{"id":"https://openalex.org/W2148041594","doi":"https://doi.org/10.1177/147323001003800622","title":"Modified Natural Cycle for In Vitro Fertilization and Embryo Transfer in Normal Ovarion Responders","display_name":"Modified Natural Cycle for In Vitro Fertilization and Embryo Transfer in Normal Ovarion Responders","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2148041594","doi":"https://doi.org/10.1177/147323001003800622","mag":"2148041594","pmid":"https://pubmed.ncbi.nlm.nih.gov/21227012"},"language":"en","primary_location":{"id":"doi:10.1177/147323001003800622","doi":"https://doi.org/10.1177/147323001003800622","is_oa":false,"landing_page_url":"https://doi.org/10.1177/147323001003800622","pdf_url":null,"source":{"id":"https://openalex.org/S62018274","display_name":"Journal of International Medical Research","issn_l":"0300-0605","issn":["0300-0605","1473-2300"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of International Medical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110252334","display_name":"HY Lou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HY Lou","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109302683","display_name":"Huang Xy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XY Huang","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4155,"currency":"USD","value_usd":4155},"apc_paid":null,"fwci":0.3792,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.74804545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"38","issue":"6","first_page":"2070","last_page":"2076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.3366999924182892,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modified-natural-cycle","display_name":"modified natural cycle","score":0.9589999914169312},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.9570000171661377},{"id":"https://openalex.org/keywords/embryo-transfer","display_name":"embryo transfer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/controlled-ovarian-stimulation","display_name":"controlled ovarian stimulation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/triptorelin","display_name":"triptorelin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gnrh-agonist","display_name":"GnRH agonist","score":0.8820000290870667},{"id":"https://openalex.org/keywords/recombinant-fsh","display_name":"recombinant FSH","score":0.8989999890327454},{"id":"https://openalex.org/keywords/human-menopausal-gonadotropin","display_name":"human menopausal gonadotropin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/implantation-rate","display_name":"implantation rate","score":0.7919999957084656},{"id":"https://openalex.org/keywords/clinical-pregnancy-rate","display_name":"clinical pregnancy rate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oocyte-retrieval","display_name":"oocyte retrieval","score":0.8460000157356262},{"id":"https://openalex.org/keywords/drug-costs","display_name":"drug costs","score":0.75},{"id":"https://openalex.org/keywords/ovarian-stimulation-complications","display_name":"ovarian stimulation complications","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2779448150","wikidata":"https://www.wikidata.org/wiki/Q1992452","display_name":"Triptorelin","level":5,"score":0.8531816005706787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7655931711196899},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.6998070478439331},{"id":"https://openalex.org/C2778478619","wikidata":"https://www.wikidata.org/wiki/Q7113249","display_name":"Controlled ovarian hyperstimulation","level":4,"score":0.6646651029586792},{"id":"https://openalex.org/C2909827854","wikidata":"https://www.wikidata.org/wiki/Q416821","display_name":"Menotropins","level":5,"score":0.6155555844306946},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.5769172310829163},{"id":"https://openalex.org/C2779058012","wikidata":"https://www.wikidata.org/wiki/Q83864","display_name":"Menstrual cycle","level":3,"score":0.5630375146865845},{"id":"https://openalex.org/C2776537878","wikidata":"https://www.wikidata.org/wiki/Q7239894","display_name":"Pregnancy rate","level":3,"score":0.46309924125671387},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.4574020504951477},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4402027428150177},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4325864911079407},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4249763488769531},{"id":"https://openalex.org/C2781065240","wikidata":"https://www.wikidata.org/wiki/Q1760461","display_name":"Ovarian hyperstimulation syndrome","level":4,"score":0.421480655670166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42033374309539795},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.40259993076324463},{"id":"https://openalex.org/C2781230225","wikidata":"https://www.wikidata.org/wiki/Q3150564","display_name":"Ovulation induction","level":4,"score":0.3744412660598755},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3676730692386627},{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.2787216901779175},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.26694995164871216},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.22875544428825378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14022594690322876},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004624","descriptor_name":"Embryo Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008597","descriptor_name":"Menstrual Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008597","descriptor_name":"Menstrual Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010062","descriptor_name":"Ovulation Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017329","descriptor_name":"Triptorelin Pamoate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/147323001003800622","doi":"https://doi.org/10.1177/147323001003800622","is_oa":false,"landing_page_url":"https://doi.org/10.1177/147323001003800622","pdf_url":null,"source":{"id":"https://openalex.org/S62018274","display_name":"Journal of International Medical Research","issn_l":"0300-0605","issn":["0300-0605","1473-2300"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of International Medical Research","raw_type":"journal-article"},{"id":"pmid:21227012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21227012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of international medical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W121686092","https://openalex.org/W1860011699","https://openalex.org/W1969634007","https://openalex.org/W2000932978","https://openalex.org/W2017123860","https://openalex.org/W2030067513","https://openalex.org/W2043756142","https://openalex.org/W2052079716","https://openalex.org/W2054448912","https://openalex.org/W2069463805","https://openalex.org/W2071128235","https://openalex.org/W2073788090","https://openalex.org/W2079455501","https://openalex.org/W2089001165","https://openalex.org/W2116231331","https://openalex.org/W2117719525","https://openalex.org/W2118401568","https://openalex.org/W2124445642","https://openalex.org/W2132455766","https://openalex.org/W2143643899","https://openalex.org/W2152588436","https://openalex.org/W2154367847","https://openalex.org/W2154924920","https://openalex.org/W2333296625","https://openalex.org/W4255286346"],"related_works":["https://openalex.org/W7099846274","https://openalex.org/W2143584006","https://openalex.org/W2559729301","https://openalex.org/W2141632069","https://openalex.org/W2758318909","https://openalex.org/W2352190301","https://openalex.org/W1976150823","https://openalex.org/W2103614529","https://openalex.org/W2097867587","https://openalex.org/W2054448912"],"abstract_inverted_index":{"Controlled":[0],"ovarian":[1,31],"hyperstimulation":[2],"(COH)":[3],"using":[4],"a":[5,29,35,80,169],"gonadotrophin-releasing":[6],"hormone":[7,59],"(GnRH)":[8],"analogue":[9],"plus":[10],"gonadotrophins":[11],"is":[12,162],"used":[13],"widely":[14],"in":[15,16,34,116],"vitro":[17],"fertilization":[18],"(IVF),":[19],"but":[20],"there":[21],"can":[22],"be":[23,168],"significant":[24],"complications.":[25],"Sixty":[26],"women":[27],"with":[28,79,173],"normal":[30],"response":[32],"participated":[33],"comparison":[36],"of":[37,48,68,106,147,155,180],"COH":[38,142],"(triptorelin":[39],"[GnRH":[40],"agonist]":[41],"0.1":[42],"mg/day":[43],"SC":[44],"from":[45,65],"day":[46,66,102],"21":[47],"the":[49,53,69,107],"menstrual":[50,108],"cycle":[51,83],"[before":[52],"IVF":[54,70],"cycle]":[55],"and":[56,120,123,128,150,158],"recombinant":[57,151],"follicle-stimulating":[58],"(FSH)":[60],"150":[61,91],"-":[62],"300":[63],"IU/day":[64,92],"2":[67,103],"cycle,":[71],"when":[72],"triptorelin":[73],"was":[74,97],"reduced":[75],"to":[76,167],"0.05":[77],"mg/day)":[78],"modified":[81],"natural":[82],"(MNC)":[84],"treatment":[85,171],"(human":[86],"menopausal":[87],"gonado":[88],"trophin":[89],"[HMG]":[90],"IM":[93],"if":[94],"serum":[95],"oestradiol":[96],"\u2264":[98],"50":[99],"pg/ml":[100],"on":[101],"or":[104],"3":[105],"cycle).":[109],"The":[110],"groups":[111],"did":[112],"not":[113],"differ":[114],"significantly":[115,138],"implantation":[117],"rate":[118,126],"(21.1%":[119],"22.6%,":[121],"respectively)":[122],"clinical":[124],"pregnancy":[125],"(30.0%":[127],"30.0%,":[129],"respectively).":[130],"When":[131],"comparing":[132],"successful":[133],"pregnancies,":[134],"MNC":[135,165],"patients":[136,143],"had":[137],"lower":[139],"values":[140],"than":[141],"for":[144],"total":[145],"amount":[146],"gonadotrophin":[148],"(HMG":[149],"FSH)":[152],"used,":[153],"number":[154],"oocytes":[156],"retrieved":[157],"medication":[159,175],"cost.":[160],"It":[161],"concluded":[163],"that":[164],"seems":[166],"feasible":[170],"option,":[172],"low":[174,178],"cost,":[176],"relatively":[177],"risk":[179],"complications":[181],"and,":[182],"possibly,":[183],"greater":[184],"patient":[185],"acceptability.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}