{"id":"https://openalex.org/W2147417795","doi":"https://doi.org/10.1158/1055-9965.epi-10-0994","title":"Genetic Polymorphisms in Inflammation Pathway Genes and Prostate Cancer Risk","display_name":"Genetic Polymorphisms in Inflammation Pathway Genes and Prostate Cancer Risk","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W2147417795","doi":"https://doi.org/10.1158/1055-9965.epi-10-0994","mag":"2147417795","pmid":"https://pubmed.ncbi.nlm.nih.gov/21430300","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3140053"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-10-0994","doi":"https://doi.org/10.1158/1055-9965.epi-10-0994","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-10-0994","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers &amp; Prevention","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3140053","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058286625","display_name":"Erika Mijin Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika M. Kwon","raw_affiliation_strings":["Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I201448701","https://openalex.org/I2799853436","https://openalex.org/I4210089486","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103567239","display_name":"Claudia A. Salinas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia A. Salinas","raw_affiliation_strings":["Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I201448701","https://openalex.org/I2799853436","https://openalex.org/I4210089486","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016200723","display_name":"Suzanne Kolb","orcid":"https://orcid.org/0000-0002-6443-644X","observed_orcids":["https://orcid.org/0000-0002-6443-644X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Kolb","raw_affiliation_strings":["Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I201448701","https://openalex.org/I2799853436","https://openalex.org/I4210089486","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102983688","display_name":"Rong Fu","orcid":"https://orcid.org/0000-0002-6961-986X","observed_orcids":["https://orcid.org/0000-0002-6961-986X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Fu","raw_affiliation_strings":["Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I201448701","https://openalex.org/I2799853436","https://openalex.org/I4210089486","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058030955","display_name":"Ziding Feng","orcid":"https://orcid.org/0000-0003-3051-8882","observed_orcids":["https://orcid.org/0000-0003-3051-8882"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziding Feng","raw_affiliation_strings":["Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I201448701","https://openalex.org/I2799853436","https://openalex.org/I4210089486","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054491363","display_name":"Janet L. Stanford","orcid":"https://orcid.org/0000-0001-5062-4784","observed_orcids":["https://orcid.org/0000-0001-5062-4784"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet L. Stanford","raw_affiliation_strings":["Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I201448701","https://openalex.org/I2799853436","https://openalex.org/I4210089486","https://openalex.org/I4210090236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045178497","display_name":"Elaine A. Ostrander","orcid":"https://orcid.org/0000-0001-6075-9738","observed_orcids":["https://orcid.org/0000-0001-6075-9738"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine A. Ostrander","raw_affiliation_strings":["Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda; 2Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle; 4Department of Epidemiology, School of Public Health; and 5Department of Biostatistics, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I201448701","https://openalex.org/I2799853436","https://openalex.org/I4210089486","https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2199,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.96766213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":"5","first_page":"923","last_page":"933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2542000114917755,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8999999761581421},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8759999871253967},{"id":"https://openalex.org/keywords/inflammatory-signaling-pathways","display_name":"inflammatory signaling","score":0.6830000281333923},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9520000219345093},{"id":"https://openalex.org/keywords/gp130","display_name":"gp130","score":0.7350000143051147},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.7310000061988831},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8960000276565552},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.9039999842643738},{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.7649999856948853},{"id":"https://openalex.org/keywords/pik3r1","display_name":"PIK3R1","score":1.0},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.6349999904632568},{"id":"https://openalex.org/keywords/disease-aggressiveness","display_name":"disease aggressiveness","score":0.7990000247955322},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8477320671081543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6180222034454346},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5527358651161194},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5054495334625244},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4316651225090027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4290487766265869},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4108530282974243},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40217679738998413},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3986617922782898},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.350249707698822},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30860215425491333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25566673278808594}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1158/1055-9965.epi-10-0994","doi":"https://doi.org/10.1158/1055-9965.epi-10-0994","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-10-0994","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers &amp; Prevention","raw_type":"journal-article"},{"id":"pmid:21430300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21430300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:3140053","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3140053","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1007.9922","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1007.9922","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cebp.aacrjournals.org/content/20/5/923.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1008.6405","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1008.6405","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cebp.aacrjournals.org/content/early/2011/03/29/1055-9965.EPI-10-0994.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1023.2374","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1023.2374","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cebp.aacrjournals.org/content/early/2011/03/18/1055-9965.EPI-10-0994.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3140053","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3140053","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G172490495","display_name":null,"funder_award_id":"N01 CN005230","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G186534930","display_name":"PROSTATE CANCER IN RELATION TO VASECTOMY","funder_award_id":"R01CA056678","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G218073325","display_name":"SURVEILLANCE EPIDEMIOLOGY AND END RESULTS","funder_award_id":"n01cn005230-022","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3543110204","display_name":"Predoctoral Training Program in Human Genetics","funder_award_id":"T32GM007814","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5294359063","display_name":null,"funder_award_id":"Z99 HG999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6444713482","display_name":"NSAIDS and Other Medications in Prostate Cancer Etiology","funder_award_id":"R01CA092579","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8563702743","display_name":"Inflammatory Pathway Gene Polymorphisms and Risk of Prostate Cancer","funder_award_id":"R03CA121871","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W77440476","https://openalex.org/W164906676","https://openalex.org/W1487226962","https://openalex.org/W1508398762","https://openalex.org/W1553274044","https://openalex.org/W1558007424","https://openalex.org/W1837402230","https://openalex.org/W1965103420","https://openalex.org/W1968365367","https://openalex.org/W1971443047","https://openalex.org/W1981287559","https://openalex.org/W1981822142","https://openalex.org/W1982552468","https://openalex.org/W1999746344","https://openalex.org/W2006382528","https://openalex.org/W2017362326","https://openalex.org/W2029048061","https://openalex.org/W2031646904","https://openalex.org/W2039456266","https://openalex.org/W2042707603","https://openalex.org/W2043557683","https://openalex.org/W2051616601","https://openalex.org/W2057668066","https://openalex.org/W2059724367","https://openalex.org/W2086478724","https://openalex.org/W2096275744","https://openalex.org/W2103115232","https://openalex.org/W2111008548","https://openalex.org/W2116554142","https://openalex.org/W2120286360","https://openalex.org/W2135455143","https://openalex.org/W2138253007","https://openalex.org/W2140283236","https://openalex.org/W2143693972","https://openalex.org/W2148702138","https://openalex.org/W2149848361","https://openalex.org/W2151625863","https://openalex.org/W2157043398","https://openalex.org/W2158734599","https://openalex.org/W2163001580","https://openalex.org/W2166794110","https://openalex.org/W2182373673","https://openalex.org/W2307239336","https://openalex.org/W2388163742","https://openalex.org/W2612575796","https://openalex.org/W4299639679","https://openalex.org/W6603054578","https://openalex.org/W6629130611"],"related_works":["https://openalex.org/W7099841332","https://openalex.org/W3176230961","https://openalex.org/W7095672699","https://openalex.org/W200439723","https://openalex.org/W1999026345","https://openalex.org/W2009452317","https://openalex.org/W2239590845","https://openalex.org/W2167579918","https://openalex.org/W2042707603","https://openalex.org/W2100510162"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chronic":[1],"inflammation":[2,26,236,265],"is":[3],"an":[4],"important":[5],"mechanism":[6],"for":[7,184,220],"the":[8,19,25,125,167,235,243,260,264],"development":[9,244,269],"and":[10,28,44,56,72,84,100,148,151,201,270],"progression":[11],"of":[12,41,63,78,110,153,170,222,245,263],"prostate":[13],"cancer":[14],"(PC).":[15],"To":[16],"better":[17],"understand":[18],"potential":[20,261],"relationship":[21],"between":[22],"genes":[23,93,142,233],"in":[24,34,54,61,91,112,124,141,161,198,232,242,267],"pathway":[27,237,266],"PC":[29,79,111,162,268],"risk,":[30],"we":[31],"evaluated":[32],"variants":[33,231],"16":[35],"candidate":[36],"genes.":[37],"METHODS:":[38],"A":[39],"total":[40],"143":[42],"tagging":[43],"amino":[45],"acid":[46],"altering":[47],"single":[48],"nucleotide":[49],"polymorphisms":[50],"(SNPs)":[51],"were":[52,102],"genotyped":[53],"Caucasian":[55],"African":[57],"American":[58],"men":[59,165],"participating":[60],"one":[62],"two":[64],"population-based,":[65],"case-control":[66],"studies":[67,249],"(n":[68],"=":[69,133,174,180,210,216],"1,458":[70],"cases":[71],"1,351":[73],"controls).":[74],"The":[75,114],"relative":[76],"risk":[77,109,119,163],"was":[80,120],"estimated":[81],"using":[82],"logistic":[83],"polytomous":[85],"regression":[86],"models.":[87],"RESULTS:":[88],"Ten":[89],"SNPs":[90,140,186,197],"seven":[92,185],"(CXCL12,":[94],"IL4,":[95],"IL6,":[96],"IL6ST,":[97,146],"PTGS2,":[98,147],"STAT3,":[99],"TNF)":[101],"nominally":[103],"associated":[104,204],"(P":[105],"<":[106,194],"0.05)":[107],"with":[108,122,196,205],"Caucasians.":[113],"most":[115],"significant":[116],"effect":[117],"on":[118],"seen":[121],"rs11574783":[123],"interleukin":[126,143],"6":[127],"signal":[128,149],"transducer":[129,150],"(IL6ST)":[130],"gene":[131],"(OR":[132,173],"0.08,":[134],"95%":[135,176],"CI:":[136,177,213],"0.01-0.63).":[137],"Cumulatively,":[138],"four":[139],"4":[144],"(IL4),":[145],"activator":[152],"transcription":[154],"3":[155],"(STAT3)":[156],"conferred":[157],"a":[158,240],"three-fold":[159],"elevation":[160],"among":[164],"carrying":[166],"maximum":[168],"number":[169],"high-risk":[171,224],"alleles":[172],"2.97,":[175],"1.41-6.25,":[178],"P(trend)":[179,215],"0.0003).":[181],"Risk":[182],"estimates":[183],"varied":[187],"significantly":[188],"according":[189],"to":[190,252],"disease":[191],"aggressiveness":[192],"(P(homogeneity)":[193],"0.05),":[195],"AKT1,":[199],"PIK3R1,":[200],"STAT3":[202],"independently":[203],"more":[206],"aggressive":[207],"PC;":[208],"OR":[209],"5.1":[211],"(95%":[212],"2.29-11.40,":[214],"3.8":[217],"\u00d7":[218],"10(-5))":[219],"carriers":[221],"all":[223],"genotypes.":[225],"CONCLUSIONS:":[226],"These":[227,257],"results":[228,258],"suggest":[229],"that":[230],"within":[234],"may":[238],"play":[239],"role":[241],"PC,":[246],"however,":[247],"further":[248],"are":[250],"needed":[251],"replicate":[253],"our":[254],"findings.":[255],"IMPACT:":[256],"underline":[259],"importance":[262],"progression.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}