{"id":"https://openalex.org/W2147354169","doi":"https://doi.org/10.1016/j.jala.2008.05.005","title":"Fabrication of Synaptotagmin II-Functionalized Neuromimetic Copolymeric Nanomembranes","display_name":"Fabrication of Synaptotagmin II-Functionalized Neuromimetic Copolymeric Nanomembranes","publication_year":2008,"publication_date":"2008-07-10","ids":{"openalex":"https://openalex.org/W2147354169","doi":"https://doi.org/10.1016/j.jala.2008.05.005","mag":"2147354169"},"language":"en","primary_location":{"id":"doi:10.1016/j.jala.2008.05.005","doi":"https://doi.org/10.1016/j.jala.2008.05.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jala.2008.05.005","pdf_url":null,"source":{"id":"https://openalex.org/S4210188720","display_name":"JALA Journal of the Association for Laboratory Automation","issn_l":"1535-5535","issn":["1535-5535","1540-2452"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JALA: Journal of the Association for Laboratory Automation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Karen C. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen C. Liu","raw_affiliation_strings":["Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110226112","display_name":"Robert Tai-Thinh Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Lam","raw_affiliation_strings":["Robert H. Lurie Comprehensive Cancer Center, Feinberg School of            Medicine, Northwestern University, Chicago, IL","#N# 2 Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Feinberg School of            Medicine, Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]},{"raw_affiliation_string":"#N# 2 Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051186858","display_name":"Siby Samuel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siby Samuel","raw_affiliation_strings":["Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023415473","display_name":"Suraj Gupta","orcid":"https://orcid.org/0000-0002-0498-6132","observed_orcids":["https://orcid.org/0000-0002-0498-6132"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suraj Gupta","raw_affiliation_strings":["Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047929482","display_name":"John Leuthner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Leuthner","raw_affiliation_strings":["Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019949606","display_name":"Erik D. Pierstorff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik Pierstorff","raw_affiliation_strings":["Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014473511","display_name":"Dean Ho","orcid":"https://orcid.org/0000-0002-7337-296X","observed_orcids":["https://orcid.org/0000-0002-7337-296X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Ho","raw_affiliation_strings":["Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert R. McCormick School of Engineering, Northwestern University,            Evanston, IL","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"#N# 1 Robert R. McCormick School of Engineering, Northwestern University, Evanston, IL","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15439546,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"4","first_page":"198","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.04780000075697899,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptotagmin-ii","display_name":"synaptotagmin II","score":0.9959999918937683},{"id":"https://openalex.org/keywords/block-copolymer-membranes","display_name":"block copolymer membranes","score":0.7620000243186951},{"id":"https://openalex.org/keywords/polydimethylsiloxane","display_name":"polydimethylsiloxane","score":0.9919999837875366},{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.9710000157356262},{"id":"https://openalex.org/keywords/botulinum-neurotoxin-type-b","display_name":"botulinum neurotoxin type B","score":0.9409999847412109},{"id":"https://openalex.org/keywords/protein-membrane-interactions","display_name":"protein-membrane interactions","score":0.6230000257492065},{"id":"https://openalex.org/keywords/toxin-detection","display_name":"toxin detection","score":0.6370000243186951},{"id":"https://openalex.org/keywords/langmuir-isotherm","display_name":"Langmuir isotherm","score":0.718999981880188},{"id":"https://openalex.org/keywords/langmuir-blodgett-films","display_name":"Langmuir-Blodgett films","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6653338670730591},{"id":"https://openalex.org/C86473631","wikidata":"https://www.wikidata.org/wiki/Q18031809","display_name":"Synaptotagmin 1","level":5,"score":0.647631049156189},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5888912081718445},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.5470758676528931},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.4670290946960449},{"id":"https://openalex.org/C26926545","wikidata":"https://www.wikidata.org/wiki/Q1939992","display_name":"Nanobiotechnology","level":3,"score":0.4584940969944},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3702009320259094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.295708566904068},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.2879394590854645},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.20350632071495056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13975724577903748},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.0},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jala.2008.05.005","doi":"https://doi.org/10.1016/j.jala.2008.05.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jala.2008.05.005","pdf_url":null,"source":{"id":"https://openalex.org/S4210188720","display_name":"JALA Journal of the Association for Laboratory Automation","issn_l":"1535-5535","issn":["1535-5535","1540-2452"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JALA: Journal of the Association for Laboratory Automation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W55638877","https://openalex.org/W1543701391","https://openalex.org/W1963894265","https://openalex.org/W1969245917","https://openalex.org/W1998461045","https://openalex.org/W2003381605","https://openalex.org/W2010548899","https://openalex.org/W2033213836","https://openalex.org/W2035102043","https://openalex.org/W2037659490","https://openalex.org/W2041010702","https://openalex.org/W2055630989","https://openalex.org/W2068089413","https://openalex.org/W2068379293","https://openalex.org/W2083325186","https://openalex.org/W2094709770","https://openalex.org/W2108049830","https://openalex.org/W2117944575","https://openalex.org/W2123773573","https://openalex.org/W2171193481"],"related_works":["https://openalex.org/W2027656104","https://openalex.org/W1543701391","https://openalex.org/W1900553567","https://openalex.org/W2937899322","https://openalex.org/W2023678566","https://openalex.org/W1911264450","https://openalex.org/W4389836492","https://openalex.org/W2113278307","https://openalex.org/W2084706576","https://openalex.org/W2540983767"],"abstract_inverted_index":{"Nanoscale":[0],"copolymer":[1,70],"membranes":[2,13],"that":[3],"mimic":[4],"the":[5,36,47,58,82,125,134],"innate":[6],"structure":[7],"and":[8,16,109,120,130,162],"properties":[9],"of":[10,29,46,127],"biological":[11],"lipid":[12],"possessing":[14],"hydrophilic":[15],"hydrophobic":[17],"elements":[18],"to":[19],"support":[20],"protein":[21,50],"folding":[22],"were":[23,136],"used":[24,137],"for":[25,96,104,111,142],"a":[26,43,75,92,102,139],"fundamental":[27],"examination":[28],"protein\u2014polymer":[30],"integration.":[31],"This":[32,87],"study":[33],"has":[34],"integrated":[35],"neural":[37,76],"synaptotagmin":[38],"II":[39,67,132],"(Syt":[40],"II)":[41],"protein,":[42],"documented":[44],"target":[45],"hemagglutinin-33":[48],"(Hn-33)":[49],"associated":[51],"with":[52,106,152],"botulinum":[53,143],"neurotoxin":[54,144],"type":[55,145],"A":[56],"during":[57],"infection":[59],"process,":[60],"into":[61,68,133],"polymethyloxazoline\u2014polydimethylsiloxane\u2014polymethyloxazoline":[62],"nanomembranes.":[63],"By":[64],"integrating":[65],"Syt":[66,131],"block":[69],"membranes,":[71],"we":[72],"have":[73],"developed":[74],"mimetic":[77],"membrane":[78,118],"toward":[79],"Hn-33":[80],"targeting":[81],"applications":[83],"in":[84],"nanomaterial-mediated":[85],"detection.":[86,114,147],"technology":[88],"can":[89],"serve":[90],"as":[91,101,138],"robust":[93],"stand-alone":[94],"platform":[95,141],"toxin":[97,121],"diagnostic":[98],"studies,":[99],"or":[100],"coating":[103],"integration":[105,149],"micro-/nanofabricated":[107],"devices":[108],"electrodes":[110],"protein\u2014protein":[112],"interaction-based":[113],"To":[115],"assess":[116],"enhanced":[117],"complexity":[119],"specificity,":[122],"studies":[123],"assessing":[124],"co-insertion":[126],"trisialoganglioside-GT1b":[128],"(GT1b)":[129],"nanomembranes":[135],"subsequent":[140],"B":[146],"Protein\u2014membrane":[148],"was":[150],"confirmed":[151],"atomic":[153],"force":[154],"microscopy":[155],"imaging,":[156],"sodium":[157],"dodecyl":[158],"sulfate-polyacrylamide":[159],"gel":[160],"electrophoresis,":[161],"Langmuir":[163],"isotherm":[164],"analysis.":[165]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}