{"id":"https://openalex.org/W2147359083","doi":"https://doi.org/10.3390/md11072472","title":"Antimetastatic Effect of Halichondramide, a Trisoxazole Macrolide from the Marine Sponge Chondrosia corticata, on Human Prostate Cancer Cells via Modulation of Epithelial-to-Mesenchymal Transition","display_name":"Antimetastatic Effect of Halichondramide, a Trisoxazole Macrolide from the Marine Sponge Chondrosia corticata, on Human Prostate Cancer Cells via Modulation of Epithelial-to-Mesenchymal Transition","publication_year":2013,"publication_date":"2013-07-15","ids":{"openalex":"https://openalex.org/W2147359083","doi":"https://doi.org/10.3390/md11072472","mag":"2147359083","pmid":"https://pubmed.ncbi.nlm.nih.gov/23860239","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3736435"},"language":"en","primary_location":{"id":"doi:10.3390/md11072472","doi":"https://doi.org/10.3390/md11072472","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md11072472","pdf_url":"https://www.mdpi.com/1660-3397/11/7/2472/pdf?version=1424782089","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1660-3397/11/7/2472/pdf?version=1424782089","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103744221","display_name":"Yoonho Shin","orcid":"https://orcid.org/0009-0006-1414-6483","observed_orcids":["https://orcid.org/0009-0006-1414-6483"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoonho Shin","raw_affiliation_strings":["College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049276892","display_name":"Gi\u2010Young Kim","orcid":"https://orcid.org/0000-0002-6878-0790","observed_orcids":["https://orcid.org/0000-0002-6878-0790"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gi Kim","raw_affiliation_strings":["College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030567973","display_name":"Ju\u2010eun Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju-eun Jeon","raw_affiliation_strings":["College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045827347","display_name":"Jongheon Shin","orcid":"https://orcid.org/0000-0002-7536-8462","observed_orcids":["https://orcid.org/0000-0002-7536-8462"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jongheon Shin","raw_affiliation_strings":["College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":"https://orcid.org/0000-0002-7536-8462","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033086793","display_name":"Sang Kook Lee","orcid":"https://orcid.org/0000-0002-4306-7024","observed_orcids":["https://orcid.org/0000-0002-4306-7024"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang Lee","raw_affiliation_strings":["College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033086793"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":2.7142,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.87354988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"7","first_page":"2472","last_page":"2485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/marine-sponge-natural-products","display_name":"marine sponge natural products","score":0.8040000200271606},{"id":"https://openalex.org/keywords/antimetastatic-activity","display_name":"antimetastatic activity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prl-3","display_name":"PRL-3","score":0.925000011920929},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.7099999785423279},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9229999780654907},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":1.0},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5774388313293457},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5676461458206177},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.518983781337738},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5110834836959839},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5018525123596191},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4806472361087799},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.45873701572418213},{"id":"https://openalex.org/C2778849931","wikidata":"https://www.wikidata.org/wiki/Q18960","display_name":"Sponge","level":2,"score":0.4161868691444397},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4160902500152588},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33231276273727417},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31579533219337463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29984405636787415},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2875882387161255},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2643284797668457},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011161","descriptor_name":"Porifera","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/md11072472","doi":"https://doi.org/10.3390/md11072472","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md11072472","pdf_url":"https://www.mdpi.com/1660-3397/11/7/2472/pdf?version=1424782089","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2729235","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3736435","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23860239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23860239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine drugs","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3736435","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3736435/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mar Drugs","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.361.2350","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.361.2350","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/1660-3397/11/7/2472/pdf?y=1","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:aa7ae8d4b2954bbe926b17914465e5fd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aa7ae8d4b2954bbe926b17914465e5fd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine Drugs, Vol 11, Iss 7, Pp 2472-2485 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/md11072472","doi":"https://doi.org/10.3390/md11072472","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md11072472","pdf_url":"https://www.mdpi.com/1660-3397/11/7/2472/pdf?version=1424782089","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147359083.pdf","grobid_xml":"https://content.openalex.org/works/W2147359083.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1553908537","https://openalex.org/W1964340419","https://openalex.org/W1967916177","https://openalex.org/W1968710790","https://openalex.org/W1968812829","https://openalex.org/W2005871242","https://openalex.org/W2015998760","https://openalex.org/W2022112367","https://openalex.org/W2023338154","https://openalex.org/W2027064373","https://openalex.org/W2028617170","https://openalex.org/W2032889069","https://openalex.org/W2034269086","https://openalex.org/W2034645284","https://openalex.org/W2052659086","https://openalex.org/W2056515815","https://openalex.org/W2066323677","https://openalex.org/W2066946457","https://openalex.org/W2068113733","https://openalex.org/W2077173862","https://openalex.org/W2079750277","https://openalex.org/W2086246413","https://openalex.org/W2100258190","https://openalex.org/W2101761370","https://openalex.org/W2107277218","https://openalex.org/W2107398206","https://openalex.org/W2111139603","https://openalex.org/W2114834029","https://openalex.org/W2140551998","https://openalex.org/W2146101976","https://openalex.org/W2148566055","https://openalex.org/W2156404831","https://openalex.org/W2157833929","https://openalex.org/W2172212550","https://openalex.org/W2346349612","https://openalex.org/W4239380575","https://openalex.org/W6681579327","https://openalex.org/W6681732257","https://openalex.org/W6683188598"],"related_works":["https://openalex.org/W2330559647","https://openalex.org/W1496247642","https://openalex.org/W7096276618","https://openalex.org/W3090194257","https://openalex.org/W4416785913","https://openalex.org/W2324964350","https://openalex.org/W4322626794","https://openalex.org/W3177369043","https://openalex.org/W2061396130","https://openalex.org/W1542038741"],"abstract_inverted_index":{"Halichondramide":[0],"(HCA),":[1],"a":[2,34,101,176],"trisoxazole-containing":[3],"macrolide":[4],"isolated":[5],"from":[6],"the":[7,40,48,56,61,67,82,98,121,140,147,161,184],"marine":[8],"sponge":[9],"Chondrosia":[10],"corticata":[11],"has":[12],"been":[13],"shown":[14],"to":[15,29,52],"exhibit":[16,30],"cytotoxicity":[17],"and":[18,129,146,153,163],"antifungal":[19],"activities.":[20],"In":[21,55,155],"our":[22],"previous":[23],"study,":[24,58],"HCA":[25,46,65,75,96,118,135,157],"was":[26,136],"also":[27,137,158],"found":[28],"antiproliferative":[31],"activity":[32,50,63,80],"against":[33],"variety":[35],"of":[36,43,45,64,81,89,100,106,115,123,134,142,149,165,179,186],"cancer":[37,73],"cells.":[38,74,112,167],"However,":[39],"precise":[41],"mechanism":[42],"action":[44],"in":[47,66,110],"antitumor":[49],"remains":[51],"be":[53],"elucidated.":[54],"present":[57],"we":[59],"identified":[60],"antimetastatic":[62,132],"highly":[68],"metastatic":[69,103],"PC3":[70,83,111,166],"human":[71],"prostate":[72],"showed":[76],"potent":[77],"growth":[78],"inhibitory":[79],"cells":[84],"with":[85,139,183],"an":[86],"IC50":[87],"value":[88],"0.81":[90],"\u00b5M.":[91],"Further":[92],"analysis":[93],"revealed":[94],"that":[95,171],"suppressed":[97,160],"expression":[99,122],"potential":[102,177],"biomarker,":[104],"phosphatase":[105],"regenerating":[107],"liver-3":[108],"(PRL-3),":[109],"The":[113,131],"suppression":[114],"PRL-3":[116],"by":[117],"sequentially":[119],"down-regulates":[120],"phosphoinositide":[124],"3-kinase":[125],"(PI3K)":[126],"subunits":[127],"p85":[128],"p110.":[130],"effect":[133],"correlated":[138],"down-regulation":[141],"matrix":[143],"metalloproteases":[144],"(MMPs)":[145],"modulation":[148,185],"cadherin":[150],"switches":[151],"N-cadherin":[152],"E-cadherin.":[154],"addition,":[156],"effectively":[159],"migration":[162],"invasion":[164],"These":[168],"findings":[169],"suggest":[170],"halichondramide":[172],"might":[173],"serve":[174],"as":[175],"inhibitor":[178],"tumor":[180],"cell":[181],"metastasis":[182],"PRL-3.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
