","https://openalex.org/W2115056513","https://openalex.org/W2119074534","https://openalex.org/W2119493074","https://openalex.org/W2124415162","https://openalex.org/W2124476281","https://openalex.org/W2124938985","https://openalex.org/W2134074039","https://openalex.org/W2134947948","https://openalex.org/W2139818451","https://openalex.org/W2142648384","https://openalex.org/W2150582334","https://openalex.org/W2157390509","https://openalex.org/W2159098596","https://openalex.org/W2163406006","https://openalex.org/W2169570354","https://openalex.org/W2421331648","https://openalex.org/W4296588288"],"related_works":["https://openalex.org/W3153869293","https://openalex.org/W2142648384","https://openalex.org/W2100829428","https://openalex.org/W2366185154","https://openalex.org/W2393290018","https://openalex.org/W3190895230","https://openalex.org/W1996185454","https://openalex.org/W4283021389","https://openalex.org/W2056212659","https://openalex.org/W2937599211"],"abstract_inverted_index":{"Podocyte":[0],"injury":[1,26,185],"is":[2,40,69,213],"the":[3,7,15,28,49,60,70,91,111,117,133,139,148,178,199],"first":[4],"step":[5],"in":[6,24,34,77,96,138,153,157,198],"progression":[8],"of":[9,18,30,38,51,62,74,102,114,121,130,147,161,180,201,204,211,217,219],"glomerulosclerosis.":[10],"Previous":[11],"studies":[12],"have":[13],"demonstrated":[14],"beneficial":[16],"effect":[17],"bone":[19],"morphogenetic":[20],"protein":[21],"7":[22],"(Bmp7)":[23],"podocyte":[25,87,105,125,162,181,184,223],"and":[27,79,144,151,170,172,208],"existence":[29],"native":[31],"Bmp":[32,45,67,75,94,103,122],"signaling":[33],"podocytes.":[35,99],"Local":[36],"activity":[37],"Bmp7":[39,52,205],"controlled":[41],"by":[42],"cell-type":[43],"specific":[44],"antagonists,":[46],"which":[47],"inhibit":[48],"binding":[50],"to":[53,86],"its":[54],"receptors.":[55],"Here":[56],"we":[57],"show":[58,191],"that":[59,80,192,209],"product":[61],"Twisted":[63],"gastrulation":[64],"(Twsg1),":[65],"a":[66,158,195,214],"antagonist,":[68],"central":[71],"negative":[72],"regulator":[73],"function":[76],"podocytes":[78],"Twsg1":[81,89,115,131,135,164,193,212],"null":[82,165],"mice":[83,166],"are":[84],"resistant":[85],"injury.":[88,163,224],"was":[90,136],"most":[92],"abundant":[93],"antagonist":[95],"murine":[97,159],"cultured":[98],"The":[100,119],"administration":[101,113,120,129],"induced":[104],"differentiation":[106],"through":[107],"Smad":[108],"signaling,":[109],"whereas":[110,127],"simultaneous":[112,128],"antagonized":[116,132],"effect.":[118,134],"also":[123],"inhibited":[124],"proliferation,":[126],"expressed":[137],"glomerular":[140,155],"parietal":[141],"cells":[142,156],"(PECs)":[143],"distal":[145],"nephron":[146],"healthy":[149],"kidney,":[150],"additionally":[152],"damaged":[154],"model":[160],"exhibited":[167],"milder":[168,173],"hypoalbuminemia":[169],"hyperlipidemia,":[171],"histological":[174],"changes":[175],"while":[176],"maintaining":[177],"expression":[179],"markers":[182],"during":[183],"model.":[186],"Taken":[187],"together,":[188],"our":[189],"results":[190],"plays":[194],"critical":[196],"role":[197],"modulation":[200],"protective":[202],"action":[203],"on":[206],"podocytes,":[207],"inhibition":[210],"promising":[215],"means":[216],"development":[218],"novel":[220],"treatment":[221],"for":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}