{"id":"https://openalex.org/W2148035451","doi":"https://doi.org/10.1109/jsen.2011.2173674","title":"An Integrated Flexible Implantable Micro-Probe for Sensing Neurotransmitters","display_name":"An Integrated Flexible Implantable Micro-Probe for Sensing Neurotransmitters","publication_year":2011,"publication_date":"2011-10-26","ids":{"openalex":"https://openalex.org/W2148035451","doi":"https://doi.org/10.1109/jsen.2011.2173674","mag":"2148035451"},"language":"en","primary_location":{"id":"doi:10.1109/jsen.2011.2173674","doi":"https://doi.org/10.1109/jsen.2011.2173674","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jsen.2011.2173674","pdf_url":null,"source":{"id":"https://openalex.org/S189694085","display_name":"IEEE Sensors Journal","issn_l":"1530-437X","issn":["1530-437X","1558-1748","2379-9153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-2","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321027","host_organization_name":"IEEE Sensors Council","host_organization_lineage":["https://openalex.org/P4310321027","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Sensors Council","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Sensors Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038366927","display_name":"Hung Cao","orcid":"https://orcid.org/0000-0003-4197-7208","observed_orcids":["https://orcid.org/0000-0003-4197-7208"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung Cao","raw_affiliation_strings":["Electrical Engineering Department, University of Texas at Arlington, Arlington, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical Engineering Department, University of Texas at Arlington, Arlington, TX, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110179402","display_name":"Ai-Ling Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ai-Ling Li","raw_affiliation_strings":["Psychology Department, University of Texas at Arlington, Arlington, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychology Department, University of Texas at Arlington, Arlington, TX, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cuong M. Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cuong M. Nguyen","raw_affiliation_strings":["Electrical Engineering Department, University of Texas at Arlington, Arlington, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical Engineering Department, University of Texas at Arlington, Arlington, TX, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038486804","display_name":"Yuan-Bo Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan-Bo Peng","raw_affiliation_strings":["Psychology Department, University of Texas at Arlington, Arlington, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychology Department, University of Texas at Arlington, Arlington, TX, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033472595","display_name":"J.\u2010C. Chiao","orcid":"https://orcid.org/0000-0001-9670-0340","observed_orcids":["https://orcid.org/0000-0001-9670-0340"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jung-Chih Chiao","raw_affiliation_strings":["Electrical Engineering Department, University of Texas at Arlington, Arlington, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical Engineering Department, University of Texas at Arlington, Arlington, TX, USA","institution_ids":["https://openalex.org/I189196454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I189196454"],"apc_list":{"value":2645,"currency":"USD","value_usd":2645},"apc_paid":null,"fwci":0.4481,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.71547472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"5","first_page":"1618","last_page":"1624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.48410001397132874,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotransmitter-detection","display_name":"neurotransmitter detection","score":0.949999988079071},{"id":"https://openalex.org/keywords/polyimide-substrate","display_name":"polyimide substrate","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ag-agcl-reference-electrode","display_name":"Ag/AgCl reference electrode","score":0.9160000085830688},{"id":"https://openalex.org/keywords/electrochemical-biosensor","display_name":"electrochemical biosensor","score":0.6119999885559082},{"id":"https://openalex.org/keywords/l-glutamate-oxidase","display_name":"L-glutamate oxidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gold-thin-film-electrodes","display_name":"gold thin film electrodes","score":0.5809999704360962},{"id":"https://openalex.org/keywords/enzyme-electrodes","display_name":"enzyme electrodes","score":0.35899999737739563},{"id":"https://openalex.org/keywords/central-nervous-system-monitoring","display_name":"central nervous system monitoring","score":0.7049999833106995},{"id":"https://openalex.org/keywords/somatosensory-stimulation","display_name":"somatosensory stimulation","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.6793239116668701},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6565266847610474},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4990651607513428},{"id":"https://openalex.org/C69118416","wikidata":"https://www.wikidata.org/wiki/Q477099","display_name":"Working electrode","level":4,"score":0.48534098267555237},{"id":"https://openalex.org/C40290423","wikidata":"https://www.wikidata.org/wiki/Q653954","display_name":"Reference electrode","level":4,"score":0.4823829233646393},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.44784417748451233},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.43768805265426636},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.4334947466850281},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.3538094758987427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29594695568084717},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/jsen.2011.2173674","doi":"https://doi.org/10.1109/jsen.2011.2173674","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jsen.2011.2173674","pdf_url":null,"source":{"id":"https://openalex.org/S189694085","display_name":"IEEE Sensors Journal","issn_l":"1530-437X","issn":["1530-437X","1558-1748","2379-9153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-2","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321027","host_organization_name":"IEEE Sensors Council","host_organization_lineage":["https://openalex.org/P4310321027","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Sensors Council","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Sensors Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309825","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W61007526","https://openalex.org/W135890937","https://openalex.org/W1508656755","https://openalex.org/W1531737357","https://openalex.org/W1576599655","https://openalex.org/W1591523569","https://openalex.org/W1686397783","https://openalex.org/W1965520712","https://openalex.org/W1969745087","https://openalex.org/W1971252257","https://openalex.org/W1977782256","https://openalex.org/W1978383567","https://openalex.org/W1985223881","https://openalex.org/W1985615006","https://openalex.org/W1987530463","https://openalex.org/W1988878611","https://openalex.org/W1989157562","https://openalex.org/W2003270702","https://openalex.org/W2003782641","https://openalex.org/W2004481724","https://openalex.org/W2018838596","https://openalex.org/W2023810799","https://openalex.org/W2024253104","https://openalex.org/W2032574753","https://openalex.org/W2039469634","https://openalex.org/W2050137045","https://openalex.org/W2058856551","https://openalex.org/W2065690417","https://openalex.org/W2066497793","https://openalex.org/W2086425346","https://openalex.org/W2087454739","https://openalex.org/W2095478308","https://openalex.org/W2099703466","https://openalex.org/W2118991951","https://openalex.org/W2124699144","https://openalex.org/W2145690375","https://openalex.org/W2148990048","https://openalex.org/W2149589531","https://openalex.org/W2153274306","https://openalex.org/W2159631572","https://openalex.org/W2479888276","https://openalex.org/W3148499377"],"related_works":["https://openalex.org/W2148990048","https://openalex.org/W2288528637","https://openalex.org/W1965182322","https://openalex.org/W3138527295","https://openalex.org/W2015526924","https://openalex.org/W2506306945","https://openalex.org/W4403208537","https://openalex.org/W6977332764","https://openalex.org/W4405490842","https://openalex.org/W1964951114"],"abstract_inverted_index":{"In":[0,179],"this":[1],"work,":[2],"we":[3],"have":[4,67],"developed":[5],"an":[6,90],"integrated":[7,42],"flexible":[8],"implantable":[9],"probe":[10,22,46],"on":[11,123],"a":[12,60,129],"polyimide-film":[13],"substrate":[14],"for":[15,31,72,85],"sensing":[16],"neurotransmitters.":[17],"The":[18,82,118,137,152,172],"flexibility":[19],"of":[20,59,87,148,162,169,189,192],"the":[21,44,48,57,78,124,135,146,167,187],"helps":[23],"to":[24,111,133,143,185,196],"prevent":[25],"scar":[26],"forming":[27],"in":[28,33,43,77],"tissues":[29],"aiming":[30],"long-term":[32],"vivo":[34,180],"monitoring.":[35],"A":[36,98],"micro":[37],"Ag/AgCl":[38],"reference":[39,62],"electrode":[40,65],"was":[41,89,106,121,140],"same":[45],"with":[47,164],"Au/Cr":[49],"or":[50],"Pt/Cr":[51],"working":[52,116,125],"electrodes":[53,126],"providing":[54],"measurements":[55],"without":[56,166],"need":[58],"separate":[61],"probe.":[63],"Several":[64],"configurations":[66],"been":[68],"considered":[69],"and":[70,102,150,157,165,177],"designed":[71],"implantation":[73],"at":[74,159],"various":[75,160],"locations":[76],"central":[79],"nervous":[80],"system.":[81],"prototype":[83],"device":[84],"proof":[86],"principle":[88],"enzyme-based":[91],"electrochemical":[92,193],"L-glutamate":[93,96,119,163],"sensor":[94],"using":[95],"oxidase.":[97],"comparison":[99],"between":[100],"Au":[101],"Pt":[103],"thin":[104],"films":[105],"conducted":[107,184],"by":[108,128],"cyclic":[109],"voltammetry":[110],"evaluate":[112],"their":[113],"performance":[114],"as":[115],"electrodes.":[117],"oxidase":[120],"deposited":[122],"followed":[127],"meta-Phenylenediamine":[130],"electropolymerization":[131],"process":[132],"improve":[134],"selectivity.":[136,151,178],"self-referencing":[138],"technique":[139],"also":[141],"utilized":[142],"enhance":[144],"both":[145],"limit":[147],"detection":[149],"assembled":[153],"sensors":[154],"were":[155,183],"calibrated":[156],"tested":[158],"concentrations":[161],"presence":[168],"interfering":[170],"molecules.":[171],"results":[173],"showed":[174],"good":[175],"sensitivity":[176],"animal":[181],"tests":[182],"show":[186],"capability":[188],"detecting":[190],"changes":[191],"signals":[194],"responding":[195],"graded":[197],"peripheral":[198],"somatosensory":[199],"stimuli.":[200]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}