{"id":"https://openalex.org/W2147903025","doi":"https://doi.org/10.1158/1078-0432.ccr-09-1531","title":"Lestaurtinib Enhances the Antitumor Efficacy of Chemotherapy in Murine Xenograft Models of Neuroblastoma","display_name":"Lestaurtinib Enhances the Antitumor Efficacy of Chemotherapy in Murine Xenograft Models of Neuroblastoma","publication_year":2010,"publication_date":"2010-02-24","ids":{"openalex":"https://openalex.org/W2147903025","doi":"https://doi.org/10.1158/1078-0432.ccr-09-1531","mag":"2147903025","pmid":"https://pubmed.ncbi.nlm.nih.gov/20179224","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2831131"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-09-1531","doi":"https://doi.org/10.1158/1078-0432.ccr-09-1531","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-09-1531","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2831131","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007459093","display_name":"Radhika Iyer","orcid":"https://orcid.org/0000-0003-1287-3995","observed_orcids":["https://orcid.org/0000-0003-1287-3995"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Radhika Iyer","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108635422","display_name":"Audrey E. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey E. Evans","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034615840","display_name":"Xiao-Xue Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxue Qi","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064896199","display_name":"Ruth Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Ho","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079323221","display_name":"Jane E. Minturn","orcid":"https://orcid.org/0000-0001-9069-8761","observed_orcids":["https://orcid.org/0000-0001-9069-8761"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane E. Minturn","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064360802","display_name":"Huaqing Zhao","orcid":"https://orcid.org/0000-0002-0953-4768","observed_orcids":["https://orcid.org/0000-0002-0953-4768"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huaqing Zhao","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040926913","display_name":"Naomi Balamuth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naomi Balamuth","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005797590","display_name":"John M. Maris","orcid":"https://orcid.org/0000-0002-8088-7929","observed_orcids":["https://orcid.org/0000-0002-8088-7929"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Maris","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004950779","display_name":"Garrett M. Brodeur","orcid":"https://orcid.org/0000-0002-6721-122X","observed_orcids":["https://orcid.org/0000-0002-6721-122X"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Garrett M. Brodeur","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Oncology and 2Biostatistics and Data Management Core, Children's Hospital of Philadelphia; 3Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004950779"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":4.2565,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.95041503,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"5","first_page":"1478","last_page":"1485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lestaurtinib","display_name":"lestaurtinib","score":0.9580000042915344},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/trk-inhibitors","display_name":"TRK inhibitors","score":0.7049999833106995},{"id":"https://openalex.org/keywords/trkb","display_name":"TrkB","score":0.8119999766349792},{"id":"https://openalex.org/keywords/trka","display_name":"TrkA","score":0.9110000133514404},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.7910000085830688},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6869999766349792},{"id":"https://openalex.org/keywords/topotecan","display_name":"topotecan","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9800000190734863},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9860000014305115},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":1.0},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9319999814033508},{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.968999981880188},{"id":"https://openalex.org/keywords/fenretinide","display_name":"fenretinide","score":0.996999979019165},{"id":"https://openalex.org/keywords/murine-xenograft-model","display_name":"murine xenograft model","score":0.703000009059906},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C134139212","wikidata":"https://www.wikidata.org/wiki/Q24719927","display_name":"Trk receptor","level":4,"score":0.7862926721572876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6625293493270874},{"id":"https://openalex.org/C171034665","wikidata":"https://www.wikidata.org/wiki/Q14897694","display_name":"Tropomyosin receptor kinase A","level":4,"score":0.6107849478721619},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5534305572509766},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5218585729598999},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4524293839931488},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.45097655057907104},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43534374237060547},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4208833873271942},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.40056365728378296},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3599396347999573},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.33323997259140015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18821948766708374},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1836758255958557},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.06867191195487976},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077204","descriptor_name":"Temozolomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019772","descriptor_name":"Topotecan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020813","descriptor_name":"Receptor, trkB","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020813","descriptor_name":"Receptor, trkB","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-09-1531","doi":"https://doi.org/10.1158/1078-0432.ccr-09-1531","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-09-1531","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:20179224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20179224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2059661","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2831131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2831131","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2831131","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2059661","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2831131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3038975145","display_name":"Neuroblastoma Biology and Therapy","funder_award_id":"P01CA097323","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3596208140","display_name":"Trk Expression and Inhibition in Human Neuroblastomas","funder_award_id":"R01CA094194","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W205110300","https://openalex.org/W1495717719","https://openalex.org/W1535614393","https://openalex.org/W1545612850","https://openalex.org/W1571073982","https://openalex.org/W1592248506","https://openalex.org/W1778509032","https://openalex.org/W1838901836","https://openalex.org/W1847024738","https://openalex.org/W1972457909","https://openalex.org/W1990127813","https://openalex.org/W1999180631","https://openalex.org/W1999260088","https://openalex.org/W2000304313","https://openalex.org/W2002714389","https://openalex.org/W2007207475","https://openalex.org/W2020244870","https://openalex.org/W2037831105","https://openalex.org/W2055343221","https://openalex.org/W2066790769","https://openalex.org/W2066887304","https://openalex.org/W2067606868","https://openalex.org/W2076436122","https://openalex.org/W2083224002","https://openalex.org/W2088892407","https://openalex.org/W2089434047","https://openalex.org/W2104320396","https://openalex.org/W2108285412","https://openalex.org/W2125481027","https://openalex.org/W2125877707","https://openalex.org/W2126358767","https://openalex.org/W2128352319","https://openalex.org/W2132154679","https://openalex.org/W2135887304","https://openalex.org/W2140366271","https://openalex.org/W2144814885","https://openalex.org/W2154653852","https://openalex.org/W2163763677","https://openalex.org/W2164014081","https://openalex.org/W2326401583","https://openalex.org/W2327522594","https://openalex.org/W2405726856","https://openalex.org/W4211031423","https://openalex.org/W6629440339","https://openalex.org/W6632160541","https://openalex.org/W6676272449","https://openalex.org/W6678853435","https://openalex.org/W6680431818","https://openalex.org/W6681322355","https://openalex.org/W6682602230","https://openalex.org/W6684075789"],"related_works":["https://openalex.org/W2287835706","https://openalex.org/W2057410682","https://openalex.org/W1666486693","https://openalex.org/W2071605237","https://openalex.org/W1971291234","https://openalex.org/W2058008860","https://openalex.org/W81068911","https://openalex.org/W2059295983","https://openalex.org/W1847024738","https://openalex.org/W1490031581"],"abstract_inverted_index":{"PURPOSE:":[0],"Neuroblastoma,":[1],"a":[2,61],"common":[3],"pediatric":[4],"tumor":[5,90,100],"of":[6,29,71,116,119,154,195,209,215,229,248,257],"the":[7,53,113,117,193,207,216,227,246],"sympathetic":[8],"nervous":[9],"system,":[10],"is":[11,31,42,236],"characterized":[12],"by":[13,213],"clinical":[14,35,255],"heterogeneity.":[15],"The":[16],"Trk":[17,249,264],"family":[18],"neurotrophin":[19],"receptors":[20],"play":[21],"an":[22,45],"important":[23],"role":[24],"in":[25,60,75,80,198,201,254],"this":[26,180],"behavior.":[27],"Expression":[28],"TrkA":[30],"associated":[32,43],"with":[33,44,77,161,174],"favorable":[34],"features":[36],"and":[37,102,128,143,200,203],"outcome,":[38],"whereas":[39],"TrkB":[40],"expression":[41],"unfavorable":[46],"prognosis.":[47],"We":[48,67,187],"wanted":[49],"to":[50,93,164,238],"determine":[51],"if":[52],"Trk-selective":[54],"inhibitor":[55],"lestaurtinib":[56,72,162,165,173,190],"had":[57,182],"therapeutic":[58],"efficacy":[59,115,208,228],"preclinical":[62],"neuroblastoma":[63,82,196,258],"model.":[64],"EXPERIMENTAL":[65],"DESIGN:":[66],"performed":[68],"intervention":[69],"trials":[70,256],"alone":[73,87],"or":[74,134,159,259],"combination":[76,181],"other":[78,260],"agents":[79],"TrkB-overexpressing":[81],"xenograft":[83],"models.":[84],"RESULTS:":[85],"Lestaurtinib":[86,110],"significantly":[88],"inhibited":[89],"growth":[91,170,194],"compared":[92,163],"vehicle-treated":[94],"animals":[95],"[P":[96],"=":[97,104,139,145],"0.0004":[98],"for":[99,106,126,132,141,147,267],"size":[101,127,142],"P":[103,129,144],"0.011":[105,140],"event-free":[107],"survival":[108,221],"(EFS)].":[109],"also":[111,225],"enhanced":[112],"antitumor":[114],"combinations":[118],"topotecan":[120],"plus":[121,136],"cyclophosphamide":[122],"(P":[123,138,176],"<":[124,130,177],"0.0001":[125,131],"EFS)":[133],"irinotecan":[135],"temozolomide":[137],"0.012":[146],"EFS).":[148],"There":[149,167],"was":[150,168],"no":[151],"additive":[152],"benefit":[153],"combining":[155,172],"either":[156],"13-cis-retinoic":[157],"acid":[158],"fenretinide":[160],"alone.":[166],"dramatic":[169],"inhibition":[171,214],"bevacizumab":[175],"0.0001),":[178],"but":[179,233],"substantial":[183],"systemic":[184],"toxicity.":[185],"CONCLUSIONS:":[186],"show":[188],"that":[189],"can":[191,204],"inhibit":[192],"both":[197],"vitro":[199],"vivo":[202],"substantially":[205],"enhance":[206,226],"conventional":[210],"chemotherapy,":[211],"presumably":[212],"Trk/brain-derived":[217],"neurotrophic":[218],"factor":[219],"autocrine":[220],"pathway.":[222],"It":[223],"may":[224],"selected":[230],"biological":[231],"agents,":[232],"further":[234],"testing":[235],"required":[237],"rule":[239],"out":[240],"unanticipated":[241],"toxicities.":[242],"Our":[243],"data":[244],"support":[245],"incorporation":[247],"inhibitors,":[250],"such":[251],"as":[252],"lestaurtinib,":[253],"tumors":[261],"relying":[262],"on":[263],"signaling":[265],"pathways":[266],"survival.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
