{"id":"https://openalex.org/W2147998910","doi":"https://doi.org/10.1158/1078-0432.ccr-06-1101","title":"In vivo Loss of Expression of Argininosuccinate Synthetase in Malignant Pleural Mesothelioma Is a Biomarker for Susceptibility to Arginine Depletion","display_name":"In vivo Loss of Expression of Argininosuccinate Synthetase in Malignant Pleural Mesothelioma Is a Biomarker for Susceptibility to Arginine Depletion","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W2147998910","doi":"https://doi.org/10.1158/1078-0432.ccr-06-1101","mag":"2147998910","pmid":"https://pubmed.ncbi.nlm.nih.gov/17145837"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-06-1101","doi":"https://doi.org/10.1158/1078-0432.ccr-06-1101","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-06-1101","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022032908","display_name":"Peter Wojciech Szlosarek","orcid":"https://orcid.org/0000-0002-5039-711X","observed_orcids":["https://orcid.org/0000-0002-5039-711X"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter W. Szlosarek","raw_affiliation_strings":["1Cancer Research UK Translational Oncology Laboratory, Barts and The London and","3Lung and Mesothelioma Unit, Department of Medical Oncology, Gloucester House, St. Bartholomew's Hospital, West Smithfield;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Research UK Translational Oncology Laboratory, Barts and The London and","institution_ids":["https://openalex.org/I2801316944"]},{"raw_affiliation_string":"3Lung and Mesothelioma Unit, Department of Medical Oncology, Gloucester House, St. Bartholomew's Hospital, West Smithfield;","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040044904","display_name":"Astero Klampatsa","orcid":"https://orcid.org/0000-0003-0572-502X","observed_orcids":["https://orcid.org/0000-0003-0572-502X"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Astero Klabatsa","raw_affiliation_strings":["2Barts Mesothelioma Research, Institute of Pathology, Royal London Hospital, Queen Mary's School of Medicine and Dentistry;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Barts Mesothelioma Research, Institute of Pathology, Royal London Hospital, Queen Mary's School of Medicine and Dentistry;","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I2801259928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081736844","display_name":"A. Pallaska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]},{"id":"https://openalex.org/I4210125479","display_name":"The Northern Ireland Cancer Centre","ror":"https://ror.org/030xykx52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1289110261","https://openalex.org/I4210125479"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Arben Pallaska","raw_affiliation_strings":["6Centre for Cancer Research and Cell Biology, Queen's University Belfast and Northern Ireland Cancer Centre, Belfast, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Centre for Cancer Research and Cell Biology, Queen's University Belfast and Northern Ireland Cancer Centre, Belfast, Northern Ireland","institution_ids":["https://openalex.org/I126231945","https://openalex.org/I4210125479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079505616","display_name":"Michael T. Sheaff","orcid":"https://orcid.org/0000-0001-9189-0181","observed_orcids":["https://orcid.org/0000-0001-9189-0181"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Sheaff","raw_affiliation_strings":["2Barts Mesothelioma Research, Institute of Pathology, Royal London Hospital, Queen Mary's School of Medicine and Dentistry;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Barts Mesothelioma Research, Institute of Pathology, Royal London Hospital, Queen Mary's School of Medicine and Dentistry;","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I2801259928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106084000","display_name":"Paul Smith","orcid":"https://orcid.org/0000-0002-8710-6830","observed_orcids":["https://orcid.org/0000-0002-8710-6830","https://orcid.org/0000-0002-1012-1530"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210090991","display_name":"Institute of Cancer Research","ror":"https://ror.org/00dpztj76","country_code":"CA","type":"facility","lineage":["https://openalex.org/I176337269","https://openalex.org/I4210090991"]}],"countries":["CA","GB"],"is_corresponding":false,"raw_author_name":"Paul Smith","raw_affiliation_strings":["4Cancer Genetics and Epigenetics, Breakthrough Breast Cancer Centre, Institute of Cancer Research;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Cancer Genetics and Epigenetics, Breakthrough Breast Cancer Centre, Institute of Cancer Research;","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210090991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056770144","display_name":"Tim Crook","orcid":"https://orcid.org/0000-0002-5005-8230","observed_orcids":["https://orcid.org/0000-0002-5005-8230"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210090991","display_name":"Institute of Cancer Research","ror":"https://ror.org/00dpztj76","country_code":"CA","type":"facility","lineage":["https://openalex.org/I176337269","https://openalex.org/I4210090991"]}],"countries":["CA","GB"],"is_corresponding":false,"raw_author_name":"Tim Crook","raw_affiliation_strings":["4Cancer Genetics and Epigenetics, Breakthrough Breast Cancer Centre, Institute of Cancer Research;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Cancer Genetics and Epigenetics, Breakthrough Breast Cancer Centre, Institute of Cancer Research;","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210090991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014297522","display_name":"Matthew J. Grimshaw","orcid":"https://orcid.org/0000-0002-4778-6114","observed_orcids":["https://orcid.org/0000-0002-4778-6114","https://orcid.org/0009-0008-8262-0874"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew J. Grimshaw","raw_affiliation_strings":["5Cancer Research UK Breast Cancer Biology Group, Guy's Hospital, London, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cancer Research UK Breast Cancer Biology Group, Guy's Hospital, London, United Kingdom; and","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113661873","display_name":"Jeremy P. C. Steele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jeremy P. Steele","raw_affiliation_strings":["3Lung and Mesothelioma Unit, Department of Medical Oncology, Gloucester House, St. Bartholomew's Hospital, West Smithfield;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Lung and Mesothelioma Unit, Department of Medical Oncology, Gloucester House, St. Bartholomew's Hospital, West Smithfield;","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111884115","display_name":"Robin Rudd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robin M. Rudd","raw_affiliation_strings":["3Lung and Mesothelioma Unit, Department of Medical Oncology, Gloucester House, St. Bartholomew's Hospital, West Smithfield;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Lung and Mesothelioma Unit, Department of Medical Oncology, Gloucester House, St. Bartholomew's Hospital, West Smithfield;","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061389369","display_name":"Frances R. Balkwill","orcid":"https://orcid.org/0000-0002-5587-9759","observed_orcids":["https://orcid.org/0000-0002-5587-9759"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Frances R. Balkwill","raw_affiliation_strings":["1Cancer Research UK Translational Oncology Laboratory, Barts and The London and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Research UK Translational Oncology Laboratory, Barts and The London and","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011181919","display_name":"Dean Anthony Fennell","orcid":"https://orcid.org/0000-0001-7373-1312","observed_orcids":["https://orcid.org/0000-0001-7373-1312"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]},{"id":"https://openalex.org/I4210125479","display_name":"The Northern Ireland Cancer Centre","ror":"https://ror.org/030xykx52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1289110261","https://openalex.org/I4210125479"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dean A. Fennell","raw_affiliation_strings":["6Centre for Cancer Research and Cell Biology, Queen's University Belfast and Northern Ireland Cancer Centre, Belfast, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Centre for Cancer Research and Cell Biology, Queen's University Belfast and Northern Ireland Cancer Centre, Belfast, Northern Ireland","institution_ids":["https://openalex.org/I126231945","https://openalex.org/I4210125479"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7184,"has_fulltext":false,"cited_by_count":181,"citation_normalized_percentile":{"value":0.94692733,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"12","issue":"23","first_page":"7126","last_page":"7131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-pleural-mesothelioma","display_name":"malignant pleural mesothelioma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/argininosuccinate-synthetase","display_name":"argininosuccinate synthetase","score":1.0},{"id":"https://openalex.org/keywords/arginine-deprivation","display_name":"arginine deprivation","score":0.968999981880188},{"id":"https://openalex.org/keywords/arginine-metabolism","display_name":"arginine metabolism","score":0.609000027179718},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7289999723434448},{"id":"https://openalex.org/keywords/promoter-cpg-methylation","display_name":"promoter CpG methylation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bax-activation","display_name":"Bax activation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/mitochondrial-membrane-depolarization","display_name":"mitochondrial depolarization","score":0.9390000104904175},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6190000176429749},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7200000286102295},{"id":"https://openalex.org/keywords/arginine-deprivation-therapy","display_name":"arginine deprivation therapy","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6419867277145386},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6019800305366516},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5807022452354431},{"id":"https://openalex.org/C188610204","wikidata":"https://www.wikidata.org/wiki/Q24741403","display_name":"Argininosuccinate synthase","level":5,"score":0.5602646470069885},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5457020998001099},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5415239334106445},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5051622986793518},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.48291656374931335},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47934016585350037},{"id":"https://openalex.org/C2776761436","wikidata":"https://www.wikidata.org/wiki/Q21173212","display_name":"Argininosuccinate lyase","level":5,"score":0.46372148394584656},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4263423681259155},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4214699864387512},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.4194491505622864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26725199818611145},{"id":"https://openalex.org/C164007495","wikidata":"https://www.wikidata.org/wiki/Q24721374","display_name":"Arginase","level":4,"score":0.24956080317497253},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18653514981269836},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001124","descriptor_name":"Argininosuccinate Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010997","descriptor_name":"Pleural Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010997","descriptor_name":"Pleural Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010997","descriptor_name":"Pleural Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051336","descriptor_name":"Mitochondrial Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1158/1078-0432.ccr-06-1101","doi":"https://doi.org/10.1158/1078-0432.ccr-06-1101","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-06-1101","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:17145837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17145837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/efa20214-5832-4f0c-9dfa-0efa63e0dff3","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/efa20214-5832-4f0c-9dfa-0efa63e0dff3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Szlosarek, PW, Klabatsa, A, Pallaska, A, Sheaff, M, Smith, P, Crook, T, Grimshaw, MJ, Steele, JP, Rudd, RM, Balkwill, FR & Fennell, DA 2006, 'In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion', Clinical Cancer Research, vol. 12, no. 23, pp. 7126 - 7131. https://doi.org/10.1158/1078-0432.CCR-06-1101","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lra.le.ac.uk:2381/13445","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2381/13445","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Journal Article"},{"id":"pmh:oai:pure.qub.ac.uk/portal:publications/471f8314-a729-44e1-bf60-a19203d991c9","doi":null,"is_oa":false,"landing_page_url":"https://pure.qub.ac.uk/en/publications/471f8314-a729-44e1-bf60-a19203d991c9","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Szlosarek, P W, Klabatsa, A, Pallaska, A, Sheaff, M, Smith, P, Crook, T, Grimshaw, M J, Steele, J P, Rudd, R M, Balkwill, F R & Fennell, D 2006, 'In vivo Loss of Expression of Argininosuccinate Synthetase in Malignant Pleural Mesothelioma is a Biomarker for Susceptibility to Arginine Depletion.', Clinical Cancer Research, vol. 12(23), no. 23, pp. 7126-7131. https://doi.org/10.1158/1078-0432.CCR-06-1101","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.46000000834465027,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W262159292","https://openalex.org/W1560524291","https://openalex.org/W1583557220","https://openalex.org/W1588371609","https://openalex.org/W1610616895","https://openalex.org/W1843927557","https://openalex.org/W1974620743","https://openalex.org/W1981158444","https://openalex.org/W1994065185","https://openalex.org/W2021227763","https://openalex.org/W2026707952","https://openalex.org/W2028953339","https://openalex.org/W2036607853","https://openalex.org/W2039962146","https://openalex.org/W2042205087","https://openalex.org/W2049066732","https://openalex.org/W2056584805","https://openalex.org/W2061950864","https://openalex.org/W2064607741","https://openalex.org/W2065249795","https://openalex.org/W2079276179","https://openalex.org/W2081477248","https://openalex.org/W2093073841","https://openalex.org/W2093907324","https://openalex.org/W2125063590","https://openalex.org/W2125690417","https://openalex.org/W2167874373","https://openalex.org/W2168974457","https://openalex.org/W2419604885","https://openalex.org/W4211134618"],"related_works":["https://openalex.org/W2040450347","https://openalex.org/W1973308486","https://openalex.org/W2245128592","https://openalex.org/W2512678052","https://openalex.org/W2245655314","https://openalex.org/W2533337811","https://openalex.org/W2483486587","https://openalex.org/W2602511395","https://openalex.org/W2595532165","https://openalex.org/W2520220390"],"abstract_inverted_index":{"PURPOSE:":[0],"Malignant":[1],"pleural":[2],"mesothelioma":[3],"(MPM)":[4],"is":[5,267],"an":[6],"increasing":[7],"health":[8],"burden":[9],"on":[10,35],"many":[11],"societies":[12],"worldwide":[13],"and,":[14],"being":[15],"generally":[16],"resistant":[17],"to":[18,42,254,256,269],"conventional":[19],"treatment,":[20],"has":[21],"a":[22,26,44,62,111,144,184,246],"poor":[23],"prognosis":[24],"with":[25,131,162,278],"median":[27],"survival":[28],"of":[29,38,58,74,79,86,91,104,134,140,154,169,171,260,273],"<1":[30],"year.":[31],"Novel":[32],"therapies":[33],"based":[34],"the":[36,53,99,102,105,138,151,155,163,192,202,271],"biology":[37],"this":[39,49],"tumor":[40],"seek":[41],"activate":[43],"proapoptotic":[45],"cellular":[46],"pathway.":[47],"In":[48,160,238],"study,":[50],"we":[51,71,240],"investigated":[52],"expression":[54],"and":[55,84,197,214,227],"biological":[56],"significance":[57],"argininosuccinate":[59],"synthetase":[60],"(AS),":[61],"rate-limiting":[63],"enzyme":[64],"in":[65,77,89,124,191,201,219,233,249,251,276],"arginine":[66,147,274],"production.":[67],"EXPERIMENTAL":[68],"DESIGN:":[69],"Initially,":[70],"documented":[72],"down-regulation":[73],"AS":[75,87,106,128,141,179,243],"mRNA":[76],"three":[78],"seven":[80,92],"MPM":[81,93,156,235,250],"cell":[82,94,125,157,164,194,204],"lines":[83,126,195],"absence":[85],"protein":[88],"four":[90],"lines.":[95,158],"We":[96],"confirmed":[97],"that":[98],"9q34":[100],"locus,":[101],"site":[103],"gene,":[107],"was":[108,119,148,209],"intact":[109],"using":[110,183],"1-Mb":[112],"comparative":[113],"genomic":[114],"hybridization":[115],"array;":[116],"however,":[117],"there":[118],"aberrant":[120],"promoter":[121],"CpG":[122],"methylation":[123],"lacking":[127],"expression,":[129],"consistent":[130],"epigenetic":[132],"regulation":[133],"transcription.":[135],"To":[136],"investigate":[137],"use":[139],"negativity":[142,244],"as":[143,181,245],"therapeutic":[145],"target,":[146],"removed":[149],"from":[150],"culture":[152],"medium":[153],"RESULTS:":[159],"keeping":[161],"line":[165],"data,":[166],"63%":[167],"(52":[168],"82)":[170],"patients":[172,277],"had":[173],"tumors":[174],"displaying":[175],"reduced":[176],"or":[177],"absent":[178],"protein,":[180],"assessed":[182],"tissue":[185],"microarray.":[186],"Cell":[187],"viability":[188],"declined":[189],"markedly":[190],"AS-negative":[193,234,279],"2591":[196],"MSTO":[198],"but":[199],"not":[200],"AS-positive":[203],"line,":[205],"28.":[206],"This":[207],"response":[208],"apparent":[210],"by":[211,216],"day":[212,217],"4":[213],"maintained":[215],"9":[218],"vitro.":[220],"Arginine":[221],"depletion":[222,275],"induced":[223],"BAX":[224],"conformation":[225],"change":[226],"mitochondrial":[228],"inner":[229],"membrane":[230],"depolarization":[231],"selectively":[232],"cells.":[236],"CONCLUSIONS:":[237],"summary,":[239],"have":[241],"identified":[242],"frequent":[247],"event":[248],"vivo,":[252],"leading":[253],"susceptibility":[255],"cytotoxicity":[257],"following":[258],"restriction":[259],"arginine.":[261],"A":[262],"phase":[263],"II":[264],"clinical":[265],"trial":[266],"planned":[268],"evaluate":[270],"role":[272],"MPM.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}