{"id":"https://openalex.org/W2148046540","doi":"https://doi.org/10.2174/15680266113136660213","title":"The Histone Deacetylase SIRT6: At the Crossroads Between Epigenetics, Metabolism and Disease","display_name":"The Histone Deacetylase SIRT6: At the Crossroads Between Epigenetics, Metabolism and Disease","publication_year":2013,"publication_date":"2013-12-03","ids":{"openalex":"https://openalex.org/W2148046540","doi":"https://doi.org/10.2174/15680266113136660213","mag":"2148046540","pmid":"https://pubmed.ncbi.nlm.nih.gov/24171769"},"language":"en","primary_location":{"id":"doi:10.2174/15680266113136660213","doi":"https://doi.org/10.2174/15680266113136660213","is_oa":false,"landing_page_url":"https://doi.org/10.2174/15680266113136660213","pdf_url":null,"source":{"id":"https://openalex.org/S107732428","display_name":"Current Topics in Medicinal Chemistry","issn_l":"1568-0266","issn":["1568-0266","1873-4294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073303183","display_name":"Jean\u2010Pierre Etchegaray","orcid":"https://orcid.org/0000-0002-6663-8870","observed_orcids":["https://orcid.org/0000-0002-6663-8870"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Etchegaray","raw_affiliation_strings":["The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA. rmostoslavsky@mgh.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA. rmostoslavsky@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071363714","display_name":"Lei Zhong","orcid":"https://orcid.org/0000-0002-1901-9698","observed_orcids":["https://orcid.org/0000-0002-1901-9698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072607124","display_name":"Ra\u00fal Mostoslavsky","orcid":"https://orcid.org/0000-0002-7740-5212","observed_orcids":["https://orcid.org/0000-0002-7740-5212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raul Mostoslavsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3651,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.94328286,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":"23","first_page":"2991","last_page":"3000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt6","display_name":"SIRT6","score":1.0},{"id":"https://openalex.org/keywords/sirtuins","display_name":"sirtuins","score":0.9660000205039978},{"id":"https://openalex.org/keywords/histone-deacetylation","display_name":"histone deacetylation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/glucose-and-lipid-metabolism","display_name":"glycolipid metabolism","score":0.6499999761581421},{"id":"https://openalex.org/keywords/telomere-maintenance","display_name":"telomere maintenance","score":0.8880000114440918},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9359999895095825},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.796999990940094},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.972000002861023},{"id":"https://openalex.org/keywords/tnf-alpha-secretion","display_name":"TNF-alpha secretion","score":0.9729999899864197},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8949999809265137},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8539999723434448},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.5889999866485596},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7229999899864197},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.953000009059906},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.9390000104904175},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.609000027179718},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.6380000114440918},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2777595374","wikidata":"https://www.wikidata.org/wiki/Q18040385","display_name":"SIRT6","level":5,"score":0.8941343426704407},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6201997995376587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5985441207885742},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.5794208645820618},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5667544603347778},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5396523475646973},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.53180330991745},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5317888259887695},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.492678701877594},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4670013189315796},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.45821326971054077},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4104991853237152},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3708844780921936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3126710057258606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28385722637176514},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2828459143638611},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20131072402000427},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1706487238407135},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14216884970664978}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/15680266113136660213","doi":"https://doi.org/10.2174/15680266113136660213","is_oa":false,"landing_page_url":"https://doi.org/10.2174/15680266113136660213","pdf_url":null,"source":{"id":"https://openalex.org/S107732428","display_name":"Current Topics in Medicinal Chemistry","issn_l":"1568-0266","issn":["1568-0266","1873-4294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:24171769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24171769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current topics in medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1341352357","display_name":null,"funder_award_id":"DK088190-01A1","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3553922135","display_name":"Mammalian SIRT6 Is A Master Regulator Of Glucose Homeostasis","funder_award_id":"R01DK088190","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4154380230","display_name":null,"funder_award_id":"GM093072-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5683922144","display_name":"The histone deacetylase SIRT6 functions as a co-repressor of Hif1 alpha in glucos","funder_award_id":"R01GM093072","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1976919123","https://openalex.org/W7100234646","https://openalex.org/W2332232004","https://openalex.org/W4410805288","https://openalex.org/W2020311873","https://openalex.org/W2133124403","https://openalex.org/W2471968619","https://openalex.org/W2800465507","https://openalex.org/W4307841950","https://openalex.org/W2014655396"],"abstract_inverted_index":{"SIRT6":[0,18,91,117,130,151,158,184,218,227,258],"is":[1,19,62,185,229],"one":[2],"of":[3,7,11,17,35,38,45,54,67,79,85,96,103,129,137,144,150,168,213,257,262],"the":[4,8,33,43,65,77,83,94,109,135,141,220,247,252,260],"seven":[5],"members":[6],"NAD-dependent":[9],"family":[10],"sirtuins":[12],"mammals.":[13],"The":[14,126],"pleotropic":[15],"identity":[16],"manifested":[20],"into":[21],"several":[22],"catalytic":[23,148,169],"activities":[24],"such":[25],"as":[26,74,76,122],"deacetylation,":[27],"deacylation":[28,127],"and":[29,49,60,82,108,181,194,203,242,254,265],"ribosylation,":[30],"which":[31,112,162,206],"allow":[32],"targeting":[34],"a":[36,101,123,166,186],"variety":[37],"protein":[39],"substrates,":[40],"that":[41],"influence":[42],"physiology":[44],"multiple":[46],"cell":[47],"types":[48],"tissues.":[50],"SIRT6-":[51],"dependent":[52],"deacetylation":[53],"histone":[55,98],"H3":[56,99],"at":[57],"lysines":[58],"9":[59],"56":[61],"required":[63,189],"for":[64],"regulation":[66,136],"genes":[68,104],"associated":[69,208,230],"with":[70,231],"glucose/":[71],"lipid":[72],"metabolism":[73,264],"well":[75],"maintenance":[78],"telomeric":[80],"regions":[81],"repair":[84,177],"DNA":[86,176,204],"double":[87],"strand":[88],"breaks.":[89],"Importantly,":[90],"depletion":[92],"alters":[93],"levels":[95],"acetylated":[97],"causing":[100],"deregulation":[102],"involved":[105],"in":[106,114,156,225,259],"glycolysis":[107],"Myc-target":[110],"network,":[111],"results":[113],"tumorigenesis.":[115],"Hence,":[116],"has":[118,131,219],"been":[119,132],"recently":[120],"categorized":[121],"tumor":[124],"suppressor.":[125],"activity":[128,149],"attributed":[133],"to":[134,153,165,190,200,209,222],"TNF-\u03b1":[138],"secretion.":[139],"However,":[140],"physiological":[142,255],"relevance":[143,256],"this":[145],"newly":[146],"discovered":[147],"remains":[152],"be":[154],"determined":[155],"vivo.":[157],"also":[159,173],"undergoes":[160],"auto-ribosylation,":[161],"might":[163],"contribute":[164],"self-regulation":[167],"functions.":[170],"SIRT6-mediated":[171],"ribosylation":[172],"enhances":[174],"PARP1-dependent":[175],"under":[178],"oxidative":[179,201],"stress":[180,202],"aging.":[182],"Overall,":[183],"critical":[187],"enzyme":[188],"maintain":[191],"glucose/lipid":[192],"homeostasis":[193],"genomic":[195],"stability,":[196],"thereby":[197],"promoting":[198],"resistance":[199],"damage,":[205],"are":[207],"age-related":[210],"illness.":[211],"Evocative":[212],"its":[214],"ancestor,":[215],"yeast":[216],"Sir2,":[217],"ability":[221],"increase":[223],"lifespan":[224],"mice.":[226],"deficiency":[228],"various":[232],"diseases":[233],"including":[234],"inflammation,":[235],"cardiac":[236],"hypertrophy,":[237],"liver":[238],"dysfunction,":[239],"adipocyte/muscle":[240],"disorders,":[241],"cancer.":[243],"This":[244],"review":[245],"describes":[246],"most":[248],"current":[249],"information":[250],"regarding":[251],"molecular":[253],"context":[261],"epigenetics,":[263],"disease.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
