{"id":"https://openalex.org/W2147681024","doi":"https://doi.org/10.1186/s13075-015-0516-6","title":"Golimumab in patients with active rheumatoid arthritis after treatment with tumor necrosis factor \u03b1 inhibitors: findings with up to five years of treatment in the multicenter, randomized, double-blind, placebo-controlled, phase 3 GO-AFTER study","display_name":"Golimumab in patients with active rheumatoid arthritis after treatment with tumor necrosis factor \u03b1 inhibitors: findings with up to five years of treatment in the multicenter, randomized, double-blind, placebo-controlled, phase 3 GO-AFTER study","publication_year":2015,"publication_date":"2015-01-22","ids":{"openalex":"https://openalex.org/W2147681024","doi":"https://doi.org/10.1186/s13075-015-0516-6","mag":"2147681024","pmid":"https://pubmed.ncbi.nlm.nih.gov/25627338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4382834"},"language":"en","primary_location":{"id":"doi:10.1186/s13075-015-0516-6","doi":"https://doi.org/10.1186/s13075-015-0516-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0516-6","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0516-6.pdf","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0516-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111657027","display_name":"Josef S Smolen","orcid":"https://orcid.org/0000-0002-8899-9087","observed_orcids":["https://orcid.org/0000-0002-8899-9087"]},"institutions":[{"id":"https://openalex.org/I4210089076","display_name":"Klinik Hietzing","ror":"https://ror.org/00621wh10","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210089076","https://openalex.org/I4210117134"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Josef S Smolen","raw_affiliation_strings":["Department of Medicine III, Hietzing Hospital, Waehringer Guertel 18-20, Vienna, A-1090, Austria. josef.smolen@wienkav.at","Department of Medicine, Medical University of Vienna, Hietzing Hospital, Vienna, Austria. josef.smolen@wienkav.at","Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria. josef.smolen@wienkav.at"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, Hietzing Hospital, Waehringer Guertel 18-20, Vienna, A-1090, Austria. josef.smolen@wienkav.at","institution_ids":["https://openalex.org/I4210089076"]},{"raw_affiliation_string":"Department of Medicine, Medical University of Vienna, Hietzing Hospital, Vienna, Austria. josef.smolen@wienkav.at","institution_ids":["https://openalex.org/I4210089076","https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria. josef.smolen@wienkav.at","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028063859","display_name":"Jonathan Kay","orcid":"https://orcid.org/0000-0002-8970-4260","observed_orcids":["https://orcid.org/0000-0002-8970-4260"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210162397","display_name":"UMass Memorial Medical Center","ror":"https://ror.org/053v00853","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303243448","https://openalex.org/I166722992","https://openalex.org/I4210162397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Kay","raw_affiliation_strings":["University of Massachusetts Medical School and UMass Memorial Center, Rheumatology Center, Memorial Campus, 119 Belmont Street, Worcester, MA, 01605, USA. jonathan.kay@umassmemorial.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Medical School and UMass Memorial Center, Rheumatology Center, Memorial Campus, 119 Belmont Street, Worcester, MA, 01605, USA. jonathan.kay@umassmemorial.org","institution_ids":["https://openalex.org/I166722992","https://openalex.org/I4210162397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051248102","display_name":"Mittie K. Doyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125492","display_name":"Alexion Pharmaceuticals (United States)","ror":"https://ror.org/031ywxc85","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mittie Doyle","raw_affiliation_strings":["Translational Medicine Group, Alexion Pharmaceuticals, 75 Sidney Street, Cambridge, MA, 02139, USA. mittiekdoyle@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Group, Alexion Pharmaceuticals, 75 Sidney Street, Cambridge, MA, 02139, USA. mittiekdoyle@hotmail.com","institution_ids":["https://openalex.org/I4210125492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000282057","display_name":"Robert Landew\u00e9","orcid":"https://orcid.org/0000-0002-0577-6620","observed_orcids":["https://orcid.org/0000-0002-0577-6620"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210127939","display_name":"Atrium Medisch Centrum Parkstad","ror":"https://ror.org/0367sye10","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127939","https://openalex.org/I4210133559","https://openalex.org/I4210166163"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert Landew\u00e9","raw_affiliation_strings":["Academic Medical Center/University of Amsterdam & Atrium Medical Center Heerlen, Henri Dunantstraat 5, Heerlen, PC, 6419, The Netherlands. landewe@rlandewe.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Medical Center/University of Amsterdam & Atrium Medical Center Heerlen, Henri Dunantstraat 5, Heerlen, PC, 6419, The Netherlands. landewe@rlandewe.nl","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210127939","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052273654","display_name":"Eric L. Matteson","orcid":"https://orcid.org/0000-0002-9866-0124","observed_orcids":["https://orcid.org/0000-0002-9866-0124"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L Matteson","raw_affiliation_strings":["Divisions of Rheumatology and Epidemiology, Mayo Clinic College of Medicine, 200 1st St. S.W., Rochester, MN, 55905, USA. matteson.eric@mayo.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Rheumatology and Epidemiology, Mayo Clinic College of Medicine, 200 1st St. S.W., Rochester, MN, 55905, USA. matteson.eric@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055224792","display_name":"NORMAN B. GAYLIS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095528","display_name":"Arthritis and Rheumatic Disease Specialties","ror":"https://ror.org/00n3baz54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman Gaylis","raw_affiliation_strings":["Arthritis & Rheumatic Disease Specialties, 21097 NE 27th Court, Suite 200, Aventura, FL, 33180, USA. ngaylis@aol.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis & Rheumatic Disease Specialties, 21097 NE 27th Court, Suite 200, Aventura, FL, 33180, USA. ngaylis@aol.com","institution_ids":["https://openalex.org/I4210095528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112722772","display_name":"J\u00fcrgen Wollenhaupt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101674","display_name":"Sch\u00f6n Klinik Hamburg Eilbek","ror":"https://ror.org/00pz61m54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088209","https://openalex.org/I4210101674"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Wollenhaupt","raw_affiliation_strings":["Schoen Klinik Hamburg Eilbek, Dehnhaide 120, Hamburg, 22081, Germany. j.wollenhaupt@t-online.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schoen Klinik Hamburg Eilbek, Dehnhaide 120, Hamburg, 22081, Germany. j.wollenhaupt@t-online.de","institution_ids":["https://openalex.org/I4210101674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028490996","display_name":"Frederick T. Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4210112965","display_name":"Altoona Center for Clinical Research","ror":"https://ror.org/022q8ez38","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210112965"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick T Murphy","raw_affiliation_strings":["Altoona Center of Clinical Research, 175 Meadowbrook Lane, PO Box 1018, Duncansville, PA, 16635, USA. ftmurphy8@gmail.com","Division of Rheumatology, University of Pennsylvania Medical School and Hospital of the University of Pennsylvania, Perelman Center 1 South, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA. ftmurphy8@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altoona Center of Clinical Research, 175 Meadowbrook Lane, PO Box 1018, Duncansville, PA, 16635, USA. ftmurphy8@gmail.com","institution_ids":["https://openalex.org/I4210112965"]},{"raw_affiliation_string":"Division of Rheumatology, University of Pennsylvania Medical School and Hospital of the University of Pennsylvania, Perelman Center 1 South, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA. ftmurphy8@gmail.com","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027011800","display_name":"Stephen Xu","orcid":"https://orcid.org/0000-0002-1516-3123","observed_orcids":["https://orcid.org/0000-0002-1516-3123"]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Xu","raw_affiliation_strings":["Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA. sxu2@its.jnj.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA. sxu2@its.jnj.com","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025049914","display_name":"Yiying Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiying Zhou","raw_affiliation_strings":["Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA. yzhou45@its.jnj.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA. yzhou45@its.jnj.com","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030325032","display_name":"Elizabeth C. Hsia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth C Hsia","raw_affiliation_strings":["Division of Rheumatology, University of Pennsylvania Medical School and Hospital of the University of Pennsylvania, Perelman Center 1 South, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA. ehsia@its.jnj.com","Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA. ehsia@its.jnj.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Pennsylvania Medical School and Hospital of the University of Pennsylvania, Perelman Center 1 South, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA. ehsia@its.jnj.com","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Janssen Research & Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA. ehsia@its.jnj.com","institution_ids":["https://openalex.org/I4405282460"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5111657027"],"corresponding_institution_ids":["https://openalex.org/I4210089076","https://openalex.org/I76134821"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":5.8787,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.96517227,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"14","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/golimumab","display_name":"golimumab","score":0.9950000047683716},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.7839999794960022},{"id":"https://openalex.org/keywords/anti-tnf-therapy","display_name":"anti-TNF therapy","score":0.6520000100135803},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8640000224113464},{"id":"https://openalex.org/keywords/long-term-treatment-safety","display_name":"long-term treatment safety","score":0.6470000147819519},{"id":"https://openalex.org/keywords/acr-response","display_name":"ACR response","score":0.6639999747276306},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.3659999966621399},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.382999986410141},{"id":"https://openalex.org/keywords/treatment-escape","display_name":"treatment escape","score":0.3370000123977661},{"id":"https://openalex.org/keywords/intention-to-treat-analysis","display_name":"intention-to-treat analysis","score":0.699999988079071},{"id":"https://openalex.org/keywords/non-responder-imputation","display_name":"non-responder imputation","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2781290027","wikidata":"https://www.wikidata.org/wiki/Q413879","display_name":"Golimumab","level":4,"score":0.9885006546974182},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8943547010421753},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7864611148834229},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6791911721229553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6335732340812683},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.6157994866371155},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.5849191546440125},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5594298839569092},{"id":"https://openalex.org/C2777226972","wikidata":"https://www.wikidata.org/wiki/Q415343","display_name":"Etanercept","level":3,"score":0.44360464811325073},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.361011803150177},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.04825010895729065},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s13075-015-0516-6","doi":"https://doi.org/10.1186/s13075-015-0516-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0516-6","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0516-6.pdf","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3348689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4382834","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4382834","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4382834","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Res Ther","raw_type":"Text"},{"id":"pmid:25627338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25627338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis research & therapy","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/64063541-dfeb-4616-9c16-3a9bb42dc574","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/64063541-dfeb-4616-9c16-3a9bb42dc574","pdf_url":"https://pure.amsterdamumc.nl/files/160696797/Golimumab-in-patients-with-active-rheumatoid-arthritis-after-treatment-with-tumor-necrosis-factor-a-inhibitors-findings.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Smolen, J S, Kay, J, Doyle, M, Landew\u00e9, R, Matteson, E L, Gaylis, N, Wollenhaupt, J, Murphy, F T, Xu, S, Zhou, Y & Hsia, E C 2015, 'Golimumab in patients with active rheumatoid arthritis after treatment with tumor necrosis factor a inhibitors: findings with up to five years of treatment in the multicenter, randomized, double-blind, placebo-controlled, phase 3 GO-AFTER study', Arthritis research & therapy, vol. 17, pp. 14. https://doi.org/10.1186/s13075-015-0516-6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/c694e603-4494-4429-9c17-c095e94800b6","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/golimumab-in-patients-with-active-rheumatoid-arthritis-after-treatment-with-tumor-necrosis-factor-a-inhibitors-findings-with-up-to-five-years-of-treatment-in-the-multicenter-randomized-doubleblind-placebocontrolled-phase-3-goafter-study(c694e603-4494-4429-9c17-c095e94800b6).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arthritis research & therapy, 17. BioMed Central","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s13075-015-0516-6","doi":"https://doi.org/10.1186/s13075-015-0516-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0516-6","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0516-6.pdf","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320309052","display_name":"Alexion Pharmaceuticals","ror":"https://ror.org/031ywxc85"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320309117","display_name":"AbbVie","ror":"https://ror.org/02g5p4n58"},{"id":"https://openalex.org/F4320318324","display_name":"Cardinal Health","ror":"https://ror.org/03pd82777"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320328692","display_name":"Medac","ror":"https://ror.org/05e0gzh77"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320333003","display_name":"Chugai Pharmaceutical","ror":"https://ror.org/01vepzj85"},{"id":"https://openalex.org/F4320337415","display_name":"Janssen Research and Development","ror":"https://ror.org/03qd7mz70"},{"id":"https://openalex.org/F4320337449","display_name":"Janssen Biotech","ror":"https://ror.org/03qd7mz70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147681024.pdf","grobid_xml":"https://content.openalex.org/works/W2147681024.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1492940207","https://openalex.org/W1977445011","https://openalex.org/W1985004174","https://openalex.org/W2006823644","https://openalex.org/W2009928292","https://openalex.org/W2017281030","https://openalex.org/W2065419533","https://openalex.org/W2099334955","https://openalex.org/W2099680326","https://openalex.org/W2109655434","https://openalex.org/W2110177517","https://openalex.org/W2127532898","https://openalex.org/W2140965629","https://openalex.org/W2143835145","https://openalex.org/W2146166312","https://openalex.org/W2152348310","https://openalex.org/W2157885750","https://openalex.org/W2159106700","https://openalex.org/W3202296429","https://openalex.org/W4210768724","https://openalex.org/W4249063051","https://openalex.org/W4308769923"],"related_works":["https://openalex.org/W7000686995","https://openalex.org/W2109655434","https://openalex.org/W2118761321","https://openalex.org/W2140965629","https://openalex.org/W2099046622","https://openalex.org/W1988975600","https://openalex.org/W4200498192","https://openalex.org/W2332542893","https://openalex.org/W1981553585","https://openalex.org/W1966756501"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1],"aim":[2],"of":[3,34,162,171,185],"this":[4,28],"study":[5,33,168],"was":[6,218,253],"to":[7,74,88,116,125,194,199,205],"assess":[8],"long-term":[9],"golimumab":[10,47,75,89,95,110,244],"therapy":[11],"in":[12,62,177],"rheumatoid":[13],"arthritis":[14],"(RA)":[15],"patients":[16,86,136,139,165,187,236],"who":[17],"discontinued":[18],"previous":[19,241],"tumor":[20],"necrosis":[21],"factor-\u03b1":[22],"(TNF)-inhibitor(s).":[23],"METHODS:":[24],"Patients":[25,61],"enrolled":[26],"into":[27],"multicenter,":[29],"randomized,":[30],"double-blind,":[31],"placebo-controlled":[32],"active":[35,238],"RA":[36,239],"(\u22654":[37],"tender,":[38],"\u22654":[39],"swollen":[40],"joints)":[41],"received":[42,166],"placebo":[43],"(Group":[44,50,55],"1)":[45],"or":[46,52],"50":[48,76,90,111,126],"mg":[49,54,97,112,121],"2)":[51],"100":[53,78,117,120],"3)":[56],"injections":[57],"every":[58],"4":[59],"weeks.":[60],"Groups":[63],"1":[64,85],"and":[65,77,101,119,138,151,175,203,226,229,246],"2":[66,93],"with":[67,146,221,237,250],"inadequate":[68],"response":[69,209],"at":[70,223],"week":[71,82,181,216,224,227],"16":[72],"escaped":[73],"mg,":[79,91,118],"respectively.":[80],"At":[81],"24,":[83],"Group":[84,92,102],"crossed-over":[87],"continued":[94],"50/100":[96],"per":[98],"escape":[99],"status,":[100],"3":[103],"maintained":[104],"dosing.":[105],"During":[106],"the":[107,167,183],"long-term-extension":[108],"(LTE),":[109],"could":[113,122],"be":[114,123],"increased":[115],"decreased":[124],"mg.":[127],"Data":[128],"through":[129,215,255],"5":[130,256],"years":[131],"are":[132],"reported":[133],"for":[134,148,154,196,201,207],"all":[135],"(safety)":[137],"using":[140],"methotrexate":[141],"(efficacy,":[142],"intention-to-treat":[143],"(ITT)":[144],"analysis":[145],"last-observation-carried-forward":[147],"missing":[149],"data":[150],"non-responder":[152],"imputation":[153],"unsatisfactory":[155],"efficacy":[156,178],"discontinuations).":[157],"RESULTS:":[158],"In":[159,234],"total,":[160],"459":[161],"461":[163],"randomized":[164,211],"agent,":[169],"304":[170],"whom":[172],"were":[173,192],"methotrexate-treated":[174,186],"included":[176],"analyses.":[179],"Through":[180],"256,":[182],"proportions":[184],"achieving":[188],"American-College-of-Rheumatology":[189],"(ACR)":[190],"responses":[191],"37.6%":[193],"47.0%":[195],"ACR20,":[197],"21.4%":[198],"35.0%":[200],"ACR50,":[202],"7.8%":[204],"17.0%":[206],"ACR70":[208],"across":[210],"groups.":[212],"Golimumab":[213],"safety":[214,245],"268":[217],"generally":[219],"consistent":[220],"that":[222],"24":[225],"160":[228],"other":[230],"anti-TNF":[231],"agents.":[232],"CONCLUSIONS:":[233],"some":[235],"discontinuing":[240],"TNF-antagonist":[242],"therapy,":[243],"efficacy,":[247],"assessed":[248],"conservatively":[249],"ITT":[251],"analyses,":[252],"confirmed":[254],"years.":[257],"TRIAL":[258],"REGISTRATION:":[259],"Clinicaltrials.gov":[260],"NCT00299546":[261],".":[262],"Registered":[263],"03":[264],"March":[265],"2006.":[266]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}