{"id":"https://openalex.org/W2147669805","doi":"https://doi.org/10.1091/mbc.e03-03-0168","title":"DNA Damage during the Spindle-Assembly Checkpoint Degrades CDC25A, Inhibits Cyclin\u2013CDC2 Complexes, and Reverses Cells to Interphase","display_name":"DNA Damage during the Spindle-Assembly Checkpoint Degrades CDC25A, Inhibits Cyclin\u2013CDC2 Complexes, and Reverses Cells to Interphase","publication_year":2003,"publication_date":"2003-07-29","ids":{"openalex":"https://openalex.org/W2147669805","doi":"https://doi.org/10.1091/mbc.e03-03-0168","mag":"2147669805","pmid":"https://pubmed.ncbi.nlm.nih.gov/14517313","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/206994"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e03-03-0168","doi":"https://doi.org/10.1091/mbc.e03-03-0168","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e03-03-0168","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC206994","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031794485","display_name":"Jeremy P.H. Chow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jeremy P.H. Chow","raw_affiliation_strings":["Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052040121","display_name":"Wai Yi Siu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Wai Yi Siu","raw_affiliation_strings":["Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025457462","display_name":"Tsz Kan Fung","orcid":"https://orcid.org/0000-0001-5285-6239","observed_orcids":["https://orcid.org/0000-0001-5285-6239"]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Tsz Kan Fung","raw_affiliation_strings":["Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103470530","display_name":"Wan Mui Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Wan Mui Chan","raw_affiliation_strings":["Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012108423","display_name":"Anita W.S. Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Anita Lau","raw_affiliation_strings":["Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018622395","display_name":"Talha Arooz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Talha Arooz","raw_affiliation_strings":["Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023559915","display_name":"Chuen-Pei Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Chuen-Pei Ng","raw_affiliation_strings":["Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111833020","display_name":"Katsumi Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsumi Yamashita","raw_affiliation_strings":["Division of Life Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Life Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070555595","display_name":"Randy Y.C. Poon","orcid":"https://orcid.org/0000-0001-5571-6231","observed_orcids":["https://orcid.org/0000-0001-5571-6231"]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Randy Y.C. Poon","raw_affiliation_strings":["Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong","institution_ids":["https://openalex.org/I200769079"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8856,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.85490568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"14","issue":"10","first_page":"3989","last_page":"4002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.09860000014305115,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.6869999766349792},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.9729999899864197},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.49900001287460327},{"id":"https://openalex.org/keywords/mitotic-arrest","display_name":"mitotic arrest","score":0.765999972820282},{"id":"https://openalex.org/keywords/chromosome-decondensation","display_name":"chromosome decondensation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6439999938011169},{"id":"https://openalex.org/keywords/h2ax-phosphorylation","display_name":"H2AX phosphorylation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.8129614591598511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7375476360321045},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6920772790908813},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6210927963256836},{"id":"https://openalex.org/C9743823","wikidata":"https://www.wikidata.org/wiki/Q5198264","display_name":"Cyclin B","level":5,"score":0.5283104777336121},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.502907931804657},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.4590607285499573},{"id":"https://openalex.org/C175732170","wikidata":"https://www.wikidata.org/wiki/Q9064829","display_name":"Spindle checkpoint","level":5,"score":0.44820713996887207},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.44563838839530945},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.419587105512619},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38425758481025696},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.32969072461128235},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.2680272161960602},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1677098274230957},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16663777828216553},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.1473071575164795},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11307042837142944},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.10693338513374329}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016195","descriptor_name":"G2 Phase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019925","descriptor_name":"Cyclin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020687","descriptor_name":"cdc25 Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026942","descriptor_name":"DNA Topoisomerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042846","descriptor_name":"CDC2-CDC28 Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056744","descriptor_name":"Cyclin B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1091/mbc.e03-03-0168","doi":"https://doi.org/10.1091/mbc.e03-03-0168","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e03-03-0168","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:440649","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC206994","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:206994","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/206994","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmid:14517313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14517313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-31061","doi":null,"is_oa":false,"landing_page_url":"http://repository.hkust.edu.hk/ir/Record/1783.1-31061","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/a2e7a0d3-c966-4f3d-81ed-2cad68935fe7","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/a2e7a0d3-c966-4f3d-81ed-2cad68935fe7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chow, J P H, Siu, W Y, Fung, T K, Chan, W M, Lau, A, Arooz, T, Ng, C-P, Yamashita, K & Poon, R Y C 2003, 'DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase', Mol Biol Cell, vol. 14, no. 10, pp. 3989-4002. https://doi.org/10.1091/mbc.E03-03-0168","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:440649","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC206994","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313289","display_name":"Lady Tata Memorial Trust","ror":"https://ror.org/019yg2621"},{"id":"https://openalex.org/F4320320904","display_name":"Croucher Foundation","ror":"https://ror.org/04741mc34"},{"id":"https://openalex.org/F4320323504","display_name":"Tata Trusts","ror":"https://ror.org/057kjcb31"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1480741751","https://openalex.org/W1481748141","https://openalex.org/W1513240752","https://openalex.org/W1537737236","https://openalex.org/W1752089945","https://openalex.org/W1967880683","https://openalex.org/W1976558883","https://openalex.org/W1985775217","https://openalex.org/W1990819034","https://openalex.org/W1991736202","https://openalex.org/W1996505651","https://openalex.org/W2004457349","https://openalex.org/W2014170738","https://openalex.org/W2014887448","https://openalex.org/W2028044172","https://openalex.org/W2047191264","https://openalex.org/W2048109276","https://openalex.org/W2048162805","https://openalex.org/W2053003378","https://openalex.org/W2064554826","https://openalex.org/W2074504531","https://openalex.org/W2075392832","https://openalex.org/W2075707444","https://openalex.org/W2080125477","https://openalex.org/W2081682283","https://openalex.org/W2083532816","https://openalex.org/W2087482859","https://openalex.org/W2088362888","https://openalex.org/W2089201777","https://openalex.org/W2092409818","https://openalex.org/W2092629964","https://openalex.org/W2099268087","https://openalex.org/W2099333957","https://openalex.org/W2112415266","https://openalex.org/W2120921507","https://openalex.org/W2124818074","https://openalex.org/W2128994729","https://openalex.org/W2129381867","https://openalex.org/W2130603065","https://openalex.org/W2131833681","https://openalex.org/W2132817913","https://openalex.org/W2139718226","https://openalex.org/W2140851951","https://openalex.org/W2143916467","https://openalex.org/W2145281774","https://openalex.org/W2150525034","https://openalex.org/W2151710109","https://openalex.org/W2155487282","https://openalex.org/W2157418947","https://openalex.org/W2159895537","https://openalex.org/W2167986457","https://openalex.org/W2168757568","https://openalex.org/W2169927110","https://openalex.org/W2170497385","https://openalex.org/W2188252613","https://openalex.org/W2211264868","https://openalex.org/W2270599862","https://openalex.org/W4252156523","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2102345699","https://openalex.org/W2588867200","https://openalex.org/W2142823539","https://openalex.org/W1989529289","https://openalex.org/W2034567120","https://openalex.org/W2092489844","https://openalex.org/W2013714072","https://openalex.org/W1977541278","https://openalex.org/W2147339231","https://openalex.org/W1992107055"],"abstract_inverted_index":{"Cell":[0],"cycle":[1],"checkpoints":[2,23],"that":[3,20,52,166],"monitor":[4],"DNA":[5,35,58,63,93,126,131,150,174,195,202,215],"damage":[6,36,59,64,132,151,175,203,216],"and":[7,18,46,74,99,139,157,201],"spindle":[8,199],"assembly":[9],"are":[10,24],"essential":[11],"for":[12],"the":[13,38,144,189,210,214,220,224],"maintenance":[14],"of":[15,48,108,155,182,191],"genetic":[16],"integrity,":[17],"drugs":[19],"target":[21],"these":[22],"important":[25],"chemotherapeutic":[26,54],"agents.":[27],"We":[28],"have":[29],"examined":[30],"how":[31],"cells":[32,110],"respond":[33],"to":[34,85,87,103,114,207],"while":[37],"spindle-assembly":[39,225],"checkpoint":[40,217],"is":[41],"activated.":[42],"Single":[43],"cell":[44,115],"electrophoresis":[45],"phosphorylation":[47],"histone":[49,71,192],"H2AX":[50],"indicated":[51],"several":[53],"agents":[55],"could":[56,218],"induce":[57],"during":[60,65,133,168],"mitotic":[61,66,109,134,149],"block.":[62],"block":[67,135,145],"triggered":[68],"CDC2":[69,186],"inactivation,":[70],"H3":[72,193],"dephosphorylation,":[73],"chromosome":[75],"decondensation.":[76],"Cells":[77],"did":[78],"not":[79,112],"progress":[80],"into":[81],"G1":[82,141],"but":[83,159],"seemed":[84],"retract":[86],"a":[88],"G2-like":[89],"state":[90],"containing":[91],"4N":[92],"content,":[94],"with":[95],"stabilized":[96],"cyclin":[97,100,137],"A":[98],"B1":[101],"binding":[102],"Thr14/Tyr15-phosphorylated":[104],"CDC2.":[105],"The":[106,148],"loss":[107],"was":[111,119,146,170],"due":[113],"death":[116],"because":[117],"there":[118],"no":[120],"discernible":[121],"effect":[122],"on":[123,163],"caspase-3":[124],"activation,":[125],"fragmentation,":[127],"or":[128,184],"viability.":[129],"Extensive":[130],"inactivated":[136],"B1-CDC2":[138],"prevented":[140],"entry":[142],"when":[143],"removed.":[147],"responses":[152],"were":[153,161],"independent":[154],"p53":[156],"pRb,":[158],"they":[160],"dependent":[162],"ATM.":[164],"CDC25A":[165,183],"accumulated":[167],"mitosis":[169],"rapidly":[171],"destroyed":[172],"after":[173,194],"in":[176],"an":[177],"ATM-dependent":[178],"manner.":[179],"Ectopic":[180],"expression":[181],"nonphosphorylatable":[185],"effectively":[187],"inhibited":[188],"dephosphorylation":[190],"damage.":[196],"Hence,":[197],"although":[198],"disruption":[200],"provide":[204],"conflicting":[205],"signals":[206],"regulate":[208],"CDC2,":[209],"negative":[211],"regulation":[212,222],"by":[213,223],"overcome":[219],"positive":[221],"checkpoint.":[226]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}