{"id":"https://openalex.org/W2148024031","doi":"https://doi.org/10.1172/jci119089","title":"Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury.","display_name":"Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury.","publication_year":1996,"publication_date":"1996-12-15","ids":{"openalex":"https://openalex.org/W2148024031","doi":"https://doi.org/10.1172/jci119089","mag":"2148024031","pmid":"https://pubmed.ncbi.nlm.nih.gov/8981909","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/507728"},"language":"en","primary_location":{"id":"doi:10.1172/jci119089","doi":"https://doi.org/10.1172/jci119089","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci119089","pdf_url":"http://www.jci.org/articles/view/119089/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/119089/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011247798","display_name":"Constance Barazzone\u2010Argiroffo","orcid":"https://orcid.org/0000-0002-8951-3149","observed_orcids":["https://orcid.org/0000-0002-8951-3149"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"C Barazzone","raw_affiliation_strings":["Department of Pediatrics, University of Geneva, Switzerland. Constance.Barazzone@medecine.unige.ch","Department of Pathology,","Department of Pediatrics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Geneva, Switzerland. Constance.Barazzone@medecine.unige.ch","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Department of Pathology,","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083905961","display_name":"Dominique Belin","orcid":"https://orcid.org/0000-0003-4686-339X","observed_orcids":["https://orcid.org/0000-0003-4686-339X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Belin","raw_affiliation_strings":["Department of Pathology,","Departments of Pedi- atrics and Pathology , Centre M\u00e9dical Universitaire , 1, rue Michel Servet , 1211 Gen\u00e8ve 4 , Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology,","institution_ids":[]},{"raw_affiliation_string":"Departments of Pedi- atrics and Pathology , Centre M\u00e9dical Universitaire , 1, rue Michel Servet , 1211 Gen\u00e8ve 4 , Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109231572","display_name":"P F Piguet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P F Piguet","raw_affiliation_strings":["Department of Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078128836","display_name":"J D Vassalli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J D Vassalli","raw_affiliation_strings":["Department of Morphology , and","Department of Morphology, and \u0288 Department of Medicine, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology , and","institution_ids":[]},{"raw_affiliation_string":"Department of Morphology, and \u0288 Department of Medicine, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111644529","display_name":"A P Sappino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A P Sappino","raw_affiliation_strings":["\u0288 Department of Medicine , University of Geneva , Geneva , Switzerland","Departments of Pedi-atrics and Pathology, Centre M\u00e9dical Universitaire, 1, rue Michel Servet, 1211 Gen\u00e8ve 4, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0288 Department of Medicine , University of Geneva , Geneva , Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Departments of Pedi-atrics and Pathology, Centre M\u00e9dical Universitaire, 1, rue Michel Servet, 1211 Gen\u00e8ve 4, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011247798"],"corresponding_institution_ids":["https://openalex.org/I114457229"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":4.9905,"has_fulltext":true,"cited_by_count":137,"citation_normalized_percentile":{"value":0.95214732,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"98","issue":"12","first_page":"2666","last_page":"2673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.38040000200271606,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.38040000200271606,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.2587999999523163,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.17190000414848328,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":1.0},{"id":"https://openalex.org/keywords/hyperoxia-induced-lung-injury","display_name":"hyperoxia-induced lung injury","score":0.8610000014305115},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hyaline-membrane-disease","display_name":"hyaline membrane disease","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pai-1-knockout-mice","display_name":"PAI-1 knockout mice","score":0.8700000047683716},{"id":"https://openalex.org/keywords/antiproteases","display_name":"antiproteases","score":0.6370000243186951},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.844986617565155},{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.7408721446990967},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.6926541328430176},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.672410249710083},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.6304118633270264},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.5306649804115295},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5288580060005188},{"id":"https://openalex.org/C118494813","wikidata":"https://www.wikidata.org/wiki/Q908438","display_name":"Hyaline","level":2,"score":0.5050252079963684},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4915786683559418},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.486175000667572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43885165452957153},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.42089593410491943},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.41393446922302246},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3777785003185272},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33676376938819885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32131505012512207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2717398405075073},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2080458104610443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15865659713745117},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11658313870429993},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006819","descriptor_name":"Hyaline Membrane Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015347","descriptor_name":"RNA Probes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018496","descriptor_name":"Hyperoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018893","descriptor_name":"Bronchoalveolar Lavage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058255","descriptor_name":"Protease Nexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci119089","doi":"https://doi.org/10.1172/jci119089","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci119089","pdf_url":"http://www.jci.org/articles/view/119089/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:8981909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8981909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:507728","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC507728/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmh:oai:unige.ch:aou:unige:8622","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:8622","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0021-9738","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:unige:8622","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:8622","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0021-9738","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci119089","doi":"https://doi.org/10.1172/jci119089","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci119089","pdf_url":"http://www.jci.org/articles/view/119089/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148024031.pdf","grobid_xml":"https://content.openalex.org/works/W2148024031.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W23122061","https://openalex.org/W88936571","https://openalex.org/W102892713","https://openalex.org/W138126045","https://openalex.org/W154856494","https://openalex.org/W1482384424","https://openalex.org/W1493771527","https://openalex.org/W1510871961","https://openalex.org/W1516214401","https://openalex.org/W1595199664","https://openalex.org/W1938846285","https://openalex.org/W1966168394","https://openalex.org/W1969331976","https://openalex.org/W1988996360","https://openalex.org/W1989499124","https://openalex.org/W1992644897","https://openalex.org/W2007818366","https://openalex.org/W2014435216","https://openalex.org/W2016918804","https://openalex.org/W2031288973","https://openalex.org/W2033850307","https://openalex.org/W2039078199","https://openalex.org/W2044478331","https://openalex.org/W2047131018","https://openalex.org/W2061417741","https://openalex.org/W2065699955","https://openalex.org/W2078196958","https://openalex.org/W2079105917","https://openalex.org/W2082419850","https://openalex.org/W2112975823","https://openalex.org/W2126563037","https://openalex.org/W2128635872","https://openalex.org/W2133310011","https://openalex.org/W2138153375","https://openalex.org/W2169502257","https://openalex.org/W2401064901","https://openalex.org/W2407742355","https://openalex.org/W2415449527","https://openalex.org/W2473383025","https://openalex.org/W6628771454"],"related_works":["https://openalex.org/W2513098853","https://openalex.org/W2031288973","https://openalex.org/W1991942422","https://openalex.org/W2016037972","https://openalex.org/W2163357677","https://openalex.org/W2044478331","https://openalex.org/W1992165616","https://openalex.org/W2525524677","https://openalex.org/W188223124","https://openalex.org/W2155639918"],"abstract_inverted_index":{"Hyperoxia-induced":[0],"lung":[1,34,152],"disease":[2],"is":[3,12,68],"associated":[4],"with":[5],"prominent":[6],"intraalveolar":[7,78,102],"fibrin":[8,31,103],"deposition.":[9],"Fibrin":[10],"turnover":[11],"tightly":[13],"regulated":[14],"by":[15],"the":[16,59,81,116,130,136],"concerted":[17],"action":[18],"of":[19,25,41,83,119,133,138,150],"proteases":[20],"and":[21,23,51,80,109,126],"antiproteases,":[22],"inhibition":[24],"plasmin-mediated":[26],"proteolysis":[27],"could":[28],"account":[29],"for":[30,76,129],"accumulation":[32],"in":[33,58,92,105,135],"alveoli.":[35],"We":[36,94],"show":[37],"here":[38],"that":[39,52,96,110],"lungs":[40],"mice":[42,89,98],"exposed":[43],"to":[44,100,107,115],"hyperoxia":[45,108],"overproduce":[46],"plasminogen":[47],"activator":[48],"inhibitor-1":[49],"(PAI-1),":[50],"PAI-1":[53,66,134,144],"upregulation":[54],"impairs":[55],"fibrinolytic":[56],"activity":[57],"alveolar":[60],"compartment.":[61],"To":[62],"explore":[63],"whether":[64],"increased":[65],"production":[67],"a":[69,73,146],"causal":[70],"or":[71],"only":[72],"correlative":[74],"event":[75],"impaired":[77],"fibrinolysis":[79],"development":[82,137],"hyaline":[84,139],"membrane":[85,140],"disease,":[86],"we":[87],"studied":[88],"genetically":[90],"deficient":[91],"PAI-1.":[93],"found":[95],"these":[97],"fail":[99],"develop":[101],"deposits":[104],"response":[106],"they":[111],"are":[112],"more":[113],"resistant":[114],"lethal":[117],"effects":[118],"hyperoxic":[120,151],"stress.":[121],"These":[122],"observations":[123],"provide":[124],"clear":[125],"novel":[127],"evidence":[128],"pathogenic":[131],"contribution":[132],"disease.":[141],"They":[142],"identify":[143],"as":[145],"major":[147],"deleterious":[148],"mediator":[149],"injury.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
