{"id":"https://openalex.org/W2147995324","doi":null,"title":"Down syndroom risicoschatting in het 1e trimester doorbepaling van PAPP-A en vrij beta-hCG in serum.","display_name":"Down syndroom risicoschatting in het 1e trimester doorbepaling van PAPP-A en vrij beta-hCG in serum.","publication_year":2003,"publication_date":"2003-08-19","ids":{"openalex":"https://openalex.org/W2147995324","mag":"2147995324"},"language":"nl","primary_location":{"id":"pmh:oai:rivm.openrepository.com:10029/256089","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10029/256089","pdf_url":null,"source":{"id":"https://openalex.org/S4306401814","display_name":"Rivm Repository (Netherlands National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Onderzoeksrapport"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10029/256089","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033681206","display_name":"Schielen Pcji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schielen Pcji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028612565","display_name":"L.H. Elvers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elvers Lh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026462999","display_name":"Loeber Jg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Loeber Jg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6455,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.73716539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9350000023841858},{"id":"https://openalex.org/keywords/prenatal-screening","display_name":"prenatal screening","score":0.8550000190734863},{"id":"https://openalex.org/keywords/first-trimester","display_name":"first trimester","score":0.7960000038146973},{"id":"https://openalex.org/keywords/papp-a","display_name":"PAPP-A","score":0.8650000095367432},{"id":"https://openalex.org/keywords/free-beta-hcg","display_name":"free beta-hCG","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nuchal-translucency","display_name":"nuchal translucency","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.4230000078678131},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.4860000014305115},{"id":"https://openalex.org/keywords/maternal-serum-markers","display_name":"maternal serum biomarkers","score":0.6589999794960022},{"id":"https://openalex.org/keywords/chorionic-villus-sampling","display_name":"chorionic villus sampling","score":0.5460000038146973},{"id":"https://openalex.org/keywords/amniocentesis","display_name":"amniocentesis","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.47143784165382385},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.43206387758255005},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.3363136053085327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3072224259376526},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.19757309556007385}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:rivm.openrepository.com:10029/256089","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10029/256089","pdf_url":null,"source":{"id":"https://openalex.org/S4306401814","display_name":"Rivm Repository (Netherlands National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Onderzoeksrapport"},{"id":"pmh:rivm:oai:rivm.openrepository.com:10029/256089","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10029/256089","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/report"},{"id":"mag:2147995324","doi":null,"is_oa":false,"landing_page_url":"https://rivm.openrepository.com/rivm/bitstream/10029/8804/1/199101008.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:rivm:oai:rivm.openrepository.com:10029/256089","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10029/256089","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/report"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1964591473","https://openalex.org/W1964682494","https://openalex.org/W1996101271","https://openalex.org/W2000421098","https://openalex.org/W2003207382","https://openalex.org/W2014981349","https://openalex.org/W2018762910","https://openalex.org/W2023850505","https://openalex.org/W2046683525","https://openalex.org/W2058995602","https://openalex.org/W2067231458","https://openalex.org/W2085565116","https://openalex.org/W2086278927","https://openalex.org/W2172110268","https://openalex.org/W2332313197","https://openalex.org/W2399017246","https://openalex.org/W2412527470"],"related_works":["https://openalex.org/W7135254519","https://openalex.org/W2023364884","https://openalex.org/W229616482","https://openalex.org/W2050065579","https://openalex.org/W2992532217","https://openalex.org/W2145615171","https://openalex.org/W2977711522","https://openalex.org/W2463904207","https://openalex.org/W4285039225","https://openalex.org/W2080937159"],"abstract_inverted_index":{"Het":[0,32],"Gezondheidsraadrapport":[1],"'Prenatale":[2],"screening.":[3],"Downsyndroom,":[4],"neuralebuisdefecten,":[5],"routine-echoscopie'":[6],"(1)":[7],"laat":[8],"nadrukkelijk":[9],"ruimte":[10],"voor":[11,17,57,188,284,320,323],"het":[12,21,46,58,106,112,119,142,148,154,193,213,220,231,303,331],"evalueren":[13],"van":[14,20,26,34,41,45,61,68,77,90,101,108,115,122,156,196,208,212,219,233,238,240,252,271,278,297,306,330,334],"nieuwe":[15,36],"methoden":[16,37],"de":[18,42,51,69,72,78,88,97,109,116,157,173,180,197,209,255,262,295,307,312,321,327],"schatting":[19],"risico":[22],"op":[23,65],"een":[24,27,40,62,66,281],"zwangerschap":[25,79,198,308],"kind":[28],"met":[29,87,141,179,268,311],"Down":[30,189,324],"syndroom.":[31,325],"onderzoeken":[33],"dergelijke":[35],"is":[38,55,319],"ook":[39],"expliciete":[43],"onderzoeksvragen":[44],"onderhavige":[47],"project.":[48],"Vooral":[49],"vanwege":[50],"verwachte":[52],"hoge":[53],"detectiegraad":[54],"gekozen":[56],"nader":[59],"uitwerken":[60],"risicoschattingsmethode":[63],"gebaseerd":[64],"meting":[67,89],"nekplooi":[70],"bij":[71,230],"foetus":[73],"in":[74,85,105,111,139,161,192,302,309],"week":[75],"10-14":[76],"(Eng:":[80],"nuchal":[81],"translucency":[82],"thickness;":[83],"NT),":[84],"combinatie":[86,310],"pregnancy-associated":[91],"plasma":[92],"protein":[93],"A":[94],"(PAPP-A)":[95],"en":[96,153,176,205,215,261,286,299,340],"vrije":[98],"beta":[99],"subunit":[100],"humaan":[102],"choriongonadodotropine":[103],"(fbeta-hCG)":[104],"bloed":[107],"moeder":[110],"1e":[113,164],"trimester":[114,165,195,305],"zwangerschap.":[117],"Voor":[118,326],"operationeel":[120],"maken":[121],"deze":[123,170,335],"methode":[124],"dienen":[125],"allereerst":[126],"betrouwbare":[127],"of":[128],"mediane":[129,234,245,257,264,314],"concentraties":[130,246,258,301,315],"(normaalwaarden)":[131],"per":[132,247,259,266,316],"zwangerschapsdag":[133,248,267,317],"vastgesteld":[134],"te":[135,224],"worden.":[136],"Dit":[137],"gebeurde":[138],"samenwerking":[140],"Onze":[143],"Lieve":[144],"Vrouwe":[145],"Gasthuis":[146],"(OLVG),":[147],"Academisch":[149],"Medisch":[150],"Centrum":[151],"(AMC),":[152],"ziekenhuis":[155],"Vrije":[158],"Universiteit":[159],"(VUMC)":[160],"Amsterdam,":[162],"die":[163,183],"sera":[166,171,243],"konden":[167],"aanleveren.":[168],"In":[169],"werden":[172,227,244],"concentratie":[174],"PAPP-A":[175,204,285,298],"fbeta-hCG":[177,206,287,300],"bepaald":[178],"AutoDelfia":[181],"methode,":[182],"al":[184],"routinematig":[185,332],"gebruikt":[186],"werd":[187],"syndroom":[190],"risicoschatting":[191],"tweede":[194],"(de":[199],"zgn.":[200],"triple":[201],"test).":[202],"De":[203,250,276],"metingen":[207],"serummonsters":[210],"afkomstig":[211],"VUMC":[214,221],"eerder":[216],"uitgevoerde":[217],"bepalingen":[218],"bleken":[222],"overeen":[223],"komen.":[225],"Ze":[226],"daarom":[228],"geincludeerd":[229],"modelleren":[232],"concentraties.":[235],"Op":[236],"basis":[237],"gegevens":[239,270],"338":[241],"geanalyseerde":[242],"berekend.":[249],"mate":[251],"overeenkomst":[253],"tussen":[254],"gevonden":[256],"zwangerschapsweek":[260],"gemodelleerde":[263,313],"waarden":[265],"beschikbare":[269],"andere":[272],"laboratoria":[273],"was":[274],"acceptabel.":[275,290],"resultaten":[277],"deelname":[279],"aan":[280],"extern":[282],"kwaliteitscontroleprogramma":[283],"waren":[288],"eveneens":[289],"Geconcludeerd":[291],"kan":[292],"worden":[293,342],"dat":[294],"bepaling":[296],"eerste":[304],"geschikt":[318],"risicoschattingen":[322,336],"verdere":[328],"voorbereiding":[329],"uitvoeren":[333],"zullen":[337],"logistieke":[338],"aspecten":[339],"kwaliteitsbewaking":[341],"uitgewerkt.":[343]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}