{"id":"https://openalex.org/W2147488335","doi":"https://doi.org/10.1152/ajplung.00460.2006","title":"Keratinocyte growth factor protects against elastase-induced pulmonary emphysema in mice","display_name":"Keratinocyte growth factor protects against elastase-induced pulmonary emphysema in mice","publication_year":2007,"publication_date":"2007-08-31","ids":{"openalex":"https://openalex.org/W2147488335","doi":"https://doi.org/10.1152/ajplung.00460.2006","mag":"2147488335","pmid":"https://pubmed.ncbi.nlm.nih.gov/17766584"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00460.2006","doi":"https://doi.org/10.1152/ajplung.00460.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00460.2006","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076886280","display_name":"Laurent Plantier","orcid":"https://orcid.org/0000-0002-3426-2936","observed_orcids":["https://orcid.org/0000-0002-3426-2936"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Plantier","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U700, Facult\u00e9 Xavier Bichat, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U700, Facult\u00e9 Xavier Bichat, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024611768","display_name":"Sylvain Marchand-Adam","orcid":"https://orcid.org/0000-0002-9522-3738","observed_orcids":["https://orcid.org/0000-0002-9522-3738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvain Marchand-Adam","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108082007","display_name":"Valeria G. Antico","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valeria G. Antico","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056326289","display_name":"Laurent Boyer","orcid":"https://orcid.org/0000-0002-2608-6696","observed_orcids":["https://orcid.org/0000-0002-2608-6696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurent Boyer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036228670","display_name":"C\u00e9cile De Coster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9cile De Coster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016639913","display_name":"J. Marchal-Somm\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo\u00eblle Marchal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011529189","display_name":"Rafik Bachoual","orcid":"https://orcid.org/0000-0003-2195-4068","observed_orcids":["https://orcid.org/0000-0003-2195-4068"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafik Bachoual","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078553375","display_name":"Arnaud Mailleux","orcid":"https://orcid.org/0000-0003-4191-1778","observed_orcids":["https://orcid.org/0000-0003-4191-1778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnaud Mailleux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022201858","display_name":"Jorge Boczkowski","orcid":"https://orcid.org/0000-0001-6619-5785","observed_orcids":["https://orcid.org/0000-0001-6619-5785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Boczkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075038951","display_name":"Bruno Crestani","orcid":"https://orcid.org/0000-0002-2961-3455","observed_orcids":["https://orcid.org/0000-0002-2961-3455","https://orcid.org/0009-0009-4987-0377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Crestani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4577,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.92416255,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"293","issue":"5","first_page":"L1230","last_page":"L1239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratinocyte-growth-factor","display_name":"keratinocyte growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.9769999980926514},{"id":"https://openalex.org/keywords/elastase-induced-lung-injury","display_name":"elastase-induced lung injury","score":0.9549999833106995},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.6309999823570251},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.890999972820282},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":1.0},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8199999928474426},{"id":"https://openalex.org/keywords/alveolitis","display_name":"alveolitis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/kgf-receptor","display_name":"KGF receptor","score":0.6290000081062317},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C2778615670","wikidata":"https://www.wikidata.org/wiki/Q3811988","display_name":"Keratinocyte growth factor","level":4,"score":0.8877986669540405},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.7828285694122314},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.71992427110672},{"id":"https://openalex.org/C2776326425","wikidata":"https://www.wikidata.org/wiki/Q976747","display_name":"Pancreatic elastase","level":4,"score":0.6313996315002441},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.537663996219635},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.4979090690612793},{"id":"https://openalex.org/C2775982285","wikidata":"https://www.wikidata.org/wiki/Q2964004","display_name":"Lung volume reduction surgery","level":4,"score":0.497759610414505},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4015674889087677},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39827001094818115},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3957098722457886},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3681172728538513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34253546595573425},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32178568840026855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2173224687576294},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.21714454889297485},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08070701360702515},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.07813313603401184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06878283619880676},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05349430441856384}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051497","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051497","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051523","descriptor_name":"Fibroblast Growth Factor 7","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.00460.2006","doi":"https://doi.org/10.1152/ajplung.00460.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00460.2006","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:17766584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17766584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1574428367","https://openalex.org/W1713255618","https://openalex.org/W1805008252","https://openalex.org/W1823110768","https://openalex.org/W1974540875","https://openalex.org/W1994008133","https://openalex.org/W2003629785","https://openalex.org/W2005659566","https://openalex.org/W2020738791","https://openalex.org/W2025955916","https://openalex.org/W2025959910","https://openalex.org/W2027983440","https://openalex.org/W2038528475","https://openalex.org/W2044833059","https://openalex.org/W2050828001","https://openalex.org/W2053602198","https://openalex.org/W2075787708","https://openalex.org/W2081881860","https://openalex.org/W2090262871","https://openalex.org/W2095538229","https://openalex.org/W2105216609","https://openalex.org/W2107225910","https://openalex.org/W2107706859","https://openalex.org/W2111002265","https://openalex.org/W2122078978","https://openalex.org/W2128890717","https://openalex.org/W2141477898","https://openalex.org/W2156634951","https://openalex.org/W2335037725","https://openalex.org/W2977568416"],"related_works":["https://openalex.org/W4251461659","https://openalex.org/W2085795832","https://openalex.org/W2978720676","https://openalex.org/W2127070461","https://openalex.org/W1590342331","https://openalex.org/W2112363620","https://openalex.org/W2065995843","https://openalex.org/W2121003873","https://openalex.org/W4323349415","https://openalex.org/W2145341186"],"abstract_inverted_index":{"Pulmonary":[0],"emphysema":[1,38,151,210],"is":[2],"characterized":[3],"by":[4,126,168],"persistent":[5],"inflammation":[6],"and":[7,20,22,71,90,96,102,111,117,180,208],"progressive":[8],"alveolar":[9,18,135,187,204],"destruction.":[10],"The":[11],"keratinocyte":[12],"growth":[13],"factor":[14],"(KGF)":[15],"favorably":[16],"influences":[17],"maintenance":[19],"repair":[21],"possesses":[23],"anti-inflammatory":[24],"properties.":[25],"We":[26,191],"aimed":[27],"to":[28],"determine":[29],"whether":[30],"exogenous":[31],"KGF":[32,49,142,158,172,194],"prevented":[33,53],"or":[34],"corrected":[35],"elastase-induced":[36,150,175,198],"pulmonary":[37,54,80,199],"in":[39,65,78,107,122,134,160,177,183,211],"vivo.":[40],"Treatment":[41,140],"with":[42,60,141],"5":[43],"mg":[44],"x":[45,47],"kg(-1)":[46],"day(-1)":[48],"before":[50],"elastase":[51,144],"instillation":[52,145],"emphysema.":[55],"This":[56],"effect":[57,148],"was":[58],"associated":[59],"1)":[61],"a":[62,76,105,119],"sharp":[63],"reduction":[64,77,106,121],"bronchoalveolar":[66],"lavage":[67],"fluid":[68],"total":[69],"protein":[70],"inflammatory":[72,94],"cell":[73,189,205],"recruitment,":[74],"2)":[75],"the":[79,83,98,153,157,161,174,184],"expression":[81,155],"of":[82,97,156,163,202],"chemokines":[84],"CCL2":[85],"(or":[86,92],"monocyte":[87],"chemoattractant":[88],"protein-1)":[89],"CXCL2":[91],"macrophage":[93],"protein-2alpha)":[95],"adhesion":[99],"molecules":[100],"ICAM-1":[101,181],"VCAM-1,":[103],"3)":[104],"matrix":[108],"metalloproteinase":[109],"(MMP)-2":[110],"MMP-9":[112],"activity":[113],"at":[114,137],"day":[115,138],"3,":[116],"4)":[118],"major":[120],"DNA":[123,206],"damage":[124],"detected":[125],"terminal":[127],"deoxynucleotidyltransferase-mediated":[128],"dUTP":[129],"nick":[130],"end":[131],"labeling":[132],"(TUNEL)":[133],"cells":[136],"7.":[139],"after":[143],"had":[146],"no":[147],"on":[149],"despite":[152],"conserved":[154],"receptor":[159],"lungs":[162],"elastase-instilled":[164],"animals":[165],"as":[166],"determined":[167],"immunohistochemistry.":[169],"In":[170],"vitro,":[171],"abolished":[173],"increase":[176],"CCL2,":[178],"CXCL2,":[179],"mRNA":[182],"MLE-12":[185],"murine":[186],"epithelial":[188],"line.":[190],"conclude":[192],"that":[193],"pretreatment":[195],"protected":[196],"against":[197],"inflammation,":[200],"activation":[201],"MMPs,":[203],"damage,":[207],"subsequent":[209],"mice.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}