{"id":"https://openalex.org/W2147477265","doi":"https://doi.org/10.4049/jimmunol.169.8.4657","title":"Dynamics of T Cells and TCR Excision Circles Differ After Treatment of Acute and Chronic HIV Infection","display_name":"Dynamics of T Cells and TCR Excision Circles Differ After Treatment of Acute and Chronic HIV Infection","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W2147477265","doi":"https://doi.org/10.4049/jimmunol.169.8.4657","mag":"2147477265","pmid":"https://pubmed.ncbi.nlm.nih.gov/12370406"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.169.8.4657","doi":"https://doi.org/10.4049/jimmunol.169.8.4657","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.8.4657","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062645957","display_name":"Sharon R. Lewin","orcid":"https://orcid.org/0000-0002-0330-8241","observed_orcids":["https://orcid.org/0000-0002-0330-8241"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sharon R Lewin","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Melbourne , Parkville, Victoria ,","Victorian Infectious Diseases Service, Royal Melbourne Hospital , Parkville, Victoria ,","*Department of Microbiology and Immunology, University of Melbourne, and","\u2020Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Melbourne , Parkville, Victoria ,","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Victorian Infectious Diseases Service, Royal Melbourne Hospital , Parkville, Victoria ,","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"*Department of Microbiology and Immunology, University of Melbourne, and","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"\u2020Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia;","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033826368","display_name":"Ruy Miguel Ribeiro","orcid":"https://orcid.org/0000-0002-3988-8241","observed_orcids":["https://orcid.org/0000-0002-3988-8241"]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruy M Ribeiro","raw_affiliation_strings":["Los Alamos National Laboratory , Los Alamos, NM 87545","\u2021Los Alamos National Laboratory, Los Alamos, NM 87545; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory , Los Alamos, NM 87545","institution_ids":["https://openalex.org/I1343871089"]},{"raw_affiliation_string":"\u2021Los Alamos National Laboratory, Los Alamos, NM 87545; and","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109946619","display_name":"Gilbert R. Kaufmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gilbert R Kaufmann","raw_affiliation_strings":["National Center for HIV Epidemiology and Clinical Research, University of New South Wales , Sydney, New South Wales ,","\u00a7National Center for HIV Epidemiology and Clinical Research, University of New South Wales, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for HIV Epidemiology and Clinical Research, University of New South Wales , Sydney, New South Wales ,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"\u00a7National Center for HIV Epidemiology and Clinical Research, University of New South Wales, and","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018068497","display_name":"Don\u00a0E. Smith","orcid":"https://orcid.org/0000-0002-1308-4595","observed_orcids":["https://orcid.org/0000-0002-1308-4595"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Don Smith","raw_affiliation_strings":["National Center for HIV Epidemiology and Clinical Research, University of New South Wales , Sydney, New South Wales ,","\u00a7National Center for HIV Epidemiology and Clinical Research, University of New South Wales, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for HIV Epidemiology and Clinical Research, University of New South Wales , Sydney, New South Wales ,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"\u00a7National Center for HIV Epidemiology and Clinical Research, University of New South Wales, and","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088309165","display_name":"John James Zaunders","orcid":"https://orcid.org/0000-0002-5912-5989","observed_orcids":["https://orcid.org/0000-0002-5912-5989"]},"institutions":[{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John Zaunders","raw_affiliation_strings":["Center for Immunology, St. Vincent\u2019s Hospital , Sydney, New South Wales ,","\u00b6Center for Immunology, St. Vincent\u2019s Hospital, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunology, St. Vincent\u2019s Hospital , Sydney, New South Wales ,","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"\u00b6Center for Immunology, St. Vincent\u2019s Hospital, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I4210087284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079993549","display_name":"Matthew G. Law","orcid":"https://orcid.org/0000-0002-3540-8837","observed_orcids":["https://orcid.org/0000-0002-3540-8837"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew Law","raw_affiliation_strings":["National Center for HIV Epidemiology and Clinical Research, University of New South Wales , Sydney, New South Wales ,","\u00a7National Center for HIV Epidemiology and Clinical Research, University of New South Wales, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for HIV Epidemiology and Clinical Research, University of New South Wales , Sydney, New South Wales ,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"\u00a7National Center for HIV Epidemiology and Clinical Research, University of New South Wales, and","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110356286","display_name":"Ajantha E. Solomon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Ajantha Solomon","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Melbourne , Parkville, Victoria ,","*Department of Microbiology and Immunology, University of Melbourne, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Melbourne , Parkville, Victoria ,","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"*Department of Microbiology and Immunology, University of Melbourne, and","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055398640","display_name":"Paul U. Cameron","orcid":"https://orcid.org/0000-0002-1906-6945","observed_orcids":["https://orcid.org/0000-0002-1906-6945"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul U Cameron","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Melbourne , Parkville, Victoria ,","*Department of Microbiology and Immunology, University of Melbourne, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Melbourne , Parkville, Victoria ,","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"*Department of Microbiology and Immunology, University of Melbourne, and","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107834622","display_name":"David A. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David Cooper","raw_affiliation_strings":["National Center for HIV Epidemiology and Clinical Research, University of New South Wales , Sydney, New South Wales ,","\u00a7National Center for HIV Epidemiology and Clinical Research, University of New South Wales, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for HIV Epidemiology and Clinical Research, University of New South Wales , Sydney, New South Wales ,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"\u00a7National Center for HIV Epidemiology and Clinical Research, University of New South Wales, and","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058338534","display_name":"Alan S. Perelson","orcid":"https://orcid.org/0000-0002-2455-0002","observed_orcids":["https://orcid.org/0000-0002-2455-0002"]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan S Perelson","raw_affiliation_strings":["Los Alamos National Laboratory , Los Alamos, NM 87545","\u2021Los Alamos National Laboratory, Los Alamos, NM 87545; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory , Los Alamos, NM 87545","institution_ids":["https://openalex.org/I1343871089"]},{"raw_affiliation_string":"\u2021Los Alamos National Laboratory, Los Alamos, NM 87545; and","institution_ids":["https://openalex.org/I1343871089"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5110356286"],"corresponding_institution_ids":["https://openalex.org/I165779595"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.3913,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.79311405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"169","issue":"8","first_page":"4657","last_page":"4666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.796999990940094},{"id":"https://openalex.org/keywords/thymic-output","display_name":"thymic output","score":0.7900000214576721},{"id":"https://openalex.org/keywords/primary-hiv-infection","display_name":"primary HIV infection","score":0.9210000038146973},{"id":"https://openalex.org/keywords/chronic-hiv-infection","display_name":"chronic HIV infection","score":1.0},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/naive-t-cells","display_name":"naive T cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/t-cell-redistribution","display_name":"T cell redistribution","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6201459169387817},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6196670532226562},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.501291036605835},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.47893935441970825},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4327899217605591},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.4317011833190918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4100561738014221},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.38769620656967163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3763088285923004},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33260440826416016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2971816658973694},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2921736538410187},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2595728039741516}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.169.8.4657","doi":"https://doi.org/10.4049/jimmunol.169.8.4657","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.8.4657","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:12370406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12370406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G236819868","display_name":null,"funder_award_id":"RR 06555","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4516738831","display_name":null,"funder_award_id":"AI28433","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G513486277","display_name":"Modeling Viral and T Lymphocyte Dynamics","funder_award_id":"R01RR006555","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W82184047","https://openalex.org/W1509269909","https://openalex.org/W1580217007","https://openalex.org/W1593218714","https://openalex.org/W1977681931","https://openalex.org/W1981399286","https://openalex.org/W1982448824","https://openalex.org/W1983297428","https://openalex.org/W1989598380","https://openalex.org/W1992991204","https://openalex.org/W1994307941","https://openalex.org/W1997784020","https://openalex.org/W2007017265","https://openalex.org/W2029545298","https://openalex.org/W2046866633","https://openalex.org/W2059778842","https://openalex.org/W2090642065","https://openalex.org/W2099188318","https://openalex.org/W2101979427","https://openalex.org/W2102145741","https://openalex.org/W2105271739","https://openalex.org/W2110819064","https://openalex.org/W2114497207","https://openalex.org/W2114932869","https://openalex.org/W2115603688","https://openalex.org/W2124860027","https://openalex.org/W2130098661","https://openalex.org/W2133836223","https://openalex.org/W2139551787","https://openalex.org/W2148910852","https://openalex.org/W2152464646","https://openalex.org/W2158035002","https://openalex.org/W2159897712","https://openalex.org/W2160430737","https://openalex.org/W2161633487","https://openalex.org/W2163236618","https://openalex.org/W2163345314","https://openalex.org/W2171605884"],"related_works":["https://openalex.org/W2159897712","https://openalex.org/W2115603688","https://openalex.org/W2305032217","https://openalex.org/W2329281458","https://openalex.org/W7096860954","https://openalex.org/W2039925909","https://openalex.org/W2130959108","https://openalex.org/W7095467538","https://openalex.org/W2006000185","https://openalex.org/W2101828653"],"abstract_inverted_index":{"We":[0],"quantified":[1],"T":[2,51,95,122,199,231,236,255,267],"cell":[3],"proliferation":[4,167,179],"and":[5,16,28,47,64,106,119,139,203],"thymic":[6,144],"function":[7],"in":[8,44,59,68,83,89,100,143,152,166,173,183,193,229,234,238,265,271],"primary":[9],"HIV":[10,18,184,242],"infection":[11,19,185],"(PHI;":[12],"n":[13,21],"=":[14,22,207,212],"19)":[15],"chronic":[17],"(CHI;":[20],"14)":[23],"by":[24],"measuring":[25],"Ki67":[26],"staining":[27],"TCR":[29],"excision":[30],"circle":[31],"(TREC)":[32],"number.":[33],"After":[34],"antiretroviral":[35,75],"therapy":[36,76],"of":[37,49,77,93,121,137,156,159,180,220,241,253,261,276],"PHI":[38,138],"there":[39,79],"is":[40,80,128,146,225,269],"a":[41,65,81,111,250],"profound":[42],"decrease":[43],"the":[45,84,90,131,150,171,218,239,272],"number":[46,92,219],"percentage":[48,85],"Ki67(+)":[50],"cells":[52,63,96,105,182,200,224,232,247,268],"(<6%":[53],"Ki67(+))":[54],"with":[55,98,130],"no":[56,191],"significant":[57],"increase":[58,67,142,151],"TREC":[60,69,102,107,132,153,160,194,221,262],"per":[61,70,103,108,161,195,222,263],"million":[62,104,196,223],"transient":[66],"milliliter.":[71,109],"In":[72,175],"contrast,":[73],"after":[74],"CHI":[78],"reduction":[82],"but":[86],"little":[87],"change":[88],"total":[91,254],"Ki67(+)CD4(+)":[94],"associated":[97],"increases":[99],"both":[101],"Using":[110],"mathematical":[112],"model":[113],"that":[114,126,140,164,245,259],"accounts":[115],"for":[116,209,214],"proliferation,":[117],"death,":[118],"redistribution":[120,127],"cells,":[123,237,256],"we":[124,189,257],"find":[125,190,258],"consistent":[129],"changes":[133,165,172],"observed":[134],"during":[135,154],"treatment":[136,155],"an":[141],"output":[145],"needed":[147],"to":[148],"explain":[149,170],"CHI.":[157],"Consideration":[158],"milliliter":[162,264],"shows":[163],"alone":[168],"cannot":[169],"TREC.":[174],"addition,":[176],"although":[177,217],"increased":[178],"memory":[181,230,246],"has":[186],"been":[187],"established,":[188],"difference":[192],"CD45RA(-)":[197,273],"\"memory\"":[198,274],"between":[201],"healthy":[202],"infected":[204,278],"individuals":[205],"(p":[206],"0.154":[208],"CD4(+);":[210],"p":[211],"0.383":[213],"CD8(+)).":[215],"Finally,":[216],"always":[226],"much":[227],"lower":[228],"than":[233],"naive":[235],"setting":[240],"infection,":[243],"given":[244],"make":[248],"up":[249],"larger":[251],"proportion":[252],"50%":[260],"CD4(+)":[266],"harbored":[270],"subset":[275],"our":[277],"subjects.":[279]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}