{"id":"https://openalex.org/W2148010067","doi":null,"title":"Acquisition of agonistic properties of nonsteroidal antiandrogens after treatment with oncostatin M in prostate cancer cells.","display_name":"Acquisition of agonistic properties of nonsteroidal antiandrogens after treatment with oncostatin M in prostate cancer cells.","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2148010067","mag":"2148010067","pmid":"https://pubmed.ncbi.nlm.nih.gov/12114440"},"language":"en","primary_location":{"id":"pmid:12114440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12114440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090236157","display_name":"Sonia Godoy\u2010Tundidor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Sonia Godoy-Tundidor","raw_affiliation_strings":["Department of Urology, University of Innsbruck, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Innsbruck, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006782095","display_name":"Alfred Hobisch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alfred Hobisch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056778131","display_name":"Karina Pfeil","orcid":"https://orcid.org/0000-0002-5363-6577","observed_orcids":["https://orcid.org/0000-0002-5363-6577"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karina Pfeil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109191522","display_name":"Georg Hans Bartsch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georg Bartsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007312106","display_name":"Zoran \u010culig","orcid":"https://orcid.org/0000-0002-5001-6153","observed_orcids":["https://orcid.org/0000-0002-5001-6153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zoran Culig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5083,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.81564845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"7","first_page":"2356","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncostatin-m","display_name":"oncostatin M","score":0.9599999785423279},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8199999928474426},{"id":"https://openalex.org/keywords/nonsteroidal-antiandrogens","display_name":"nonsteroidal antiandrogens","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hydroxyflutamide","display_name":"hydroxyflutamide","score":0.9340000152587891},{"id":"https://openalex.org/keywords/bicalutamide","display_name":"bicalutamide","score":1.0},{"id":"https://openalex.org/keywords/ligand-independent-activation","display_name":"ligand-independent receptor activation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7960000038146973},{"id":"https://openalex.org/keywords/il-6-family-cytokines","display_name":"IL-6 family cytokines","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7549999952316284},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.7200000286102295},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.828000009059906},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.652999997138977},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.7699999809265137},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.7844233512878418},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7648307085037231},{"id":"https://openalex.org/C2777667943","wikidata":"https://www.wikidata.org/wiki/Q909425","display_name":"Oncostatin M","level":4,"score":0.7269676923751831},{"id":"https://openalex.org/C2910016293","wikidata":"https://www.wikidata.org/wiki/Q574820","display_name":"Antiandrogens","level":5,"score":0.6402798891067505},{"id":"https://openalex.org/C2780962315","wikidata":"https://www.wikidata.org/wiki/Q1988832","display_name":"Bicalutamide","level":5,"score":0.5961551070213318},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.528342604637146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4651172459125519},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46245670318603516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45512861013412476},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4384620785713196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3640572428703308},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.31866157054901123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26050132513046265},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.14053690433502197},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12056982517242432}],"mesh":[{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002701","descriptor_name":"Chloramphenicol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002701","descriptor_name":"Chloramphenicol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005485","descriptor_name":"Flutamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005485","descriptor_name":"Flutamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014105","descriptor_name":"Tosyl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053677","descriptor_name":"Receptors, Oncostatin M","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053683","descriptor_name":"Oncostatin M","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12114440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12114440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2148010067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12114440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1529553588","https://openalex.org/W1580523172","https://openalex.org/W1595712080","https://openalex.org/W1948931726","https://openalex.org/W1966034415","https://openalex.org/W1979097970","https://openalex.org/W1985827132","https://openalex.org/W1988679331","https://openalex.org/W2000906131","https://openalex.org/W2006715649","https://openalex.org/W2015694069","https://openalex.org/W2023266885","https://openalex.org/W2031687428","https://openalex.org/W2033304819","https://openalex.org/W2042754208","https://openalex.org/W2043236550","https://openalex.org/W2049255846","https://openalex.org/W2057360439","https://openalex.org/W2058482726","https://openalex.org/W2070348355","https://openalex.org/W2070498132","https://openalex.org/W2073069369","https://openalex.org/W2088146533","https://openalex.org/W2091164732","https://openalex.org/W2091245777","https://openalex.org/W2095873383","https://openalex.org/W2103023842","https://openalex.org/W2131801187","https://openalex.org/W2143211793","https://openalex.org/W2149244210","https://openalex.org/W2160392214","https://openalex.org/W2165631552","https://openalex.org/W2166912270","https://openalex.org/W2325609367","https://openalex.org/W2475325796"],"related_works":["https://openalex.org/W2121699326","https://openalex.org/W1529553588","https://openalex.org/W2160392214","https://openalex.org/W2025962890","https://openalex.org/W2087670407","https://openalex.org/W183250853","https://openalex.org/W2063580912","https://openalex.org/W2566324110","https://openalex.org/W1988049837","https://openalex.org/W179545155"],"abstract_inverted_index":{"PURPOSE:":[0],"Interleukin-6":[1],"(IL-6),":[2],"a":[3,24,46,209,252,276],"proinflammatory":[4],"cytokine":[5,36],"the":[6,19,39,56,68,71,78,88,92,131,170,176,185,190,217,245,279,289,309,339],"serum":[7],"andtissue":[8],"levels":[9],"of":[10,41,58,70,80,87,135,169,181,192,211,216,230,244,255,278,282,288,311,319,332,335,341,346],"which":[11,284],"are":[12],"elevated":[13],"in":[14,23,45,77,91,130,157,162,172,266,308,338,349],"prostate":[15,42,93,350],"cancer":[16,43,94,351],"patients,":[17],"activates":[18],"androgen":[20,127,187],"receptor":[21,293],"(AR)":[22],"ligand-independent":[25,167,286],"and":[26,61,75,99,107,116,159,175,224,228,327],"synergistic":[27],"manner.":[28],"Oncostatin":[29],"M":[30],"(OSM)":[31],"is":[32,275],"an":[33,113,197],"IL-6":[34,280],"type":[35],"that":[37,182],"regulates":[38],"growth":[40],"cells":[44,109,268],"paracrine":[47],"fashion.":[48],"The":[49,214,242,330],"present":[50],"study":[51],"was":[52,101,122,146,155,179],"designed":[53],"to":[54,297,317],"investigate":[55],"regulation":[57],"AR":[59,117,141,171,198,202,238,264,271,290,298,303,336],"expression":[60,142,154,265],"function":[62],"by":[63,103,148,184,205,240,300,325],"OSM,":[64,193],"as":[65,67,196,306],"well":[66],"efficacy":[69],"nonsteroidal":[72,302],"antiandrogens":[73,136],"hydroxyflutamide":[74,194],"bicalutamide":[76],"inhibition":[79],"AR-mediated":[81],"signal":[82,226,322],"transduction.":[83],"EXPERIMENTAL":[84],"DESIGN:":[85],"Expression":[86],"OSM":[89,129,144,152,165,206,260,274,326,342],"receptor-beta":[90,153],"cell":[95],"lines":[96],"LNCaP,":[97],"PC-3,":[98],"DU-145":[100,106,158,173,267],"investigated":[102],"reverse":[104],"transcription-PCR.":[105],"PC-3":[108,160],"were":[110],"cotransfected":[111],"with":[112,126,270],"androgen-responsive":[114],"gene":[115,120,258],"cDNA.":[118,272],"Reporter":[119],"activity":[121],"measured":[123],"after":[124,143],"treatment":[125,145],"and/or":[128],"absence":[132],"or":[133,137],"presence":[134,191,310,340],"protein":[138,218],"kinase":[139,219],"inhibitors.":[140],"assessed":[147],"Western":[149],"blot.":[150],"RESULTS:":[151],"higher":[156],"than":[161],"LNCaP":[163],"cells.":[164],"caused":[166,204,250],"activation":[168,178,203,239,287,299],"cells,":[174],"maximal":[177],"62%":[180],"induced":[183],"synthetic":[186],"methyltrienolone.":[188],"In":[189,295],"behaved":[195],"agonist.":[199],"Bicalutamide":[200],"down-regulated":[201],"only":[207,251],"at":[208],"concentration":[210],"1":[212],"microM.":[213],"inhibitor":[215,243],"A":[220],"signaling":[221],"pathway":[222],"PKI":[223],"dn":[225],"transducers":[227],"activators":[229],"transcription":[231],"(STAT)":[232],"3":[233],"showed":[234],"no":[235],"effect":[236],"on":[237],"OSM.":[241,312],"MAPK":[246],"pathway,":[247],"PD":[248],"98059,":[249],"minor":[253],"down-regulation":[254],"OSM-induced":[256],"reporter":[257],"activity.":[259],"did":[261],"not":[262],"change":[263],"transfected":[269],"CONCLUSIONS:":[273],"member":[277],"family":[281],"cytokines,":[283],"causes":[285],"without":[291],"altering":[292],"expression.":[294],"contrast":[296],"IL-6,":[301,328],"antagonists":[304],"act":[305],"agonists":[307],"This":[313],"may":[314],"be":[315],"attributable":[316],"recruitment":[318],"different":[320],"intermediary":[321],"transduction":[323],"proteins":[324],"respectively.":[329],"acquisition":[331],"agonistic":[333],"properties":[334],"blockers":[337],"might":[343],"compromise":[344],"use":[345],"these":[347],"drugs":[348],"treatment.":[352]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
