{"id":"https://openalex.org/W2147652168","doi":"https://doi.org/10.1128/mcb.8.5.2105-2116.1988","title":"Intracellular Sorting and Processing of a Yeast Vacuolar Hydrolase: Proteinase A Propeptide Contains Vacuolar Targeting Information","display_name":"Intracellular Sorting and Processing of a Yeast Vacuolar Hydrolase: Proteinase A Propeptide Contains Vacuolar Targeting Information","publication_year":1988,"publication_date":"1988-05-01","ids":{"openalex":"https://openalex.org/W2147652168","doi":"https://doi.org/10.1128/mcb.8.5.2105-2116.1988","mag":"2147652168","pmid":"https://pubmed.ncbi.nlm.nih.gov/3290649","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/363391"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.8.5.2105-2116.1988","doi":"https://doi.org/10.1128/mcb.8.5.2105-2116.1988","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.8.5.2105-2116.1988","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2147652168"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://mcb.asm.org/content/mcb/8/5/2105.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066515392","display_name":"Daniel J. Klionsky","orcid":"https://orcid.org/0000-0002-7828-8118","observed_orcids":["https://orcid.org/0000-0002-7828-8118"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D J Klionsky","raw_affiliation_strings":["Division of Biology, 147-75, California Institute of Technology, Pasadena, California 91125"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, 147-75, California Institute of Technology, Pasadena, California 91125","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056701942","display_name":"Lois M. Banta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L M Banta","raw_affiliation_strings":["Division of Biology, 147-75, California Institute of Technology, Pasadena, California 91125"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, 147-75, California Institute of Technology, Pasadena, California 91125","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025638265","display_name":"Scott D. Emr","orcid":"https://orcid.org/0000-0002-5408-6781","observed_orcids":["https://orcid.org/0000-0002-5408-6781"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S D Emr","raw_affiliation_strings":["Division of Biology, 147-75, California Institute of Technology, Pasadena, California 91125"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, 147-75, California Institute of Technology, Pasadena, California 91125","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":null,"apc_paid":null,"fwci":6.7343,"has_fulltext":true,"cited_by_count":281,"citation_normalized_percentile":{"value":0.98023287,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"5","first_page":"2105","last_page":"2116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.266400009393692,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteinase-a","display_name":"proteinase A","score":0.9139999747276306},{"id":"https://openalex.org/keywords/propeptide","display_name":"propeptide","score":0.7590000033378601},{"id":"https://openalex.org/keywords/vacuolar-protein-sorting","display_name":"vacuolar protein sorting","score":0.9039999842643738},{"id":"https://openalex.org/keywords/yeast-vacuole","display_name":"yeast vacuole","score":0.7260000109672546},{"id":"https://openalex.org/keywords/pep4","display_name":"PEP4","score":0.6620000004768372},{"id":"https://openalex.org/keywords/hybrid-proteins","display_name":"hybrid proteins","score":0.6079999804496765},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.7559999823570251},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.9259999990463257},{"id":"https://openalex.org/keywords/early-secretory-pathway","display_name":"early secretory pathway","score":0.7250000238418579},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.8217787742614746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8131149411201477},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6514663696289062},{"id":"https://openalex.org/C7860815","wikidata":"https://www.wikidata.org/wiki/Q258658","display_name":"Protein precursor","level":3,"score":0.553410530090332},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.5131493210792542},{"id":"https://openalex.org/C2778252681","wikidata":"https://www.wikidata.org/wiki/Q419189","display_name":"Invertase","level":3,"score":0.49453040957450867},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4928467273712158},{"id":"https://openalex.org/C2779190341","wikidata":"https://www.wikidata.org/wiki/Q7512720","display_name":"Signal peptidase","level":5,"score":0.49265891313552856},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.45792895555496216},{"id":"https://openalex.org/C2908929163","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein Sorting Signals","level":5,"score":0.4503364861011505},{"id":"https://openalex.org/C559089031","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein targeting","level":4,"score":0.44871336221694946},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.42556023597717285},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.4136945605278015},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36129918694496155},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34408026933670044},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33687731623649597},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.17901349067687988},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.176273375749588},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021382","descriptor_name":"Protein Sorting Signals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043324","descriptor_name":"beta-Fructofuranosidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/mcb.8.5.2105-2116.1988","doi":"https://doi.org/10.1128/mcb.8.5.2105-2116.1988","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.8.5.2105-2116.1988","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1128/mcb.8.5.2105","doi":"https://doi.org/10.1128/mcb.8.5.2105","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mcb.8.5.2105","pdf_url":"https://mcb.asm.org/content/mcb/8/5/2105.full.pdf","source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmid:3290649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3290649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:363391","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC363391/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmh:oai:authors.library.caltech.edu:4540","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:KLImcb88","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1128/mcb.8.5.2105","doi":"https://doi.org/10.1128/mcb.8.5.2105","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mcb.8.5.2105","pdf_url":"https://mcb.asm.org/content/mcb/8/5/2105.full.pdf","source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6890393196","display_name":"PROTEIN SORTING TO THE LYSOSOME-LIKE VACUOLE IN YEAST","funder_award_id":"R01GM032703","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308318","display_name":"Helen Hay Whitney Foundation","ror":"https://ror.org/037ebw447"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147652168.pdf","grobid_xml":"https://content.openalex.org/works/W2147652168.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W74095970","https://openalex.org/W391753069","https://openalex.org/W627044590","https://openalex.org/W1030799694","https://openalex.org/W1487890301","https://openalex.org/W1496034005","https://openalex.org/W1504929892","https://openalex.org/W1537782690","https://openalex.org/W1542314887","https://openalex.org/W1546783991","https://openalex.org/W1574233827","https://openalex.org/W1666648188","https://openalex.org/W1687563194","https://openalex.org/W1854614617","https://openalex.org/W1966446749","https://openalex.org/W1970755262","https://openalex.org/W1973152909","https://openalex.org/W1976979808","https://openalex.org/W1978913949","https://openalex.org/W1979178866","https://openalex.org/W1979387670","https://openalex.org/W1983384469","https://openalex.org/W1984640298","https://openalex.org/W1993028041","https://openalex.org/W1999293035","https://openalex.org/W2002804906","https://openalex.org/W2003323080","https://openalex.org/W2006943139","https://openalex.org/W2007479961","https://openalex.org/W2011985054","https://openalex.org/W2023314628","https://openalex.org/W2032508482","https://openalex.org/W2033035604","https://openalex.org/W2040954100","https://openalex.org/W2042027043","https://openalex.org/W2044804894","https://openalex.org/W2052406391","https://openalex.org/W2057541985","https://openalex.org/W2058075461","https://openalex.org/W2059775037","https://openalex.org/W2063334402","https://openalex.org/W2063369485","https://openalex.org/W2065723356","https://openalex.org/W2070564324","https://openalex.org/W2071427211","https://openalex.org/W2073073066","https://openalex.org/W2077419364","https://openalex.org/W2090756504","https://openalex.org/W2104229396","https://openalex.org/W2124682700","https://openalex.org/W2132367941","https://openalex.org/W2132907474","https://openalex.org/W2138270253","https://openalex.org/W2138879032","https://openalex.org/W2151585536","https://openalex.org/W2155214210","https://openalex.org/W2156163052","https://openalex.org/W2156847800","https://openalex.org/W2160277380","https://openalex.org/W2167411685","https://openalex.org/W2169654956","https://openalex.org/W2246579295","https://openalex.org/W2267943806","https://openalex.org/W2298534472","https://openalex.org/W2323037227","https://openalex.org/W4231391803"],"related_works":["https://openalex.org/W2907026632","https://openalex.org/W2023314628","https://openalex.org/W2021067501","https://openalex.org/W2090756504","https://openalex.org/W2023945859","https://openalex.org/W2091995564","https://openalex.org/W2077419364","https://openalex.org/W2003323080","https://openalex.org/W2036578410","https://openalex.org/W2162757636"],"abstract_inverted_index":{"An":[0],"inactive":[1],"precursor":[2],"form":[3],"of":[4,54,75,120,137,153,162,179],"proteinase":[5],"A":[6],"(PrA)":[7],"transits":[8],"through":[9],"the":[10,23,30,34,45,51,70,73,76,81,102,121,127,138,167],"early":[11],"secretory":[12,35],"pathway":[13],"before":[14],"final":[15],"vacuolar":[16,41,87,151],"delivery.":[17],"We":[18,48],"used":[19],"gene":[20,24,31,130],"fusions":[21],"between":[22],"coding":[25,32],"for":[26,33,150],"PrA":[27,46,55,122,140,168],"(PEP4)":[28],"and":[29,110],"enzyme":[36],"invertase":[37],"(SUC2)":[38],"to":[39,101,176],"identify":[40],"protein-sorting":[42,88],"information":[43,97],"in":[44,166],"precursor.":[47],"found":[49],"that":[50,66,93,143,171],"76-amino-acid":[52],"preprosegment":[53],"contains":[56],"at":[57,72],"least":[58],"two":[59],"sorting":[60,152],"signals:":[61],"an":[62,135],"amino-terminal":[63],"signal":[64],"peptide":[65],"is":[67],"cleaved":[68],"from":[69,126],"protein":[71,141],"level":[74],"endoplasmic":[77],"reticulum":[78],"followed":[79],"by":[80,107],"prosegment":[82,123,169],"which":[83],"functions":[84],"as":[85,105],"a":[86,118,160,183],"signal.":[89],"PrA-invertase":[90],"hybrid":[91],"proteins":[92,114],"carried":[94],"this":[95,154,172,180],"sequence":[96,173],"were":[98,124],"accurately":[99],"sorted":[100],"yeast":[103],"vacuole":[104],"determined":[106],"cell":[108],"fractionation":[109],"immunolocalization":[111],"studies.":[112],"Hybrid":[113],"lacking":[115],"all":[116],"or":[117],"portion":[119],"secreted":[125],"cell.":[128],"Our":[129],"fusion":[131],"data":[132],"together":[133],"with":[134,159],"analysis":[136],"wild-type":[139],"indicated":[142,170],"N-linked":[144],"carbohydrate":[145],"modifications":[146],"are":[147],"not":[148],"required":[149],"protein.":[155],"Furthermore,":[156],"results":[157],"obtained":[158],"set":[161],"deletion":[163],"mutations":[164],"constructed":[165],"also":[174],"contributes":[175],"proper":[177],"folding":[178],"polypeptide":[181],"into":[182],"stable":[184],"transit-competent":[185],"molecule.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
