{"id":"https://openalex.org/W2147495602","doi":"https://doi.org/10.1128/aac.02085-15","title":"Type III Secretion-Dependent Sensitivity of Escherichia coli O157 to Specific Ketolides","display_name":"Type III Secretion-Dependent Sensitivity of Escherichia coli O157 to Specific Ketolides","publication_year":2015,"publication_date":"2015-11-03","ids":{"openalex":"https://openalex.org/W2147495602","doi":"https://doi.org/10.1128/aac.02085-15","mag":"2147495602","pmid":"https://pubmed.ncbi.nlm.nih.gov/26525795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4704242"},"language":"en","primary_location":{"id":"doi:10.1128/aac.02085-15","doi":"https://doi.org/10.1128/aac.02085-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.02085-15","pdf_url":"https://aac.asm.org/content/aac/60/1/459.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://aac.asm.org/content/aac/60/1/459.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008156114","display_name":"Romina Jimena Fern\u00e1ndez\u2010Brando","orcid":"https://orcid.org/0000-0003-4470-5857","observed_orcids":["https://orcid.org/0000-0003-4470-5857"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["AR","GB"],"is_corresponding":false,"raw_author_name":"Romina J. Fernandez-Brando","raw_affiliation_strings":["Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom","Laboratory of Pathogenesis and Immunology of Infectious Diseases, IMEX-CONICET, National Academy of Medicine, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Laboratory of Pathogenesis and Immunology of Infectious Diseases, IMEX-CONICET, National Academy of Medicine, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113440642","display_name":"Nao Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nao Yamaguchi","raw_affiliation_strings":["Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082254037","display_name":"Amin Abd Elhady Tahoun","orcid":"https://orcid.org/0000-0002-9239-622X","observed_orcids":["https://orcid.org/0000-0002-9239-622X"]},"institutions":[{"id":"https://openalex.org/I130309236","display_name":"Kafrelsheikh University","ror":"https://ror.org/04a97mm30","country_code":"EG","type":"education","lineage":["https://openalex.org/I130309236"]},{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["EG","GB"],"is_corresponding":false,"raw_author_name":"Amin Tahoun","raw_affiliation_strings":["Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom","Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrel-Sheikh, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrel-Sheikh, Egypt","institution_ids":["https://openalex.org/I130309236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073492235","display_name":"Sean P. McAteer","orcid":"https://orcid.org/0000-0002-1257-2175","observed_orcids":["https://orcid.org/0000-0002-1257-2175"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sean P. McAteer","raw_affiliation_strings":["Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111580787","display_name":"Trudi Gillespie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Trudi Gillespie","raw_affiliation_strings":["IMPACT Facility, Centre for Integrative Physiology, The University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMPACT Facility, Centre for Integrative Physiology, The University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101574290","display_name":"Dai Wang","orcid":"https://orcid.org/0000-0003-2281-8586","observed_orcids":["https://orcid.org/0000-0003-2281-8586"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Dai Wang","raw_affiliation_strings":["Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom","State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Xiamen University, Xiamen, Fujian, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]},{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Xiamen University, Xiamen, Fujian, People's Republic of China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022233803","display_name":"Sally Anne Argyle","orcid":"https://orcid.org/0000-0002-9198-4775","observed_orcids":["https://orcid.org/0000-0002-9198-4775"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sally A. Argyle","raw_affiliation_strings":["Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022419643","display_name":"Marina Sandra Palermo","orcid":"https://orcid.org/0000-0003-0533-9516","observed_orcids":["https://orcid.org/0000-0003-0533-9516"]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marina S. Palermo","raw_affiliation_strings":["Laboratory of Pathogenesis and Immunology of Infectious Diseases, IMEX-CONICET, National Academy of Medicine, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathogenesis and Immunology of Infectious Diseases, IMEX-CONICET, National Academy of Medicine, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000572566","display_name":"David L. Gally","orcid":"https://orcid.org/0000-0002-2566-0844","observed_orcids":["https://orcid.org/0000-0002-2566-0844"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David L. Gally","raw_affiliation_strings":["Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunity and Infection, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5000572566"],"corresponding_institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":1.3738,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.78421569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"1","first_page":"459","last_page":"470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-iii-secretion-system","display_name":"type III secretion system","score":0.984000027179718},{"id":"https://openalex.org/keywords/escherichia-coli-o157","display_name":"Escherichia coli O157","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ketolides","display_name":"ketolides","score":0.8429999947547913},{"id":"https://openalex.org/keywords/solithromycin","display_name":"solithromycin","score":0.9300000071525574},{"id":"https://openalex.org/keywords/telithromycin","display_name":"telithromycin","score":1.0},{"id":"https://openalex.org/keywords/enterohemorrhagic-escherichia-coli","display_name":"enterohemorrhagic Escherichia coli","score":0.9210000038146973},{"id":"https://openalex.org/keywords/effector-proteins","display_name":"effector proteins","score":0.6690000295639038},{"id":"https://openalex.org/keywords/intracellular-bacteria","display_name":"intracellular bacteria","score":0.6669999957084656},{"id":"https://openalex.org/keywords/antibiotic-susceptibility","display_name":"antibiotic susceptibility","score":0.36000001430511475},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2780894585","wikidata":"https://www.wikidata.org/wiki/Q1445686","display_name":"Ketolide","level":4,"score":0.9688553810119629},{"id":"https://openalex.org/C2780810561","wikidata":"https://www.wikidata.org/wiki/Q2736135","display_name":"Telithromycin","level":4,"score":0.9156554341316223},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8314568996429443},{"id":"https://openalex.org/C130211564","wikidata":"https://www.wikidata.org/wiki/Q21199165","display_name":"Type three secretion system","level":4,"score":0.7935795783996582},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7411986589431763},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6932977437973022},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6842236518859863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6769999265670776},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6155142784118652},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5277191996574402},{"id":"https://openalex.org/C2778883795","wikidata":"https://www.wikidata.org/wiki/Q804517","display_name":"Pathogenic bacteria","level":3,"score":0.5092839002609253},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.49680641293525696},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.42152369022369385},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.29817357659339905},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1357177197933197},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10239997506141663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09741941094398499},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069296","descriptor_name":"Type III Secretion Systems","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000069296","descriptor_name":"Type III Secretion Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000069296","descriptor_name":"Type III Secretion Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019453","descriptor_name":"Escherichia coli O157","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019453","descriptor_name":"Escherichia coli O157","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019453","descriptor_name":"Escherichia coli O157","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D048628","descriptor_name":"Ketolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048628","descriptor_name":"Ketolides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1128/aac.02085-15","doi":"https://doi.org/10.1128/aac.02085-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.02085-15","pdf_url":"https://aac.asm.org/content/aac/60/1/459.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4704242","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4704242","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:26525795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26525795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:3087855","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3087855","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:pure.ed.ac.uk:publications/8b72fd91-1c56-4402-85bb-d22b154a35a3","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11820/8b72fd91-1c56-4402-85bb-d22b154a35a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fernandez-brando, R, Yamaguchi, N, Tahoun, A, Mcateer, S P, Gillespie, T, Wang, D, Argyle, S A, Palermo, M S & Gally, D L 2016, 'Type III Secretion-Dependent Sensitivity of Escherichia coli O157 to Specific Ketolides', Antimicrobial Agents and Chemotherapy, vol. 60, no. 1, pp. 459\u2013470. https://doi.org/10.1128/AAC.02085-15","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/42742","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/42742","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"doi:10.60692/0yx16-e8f56","doi":"https://doi.org/10.60692/0yx16-e8f56","is_oa":true,"landing_page_url":"https://doi.org/10.60692/0yx16-e8f56","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/2t1mx-7k306","doi":"https://doi.org/10.60692/2t1mx-7k306","is_oa":true,"landing_page_url":"https://doi.org/10.60692/2t1mx-7k306","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1128/aac.02085-15","doi":"https://doi.org/10.1128/aac.02085-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.02085-15","pdf_url":"https://aac.asm.org/content/aac/60/1/459.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1989209763","display_name":"Rational selection of targets for control of bacterial pathogens of food-producing animals","funder_award_id":"BBS/E/D/20231761","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4163894701","display_name":"Tackling Enterohaemorrhagic E. coli infection across continents","funder_award_id":"BB/L026740/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G707999305","display_name":"Defining the molecular basis of H7 flagellin as an adhesin and mucosal adjuvant for vaccine development","funder_award_id":"BB/I011625/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8454821118","display_name":null,"funder_award_id":"BB/L026740/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8807226939","display_name":"BBSRC Doctoral Training Grant - 2005","funder_award_id":"BB/D526245/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147495602.pdf","grobid_xml":"https://content.openalex.org/works/W2147495602.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1536177234","https://openalex.org/W1831336687","https://openalex.org/W1922809098","https://openalex.org/W1964868893","https://openalex.org/W1964902749","https://openalex.org/W1966597734","https://openalex.org/W1968294861","https://openalex.org/W1974345521","https://openalex.org/W1975057095","https://openalex.org/W1984827890","https://openalex.org/W1988771590","https://openalex.org/W1990619678","https://openalex.org/W1998289449","https://openalex.org/W2004974024","https://openalex.org/W2006805047","https://openalex.org/W2007749440","https://openalex.org/W2009916715","https://openalex.org/W2014742892","https://openalex.org/W2015150314","https://openalex.org/W2022422382","https://openalex.org/W2023184347","https://openalex.org/W2023613110","https://openalex.org/W2030640784","https://openalex.org/W2031623901","https://openalex.org/W2031937387","https://openalex.org/W2032160956","https://openalex.org/W2032306900","https://openalex.org/W2036436474","https://openalex.org/W2039457979","https://openalex.org/W2043972155","https://openalex.org/W2046520563","https://openalex.org/W2047669630","https://openalex.org/W2051347791","https://openalex.org/W2052839211","https://openalex.org/W2053932784","https://openalex.org/W2054941036","https://openalex.org/W2057081565","https://openalex.org/W2061060437","https://openalex.org/W2061643429","https://openalex.org/W2066610167","https://openalex.org/W2067731330","https://openalex.org/W2070995494","https://openalex.org/W2071224695","https://openalex.org/W2075542287","https://openalex.org/W2079528125","https://openalex.org/W2088522355","https://openalex.org/W2095744711","https://openalex.org/W2099514668","https://openalex.org/W2101083642","https://openalex.org/W2102138827","https://openalex.org/W2111606893","https://openalex.org/W2112111992","https://openalex.org/W2113427258","https://openalex.org/W2117192186","https://openalex.org/W2118128934","https://openalex.org/W2121202615","https://openalex.org/W2123487146","https://openalex.org/W2124312530","https://openalex.org/W2126416660","https://openalex.org/W2127318266","https://openalex.org/W2127541870","https://openalex.org/W2129623039","https://openalex.org/W2131242123","https://openalex.org/W2132877052","https://openalex.org/W2137994690","https://openalex.org/W2138901184","https://openalex.org/W2144385318","https://openalex.org/W2156242960","https://openalex.org/W2157116022","https://openalex.org/W2159498945","https://openalex.org/W2159766553","https://openalex.org/W2165524414","https://openalex.org/W2166754034","https://openalex.org/W2166802829","https://openalex.org/W2167145507","https://openalex.org/W2169231066","https://openalex.org/W2170846767","https://openalex.org/W2172129566","https://openalex.org/W2324397673"],"related_works":["https://openalex.org/W7099711746","https://openalex.org/W3199617884","https://openalex.org/W7221520693","https://openalex.org/W2113049807","https://openalex.org/W2019936208","https://openalex.org/W2115696210","https://openalex.org/W2886739398","https://openalex.org/W2172129566","https://openalex.org/W2113437634","https://openalex.org/W2160564076"],"abstract_inverted_index":{"A":[0],"subset":[1],"of":[2,67,88,98,118,143,179,182,200],"Gram-negative":[3],"bacterial":[4,32,69,78],"pathogens":[5],"uses":[6],"a":[7,16,223],"type":[8],"III":[9],"secretion":[10],"system":[11],"(T3SS)":[12],"to":[13,23,30,74,110,127,134],"open":[14],"up":[15],"conduit":[17],"into":[18,163],"eukaryotic":[19],"cells":[20,90,129,159],"in":[21,49,77,94,157],"order":[22],"inject":[24],"effector":[25],"proteins.":[26],"These":[27,203],"modulate":[28],"pathways":[29],"enhance":[31],"colonization.":[33],"In":[34],"this":[35,148,180],"study,":[36],"we":[37],"screened":[38],"established":[39],"bioactive":[40],"compounds":[41],"for":[42,190,198,210],"any":[43],"that":[44,130,151,154,170,221],"could":[45],"repress":[46],"T3SS":[47,70,106],"expression":[48,66,142],"enterohemorrhagic":[50],"Escherichia":[51],"coli":[52,100,120],"(EHEC)":[53],"O157.":[54,101],"The":[55],"ketolides":[56],"telithromycin":[57],"and,":[58],"subsequently,":[59],"solithromycin":[60,92],"both":[61],"demonstrated":[62],"repressive":[63],"effects":[64],"on":[65,84,141],"the":[68,105,135,144,152,164,167,174],"at":[71],"sub-MICs,":[72],"leading":[73],"significant":[75,115],"reductions":[76],"binding":[79],"and":[80,112,193],"actin-rich":[81],"pedestal":[82],"formation":[83],"epithelial":[85,89,128,158],"cells.":[86],"Preincubation":[87],"with":[91],"resulted":[93],"significantly":[95],"less":[96],"attachment":[97],"E.":[99,119],"Moreover,":[102],"bacteria":[103,122,165],"expressing":[104],"were":[107,125],"more":[108],"susceptible":[109],"solithromycin,":[111,186],"there":[113],"was":[114,139],"preferential":[116],"killing":[117,138],"O157":[121],"when":[123],"they":[124],"added":[126],"had":[131],"been":[132],"preexposed":[133],"ketolide.":[136],"This":[137],"dependent":[140],"T3SS.":[145,168,224],"Taken":[146],"together,":[147],"research":[149],"indicates":[150],"ketolide":[153,172],"has":[155],"accumulated":[156],"may":[160,205],"traffic":[161],"back":[162],"via":[166],"Considering":[169],"neither":[171],"induces":[173],"SOS":[175],"response,":[176],"nontoxic":[177],"members":[178],"class":[181],"antibiotics,":[183],"such":[184],"as":[185],"should":[187],"be":[188],"considered":[189],"future":[191],"testing":[192],"trials":[194],"evaluating":[195],"their":[196],"use":[197],"treatment":[199],"EHEC":[201],"infections.":[202],"antibiotics":[204],"also":[206],"have":[207],"broader":[208],"significance":[209],"treating":[211],"infections":[212],"caused":[213],"by":[214],"other":[215],"pathogenic":[216],"bacteria,":[217,220],"including":[218],"intracellular":[219],"express":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
