{"id":"https://openalex.org/W2147758045","doi":"https://doi.org/10.1099/0022-1317-33-1-1","title":"The Effects of Cytochalasin and Colchicine on Interferon Production","display_name":"The Effects of Cytochalasin and Colchicine on Interferon Production","publication_year":1976,"publication_date":"1976-10-01","ids":{"openalex":"https://openalex.org/W2147758045","doi":"https://doi.org/10.1099/0022-1317-33-1-1","mag":"2147758045","pmid":"https://pubmed.ncbi.nlm.nih.gov/185321"},"language":"en","primary_location":{"id":"doi:10.1099/0022-1317-33-1-1","doi":"https://doi.org/10.1099/0022-1317-33-1-1","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-33-1-1","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045428983","display_name":"Yasutoshi Ito","orcid":"https://orcid.org/0000-0001-9515-953X","observed_orcids":["https://orcid.org/0000-0001-9515-953X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Ito","raw_affiliation_strings":["Germfree Life Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Germfree Life Research Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111793377","display_name":"Yukiko Nishiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Nishiyama","raw_affiliation_strings":["Germfree Life Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Germfree Life Research Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010928312","display_name":"Kaoru Shimokata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Shimokata","raw_affiliation_strings":["Germfree Life Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Germfree Life Research Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Kimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Kimura","raw_affiliation_strings":["Germfree Life Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Germfree Life Research Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052092167","display_name":"Ikuya Nagata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Nagata","raw_affiliation_strings":["Germfree Life Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Germfree Life Research Institute","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043594973","display_name":"Akira Kunii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A. Kunii","raw_affiliation_strings":["1st Department of Internal Medicine Nagoya University School of Medicine Showa-ku, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine Nagoya University School of Medicine Showa-ku, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3699,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.58744654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"33","issue":"1","first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-production","display_name":"interferon production","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cytochalasin-b","display_name":"cytochalasin B","score":0.9890000224113464},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":1.0},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.8709999918937683},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":1.0},{"id":"https://openalex.org/keywords/sendai-virus","display_name":"Sendai virus","score":0.765999972820282},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.9039999842643738},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.8625322580337524},{"id":"https://openalex.org/C2780127873","wikidata":"https://www.wikidata.org/wiki/Q1055751","display_name":"Sendai virus","level":3,"score":0.8464030027389526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8212928771972656},{"id":"https://openalex.org/C2779012151","wikidata":"https://www.wikidata.org/wiki/Q26998028","display_name":"Cytochalasin B","level":3,"score":0.6677210927009583},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.650478720664978},{"id":"https://openalex.org/C33263850","wikidata":"https://www.wikidata.org/wiki/Q4838438","display_name":"Baby hamster kidney cell","level":3,"score":0.5973078608512878},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5802415013313293},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.5085920095443726},{"id":"https://openalex.org/C189040839","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Microfilament","level":4,"score":0.48456183075904846},{"id":"https://openalex.org/C2775995422","wikidata":"https://www.wikidata.org/wiki/Q5201335","display_name":"Cytochalasin","level":4,"score":0.4374780058860779},{"id":"https://openalex.org/C2779617845","wikidata":"https://www.wikidata.org/wiki/Q1563808","display_name":"Superinfection","level":3,"score":0.4304947853088379},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.27009838819503784},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2529767155647278},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23393359780311584},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1757661998271942},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16515123844146729},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.10853096842765808}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003571","descriptor_name":"Cytochalasin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003572","descriptor_name":"Cytochalasins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010222","descriptor_name":"Parainfluenza Virus 1, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1099/0022-1317-33-1-1","doi":"https://doi.org/10.1099/0022-1317-33-1-1","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-33-1-1","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmid:185321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/185321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1550153657","https://openalex.org/W1987581189","https://openalex.org/W2008190738"],"related_works":["https://openalex.org/W7099398023","https://openalex.org/W2063338647","https://openalex.org/W7096986365","https://openalex.org/W2335542911","https://openalex.org/W2115148001","https://openalex.org/W1987581189","https://openalex.org/W1847462117","https://openalex.org/W2139523841","https://openalex.org/W2182619106","https://openalex.org/W2012267833"],"abstract_inverted_index":{"The":[0],"present":[1],"study":[2],"was":[3],"undertaken":[4],"to":[5,40],"investigate":[6],"the":[7,28,46],"mechanism":[8],"of":[9,33,70],"interferon":[10,71],"production":[11,72],"by":[12],"mouse":[13],"spleen":[14],"cells":[15,24],"co-cultivated":[16],"with":[17,27],"BHK-HVJ":[18],"cells,":[19],"i.e.":[20],"baby":[21],"hamster":[22],"kidney":[23],"persistently":[25],"infected":[26],"HVJ":[29],"(or":[30],"Sendai)":[31],"strain":[32],"para-influenza":[34],"I":[35],"virus.":[36],"Cytochalasin":[37],"B":[38],"appears":[39],"inhibit":[41],"an":[42,67],"early":[43],"stage":[44,69],"in":[45,63,73],"process":[47],"and":[48,59],"colchicine":[49],"a":[50],"relatively":[51],"late":[52],"stage.":[53],"It":[54],"is":[55],"suggested":[56],"that":[57],"microfilaments":[58],"microtubules":[60],"may":[61],"play":[62],"important":[64],"role":[65],"at":[66],"initial":[68],"this":[74],"system.":[75]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}