{"id":"https://openalex.org/W2147679857","doi":"https://doi.org/10.1152/physiolgenomics.00069.2012","title":"Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition","display_name":"Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition","publication_year":2012,"publication_date":"2012-09-19","ids":{"openalex":"https://openalex.org/W2147679857","doi":"https://doi.org/10.1152/physiolgenomics.00069.2012","mag":"2147679857","pmid":"https://pubmed.ncbi.nlm.nih.gov/22991207"},"language":"en","primary_location":{"id":"doi:10.1152/physiolgenomics.00069.2012","doi":"https://doi.org/10.1152/physiolgenomics.00069.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiolgenomics.00069.2012","pdf_url":null,"source":{"id":"https://openalex.org/S57123121","display_name":"Physiological Genomics","issn_l":"1094-8341","issn":["1094-8341","1531-2267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041753848","display_name":"Martin J. J. Ronis","orcid":"https://orcid.org/0000-0002-0116-3771","observed_orcids":["https://orcid.org/0000-0002-0116-3771"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. J. J. Ronis","raw_affiliation_strings":["Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","Department of Pharmacology &amp; Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pharmacology &amp; Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046979664","display_name":"January N. Baumgardner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. N. Baumgardner","raw_affiliation_strings":["Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","Department of Pharmacology &amp; Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pharmacology &amp; Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000620718","display_name":"John C. Marecki","orcid":"https://orcid.org/0000-0003-1991-8949","observed_orcids":["https://orcid.org/0000-0003-1991-8949"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. Marecki","raw_affiliation_strings":["Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013397406","display_name":"Leah J. Hennings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Hennings","raw_affiliation_strings":["Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023588495","display_name":"Xianli Wu","orcid":"https://orcid.org/0000-0002-0094-3258","observed_orcids":["https://orcid.org/0000-0002-0094-3258"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Wu","raw_affiliation_strings":["Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035081477","display_name":"Kartik Shankar","orcid":"https://orcid.org/0000-0002-7964-9026","observed_orcids":["https://orcid.org/0000-0002-7964-9026"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Shankar","raw_affiliation_strings":["Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085115101","display_name":"Mario Alberto Cleves","orcid":"https://orcid.org/0000-0003-1645-494X","observed_orcids":["https://orcid.org/0000-0003-1645-494X"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. Cleves","raw_affiliation_strings":["Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056294115","display_name":"Horacio G\u00f3mez-Acevedo","orcid":"https://orcid.org/0000-0002-1570-1606","observed_orcids":["https://orcid.org/0000-0002-1570-1606"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Gomez-Acevedo","raw_affiliation_strings":["Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076259954","display_name":"Thomas M. Badger","orcid":"https://orcid.org/0000-0003-1159-7191","observed_orcids":["https://orcid.org/0000-0003-1159-7191"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. M. Badger","raw_affiliation_strings":["Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","Department of Physiology &amp; Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas;","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Physiology &amp; Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041753848"],"corresponding_institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"],"apc_list":null,"apc_paid":null,"fwci":3.3417,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.92,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"44","issue":"22","first_page":"1073","last_page":"1089"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dietary-fat-source","display_name":"dietary fat source","score":0.7979999780654907},{"id":"https://openalex.org/keywords/olive-oil","display_name":"olive oil","score":0.9909999966621399},{"id":"https://openalex.org/keywords/corn-oil","display_name":"corn oil","score":0.9980000257492065},{"id":"https://openalex.org/keywords/echium-oil","display_name":"echium oil","score":0.9850000143051147},{"id":"https://openalex.org/keywords/total-enteral-nutrition","display_name":"total enteral nutrition","score":0.871999979019165},{"id":"https://openalex.org/keywords/overfeeding","display_name":"overfeeding","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hepatic-gene-expression","display_name":"hepatic gene expression","score":0.9449999928474426},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6769999861717224},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.5899999737739563},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/srebp-1c","display_name":"SREBP-1c","score":0.8529999852180481},{"id":"https://openalex.org/keywords/chrebp","display_name":"ChREBP","score":0.9089999794960022},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.906000018119812},{"id":"https://openalex.org/keywords/antioxidant-pathways","display_name":"antioxidant pathways","score":0.7870000004768372},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.6579999923706055},{"id":"https://openalex.org/keywords/mediterranean-diet","display_name":"Mediterranean diet","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.8481313586235046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.718993604183197},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.6605199575424194},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6492012143135071},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6167730689048767},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5938429832458496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.554569661617279},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.41253384947776794},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.37940871715545654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2746966779232025},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16648423671722412},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1333445906639099}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004750","descriptor_name":"Enteral Nutrition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/physiolgenomics.00069.2012","doi":"https://doi.org/10.1152/physiolgenomics.00069.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiolgenomics.00069.2012","pdf_url":null,"source":{"id":"https://openalex.org/S57123121","display_name":"Physiological Genomics","issn_l":"1094-8341","issn":["1094-8341","1531-2267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Genomics","raw_type":"journal-article"},{"id":"pmid:22991207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22991207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological genomics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1584212931","https://openalex.org/W1956927897","https://openalex.org/W1959040427","https://openalex.org/W1965150061","https://openalex.org/W1965188580","https://openalex.org/W1973916444","https://openalex.org/W1976892396","https://openalex.org/W1980926706","https://openalex.org/W1983310681","https://openalex.org/W1983889476","https://openalex.org/W1989470245","https://openalex.org/W1992864925","https://openalex.org/W1996031139","https://openalex.org/W1996810966","https://openalex.org/W1998323589","https://openalex.org/W1999005524","https://openalex.org/W2000887769","https://openalex.org/W2006083028","https://openalex.org/W2006383327","https://openalex.org/W2007980073","https://openalex.org/W2012121683","https://openalex.org/W2013813851","https://openalex.org/W2017554448","https://openalex.org/W2022792869","https://openalex.org/W2030552585","https://openalex.org/W2030691539","https://openalex.org/W2031795728","https://openalex.org/W2032106211","https://openalex.org/W2034200174","https://openalex.org/W2034216887","https://openalex.org/W2042427787","https://openalex.org/W2043422476","https://openalex.org/W2048104183","https://openalex.org/W2050385934","https://openalex.org/W2052045228","https://openalex.org/W2060201737","https://openalex.org/W2065173009","https://openalex.org/W2065612971","https://openalex.org/W2066453798","https://openalex.org/W2071991978","https://openalex.org/W2080082392","https://openalex.org/W2084212236","https://openalex.org/W2096650959","https://openalex.org/W2096764074","https://openalex.org/W2099190538","https://openalex.org/W2099633930","https://openalex.org/W2101658474","https://openalex.org/W2101797210","https://openalex.org/W2103969000","https://openalex.org/W2109165881","https://openalex.org/W2111187697","https://openalex.org/W2112317454","https://openalex.org/W2113047132","https://openalex.org/W2114472618","https://openalex.org/W2114489116","https://openalex.org/W2118041861","https://openalex.org/W2118983842","https://openalex.org/W2121756640","https://openalex.org/W2122446546","https://openalex.org/W2122863697","https://openalex.org/W2124264736","https://openalex.org/W2125627604","https://openalex.org/W2134466661","https://openalex.org/W2135316567","https://openalex.org/W2147876165","https://openalex.org/W2148824946","https://openalex.org/W2150861575","https://openalex.org/W2151835277","https://openalex.org/W2153321120","https://openalex.org/W2153525019","https://openalex.org/W2158594746","https://openalex.org/W2165103770","https://openalex.org/W2170710595","https://openalex.org/W2170728971","https://openalex.org/W2409001433","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2163446445","https://openalex.org/W2031008058","https://openalex.org/W2170710595","https://openalex.org/W2134467287","https://openalex.org/W1964055340","https://openalex.org/W2405364110","https://openalex.org/W2949731161","https://openalex.org/W1897588166","https://openalex.org/W2158308396","https://openalex.org/W2788256329"],"abstract_inverted_index":{"To":[0],"determine":[1],"if":[2],"dietary":[3,222],"fat":[4,25,29,223],"composition":[5],"affects":[6],"the":[7,51,98,162,169,191,227,242],"progression":[8,212,228],"of":[9,50,114,129,161,183,211,213,229,244],"nonalcoholic":[10,248],"fatty":[11,82,91],"liver":[12],"disease":[13],"(NAFLD),":[14],"we":[15],"overfed":[16,204],"male":[17],"Sprague-Dawley":[18],"rats":[19],"low":[20],"(5%)":[21],"or":[22,37,54,117,133],"high":[23,236],"(70%)":[24],"diets":[26,57],"with":[27,41,80,102,158],"different":[28],"sources:":[30],"olive":[31,238],"oil":[32,35,39,239],"(OO),":[33],"corn":[34],"(CO),":[36],"echium":[38],"(EO),":[40],"total":[42],"enteral":[43],"nutrition":[44],"(TEN)":[45],"for":[46,205],"21":[47],"days.":[48],"Overfeeding":[49],"5%":[52,55,63,99,103,148],"CO":[53,104,121,174],"EO":[56,124],"resulted":[58],"in":[59,74,97,190,198,237],"less":[60],"steatosis":[61],"than":[62],"OO":[64,100,107,171,193,201],"(P":[65,94,150],"<":[66,95,151],"0.05).":[67,152],"Affymetrix":[68,165],"array":[69,166],"analysis":[70,167],"revealed":[71,176],"significant":[72],"differences":[73],"hepatic":[75],"gene":[76],"expression":[77,182],"signatures":[78],"associated":[79],"greater":[81],"acid":[83,92],"synthesis,":[84],"ChREBP,":[85],"and":[86,89,122,131,140,155,172,180,188,231],"SREBP-1c":[87],"signaling":[88],"increased":[90,137,141,177],"transport":[93],"0.05)":[96],"compared":[101],"group.":[105,194],"The":[106,119],"groups":[108,125,149,175],"had":[109,126],"macrosteatosis,":[110],"but":[111],"no":[112,209],"evidence":[113,210],"oxidative":[115,138],"stress":[116,154],"necrosis.":[118],"70%":[120,123,170,173,192,200],"a":[127,233],"mixture":[128],"micro-":[130],"macrosteatosis":[132],"only":[134],"microsteatosis,":[135],"respectively;":[136],"stress;":[139],"necrotic":[142],"injury":[143,214],"relative":[144],"to":[145,186,247],"their":[146],"respective":[147],"Oxidative":[153],"necrosis":[156],"correlated":[157],"increasing":[159],"peroxidizability":[160],"accumulated":[163],"triglycerides.":[164],"comparing":[168],"antioxidant":[178],"pathways":[179],"lower":[181],"genes":[184],"linked":[185],"inflammation":[187],"fibrosis":[189],"A":[195],"second":[196],"study":[197],"which":[199],"diet":[202,235],"was":[203],"50":[206],"days":[207],"produced":[208],"beyond":[215],"simple":[216],"steatosis.":[217],"These":[218],"data":[219],"suggest":[220],"that":[221,232],"type":[224],"strongly":[225],"influences":[226],"NAFLD":[230,245],"Mediterranean":[234],"may":[240],"reduce":[241],"risk":[243],"progressing":[246],"steatohepatitis.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}