{"id":"https://openalex.org/W2147449043","doi":"https://doi.org/10.1261/rna.2328806","title":"Restoration in vivo of defective hepatitis delta virus RNA genomes","display_name":"Restoration in vivo of defective hepatitis delta virus RNA genomes","publication_year":2006,"publication_date":"2006-04-17","ids":{"openalex":"https://openalex.org/W2147449043","doi":"https://doi.org/10.1261/rna.2328806","mag":"2147449043","pmid":"https://pubmed.ncbi.nlm.nih.gov/16618966","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1464851"},"language":"en","primary_location":{"id":"doi:10.1261/rna.2328806","doi":"https://doi.org/10.1261/rna.2328806","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.2328806","pdf_url":"http://rnajournal.cshlp.org/content/12/6/1061.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://rnajournal.cshlp.org/content/12/6/1061.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065074773","display_name":"Severin O. Gudima","orcid":"https://orcid.org/0000-0003-3824-8952","observed_orcids":["https://orcid.org/0000-0003-3824-8952"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Severin O. Gudima","raw_affiliation_strings":["Fox Chase Cancer Center, Philadephia, Pennsylvania 19111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadephia, Pennsylvania 19111, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023737081","display_name":"Jinhong Chang","orcid":"https://orcid.org/0000-0002-6723-494X","observed_orcids":["https://orcid.org/0000-0002-6723-494X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinhong Chang","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088766033","display_name":"John M. Taylor","orcid":"https://orcid.org/0000-0002-4275-077X","observed_orcids":["https://orcid.org/0000-0002-4275-077X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John M. Taylor","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497, USA","Fox Chase Cancer Center, Philadelphia, PA 19111-2497, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA 19111-2497, USA;","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088766033"],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":null,"apc_paid":null,"fwci":0.732,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.76499443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"6","first_page":"1061","last_page":"1073"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-delta-virus","display_name":"hepatitis delta virus","score":0.996999979019165},{"id":"https://openalex.org/keywords/rna-replication","display_name":"RNA replication","score":0.5799999833106995},{"id":"https://openalex.org/keywords/rna-recombination","display_name":"RNA recombination","score":0.7379999756813049},{"id":"https://openalex.org/keywords/intramolecular-base-pairing","display_name":"intramolecular base pairing","score":0.777999997138977},{"id":"https://openalex.org/keywords/template-switching","display_name":"template switching","score":0.5879999995231628},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8686597347259521},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.8207778930664062},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5886595845222473},{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.5430857539176941},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.5041879415512085},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.503419816493988},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46225327253341675},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.43591347336769104},{"id":"https://openalex.org/C25281209","wikidata":"https://www.wikidata.org/wiki/Q3502188","display_name":"RNA polymerase I","level":5,"score":0.4314609169960022},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39658886194229126},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33320820331573486},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24489644169807434},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020029","descriptor_name":"Base Pairing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1261/rna.2328806","doi":"https://doi.org/10.1261/rna.2328806","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.2328806","pdf_url":"http://rnajournal.cshlp.org/content/12/6/1061.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},{"id":"pmid:16618966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16618966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:rna:12/6/1061","doi":null,"is_oa":false,"landing_page_url":"http://rnajournal.cshlp.org/cgi/content/short/12/6/1061","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1261/rna.2328806","doi":"https://doi.org/10.1261/rna.2328806","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.2328806","pdf_url":"http://rnajournal.cshlp.org/content/12/6/1061.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3253785729","display_name":null,"funder_award_id":"AI-26522","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4038086905","display_name":"Structure and Replication of Hepatitis Delta Virus","funder_award_id":"R01AI026522","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000027172","display_name":null,"funder_award_id":"CA-06927","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G921727105","display_name":null,"funder_award_id":"CA06927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147449043.pdf","grobid_xml":"https://content.openalex.org/works/W2147449043.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1495704598","https://openalex.org/W1532982349","https://openalex.org/W1539027848","https://openalex.org/W1569265439","https://openalex.org/W1593064378","https://openalex.org/W1608621108","https://openalex.org/W1673429509","https://openalex.org/W1678644792","https://openalex.org/W1768947898","https://openalex.org/W1828431905","https://openalex.org/W1898981622","https://openalex.org/W1921884377","https://openalex.org/W1938880095","https://openalex.org/W1946946449","https://openalex.org/W1967901693","https://openalex.org/W1969699638","https://openalex.org/W1975629937","https://openalex.org/W1984264997","https://openalex.org/W2002316477","https://openalex.org/W2003585432","https://openalex.org/W2013659134","https://openalex.org/W2020769208","https://openalex.org/W2028509576","https://openalex.org/W2028647173","https://openalex.org/W2029863584","https://openalex.org/W2035991334","https://openalex.org/W2053312292","https://openalex.org/W2066200825","https://openalex.org/W2073070999","https://openalex.org/W2076037594","https://openalex.org/W2079065027","https://openalex.org/W2096558833","https://openalex.org/W2114624600","https://openalex.org/W2115465004","https://openalex.org/W2118146768","https://openalex.org/W2119906769","https://openalex.org/W2127338048","https://openalex.org/W2131136045","https://openalex.org/W2131753705","https://openalex.org/W2139689812","https://openalex.org/W2140542253","https://openalex.org/W2141157874","https://openalex.org/W2147663236","https://openalex.org/W2149458214","https://openalex.org/W2152575791","https://openalex.org/W2157441620","https://openalex.org/W2161160410","https://openalex.org/W2165457619","https://openalex.org/W2348414321","https://openalex.org/W2403316463","https://openalex.org/W2478271910","https://openalex.org/W4248600275"],"related_works":["https://openalex.org/W2115465004","https://openalex.org/W2069944578","https://openalex.org/W2028509576","https://openalex.org/W2124304622","https://openalex.org/W2621404757","https://openalex.org/W2058026064","https://openalex.org/W2139689812","https://openalex.org/W1593064378","https://openalex.org/W162259529","https://openalex.org/W2020769208"],"abstract_inverted_index":{"The":[0,56,95,116,150],"1679-nt":[1],"single-stranded":[2],"RNA":[3,28,33,65,85,129,183,189],"genome":[4,190],"of":[5,62,70,75,82,103,122,152,160,173,181,187,211,215],"hepatitis":[6],"delta":[7],"virus":[8],"(HDV)":[9],"is":[10,15,29,40,45,191],"circular":[11],"in":[12,109,204],"conformation.":[13],"It":[14],"able":[16],"to":[17,51,67,72,106,124,136],"fold":[18],"into":[19],"an":[20,80],"unbranched":[21],"rodlike":[22,84,213],"structure":[23,86,214],"via":[24],"intramolecular":[25,197],"base-pairing.":[26],"This":[27],"replicated":[30],"by":[31,111,147],"host":[32],"polymerase":[34],"II":[35,44],"(Pol":[36],"II).":[37],"Such":[38,185],"transcription":[39],"unique,":[41],"because":[42],"Pol":[43],"known":[46],"only":[47],"for":[48,209],"its":[49],"ability":[50,61,102,121],"act":[52],"on":[53],"DNA":[54],"templates.":[55],"present":[57],"study":[58],"addressed":[59],"the":[60,63,83,93,101,120,153,161,188,212,216],"HDV":[64,142],"replication":[66],"tolerate":[68],"insertions":[69,96,117],"up":[71],"1000":[73],"nt":[74],"non-HDV":[76],"sequence":[77],"either":[78],"at":[79,88],"end":[81],"or":[87,177],"a":[89,194],"site":[90],"embedded":[91],"within":[92],"rod.":[94],"did":[97],"not":[98],"interfere":[99],"with":[100,158,176,193,206],"primary":[104],"transcripts":[105],"be":[107,145],"processed":[108],"vivo":[110],"ribozyme":[112],"cleavage":[113],"and":[114,166],"ligation.":[115],"greatly":[118],"reduced":[119],"genomes":[123],"replicate.":[125],"However,":[126],"when":[127],"total":[128],"from":[130],"such":[131],"transfected":[132],"cells":[133],"was":[134,156],"used":[135],"transfect":[137],"new":[138],"recipient":[139],"cells,":[140],"replicating":[141],"RNAs":[143,155],"could":[144],"detected":[146],"Northern":[148],"analyses.":[149],"size":[151],"emerged":[154],"consistent":[157,192],"loss":[159],"inserted":[162,174],"sequences.":[163,184],"RT-PCR,":[164],"cloning,":[165],"sequencing":[167],"showed":[168],"that":[169],"recovery":[170],"involved":[171],"removal":[172],"sequences":[175],"without":[178],"small":[179],"deletions":[180],"adjacent":[182],"restoration":[186],"model":[195],"requiring":[196],"template-switching":[198],"(RNA":[199],"recombination)":[200],"during":[201],"RNA-directed":[202],"transcription,":[203],"combination":[205],"biological":[207],"selection":[208],"maintenance":[210],"template.":[217]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
