{"id":"https://openalex.org/W2147443365","doi":"https://doi.org/10.1161/circresaha.109.205310","title":"p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content","display_name":"p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content","publication_year":2009,"publication_date":"2009-08-21","ids":{"openalex":"https://openalex.org/W2147443365","doi":"https://doi.org/10.1161/circresaha.109.205310","mag":"2147443365","pmid":"https://pubmed.ncbi.nlm.nih.gov/19696408","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2761626"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.109.205310","doi":"https://doi.org/10.1161/circresaha.109.205310","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.109.205310","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.109.205310","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.109.205310","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072367924","display_name":"Joon\u2010Young Park","orcid":"https://orcid.org/0000-0002-7705-7086","observed_orcids":["https://orcid.org/0000-0002-7705-7086"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Joon-Young Park","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045620483","display_name":"Pingyuan Wang","orcid":"https://orcid.org/0009-0005-0368-5070","observed_orcids":["https://orcid.org/0009-0005-0368-5070"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Ping-yuan Wang","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003229709","display_name":"Takumi Matsumoto","orcid":"https://orcid.org/0000-0003-2363-9803","observed_orcids":["https://orcid.org/0000-0003-2363-9803"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Takumi Matsumoto","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102860187","display_name":"Ho Joong Sung","orcid":"https://orcid.org/0000-0002-5614-1350","observed_orcids":["https://orcid.org/0000-0002-5614-1350"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Ho Joong Sung","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010671008","display_name":"Wenzhe Ma","orcid":"https://orcid.org/0000-0001-9475-6981","observed_orcids":["https://orcid.org/0000-0001-9475-6981"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Wenzhe Ma","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027525615","display_name":"Jeong Won Choi","orcid":"https://orcid.org/0000-0003-4299-7155","observed_orcids":["https://orcid.org/0000-0003-4299-7155"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Jeong W. Choi","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038081351","display_name":"Stasia A. Anderson","orcid":"https://orcid.org/0000-0002-2566-6947","observed_orcids":["https://orcid.org/0000-0002-2566-6947"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Stasia A. Anderson","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048383846","display_name":"Scot C. Leary","orcid":"https://orcid.org/0000-0001-8488-7822","observed_orcids":["https://orcid.org/0000-0001-8488-7822"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Scot C. Leary","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089240456","display_name":"Robert S. Balaban","orcid":"https://orcid.org/0000-0003-4086-0948","observed_orcids":["https://orcid.org/0000-0003-4086-0948"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Robert S. Balaban","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008147474","display_name":"Ju\u2010Gyeong Kang","orcid":"https://orcid.org/0000-0002-3397-232X","observed_orcids":["https://orcid.org/0000-0002-3397-232X"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Ju-Gyeong Kang","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057804839","display_name":"Paul M. Hwang","orcid":"https://orcid.org/0000-0002-5976-7834","observed_orcids":["https://orcid.org/0000-0002-5976-7834"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Paul M. Hwang","raw_affiliation_strings":["From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","Temple University (J.P.), Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Translational Medicine Branch (J.P., P.W., T.M., H.J.S, W.M., J.W.C., S.A.A., R.S.B., J.K., P.M.H.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; Temple University (J.P.), Philadelphia, Pa; and Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I5023651","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Montreal Neurological Institute and Department of Human Genetics (S.C.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Temple University (J.P.), Philadelphia, Pa","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9555,"has_fulltext":true,"cited_by_count":202,"citation_normalized_percentile":{"value":0.95269315,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"105","issue":"7","first_page":"705","last_page":"712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.11219999939203262,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aerobic-exercise-capacity","display_name":"aerobic exercise capacity","score":0.9480000138282776},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mitochondrial-dna-content","display_name":"mitochondrial DNA content","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tfam","display_name":"TFAM","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/aerobic-metabolism","display_name":"aerobic metabolism","score":0.8109999895095825},{"id":"https://openalex.org/keywords/glycolytic-muscle","display_name":"glycolytic muscle","score":0.5929999947547913},{"id":"https://openalex.org/keywords/myoblasts","display_name":"myoblasts","score":0.7820000052452087},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.640999972820282},{"id":"https://openalex.org/keywords/tissue-specific-gene-regulation","display_name":"tissue-specific gene regulation","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7222297787666321},{"id":"https://openalex.org/C2992361435","wikidata":"https://www.wikidata.org/wiki/Q60354","display_name":"Aerobic capacity","level":2,"score":0.630839467048645},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6154891848564148},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.5454252362251282},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.47081929445266724},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.43858933448791504},{"id":"https://openalex.org/C133165541","wikidata":"https://www.wikidata.org/wiki/Q472094","display_name":"Exercise physiology","level":2,"score":0.43806764483451843},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43094560503959656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37690281867980957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36708658933639526},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3371204137802124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31952205300331116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2806660532951355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2499832808971405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1697644591331482}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005082","descriptor_name":"Physical Exertion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008931","descriptor_name":"Mitochondria, Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013550","descriptor_name":"Swimming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017079","descriptor_name":"Exercise Tolerance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032448","descriptor_name":"Myoblasts, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053580","descriptor_name":"Muscle Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/circresaha.109.205310","doi":"https://doi.org/10.1161/circresaha.109.205310","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.109.205310","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.109.205310","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:19696408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19696408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2761626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2761626","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/circresaha.109.205310","doi":"https://doi.org/10.1161/circresaha.109.205310","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.109.205310","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.109.205310","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5183633300","display_name":"Genetic insights into cardiovascular function and disease","funder_award_id":"Z01HL005101","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147443365.pdf","grobid_xml":"https://content.openalex.org/works/W2147443365.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W397537768","https://openalex.org/W1596431542","https://openalex.org/W1607363557","https://openalex.org/W1675626679","https://openalex.org/W1774344187","https://openalex.org/W1964465796","https://openalex.org/W1964719993","https://openalex.org/W1967072539","https://openalex.org/W1968197570","https://openalex.org/W1969025184","https://openalex.org/W1975514666","https://openalex.org/W1981311057","https://openalex.org/W1985790764","https://openalex.org/W1990287702","https://openalex.org/W1990990690","https://openalex.org/W1994089967","https://openalex.org/W2022957486","https://openalex.org/W2032811482","https://openalex.org/W2034059961","https://openalex.org/W2038621442","https://openalex.org/W2045307498","https://openalex.org/W2048771411","https://openalex.org/W2054368198","https://openalex.org/W2062515127","https://openalex.org/W2062867597","https://openalex.org/W2063707356","https://openalex.org/W2068456988","https://openalex.org/W2074831613","https://openalex.org/W2088053459","https://openalex.org/W2093361250","https://openalex.org/W2095370504","https://openalex.org/W2107621770","https://openalex.org/W2109123740","https://openalex.org/W2111245253","https://openalex.org/W2113515610","https://openalex.org/W2118397007","https://openalex.org/W2119239003","https://openalex.org/W2122612452","https://openalex.org/W2126390187","https://openalex.org/W2128919887","https://openalex.org/W2130246533","https://openalex.org/W2130661160","https://openalex.org/W2138553207","https://openalex.org/W2144794300","https://openalex.org/W2153268661","https://openalex.org/W2166994240","https://openalex.org/W2271368734","https://openalex.org/W2328965873","https://openalex.org/W2567749685","https://openalex.org/W3162215120","https://openalex.org/W4250014314"],"related_works":["https://openalex.org/W2085772221","https://openalex.org/W1973729267","https://openalex.org/W1998385969","https://openalex.org/W2105618103","https://openalex.org/W3173717871","https://openalex.org/W2770749640","https://openalex.org/W2109123740","https://openalex.org/W2892834843","https://openalex.org/W3158026989","https://openalex.org/W2922718404"],"abstract_inverted_index":{"RATIONALE:":[0],"Exercise":[1],"capacity":[2,44,94,243],"is":[3,34],"a":[4,81,138,157,252],"physiological":[5],"characteristic":[6],"associated":[7],"with":[8,151,191],"protection":[9],"from":[10],"both":[11,51,217],"cardiovascular":[12,52],"and":[13,20,86,95,103,109,135,166,168,219,241,249],"all-cause":[14],"mortality.":[15],"p53":[16,41,72,117,142,149,212,237],"regulates":[17,73,169],"mitochondrial":[18,104,114,147,162,247],"function":[19,123],"its":[21],"deletion":[22],"markedly":[23],"diminishes":[24],"exercise":[25,43,75,93,107,242],"capacity,":[26,108],"but":[27],"the":[28,37,67,96,130],"underlying":[29],"genetic":[30,68],"mechanism":[31,69],"orchestrating":[32],"this":[33,62],"unclear.":[35],"Understanding":[36],"biology":[38],"of":[39,61,83,98,106,113,132,211,224],"how":[40],"improves":[42],"may":[45],"provide":[46],"useful":[47],"insights":[48],"for":[49,141,161],"improving":[50],"as":[53,55],"well":[54],"general":[56],"health.":[57],"OBJECTIVE:":[58],"The":[59,172],"purpose":[60],"study":[63],"was":[64,181],"to":[65,178],"understand":[66],"by":[70,205,226,244],"which":[71],"aerobic":[74,185,239],"capacity.":[76],"METHODS":[77],"AND":[78],"RESULTS:":[79],"Using":[80],"variety":[82],"physiological,":[84],"metabolic,":[85],"molecular":[87],"techniques,":[88],"we":[89,127],"further":[90,203],"characterized":[91],"maximum":[92],"effects":[97],"training,":[99],"measured":[100],"various":[101],"nonmitochondrial":[102],"determinants":[105],"examined":[110],"putative":[111],"regulators":[112],"biogenesis.":[115],"As":[116],"did":[118],"not":[119],"affect":[120],"baseline":[121],"cardiac":[122,196],"or":[124],"inotropic":[125],"reserve,":[126],"focused":[128],"on":[129],"involvement":[131],"skeletal":[133,145,188],"muscle":[134,146,189],"now":[136],"report":[137],"wider":[139],"role":[140],"in":[143,175,184,195,199,206,213,251],"modulating":[144],"function.":[148],"interacts":[150],"Mitochondrial":[152],"Transcription":[153],"Factor":[154],"A":[155],"(TFAM),":[156],"nuclear-encoded":[158],"gene":[159],"important":[160],"DNA":[163],"(mtDNA)":[164],"transcription":[165],"maintenance,":[167],"mtDNA":[170,174,220,229],"content.":[171,230],"increased":[173],"p53(+/+)":[176],"compared":[177],"p53(-/-)":[179],"mice":[180],"more":[182],"marked":[183],"versus":[186],"glycolytic":[187],"groups":[190],"no":[192],"significant":[193],"changes":[194],"tissue.":[197],"These":[198],"vivo":[200],"observations":[201],"were":[202],"supported":[204],"vitro":[207],"studies":[208],"showing":[209],"overexpression":[210],"mouse":[214],"myoblasts":[215],"increases":[216],"TFAM":[218,225],"levels":[221],"whereas":[222],"depletion":[223],"shRNA":[227],"decreases":[228],"CONCLUSIONS:":[231],"Our":[232],"current":[233],"findings":[234],"indicate":[235],"that":[236],"promotes":[238],"metabolism":[240],"using":[245],"different":[246],"genes":[248],"mechanisms":[250],"tissue-specific":[253],"manner.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}