{"id":"https://openalex.org/W2147499861","doi":"https://doi.org/10.1128/mcb.26.1.131-139.2006","title":"Alternative Pathways for the Repair of RAG-Induced DNA Breaks","display_name":"Alternative Pathways for the Repair of RAG-Induced DNA Breaks","publication_year":2005,"publication_date":"2005-12-14","ids":{"openalex":"https://openalex.org/W2147499861","doi":"https://doi.org/10.1128/mcb.26.1.131-139.2006","mag":"2147499861","pmid":"https://pubmed.ncbi.nlm.nih.gov/16354685","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1317616"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.26.1.131-139.2006","doi":"https://doi.org/10.1128/mcb.26.1.131-139.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.26.1.131-139.2006","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1317616","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026688095","display_name":"David M. Weinstock","orcid":"https://orcid.org/0000-0002-8724-3907","observed_orcids":["https://orcid.org/0000-0002-8724-3907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M. Weinstock","raw_affiliation_strings":["Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089227056","display_name":"Maria Jasin","orcid":"https://orcid.org/0000-0002-7976-2379","observed_orcids":["https://orcid.org/0000-0002-7976-2379"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maria Jasin","raw_affiliation_strings":["Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089227056"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":1.6313,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.82026372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"1","first_page":"131","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rag1","display_name":"RAG1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/rag2","display_name":"RAG2","score":1.0},{"id":"https://openalex.org/keywords/v-d-j-recombination","display_name":"V(D)J recombination","score":0.9679999947547913},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8569999933242798},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9580000042915344},{"id":"https://openalex.org/keywords/homology-directed-repair","display_name":"homology-directed repair","score":0.996999979019165},{"id":"https://openalex.org/keywords/single-strand-annealing","display_name":"single-strand annealing","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ku70","display_name":"Ku70","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ku80","display_name":"Ku80","score":0.8339999914169312},{"id":"https://openalex.org/keywords/dna-pkcs","display_name":"DNA-PKcs","score":0.9729999899864197},{"id":"https://openalex.org/keywords/xrcc4","display_name":"XRCC4","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/antigen-receptor-diversity","display_name":"antigen receptor diversity","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2780919815","wikidata":"https://www.wikidata.org/wiki/Q6440930","display_name":"Ku70","level":4,"score":0.8794130086898804},{"id":"https://openalex.org/C145803527","wikidata":"https://www.wikidata.org/wiki/Q18032396","display_name":"DNA repair protein XRCC4","level":5,"score":0.850693941116333},{"id":"https://openalex.org/C193104389","wikidata":"https://www.wikidata.org/wiki/Q18032397","display_name":"Ku80","level":5,"score":0.8118389844894409},{"id":"https://openalex.org/C2780254951","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"V(D)J recombination","level":4,"score":0.7727034091949463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7442494034767151},{"id":"https://openalex.org/C122917832","wikidata":"https://www.wikidata.org/wiki/Q2065945","display_name":"Non-homologous end joining","level":4,"score":0.6896957755088806},{"id":"https://openalex.org/C2781376893","wikidata":"https://www.wikidata.org/wiki/Q18031023","display_name":"RAG2","level":4,"score":0.5996586680412292},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5707136392593384},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5287798643112183},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5193756222724915},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46853107213974},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41565167903900146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2886991500854492},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.21932542324066162},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.21760499477386475},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.15593373775482178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1342265009880066},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07026973366737366}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019457","descriptor_name":"Chromosome Breakage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045567","descriptor_name":"VDJ Recombinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045567","descriptor_name":"VDJ Recombinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.26.1.131-139.2006","doi":"https://doi.org/10.1128/mcb.26.1.131-139.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.26.1.131-139.2006","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1317616","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1317616","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:16354685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16354685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.3211","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.3211","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcb.asm.org/content/26/1/131.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1317616","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1317616","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1634001056","display_name":null,"funder_award_id":"CA-09512","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3040537415","display_name":null,"funder_award_id":"54688","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G9000856337","display_name":"Clinical Scholars Biomedical Research Training Program","funder_award_id":"T32CA009512","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1513105954","https://openalex.org/W1527297546","https://openalex.org/W1545180988","https://openalex.org/W1585985640","https://openalex.org/W1660787335","https://openalex.org/W1750064874","https://openalex.org/W1967167923","https://openalex.org/W1968469516","https://openalex.org/W1987705460","https://openalex.org/W1987764631","https://openalex.org/W1988096153","https://openalex.org/W1988922095","https://openalex.org/W1992688638","https://openalex.org/W1995252171","https://openalex.org/W2001748204","https://openalex.org/W2007919127","https://openalex.org/W2011522975","https://openalex.org/W2012090280","https://openalex.org/W2017351036","https://openalex.org/W2021101157","https://openalex.org/W2022959050","https://openalex.org/W2028138760","https://openalex.org/W2029164849","https://openalex.org/W2031292590","https://openalex.org/W2038794308","https://openalex.org/W2058800908","https://openalex.org/W2060453248","https://openalex.org/W2062428046","https://openalex.org/W2064631075","https://openalex.org/W2064747414","https://openalex.org/W2068426541","https://openalex.org/W2070721957","https://openalex.org/W2076328665","https://openalex.org/W2084354924","https://openalex.org/W2088091759","https://openalex.org/W2089155355","https://openalex.org/W2096753300","https://openalex.org/W2102618729","https://openalex.org/W2103770333","https://openalex.org/W2109456034","https://openalex.org/W2110508317","https://openalex.org/W2115626825","https://openalex.org/W2117330818","https://openalex.org/W2119125321","https://openalex.org/W2122516453","https://openalex.org/W2123909581","https://openalex.org/W2144550200","https://openalex.org/W2148267271","https://openalex.org/W2150198330","https://openalex.org/W2167863101","https://openalex.org/W2168809955","https://openalex.org/W2300651393","https://openalex.org/W2313831534","https://openalex.org/W4252689815"],"related_works":["https://openalex.org/W2094950317","https://openalex.org/W2107720648","https://openalex.org/W4206598121","https://openalex.org/W2157088707","https://openalex.org/W2001748204","https://openalex.org/W3207826914","https://openalex.org/W131905485","https://openalex.org/W3192950407","https://openalex.org/W7096239028","https://openalex.org/W1620761868"],"abstract_inverted_index":{"RAG1":[0],"and":[1,10,113,149],"RAG2":[2],"cleave":[3],"DNA":[4,188],"to":[5,39,59,102,123,178],"generate":[6],"blunt":[7],"signal":[8,114],"ends":[9,13],"hairpin":[11,173],"coding":[12,111],"at":[14,91,125],"antigen":[15,41],"receptor":[16,42],"loci":[17],"in":[18,79,140,159,172,182,191,205,209,227],"lymphoid":[19],"cells.":[20,229],"During":[21],"V(D)J":[22,135],"recombination,":[23],"repair":[24,62,86],"of":[25,56,161,212,218],"these":[26,88,228],"RAG-generated":[27,57,68,196],"double-strand":[28],"breaks":[29,58,70,219],"(DSBs)":[30],"by":[31,74,87,118,201],"the":[32,40,54,144,162,179,186,202,210],"nonhomologous":[33],"end-joining":[34],"(NHEJ)":[35],"pathway":[36,193,204],"contributes":[37],"substantially":[38,138],"diversity":[43],"necessary":[44],"for":[45,109,143],"immune":[46],"system":[47],"function,":[48],"although":[49,85],"recent":[50],"evidence":[51],"also":[52],"supports":[53],"ability":[55],"undergo":[60],"homology-directed":[61],"(HDR).":[63],"We":[64],"have":[65],"determined":[66],"that":[67],"chromosomal":[69],"can":[71,220],"be":[72,103,221],"repaired":[73,200],"pathways":[75,89,226],"other":[76],"than":[77,96,106,131],"NHEJ":[78,107,145,203,213],"mouse":[80],"embryonic":[81],"stem":[82],"(ES)":[83],"cells,":[84,184,207],"occurs":[90],"a":[92,126,215],"significantly":[93],"lower":[94,105,129],"frequency":[95,99,108,130],"NHEJ.":[97],"HDR":[98,156,175],"was":[100,121,137,157,176],"estimated":[101,122],">or=40-fold":[104],"both":[110],"end":[112,115],"reporters.":[116],"Repair":[117],"single-strand":[119],"annealing":[120],"occur":[124],"comparable":[127],"or":[128],"HDR.":[132],"As":[133],"expected,":[134],"recombination":[136],"impaired":[139],"cells":[141,165],"deficient":[142],"components":[146],"Ku70,":[147],"XRCC4,":[148],"DNA-PKcs.":[150],"Concomitant":[151],"with":[152],"decreased":[153],"NHEJ,":[154],"RAG-induced":[155],"increased":[158,177],"each":[160],"mutants,":[163],"including":[164],"lacking":[166],"DNA-PKcs,":[167],"which":[168],"has":[169],"been":[170],"implicated":[171],"opening.":[174],"largest":[180],"extent":[181],"Ku70-/-":[183],"implicating":[185],"Ku70/80":[187],"end-binding":[189],"protein":[190],"regulating":[192],"choice.":[194],"Thus,":[195],"DSBs":[197],"are":[198],"typically":[199],"ES":[206],"but":[208],"absence":[211],"components,":[214],"substantial":[216],"fraction":[217],"efficiently":[222],"channeled":[223],"into":[224],"alternative":[225]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
