{"id":"https://openalex.org/W2147459701","doi":"https://doi.org/10.1194/jlr.m041954","title":"Cholesterol lowering drug may influence cellular immune response by altering MHC II function","display_name":"Cholesterol lowering drug may influence cellular immune response by altering MHC II function","publication_year":2013,"publication_date":"2013-09-14","ids":{"openalex":"https://openalex.org/W2147459701","doi":"https://doi.org/10.1194/jlr.m041954","mag":"2147459701","pmid":"https://pubmed.ncbi.nlm.nih.gov/24038316","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3793615"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.m041954","doi":"https://doi.org/10.1194/jlr.m041954","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m041954","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1194/jlr.m041954","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080237062","display_name":"Koushik Roy","orcid":"https://orcid.org/0000-0002-9525-7196","observed_orcids":["https://orcid.org/0000-0002-9525-7196"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Koushik Roy","raw_affiliation_strings":["Infectious Diseases and Immunology and CSIR -Indian Institute of Chemical Biology, Jadavpur, Kolkata-700032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Immunology and CSIR -Indian Institute of Chemical Biology, Jadavpur, Kolkata-700032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Moumita Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Moumita Ghosh","raw_affiliation_strings":["Infectious Diseases and Immunology and CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata-700032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Immunology and CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata-700032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069567491","display_name":"Tuhin Kumar Pal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tuhin Kumar Pal","raw_affiliation_strings":["Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata-700032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata-700032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061689047","display_name":"Saikat Chakrabarti","orcid":"https://orcid.org/0000-0002-8644-6016","observed_orcids":["https://orcid.org/0000-0002-8644-6016","https://orcid.org/0000-0003-1015-4014"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saikat Chakrabarti","raw_affiliation_strings":["Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata-700032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata-700032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108549837","display_name":"Syamal Roy","orcid":"https://orcid.org/0000-0002-8942-6846","observed_orcids":["https://orcid.org/0000-0002-8942-6846"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Syamal Roy","raw_affiliation_strings":["Infectious Diseases and Immunology and CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata-700032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Immunology and CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata-700032, India","institution_ids":["https://openalex.org/I160344538"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108549837"],"corresponding_institution_ids":["https://openalex.org/I160344538"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.3432,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.80479532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"54","issue":"11","first_page":"3106","last_page":"3115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.3734999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.3734999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.19419999420642853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.703000009059906},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.972000002861023},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/peptide-mhc-class-ii-complexes","display_name":"peptide-MHC class II complexes","score":0.6959999799728394},{"id":"https://openalex.org/keywords/methyl-beta-cyclodextrin","display_name":"methyl-\u03b2-cyclodextrin","score":0.7680000066757202},{"id":"https://openalex.org/keywords/membrane-cholesterol-depletion","display_name":"membrane cholesterol depletion","score":0.7129999995231628},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/allosteric-modulation","display_name":"allosteric modulation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/peptide-binding-groove","display_name":"peptide binding groove","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cholesterol-binding-sites","display_name":"cholesterol binding sites","score":0.722000002861023},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.7990000247955322},{"id":"https://openalex.org/keywords/conformational-antibodies","display_name":"conformational antibodies","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cholesterol-lowering-drugs","display_name":"cholesterol-lowering drugs","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7774114608764648},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.7118277549743652},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5077632665634155},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48467424511909485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4638725519180298},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4100508391857147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39116039872169495},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28332164883613586},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2549400329589844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24823632836341858}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1194/jlr.m041954","doi":"https://doi.org/10.1194/jlr.m041954","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m041954","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3793615","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3793615","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Lipid Res","raw_type":"Text"},{"id":"pmid:24038316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24038316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3a47ed7b78754c2e92a9a883cd075840","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3a47ed7b78754c2e92a9a883cd075840","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 54, Iss 11, Pp 3106-3115 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.m041954","doi":"https://doi.org/10.1194/jlr.m041954","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m041954","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W15271215","https://openalex.org/W1503369148","https://openalex.org/W1525331105","https://openalex.org/W1576161848","https://openalex.org/W1582431384","https://openalex.org/W1661544713","https://openalex.org/W1794773046","https://openalex.org/W1970621786","https://openalex.org/W1970665499","https://openalex.org/W1977651369","https://openalex.org/W1979166300","https://openalex.org/W1986849641","https://openalex.org/W1989804720","https://openalex.org/W1990394752","https://openalex.org/W1991179466","https://openalex.org/W1992879374","https://openalex.org/W1994305957","https://openalex.org/W1996864556","https://openalex.org/W2006650314","https://openalex.org/W2007881211","https://openalex.org/W2010122297","https://openalex.org/W2012461056","https://openalex.org/W2017451770","https://openalex.org/W2019406534","https://openalex.org/W2020770907","https://openalex.org/W2041915582","https://openalex.org/W2044037092","https://openalex.org/W2044275643","https://openalex.org/W2045292502","https://openalex.org/W2046524985","https://openalex.org/W2050882825","https://openalex.org/W2059496396","https://openalex.org/W2060205179","https://openalex.org/W2063186096","https://openalex.org/W2063907861","https://openalex.org/W2066857663","https://openalex.org/W2067236087","https://openalex.org/W2069159000","https://openalex.org/W2070505676","https://openalex.org/W2071251525","https://openalex.org/W2071953701","https://openalex.org/W2073802090","https://openalex.org/W2086210763","https://openalex.org/W2086777628","https://openalex.org/W2087724831","https://openalex.org/W2092233799","https://openalex.org/W2096262020","https://openalex.org/W2109188460","https://openalex.org/W2110505997","https://openalex.org/W2114789036","https://openalex.org/W2128766971","https://openalex.org/W2132746917","https://openalex.org/W2132887964","https://openalex.org/W2136640191","https://openalex.org/W2137323006","https://openalex.org/W2151460035","https://openalex.org/W2158898372","https://openalex.org/W2160979794","https://openalex.org/W2165402484","https://openalex.org/W2165660520","https://openalex.org/W2165679020","https://openalex.org/W2171268876","https://openalex.org/W3048187409"],"related_works":["https://openalex.org/W2885126156","https://openalex.org/W1967004740","https://openalex.org/W2087173876","https://openalex.org/W2271423585","https://openalex.org/W1978665494","https://openalex.org/W2096262020","https://openalex.org/W2062115874","https://openalex.org/W2112276726","https://openalex.org/W3119921576","https://openalex.org/W1970621786"],"abstract_inverted_index":{"Major":[0],"histocompatibility":[1],"complex":[2,34],"class":[3],"II":[4,33,61,95,175],"(MHC":[5],"II)":[6],"expressed":[7],"on":[8],"the":[9,47,55,82,90,98,109,125,128,169],"surface":[10,58],"of":[11,22,40,51,59,84,93,116,134,157,164,173],"antigen-presenting":[12],"cells":[13,136,152],"(APCs)":[14],"displays":[15],"peptides":[16],"to":[17,46,148,177],"CD4\u207a":[18],"T":[19,151,178],"cells.":[20],"Depletion":[21],"membrane":[23,71],"cholesterol":[24,86,117],"from":[25],"APCs":[26],"by":[27,69],"methyl":[28],"\u03b2-cyclodextrin":[29],"treatment":[30],"compromises":[31],"peptide-MHC":[32],"formation":[35],"coupled":[36,153],"with":[37,77,108,137,154],"impaired":[38],"binding":[39,49,87,99,118,156,171],"conformational":[41,162],"antibody,":[42],"which":[43],"binds":[44],"close":[45],"peptide":[48,170],"groove":[50,172],"MHC":[52,60,94,140,145,174],"II.":[53],"Interestingly,":[54],"total":[56],"cell":[57,179],"remains":[62],"unaltered.":[63],"These":[64],"defects":[65],"can":[66],"be":[67],"corrected":[68],"restoring":[70],"cholesterol.":[72,131],"In":[73],"silico":[74],"docking":[75],"studies":[76,100],"a":[78,85],"three-dimensional":[79],"model":[80],"showed":[81],"presence":[83],"site":[88],"in":[89,124],"transmembrane":[91],"domain":[92],"(TM-MHC-II).":[96],"From":[97],"it":[101],"was":[102],"clear":[103],"that":[104],"cholesterol,":[105],"indeed,":[106],"interacts":[107],"TM-MHC-II":[110,126,165],"and":[111,122],"alters":[112],"its":[113],"conformation.":[114],"Mutation":[115],"residues":[119],"(F240,":[120],"L243,":[121],"F246)":[123],"decreased":[127,155],"affinity":[129],"for":[130],"Furthermore,":[132],"transfection":[133],"CHO":[135],"full-length":[138],"mutant":[139],"II,":[141,146],"but":[142],"not":[143],"wild-type":[144],"failed":[147],"activate":[149],"antigen-specific":[150],"conformation-specific":[158],"antibodies.":[159],"Thus,":[160],"cholesterol-induced":[161],"change":[163],"may":[166],"allosterically":[167],"modulate":[168],"leading":[176],"activation.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
