{"id":"https://openalex.org/W2147602249","doi":"https://doi.org/10.2337/dc13-2112","title":"The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview","display_name":"The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview","publication_year":2013,"publication_date":"2013-12-11","ids":{"openalex":"https://openalex.org/W2147602249","doi":"https://doi.org/10.2337/dc13-2112","mag":"2147602249","pmid":"https://pubmed.ncbi.nlm.nih.gov/24356592","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3867999"},"language":"en","primary_location":{"id":"doi:10.2337/dc13-2112","doi":"https://doi.org/10.2337/dc13-2112","is_oa":true,"landing_page_url":"https://doi.org/10.2337/dc13-2112","pdf_url":"https://care.diabetesjournals.org/content/diacare/37/1/9.full.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://care.diabetesjournals.org/content/diacare/37/1/9.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113797452","display_name":"David M. Nathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Nathan","raw_affiliation_strings":["Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Data Coordinating Center, George Washington University, Biostatistics Center, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Data Coordinating Center, George Washington University, Biostatistics Center, Bethesda, MD","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113797452"],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":null,"apc_paid":null,"fwci":68.6448,"has_fulltext":true,"cited_by_count":1901,"citation_normalized_percentile":{"value":0.99961956,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"37","issue":"1","first_page":"9","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/intensive-insulin-therapy","display_name":"intensive insulin therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8880000114440918},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.5889999866485596},{"id":"https://openalex.org/keywords/microvascular-disease","display_name":"microangiopathy","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/metabolic-memory","display_name":"metabolic memory","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8610000014305115},{"id":"https://openalex.org/keywords/long-term-outcomes","display_name":"long-term outcomes","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9458461999893188},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7713313698768616},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.6866920590400696},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.5602874159812927},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.5529690384864807},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5389796495437622},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5363567471504211},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.49537742137908936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46793505549430847},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.44888392090797424},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4416593611240387},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.41986584663391113},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3689664304256439},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17371121048927307}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007332","descriptor_name":"Insulin Infusion Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2337/dc13-2112","doi":"https://doi.org/10.2337/dc13-2112","is_oa":true,"landing_page_url":"https://doi.org/10.2337/dc13-2112","pdf_url":"https://care.diabetesjournals.org/content/diacare/37/1/9.full.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3245976","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3867999","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3867999","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3867999","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"Text"},{"id":"pmid:24356592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24356592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.772.9545","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.772.9545","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a8/16/9.PMC3867999.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2337/dc13-2112","doi":"https://doi.org/10.2337/dc13-2112","is_oa":true,"landing_page_url":"https://doi.org/10.2337/dc13-2112","pdf_url":"https://care.diabetesjournals.org/content/diacare/37/1/9.full.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1233699070","display_name":"University of New Mexico Clinical and Translational Science Center","funder_award_id":"UL1TR000041","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2270925699","display_name":"Epidemiology of Diabetes Interventions and Complications (EDIC) Study","funder_award_id":"5u01dk094157-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2690230426","display_name":"Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Biostatistics Center","funder_award_id":"U01DK094176","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2855633920","display_name":null,"funder_award_id":"U01 DK094176 and U01 DK094157","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3010402974","display_name":null,"funder_award_id":"U01-DK094157","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3227140044","display_name":"UNM HSC Clinical and Translational Science Center","funder_award_id":"UL1TR001449","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7225957187","display_name":"Clinical and Translational Science Center","funder_award_id":"UL1TR000457","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320317364","display_name":"BD","ror":"https://ror.org/048vrgr14"},{"id":"https://openalex.org/F4320329624","display_name":"Roche Diabetes Care","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333256","display_name":"Abbott Diabetes Care","ror":"https://ror.org/03vb88585"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147602249.pdf","grobid_xml":"https://content.openalex.org/works/W2147602249.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W55058915","https://openalex.org/W71525847","https://openalex.org/W746412135","https://openalex.org/W1667957779","https://openalex.org/W1690043650","https://openalex.org/W1752045965","https://openalex.org/W1992103610","https://openalex.org/W2004119978","https://openalex.org/W2014337700","https://openalex.org/W2028000684","https://openalex.org/W2036045723","https://openalex.org/W2048751182","https://openalex.org/W2088134829","https://openalex.org/W2100972808","https://openalex.org/W2102643074","https://openalex.org/W2112366494","https://openalex.org/W2115038969","https://openalex.org/W2131363230","https://openalex.org/W2141495158","https://openalex.org/W2156593233","https://openalex.org/W2160388935","https://openalex.org/W2160635731","https://openalex.org/W2165563030","https://openalex.org/W2169095364","https://openalex.org/W2171951607","https://openalex.org/W2172157568","https://openalex.org/W2340948203","https://openalex.org/W2414595756","https://openalex.org/W2675742348","https://openalex.org/W2734011609","https://openalex.org/W2757208104","https://openalex.org/W2760585829","https://openalex.org/W2769264260","https://openalex.org/W4214893901","https://openalex.org/W4230692045","https://openalex.org/W4230823162","https://openalex.org/W4232564846","https://openalex.org/W4234918738","https://openalex.org/W4240531687","https://openalex.org/W4242053217","https://openalex.org/W4248932937","https://openalex.org/W4252759459","https://openalex.org/W4285719527","https://openalex.org/W4299436089"],"related_works":["https://openalex.org/W7100183460","https://openalex.org/W4409781914","https://openalex.org/W2153558667","https://openalex.org/W2171475455","https://openalex.org/W2169095364","https://openalex.org/W1595367857","https://openalex.org/W7100350101","https://openalex.org/W1989813262","https://openalex.org/W2054720723","https://openalex.org/W3127523362"],"abstract_inverted_index":{"OBJECTIVE":[0],"The":[1,30,62,133,175],"Diabetes":[2,33],"Control":[3],"and":[4,15,35,146,220,238,255],"Complications":[5,36],"Trial":[6],"(DCCT)":[7],"was":[8,65,181,189],"designed":[9],"to":[10,87,100],"test":[11],"the":[12,18,41,44,48,88,129,138,152,215,223,229,244,250,257],"glucose":[13,104],"hypothesis":[14],"determine":[16],"whether":[17],"complications":[19,53,227,237,252],"of":[20,32,43,51,83,128,137,143,155,164,173,179,186,200,207,214,246,253],"type":[21],"1":[22],"diabetes":[23,52],"(T1DM)":[24],"could":[25],"be":[26],"prevented":[27],"or":[28,109,114,198],"delayed.":[29],"Epidemiology":[31],"Interventions":[34],"(EDIC)":[37],"observational":[38,126],"follow-up":[39],"determined":[40],"durability":[42],"DCCT":[45,63,130,134,230],"effects":[46],"on":[47],"more-advanced":[49],"stages":[50,154],"including":[54],"cardiovascular":[55],"disease":[56,157],"(CVD).":[57],"RESEARCH":[58],"DESIGN":[59],"AND":[60],"METHODS":[61],"(1982-1993)":[64],"a":[66,141,148,161,170,182,193,204,212,260],"controlled":[67],"clinical":[68],"trial":[69],"in":[70,151,195,225,235,248],"1,441":[71],"subjects":[72],"with":[73,94,158,160,167,169,192],"T1DM":[74,254],"comparing":[75],"intensive":[76],"therapy":[77,96,117],"(INT),":[78],"aimed":[79,99],"at":[80],"achieving":[81],"levels":[82],"glycemia":[84],"as":[85,91],"close":[86],"nondiabetic":[89],"range":[90],"safely":[92],"possible,":[93],"conventional":[95],"(CON),":[97],"which":[98,188],"maintain":[101],"safe":[102],"asymptomatic":[103],"control.":[105],"INT":[106,180,247],"utilized":[107],"three":[108],"more":[110],"daily":[111],"insulin":[112,115],"injections":[113],"pump":[116],"guided":[118],"by":[119],"self-monitored":[120],"glucose.":[121],"EDIC":[122,202],"(1994-present)":[123],"is":[124],"an":[125],"study":[127],"cohort.":[131],"RESULTS":[132],"followed":[135],">99%":[136],"cohort":[139],"for":[140,259],"mean":[142],"6.5":[144],"years":[145],"demonstrated":[147,221,243],"35-76%":[149],"reduction":[150,224],"early":[153],"microvascular":[156],"INT,":[159],"median":[162,171],"HbA1c":[163,172],"7%,":[165],"compared":[166],"CONV,":[168],"9%.":[174],"major":[176],"adverse":[177],"effect":[178,206],"threefold":[183],"increased":[184],"risk":[185],"hypoglycemia,":[187],"not":[190],"associated":[191],"decline":[194],"cognitive":[196],"function":[197],"quality":[199],"life.":[201],"showed":[203],"durable":[205],"initial":[208],"assigned":[209],"therapies":[210],"despite":[211],"loss":[213],"glycemic":[216],"separation":[217],"(metabolic":[218],"memory)":[219],"that":[222],"early-stage":[226],"during":[228],"translated":[231],"into":[232],"substantial":[233],"reductions":[234],"severe":[236],"CVD.":[239],"CONCLUSIONS":[240],"DCCT/EDIC":[241],"has":[242],"effectiveness":[245],"reducing":[249],"long-term":[251],"improving":[256],"prospects":[258],"healthy":[261],"life":[262],"span.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":98},{"year":2025,"cited_by_count":132},{"year":2024,"cited_by_count":158},{"year":2023,"cited_by_count":164},{"year":2022,"cited_by_count":219},{"year":2021,"cited_by_count":202},{"year":2020,"cited_by_count":196},{"year":2019,"cited_by_count":159},{"year":2018,"cited_by_count":123},{"year":2017,"cited_by_count":98},{"year":2016,"cited_by_count":77},{"year":2015,"cited_by_count":105},{"year":2014,"cited_by_count":78},{"year":2013,"cited_by_count":77},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
