{"id":"https://openalex.org/W2147449633","doi":null,"title":"Fecal bile acids and cholesterol metabolites of patients with ulcerative colitis, a high-risk group for development of colon cancer.","display_name":"Fecal bile acids and cholesterol metabolites of patients with ulcerative colitis, a high-risk group for development of colon cancer.","publication_year":1977,"publication_date":"1977-06-01","ids":{"openalex":"https://openalex.org/W2147449633","mag":"2147449633","pmid":"https://pubmed.ncbi.nlm.nih.gov/322859"},"language":"en","primary_location":{"id":"pmid:322859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/322859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104045263","display_name":"Bandaru S. Reddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B S Reddy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C W Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C W Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109099995","display_name":"Ernst L. Wynder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E L Wynder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.3433,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.98353437,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"37","issue":"6","first_page":"1697","last_page":"701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.17960000038146973,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.11410000175237656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fecal-bile-acids","display_name":"fecal bile acids","score":0.9559999704360962},{"id":"https://openalex.org/keywords/fecal-cholesterol","display_name":"fecal cholesterol","score":0.7170000076293945},{"id":"https://openalex.org/keywords/coprostanol","display_name":"coprostanol","score":0.875},{"id":"https://openalex.org/keywords/cholestane-3beta-5alpha-6beta-triol","display_name":"cholestane-3\u03b2,5\u03b1,6\u03b2-triol","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neutral-sterols","display_name":"neutral sterols","score":0.8560000061988831},{"id":"https://openalex.org/keywords/colon-cancer-risk","display_name":"colon cancer risk","score":0.8420000076293945},{"id":"https://openalex.org/keywords/colon-carcinogenesis","display_name":"colon carcinogenesis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/colonic-epithelial-cells","display_name":"colonic epithelial cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/fecal-excretion","display_name":"fecal excretion","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.9099838137626648},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7948774099349976},{"id":"https://openalex.org/C2777585577","wikidata":"https://www.wikidata.org/wiki/Q5168983","display_name":"Coprostanol","level":4,"score":0.7517760992050171},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.7077099680900574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7041356563568115},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5989372730255127},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.59608393907547},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49182581901550293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.487959086894989},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.43241024017333984},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.4296957850456238},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.42474913597106934},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.2678893506526947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19336014986038208},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.07567852735519409},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07143846154212952}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004083","descriptor_name":"Cholestanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007417","descriptor_name":"Intestinal Polyps","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:322859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/322859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2147449633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/322859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W151527501","https://openalex.org/W1922079366","https://openalex.org/W1933422699","https://openalex.org/W1974248729","https://openalex.org/W1981409857","https://openalex.org/W2002689685","https://openalex.org/W2006839756","https://openalex.org/W2011756451","https://openalex.org/W2026555450","https://openalex.org/W2029828770","https://openalex.org/W2030080953","https://openalex.org/W2044681635","https://openalex.org/W2047298817","https://openalex.org/W2078959605","https://openalex.org/W2253093851","https://openalex.org/W2271159090","https://openalex.org/W2427496861"],"related_works":["https://openalex.org/W1981409857","https://openalex.org/W1987094412","https://openalex.org/W1785999508","https://openalex.org/W58228290","https://openalex.org/W2064481852","https://openalex.org/W1985302199","https://openalex.org/W7204796941","https://openalex.org/W2169546022","https://openalex.org/W2289641600","https://openalex.org/W2041152993"],"abstract_inverted_index":{"Patients":[0,91,106],"with":[1,50,62,84,92,107],"chronic":[2],"ulcerative":[3,51,85,108],"colitis":[4,86,109],"are":[5],"at":[6],"increased":[7],"risk":[8],"of":[9,12,22,59,73,103,112],"developing":[10],"carcinoma":[11],"the":[13,20,36],"colon.":[14],"It":[15],"has":[16],"been":[17],"shown":[18],"that":[19,128],"concentration":[21],"fecal":[23,71],"bile":[24,44,113],"acids":[25,45,114],"and":[26,43,66,76,97,134],"neutral":[27,41,104],"sterols":[28],"was":[29,80],"higher":[30,81],"in":[31,35,48,82,88,115,141],"cancer":[32],"patients":[33,49,61,83],"than":[34,87],"comparable":[37,101,118],"healthy":[38,67],"controls.":[39,69],"Fecal":[40],"steroids":[42],"were":[46,56],"measured":[47],"colitis,":[52],"family":[53,95],"controls":[54,99],"who":[55],"immediate":[57],"relatives":[58],"patients,":[60],"other":[63,89,93,123],"digestive":[64],"diseases,":[65,94],"unrelated":[68,98],"The":[70],"excretion":[72],"cholesterol,":[74],"coprostanol,":[75],"cholestane-3beta,":[77],"5alpha,":[78],"6beta-triol":[79],"groups.":[90,124],"controls,":[96],"excreted":[100,110,121],"levels":[102,111],"sterols.":[105],"their":[116],"feces":[117],"to":[119],"those":[120],"by":[122],"These":[125],"findings":[126],"suggest":[127],"possible":[129],"interactions":[130],"between":[131],"cholesterol":[132],"metabolites":[133],"colonic":[135],"epithelial":[136],"cells":[137],"may":[138],"be":[139],"relevant":[140],"colon":[142],"carcinogenesis.":[143]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
