{"id":"https://openalex.org/W2147916997","doi":"https://doi.org/10.1111/j.1469-8137.2008.02637.x","title":"Functional analysis of the heavy metal binding domains of the Zn/Cd\u2010transporting ATPase, HMA2, in Arabidopsis thaliana","display_name":"Functional analysis of the heavy metal binding domains of the Zn/Cd\u2010transporting ATPase, HMA2, in Arabidopsis thaliana","publication_year":2008,"publication_date":"2008-10-09","ids":{"openalex":"https://openalex.org/W2147916997","doi":"https://doi.org/10.1111/j.1469-8137.2008.02637.x","mag":"2147916997","pmid":"https://pubmed.ncbi.nlm.nih.gov/19076719"},"language":"en","primary_location":{"id":"doi:10.1111/j.1469-8137.2008.02637.x","doi":"https://doi.org/10.1111/j.1469-8137.2008.02637.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1469-8137.2008.02637.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1469-8137.2008.02637.x","source":{"id":"https://openalex.org/S58631098","display_name":"New Phytologist","issn_l":"0028-646X","issn":["0028-646X","1469-8137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New Phytologist","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1469-8137.2008.02637.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006439843","display_name":"Chong Kum Edwin Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chong Kum Edwin Wong","raw_affiliation_strings":["Department of Genetics, The University of Melbourne, Parkville, Australia, 3010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The University of Melbourne, Parkville, Australia, 3010","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053917335","display_name":"Ren\u00e9e S. Jarvis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ren\u00e9e S. Jarvis","raw_affiliation_strings":["Department of Genetics, The University of Melbourne, Parkville, Australia, 3010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The University of Melbourne, Parkville, Australia, 3010","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005646876","display_name":"Sarah M. Sherson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sarah M. Sherson","raw_affiliation_strings":["Department of Genetics, The University of Melbourne, Parkville, Australia, 3010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The University of Melbourne, Parkville, Australia, 3010","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039291145","display_name":"Christopher S. Cobbett","orcid":"https://orcid.org/0000-0002-9480-395X","observed_orcids":["https://orcid.org/0000-0002-9480-395X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Christopher S. Cobbett","raw_affiliation_strings":["Department of Genetics, The University of Melbourne, Parkville, Australia, 3010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The University of Melbourne, Parkville, Australia, 3010","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039291145"],"corresponding_institution_ids":["https://openalex.org/I165779595"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":{"value":5790,"currency":"USD","value_usd":5790},"fwci":6.9738,"has_fulltext":true,"cited_by_count":121,"citation_normalized_percentile":{"value":0.96672618,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"181","issue":"1","first_page":"79","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11418","display_name":"Plant Micronutrient Interactions and Effects","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11418","display_name":"Plant Micronutrient Interactions and Effects","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13079","display_name":"Heavy Metals in Plants","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hma2","display_name":"HMA2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/zinc-transport","display_name":"zinc transport","score":0.5580000281333923},{"id":"https://openalex.org/keywords/cadmium-translocation","display_name":"cadmium translocation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/zinc-deficiency","display_name":"zinc deficiency","score":0.6940000057220459},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.8240000009536743},{"id":"https://openalex.org/keywords/transgenic-complementation","display_name":"transgenic complementation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.871074914932251},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.6644297242164612},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.5722641348838806},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5224553346633911},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.5141937732696533},{"id":"https://openalex.org/C2776053758","wikidata":"https://www.wikidata.org/wiki/Q105789","display_name":"Heavy metals","level":2,"score":0.43796834349632263},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43396157026290894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39271068572998047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38784724473953247},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3853292763233185},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29398196935653687},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.2062143087387085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15917634963989258},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.1375216841697693}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011868","descriptor_name":"Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018520","descriptor_name":"Plant Shoots","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1469-8137.2008.02637.x","doi":"https://doi.org/10.1111/j.1469-8137.2008.02637.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1469-8137.2008.02637.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1469-8137.2008.02637.x","source":{"id":"https://openalex.org/S58631098","display_name":"New Phytologist","issn_l":"0028-646X","issn":["0028-646X","1469-8137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New Phytologist","raw_type":"journal-article"},{"id":"pmid:19076719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19076719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New phytologist","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.955.3369","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.955.3369","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Chong_Wong2/publication/23657589_Functional_analysis_of_the_heavy_metal_binding_domains_of_the_ZnCd-transporting_ATPase_HMA2_in_Arabidopsis_thaliana/links/5473aefd0cf29afed60f5930.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1111/j.1469-8137.2008.02637.x","doi":"https://doi.org/10.1111/j.1469-8137.2008.02637.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1469-8137.2008.02637.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1469-8137.2008.02637.x","source":{"id":"https://openalex.org/S58631098","display_name":"New Phytologist","issn_l":"0028-646X","issn":["0028-646X","1469-8137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New Phytologist","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147916997.pdf","grobid_xml":"https://content.openalex.org/works/W2147916997.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1697247706","https://openalex.org/W1964339058","https://openalex.org/W1975062214","https://openalex.org/W1981119799","https://openalex.org/W1983828769","https://openalex.org/W1988821469","https://openalex.org/W1994421318","https://openalex.org/W1996500548","https://openalex.org/W2000647863","https://openalex.org/W2010320288","https://openalex.org/W2015732828","https://openalex.org/W2026831681","https://openalex.org/W2035056600","https://openalex.org/W2037444850","https://openalex.org/W2043715540","https://openalex.org/W2046274277","https://openalex.org/W2060913542","https://openalex.org/W2066158498","https://openalex.org/W2066543796","https://openalex.org/W2067826437","https://openalex.org/W2068251763","https://openalex.org/W2072950818","https://openalex.org/W2074905365","https://openalex.org/W2079464746","https://openalex.org/W2090895095","https://openalex.org/W2091899758","https://openalex.org/W2116122104","https://openalex.org/W2132194068","https://openalex.org/W2133332147","https://openalex.org/W2134695690","https://openalex.org/W2137481783"],"related_works":["https://openalex.org/W7100197424","https://openalex.org/W2810997679","https://openalex.org/W2037444850","https://openalex.org/W2010320288","https://openalex.org/W7098635594","https://openalex.org/W2139596562","https://openalex.org/W572258338","https://openalex.org/W7066245554","https://openalex.org/W1975062214","https://openalex.org/W2092350661"],"abstract_inverted_index":{"The":[0,87],"Zn/Cd-transporting":[1],"ATPase,":[2],"HMA2,":[3],"has":[4],"N-":[5],"and":[6,36,109,116],"C-terminal":[7,39,62,107,148],"domains":[8,27],"that":[9,134],"can":[10],"bind":[11],"Zn":[12],"ions":[13],"with":[14,35,73],"high":[15],"affinity.":[16],"Mutant":[17,33],"derivatives":[18,104],"were":[19,42],"generated":[20],"to":[21,28,53,126],"determine":[22],"the":[23,45,61,69,74,94,106,128,135,147,161,165],"significance":[24],"of":[25,68,76,138,164],"these":[26],"HMA2":[29,46,139],"function":[30,143],"in":[31,48,93,98,144],"planta.":[32],"derivatives,":[34],"without":[37],"a":[38,157],"GFP":[40],"tag,":[41],"expressed":[43],"from":[44],"promoter":[47],"transgenic":[49],"hma2,hma4,":[50],"Zn-deficient,":[51],"plants":[52],"test":[54],"for":[55,142,153,160],"functionality.":[56],"A":[57],"deletion":[58],"mutant":[59],"lacking":[60,105],"244":[63],"amino":[64,111],"acids":[65,112],"rescued":[66,113],"most":[67],"hma2,hma4":[70,129],"Zn-deficiency":[71],"phenotypes":[72,115],"exception":[75],"embryo":[77],"or":[78],"seed":[79],"development.":[80],"Root-to-shoot":[81],"Cd":[82],"translocation":[83],"was":[84,90,101],"fully":[85],"rescued.":[86],"GFP-tagged":[88],"derivative":[89],"partially":[91],"mis-localized":[92],"root":[95],"pericycle":[96],"cells":[97],"which":[99],"it":[100],"expressed.":[102],"Deletion":[103],"121":[108],"21":[110],"all":[114],"localized":[117,122],"normally.":[118],"N-terminal":[119,136],"domain":[120,137],"mutants":[121],"normally":[123],"but":[124],"failed":[125],"complement":[127],"phenotypes.":[130],"These":[131],"observations":[132],"suggest":[133],"is":[140],"essential":[141,152],"planta":[145],"while":[146],"domain,":[149],"although":[150],"not":[151],"function,":[154],"may":[155],"contain":[156],"signal":[158],"important":[159],"subcellular":[162],"localization":[163],"protein.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
