{"id":"https://openalex.org/W2147678713","doi":"https://doi.org/10.1093/eurheartj/ehp396","title":"Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction","display_name":"Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2147678713","doi":"https://doi.org/10.1093/eurheartj/ehp396","mag":"2147678713","pmid":"https://pubmed.ncbi.nlm.nih.gov/19797329","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2800920"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehp396","doi":"https://doi.org/10.1093/eurheartj/ehp396","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehp396","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2800920","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071216592","display_name":"Stuart A. Cook","orcid":"https://orcid.org/0000-0001-6628-194X","observed_orcids":["https://orcid.org/0000-0001-6628-194X"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stuart A. Cook","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK","Imperial College NHS Trust, Hammersmith Hospital, London, UK","National Heart and Lung Institute, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Imperial College NHS Trust, Hammersmith Hospital, London, UK","institution_ids":["https://openalex.org/I2801748203"]},{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110815765","display_name":"Anabel Varela\u2010Carver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anabel Varela-Carver","raw_affiliation_strings":["National Heart and Lung Institute, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006841020","display_name":"Marco Mongillo","orcid":"https://orcid.org/0000-0002-1102-8709","observed_orcids":["https://orcid.org/0000-0002-1102-8709"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marco Mongillo","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042515390","display_name":"Christina Kleinert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christina Kleinert","raw_affiliation_strings":["National Heart and Lung Institute, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Muhammad T. Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Muhammad T. Khan","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083126449","display_name":"Lucia Leccisotti","orcid":"https://orcid.org/0000-0002-6000-2898","observed_orcids":["https://orcid.org/0000-0002-6000-2898"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lucia Leccisotti","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110598474","display_name":"Nicola H. Strickland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicola Strickland","raw_affiliation_strings":["Imperial College NHS Trust, Hammersmith Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College NHS Trust, Hammersmith Hospital, London, UK","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103053441","display_name":"Takashi Matsui","orcid":"https://orcid.org/0000-0001-9442-9649","observed_orcids":["https://orcid.org/0000-0001-9442-9649"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takashi Matsui","raw_affiliation_strings":["Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017137382","display_name":"Saumya Das","orcid":"https://orcid.org/0000-0002-4521-4606","observed_orcids":["https://orcid.org/0000-0002-4521-4606"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saumya Das","raw_affiliation_strings":["Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050240892","display_name":"Anthony Rosenzweig","orcid":"https://orcid.org/0000-0001-6387-0386","observed_orcids":["https://orcid.org/0000-0001-6387-0386"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Rosenzweig","raw_affiliation_strings":["Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084304859","display_name":"Prakash P Punjabi","orcid":"https://orcid.org/0000-0002-6587-1603","observed_orcids":["https://orcid.org/0000-0002-6587-1603"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Prakash Punjabi","raw_affiliation_strings":["Imperial College NHS Trust, Hammersmith Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College NHS Trust, Hammersmith Hospital, London, UK","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090207956","display_name":"Paolo Guido Camici","orcid":"https://orcid.org/0000-0001-5584-0750","observed_orcids":["https://orcid.org/0000-0001-5584-0750"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paolo G. Camici","raw_affiliation_strings":["Imperial College NHS Trust, Hammersmith Hospital, London, UK","Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK","National Heart and Lung Institute, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College NHS Trust, Hammersmith Hospital, London, UK","institution_ids":["https://openalex.org/I2801748203"]},{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090207956"],"corresponding_institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984","https://openalex.org/I90344618"],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":3.6071,"has_fulltext":false,"cited_by_count":170,"citation_normalized_percentile":{"value":0.93677784,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"31","issue":"1","first_page":"100","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.725600004196167,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.725600004196167,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.14249999821186066,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.08799999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-insulin-resistance","display_name":"myocardial insulin resistance","score":0.8980000019073486},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/left-ventricular-dysfunction","display_name":"left ventricular dysfunction","score":0.9509999752044678},{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glucose-transporter-4","display_name":"glucose transporter 4","score":0.9020000100135803},{"id":"https://openalex.org/keywords/skeletal-muscle-insulin-resistance","display_name":"skeletal muscle insulin resistance","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.9142826199531555},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8247605562210083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7512356042861938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7442221641540527},{"id":"https://openalex.org/C201624660","wikidata":"https://www.wikidata.org/wiki/Q15334084","display_name":"IRS1","level":5,"score":0.6838394403457642},{"id":"https://openalex.org/C199096232","wikidata":"https://www.wikidata.org/wiki/Q1545001","display_name":"Sarcolemma","level":3,"score":0.6153937578201294},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6060640811920166},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5487563610076904},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5202492475509644},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4353697597980499},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.42679911851882935},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.4206240177154541},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.41512736678123474},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.35315343737602234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15165603160858154},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.05965346097946167},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018810","descriptor_name":"Magnetic Resonance Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051275","descriptor_name":"Glucose Transporter Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/eurheartj/ehp396","doi":"https://doi.org/10.1093/eurheartj/ehp396","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehp396","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2800920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2800920","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Heart J","raw_type":"Text"},{"id":"pmid:19797329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19797329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/149950","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/149950","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:open-archive.highwire.org:ehj:ehp396v1","doi":null,"is_oa":false,"landing_page_url":"http://eurheartj.oxfordjournals.org/cgi/content/short/ehp396v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:www.research.unipd.it:11577/2425548","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/2425548","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2800920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2800920","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Heart J","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5015053211","display_name":null,"funder_award_id":"HL HL077543","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5174186423","display_name":"Mechanisms of myocardial insulin resistance in patients with T2DM or LVD and characterisation of the effects of insulin resistance on cardiac gene expression","funder_award_id":"FS/08/019/24776","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G6516338177","display_name":"Signaling mechanisms of cardioprotection and remodeling","funder_award_id":"R01HL077543","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8480863806","display_name":null,"funder_award_id":"PG/05/033","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G8527257172","display_name":"Molecular mechanisms of electrical remodeling in cardiac hypertrophy","funder_award_id":"K08HL089319","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1985402074","https://openalex.org/W1989950796","https://openalex.org/W2003015009","https://openalex.org/W2009661186","https://openalex.org/W2015774467","https://openalex.org/W2018542799","https://openalex.org/W2020050304","https://openalex.org/W2036515253","https://openalex.org/W2037256523","https://openalex.org/W2046345048","https://openalex.org/W2061083576","https://openalex.org/W2061914106","https://openalex.org/W2067837318","https://openalex.org/W2068905608","https://openalex.org/W2070647639","https://openalex.org/W2071267729","https://openalex.org/W2072312403","https://openalex.org/W2078517954","https://openalex.org/W2079386322","https://openalex.org/W2096773810","https://openalex.org/W2109607186","https://openalex.org/W2114170344","https://openalex.org/W2118668550","https://openalex.org/W2119605294","https://openalex.org/W2121894027","https://openalex.org/W2126317966","https://openalex.org/W2127014382","https://openalex.org/W2136036129","https://openalex.org/W2142980653","https://openalex.org/W2144650168","https://openalex.org/W2144766505","https://openalex.org/W2164323243","https://openalex.org/W2167843337","https://openalex.org/W2169472606","https://openalex.org/W2170971873","https://openalex.org/W2171290692","https://openalex.org/W2327640792","https://openalex.org/W4236765824"],"related_works":["https://openalex.org/W2009509125","https://openalex.org/W2747929758","https://openalex.org/W2142781702","https://openalex.org/W2001127150","https://openalex.org/W3173015173","https://openalex.org/W2032308251","https://openalex.org/W2379596380","https://openalex.org/W2409759105","https://openalex.org/W2137131936","https://openalex.org/W3181937406"],"abstract_inverted_index":{"AIMS:":[0],"Whole":[1],"body":[2],"and":[3,14,30,50,68,81,107,117,144,164,171,183,212],"myocardial":[4,51,205],"insulin":[5,23,38,151,206],"resistance":[6,207],"are":[7,208],"features":[8],"of":[9,22,99,104,142,161,195,204],"non-insulin-dependent":[10],"diabetes":[11],"mellitus":[12],"(NIDDM)":[13],"left-ventricular":[15],"dysfunction":[16],"(LVD).":[17],"We":[18,43,94,139],"determined":[19],"whether":[20],"abnormalities":[21],"receptor":[24],"substrate-1":[25],"(IRS1),":[26],"IRS1-associated":[27],"PI3K":[28,170,179],"(IRS1-PI3K),":[29],"glucose":[31],"transporter":[32],"4":[33],"(GLUT4)":[34],"contribute":[35],"to":[36],"tissue-specific":[37],"resistance.":[39],"METHODS":[40],"AND":[41],"RESULTS:":[42],"collected":[44],"skeletal":[45,102],"muscle":[46,103],"(n":[47,53,59,65,72],"=":[48,54,60,66,73],"27)":[49],"biopsies":[52],"24)":[55],"from":[56],"control":[57],"patients":[58,62,69,106,132],"7),":[61],"with":[63,70,133],"NIDDM":[64,116,211],"9)":[67],"LVD":[71,105,118,134],"8),":[74],"who":[75],"were":[76,87],"characterized":[77],"by":[78],"euglycaemic-hyperinsulinaemic":[79],"clamp":[80],"positron":[82],"emission":[83],"tomography.":[84],"Comparative":[85],"studies":[86],"carried":[88],"out":[89],"in":[90,101,111,115,127,131,146,149,175,180,191],"three":[91],"mouse":[92,154,193],"models.":[93],"demonstrate":[95,159],"an":[96,108],"unrecognized":[97],"reduction":[98,126,145],"IRS1":[100],"unexpected":[109],"increase":[110],"cardiac":[112],"IRS1-PI3K":[113,143],"activity":[114],"patients.":[119],"In":[120],"NIDDM,":[121],"there":[122],"was":[123,137,173,189],"a":[124,192],"concomitant":[125],"sarcolemmal":[128,135,147],"GLUT4,":[129],"whereas":[130],"GLUT4":[136,148,162,172,185],"increased.":[138],"confirm":[140],"activation":[141],"the":[150,181,187,202],"resistant":[152],"ob/ob":[153],"heart":[155,182],"where":[156],"we":[157],"also":[158],"perturbation":[160],"docking":[163],"fusion.":[165],"A":[166],"direct":[167],"relationship":[168],"between":[169,210],"demonstrated":[174],"mice":[176],"expressing":[177],"activated":[178],"increased":[184],"at":[186],"sarcolemma":[188],"confirmed":[190],"model":[194],"LVD.":[196,213],"CONCLUSION:":[197],"Our":[198],"data":[199],"show":[200],"that":[201],"mechanisms":[203],"different":[209]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
