{"id":"https://openalex.org/W2147586896","doi":"https://doi.org/10.1189/jlb.0713368","title":"HIV-1 envelope\u2013receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies","display_name":"HIV-1 envelope\u2013receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies","publication_year":2013,"publication_date":"2013-10-24","ids":{"openalex":"https://openalex.org/W2147586896","doi":"https://doi.org/10.1189/jlb.0713368","mag":"2147586896","pmid":"https://pubmed.ncbi.nlm.nih.gov/24158961","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868190"},"language":"en","primary_location":{"id":"doi:10.1189/jlb.0713368","doi":"https://doi.org/10.1189/jlb.0713368","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0713368","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868190","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091208578","display_name":"Paul R. Gorry","orcid":"https://orcid.org/0000-0001-5407-7124","observed_orcids":["https://orcid.org/0000-0001-5407-7124"]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Paul R Gorry","raw_affiliation_strings":["Center for Biomedical Research, Burnet Institute , Melbourne, Victoria, Australia","Department of Infectious Diseases, Central Clinical School, Monash University , Melbourne, Victoria, Australia","Department of Microbiology and Immunology, University of Melbourne , Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomedical Research, Burnet Institute , Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I145902186"]},{"raw_affiliation_string":"Department of Infectious Diseases, Central Clinical School, Monash University , Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Melbourne , Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018338227","display_name":"Nicholas Francella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Francella","raw_affiliation_strings":["Department of Medicine, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062645957","display_name":"Sharon R. Lewin","orcid":"https://orcid.org/0000-0002-0330-8241","observed_orcids":["https://orcid.org/0000-0002-0330-8241"]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sharon R Lewin","raw_affiliation_strings":["Center for Biomedical Research, Burnet Institute , Melbourne, Victoria, Australia","Department of Infectious Diseases, Central Clinical School, Monash University , Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomedical Research, Burnet Institute , Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I145902186"]},{"raw_affiliation_string":"Department of Infectious Diseases, Central Clinical School, Monash University , Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074582058","display_name":"Ronald G. Collman","orcid":"https://orcid.org/0000-0002-0508-3701","observed_orcids":["https://orcid.org/0000-0002-0508-3701"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald G Collman","raw_affiliation_strings":["Department of Medicine, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074582058","https://openalex.org/A5091208578"],"corresponding_institution_ids":["https://openalex.org/I145902186","https://openalex.org/I165779595","https://openalex.org/I56590836","https://openalex.org/I79576946"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.7188,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.5559322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"95","issue":"1","first_page":"71","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/macrophage-infection","display_name":"macrophage infection","score":0.7820000052452087},{"id":"https://openalex.org/keywords/viral-envelope","display_name":"viral envelope","score":0.5680000185966492},{"id":"https://openalex.org/keywords/receptor-interaction","display_name":"receptor interaction","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":1.0},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hiv-1-tropism","display_name":"HIV-1 tropism","score":0.8579999804496765},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.6240000128746033},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/central-nervous-system-infection","display_name":"central nervous system infection","score":0.49399998784065247},{"id":"https://openalex.org/keywords/lymphoid-tissue","display_name":"lymphoid tissue","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8693934679031372},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6184467077255249},{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.6143510341644287},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.6078959703445435},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5993900895118713},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5667045712471008},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4882955551147461},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4789862632751465},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45889803767204285},{"id":"https://openalex.org/C33602714","wikidata":"https://www.wikidata.org/wiki/Q7809666","display_name":"Tissue tropism","level":4,"score":0.45532870292663574},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4103226661682129},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.40958350896835327},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33997398614883423},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.3354322612285614},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3048518896102905},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1331343948841095},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08373156189918518},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056189","descriptor_name":"Viral Tropism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1189/jlb.0713368","doi":"https://doi.org/10.1189/jlb.0713368","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0713368","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3868190","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868190","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Leukoc Biol","raw_type":"Text"},{"id":"pmid:24158961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24158961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"},{"id":"pmh:oai:alma.61RMIT_INST:11247728670001341","doi":null,"is_oa":false,"landing_page_url":"http://www.jleukbio.org/content/95/1/71.full.pdf","pdf_url":"http://www.jleukbio.org/content/95/1/71.full.pdf","source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:alma61RMIT.INST:11247728670001341","doi":null,"is_oa":false,"landing_page_url":"https://researchrepository.rmit.edu.au/esploro/outputs/journalArticle/HIV-1-envelope-receptor-interactions-required-for-macrophage/9921862042201341","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/27473268","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/HIV-1_envelope-receptor_interactions_required_for_macrophage_infection_and_implications_for_current_HIV-1_cure_strategies/27473268","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/57217","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11343/57217","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3868190","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868190","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Leukoc Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1596006383","display_name":"The role of chemokines in the establishment of HIV latency","funder_award_id":"R56AI095073","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3357657595","display_name":"DARE: Delaney AIDS Research Enterprise to find a cure.","funder_award_id":"U19AI096109","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4939131516","display_name":"HIV Pathogenesis, Vaccination and Cure","funder_award_id":"T32AI007632","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5812077480","display_name":null,"funder_award_id":"MH061139","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6029894818","display_name":"Entry Coreceptor Use & Target Cell Tropism in Nonpathogenic SIV Infection","funder_award_id":"R56AI091516","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G674907753","display_name":null,"funder_award_id":"AI045008","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7926186636","display_name":"Downmodulating Monocyte/Macrophage Activation for HAND","funder_award_id":"R01MH061139","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8260647612","display_name":null,"funder_award_id":"AI091516","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8883985553","display_name":null,"funder_award_id":"AI045008","funder_id":"https://openalex.org/F4320332480","funder_display_name":"Center for AIDS Research, Duke University"},{"id":"https://openalex.org/G9000878594","display_name":"Tulane National Primate Research Center","funder_award_id":"P51OD011104","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000887542","display_name":"Penn Center for AIDS Research","funder_award_id":"P30AI045008","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320310619","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332480","display_name":"Center for AIDS Research, Duke University","ror":"https://ror.org/00py81415"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"},{"id":"https://openalex.org/F4320335055","display_name":"Health and Medical Research Fund","ror":"https://ror.org/03qh32912"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":150,"referenced_works":["https://openalex.org/W21743542","https://openalex.org/W82820957","https://openalex.org/W188740783","https://openalex.org/W188945215","https://openalex.org/W1490928025","https://openalex.org/W1523087205","https://openalex.org/W1546578324","https://openalex.org/W1571416991","https://openalex.org/W1656832641","https://openalex.org/W1664573657","https://openalex.org/W1741697594","https://openalex.org/W1840516913","https://openalex.org/W1946734657","https://openalex.org/W1964017631","https://openalex.org/W1964567249","https://openalex.org/W1965019797","https://openalex.org/W1965495859","https://openalex.org/W1968478258","https://openalex.org/W1970547415","https://openalex.org/W1970586339","https://openalex.org/W1971553870","https://openalex.org/W1973398091","https://openalex.org/W1973712612","https://openalex.org/W1981644527","https://openalex.org/W1982410222","https://openalex.org/W1986079838","https://openalex.org/W1986994531","https://openalex.org/W1988165884","https://openalex.org/W1990773400","https://openalex.org/W1996183144","https://openalex.org/W1996845333","https://openalex.org/W1997979614","https://openalex.org/W2002702640","https://openalex.org/W2002915433","https://openalex.org/W2004319639","https://openalex.org/W2004335990","https://openalex.org/W2005273976","https://openalex.org/W2008228173","https://openalex.org/W2009695591","https://openalex.org/W2010072143","https://openalex.org/W2010494348","https://openalex.org/W2010521915","https://openalex.org/W2011630381","https://openalex.org/W2014990531","https://openalex.org/W2015983043","https://openalex.org/W2018808081","https://openalex.org/W2021932640","https://openalex.org/W2022098233","https://openalex.org/W2022100968","https://openalex.org/W2022450093","https://openalex.org/W2023368657","https://openalex.org/W2025302903","https://openalex.org/W2027775943","https://openalex.org/W2028179886","https://openalex.org/W2028207327","https://openalex.org/W2028968370","https://openalex.org/W2029116452","https://openalex.org/W2035813371","https://openalex.org/W2038199781","https://openalex.org/W2039447409","https://openalex.org/W2042439779","https://openalex.org/W2042482120","https://openalex.org/W2042982138","https://openalex.org/W2046716698","https://openalex.org/W2054839188","https://openalex.org/W2056341292","https://openalex.org/W2058618886","https://openalex.org/W2064541590","https://openalex.org/W2066163381","https://openalex.org/W2067577412","https://openalex.org/W2069554621","https://openalex.org/W2071396452","https://openalex.org/W2076931074","https://openalex.org/W2083799578","https://openalex.org/W2085464725","https://openalex.org/W2086120330","https://openalex.org/W2087226059","https://openalex.org/W2087423729","https://openalex.org/W2087468350","https://openalex.org/W2090381977","https://openalex.org/W2091061672","https://openalex.org/W2092664889","https://openalex.org/W2095164254","https://openalex.org/W2095637140","https://openalex.org/W2097183306","https://openalex.org/W2097433834","https://openalex.org/W2098003313","https://openalex.org/W2099308199","https://openalex.org/W2099666067","https://openalex.org/W2099749788","https://openalex.org/W2100109619","https://openalex.org/W2105028368","https://openalex.org/W2105267808","https://openalex.org/W2105781049","https://openalex.org/W2106400912","https://openalex.org/W2107222418","https://openalex.org/W2108256128","https://openalex.org/W2112352354","https://openalex.org/W2113282092","https://openalex.org/W2113591371","https://openalex.org/W2114787375","https://openalex.org/W2114903401","https://openalex.org/W2117555836","https://openalex.org/W2118097108","https://openalex.org/W2118208453","https://openalex.org/W2119480459","https://openalex.org/W2120880145","https://openalex.org/W2121511328","https://openalex.org/W2121593652","https://openalex.org/W2122003863","https://openalex.org/W2122224981","https://openalex.org/W2123160399","https://openalex.org/W2124058652","https://openalex.org/W2125291686","https://openalex.org/W2126334008","https://openalex.org/W2127156420","https://openalex.org/W2131242389","https://openalex.org/W2131550599","https://openalex.org/W2132076800","https://openalex.org/W2133750999","https://openalex.org/W2134260333","https://openalex.org/W2135781036","https://openalex.org/W2137903260","https://openalex.org/W2139250164","https://openalex.org/W2141335991","https://openalex.org/W2141489451","https://openalex.org/W2142035308","https://openalex.org/W2143614051","https://openalex.org/W2146281175","https://openalex.org/W2146426059","https://openalex.org/W2150001263","https://openalex.org/W2151050278","https://openalex.org/W2151211612","https://openalex.org/W2151344352","https://openalex.org/W2154142064","https://openalex.org/W2154626432","https://openalex.org/W2154715621","https://openalex.org/W2158409022","https://openalex.org/W2159006922","https://openalex.org/W2163611230","https://openalex.org/W2166122762","https://openalex.org/W2168835960","https://openalex.org/W2168864508","https://openalex.org/W2169054534","https://openalex.org/W2171136144","https://openalex.org/W2324626026","https://openalex.org/W2332747917","https://openalex.org/W3148829076","https://openalex.org/W6607614513","https://openalex.org/W6607705274"],"related_works":["https://openalex.org/W2409519710","https://openalex.org/W2166161018","https://openalex.org/W2954244383","https://openalex.org/W7221554328","https://openalex.org/W1830857550","https://openalex.org/W1968671577","https://openalex.org/W2027809408","https://openalex.org/W4281624862","https://openalex.org/W2058618886","https://openalex.org/W2054839188"],"abstract_inverted_index":{"Myeloid":[0],"cells":[1],"residing":[2],"in":[3,36,60],"the":[4,20,84,106,114,118],"CNS":[5],"and":[6,15,63,104],"lymphoid":[7],"tissues":[8],"are":[9,92],"targets":[10],"for":[11,58,70,90],"productive":[12],"HIV-1":[13,24,61,88],"replication,":[14],"their":[16],"infection":[17],"contributes":[18],"to":[19,32,67],"pathological":[21],"manifestations":[22],"of":[23,45,108,117],"infection.":[25],"The":[26],"Envs":[27],"can":[28],"adopt":[29],"altered":[30,43,97],"configurations":[31],"overcome":[33],"entry":[34],"restrictions":[35],"macrophages":[37,59,91],"via":[38],"a":[39,75],"more":[40],"efficient":[41],"and/or":[42,96,102],"mechanism":[44],"engagement":[46],"with":[47,99],"cellular":[48],"receptors.":[49],"This":[50],"review":[51],"highlights":[52],"evidence":[53],"supporting":[54],"an":[55],"important":[56],"role":[57],"pathogenesis":[62],"persistence,":[64],"which":[65],"need":[66],"be":[68],"considered":[69],"strategies":[71],"aimed":[72],"at":[73],"achieving":[74],"functional":[76],"or":[77],"sterilizing":[78],"cure.":[79],"We":[80],"also":[81],"highlight":[82],"that":[83,105],"molecular":[85],"mechanisms":[86],"underlying":[87],"tropism":[89],"complex,":[93],"involving":[94],"enhanced":[95],"interactions":[98,110],"CD4,":[100],"CCR5,":[101],"CXCR4,":[103],"nature":[107],"these":[109],"may":[111],"depend":[112],"on":[113],"anatomical":[115],"location":[116],"virus.":[119]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}