{"id":"https://openalex.org/W2147346150","doi":"https://doi.org/10.1158/0008-5472.can-06-3290","title":"Peptide Vaccine Given with a Toll-Like Receptor Agonist Is Effective for the Treatment and Prevention of Spontaneous Breast Tumors","display_name":"Peptide Vaccine Given with a Toll-Like Receptor Agonist Is Effective for the Treatment and Prevention of Spontaneous Breast Tumors","publication_year":2007,"publication_date":"2007-02-01","ids":{"openalex":"https://openalex.org/W2147346150","doi":"https://doi.org/10.1158/0008-5472.can-06-3290","mag":"2147346150","pmid":"https://pubmed.ncbi.nlm.nih.gov/17283170","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1988785"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-06-3290","doi":"https://doi.org/10.1158/0008-5472.can-06-3290","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-3290","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/67/3/1326/2577216/1326.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/67/3/1326/2577216/1326.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071063531","display_name":"Pilar Nava-Parada","orcid":"https://orcid.org/0000-0002-5405-1183","observed_orcids":["https://orcid.org/0000-0002-5405-1183"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pilar Nava-Parada","raw_affiliation_strings":["1Department of Immunology, Mayo Clinic, Rochester, Minnesota;","Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Immunology, Mayo Clinic, Rochester, Minnesota;","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105787954","display_name":"Guido Forni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guido Forni","raw_affiliation_strings":["2Department of Clinical and Biological Sciences, University of Torino, Torino, Italy; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Clinical and Biological Sciences, University of Torino, Torino, Italy; and","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031005364","display_name":"Keith L. Knutson","orcid":"https://orcid.org/0000-0001-9932-4467","observed_orcids":["https://orcid.org/0000-0001-9932-4467"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith L. Knutson","raw_affiliation_strings":["1Department of Immunology, Mayo Clinic, Rochester, Minnesota;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Immunology, Mayo Clinic, Rochester, Minnesota;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060299347","display_name":"Larry R. Pease","orcid":"https://orcid.org/0000-0001-9770-1740","observed_orcids":["https://orcid.org/0000-0001-9770-1740"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry R. Pease","raw_affiliation_strings":["1Department of Immunology, Mayo Clinic, Rochester, Minnesota;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Immunology, Mayo Clinic, Rochester, Minnesota;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032554768","display_name":"Esteban Celis","orcid":"https://orcid.org/0000-0001-8299-4480","observed_orcids":["https://orcid.org/0000-0001-8299-4480"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esteban Celis","raw_affiliation_strings":["3Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.1735,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.97208498,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"67","issue":"3","first_page":"1326","last_page":"1334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide-vaccine","display_name":"peptide vaccine","score":0.9800000190734863},{"id":"https://openalex.org/keywords/toll-like-receptor-agonists","display_name":"TLR agonists","score":0.9480000138282776},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.718999981880188},{"id":"https://openalex.org/keywords/spontaneous-tumors","display_name":"spontaneous tumors","score":0.8180000185966492},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ctl-response","display_name":"CTL response","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tumor-antigen-specific-t-cells","display_name":"tumor antigen-specific T cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cd25-regulatory-t-cells","display_name":"CD25+ regulatory T cells","score":0.6470000147819519},{"id":"https://openalex.org/keywords/epitope-spreading","display_name":"epitope spreading","score":0.9129999876022339},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.4269999861717224},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6682397127151489},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5834360718727112},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.550190806388855},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.549089789390564},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5341237187385559},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5205122828483582},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.5062955617904663},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4952925741672516},{"id":"https://openalex.org/C2778378633","wikidata":"https://www.wikidata.org/wiki/Q2378309","display_name":"Cancer vaccine","level":4,"score":0.48974180221557617},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4707741439342499},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.4605386257171631},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4536556303501129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43834561109542847},{"id":"https://openalex.org/C2776624504","wikidata":"https://www.wikidata.org/wiki/Q7907955","display_name":"Vaccine therapy","level":4,"score":0.43594983220100403},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.43010807037353516},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41381531953811646},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3924816846847534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39052826166152954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2703193426132202},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.24482238292694092}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-06-3290","doi":"https://doi.org/10.1158/0008-5472.can-06-3290","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-3290","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/67/3/1326/2577216/1326.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:17283170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17283170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1988785","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1988785","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},{"id":"pmh:oai:iris.unito.it:2318/101223","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/101223","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-06-3290","doi":"https://doi.org/10.1158/0008-5472.can-06-3290","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-3290","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/67/3/1326/2577216/1326.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2016363180","display_name":"Optimization of Peptide Based Vaccines for Cancer","funder_award_id":"R01CA103921","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G401743407","display_name":"Trojan Antigens: A Multiple-Epitope Vaccine for Cancer","funder_award_id":"R01CA080782","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147346150.pdf","grobid_xml":"https://content.openalex.org/works/W2147346150.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1168628786","https://openalex.org/W1675081787","https://openalex.org/W1893184572","https://openalex.org/W1967425011","https://openalex.org/W1968792745","https://openalex.org/W1972586314","https://openalex.org/W1978467424","https://openalex.org/W1979842508","https://openalex.org/W1982093899","https://openalex.org/W1982951034","https://openalex.org/W1990293928","https://openalex.org/W1994048581","https://openalex.org/W2004316987","https://openalex.org/W2008824139","https://openalex.org/W2023389612","https://openalex.org/W2047203592","https://openalex.org/W2064793974","https://openalex.org/W2068515672","https://openalex.org/W2077989877","https://openalex.org/W2082837925","https://openalex.org/W2085583663","https://openalex.org/W2103210701","https://openalex.org/W2105910061","https://openalex.org/W2106414148","https://openalex.org/W2113657892","https://openalex.org/W2114333002","https://openalex.org/W2116094134","https://openalex.org/W2119591058","https://openalex.org/W2121870317","https://openalex.org/W2124904079","https://openalex.org/W2138163780","https://openalex.org/W2142294973","https://openalex.org/W2148182397","https://openalex.org/W2149723200","https://openalex.org/W2149864243","https://openalex.org/W2166831581","https://openalex.org/W2172267929","https://openalex.org/W2420499553"],"related_works":["https://openalex.org/W7218214848","https://openalex.org/W2164486810","https://openalex.org/W2519935657","https://openalex.org/W7096414848","https://openalex.org/W1991841265","https://openalex.org/W2387985633","https://openalex.org/W2133294143","https://openalex.org/W2009648532","https://openalex.org/W2129846539","https://openalex.org/W1972012970"],"abstract_inverted_index":{"Our":[0,139],"goal":[1],"is":[2,89],"to":[3,22,29,49,143,155,168,187],"develop":[4],"peptide":[5,51,85,118,202],"vaccines":[6,52],"that":[7,21,106,142,176,219],"stimulate":[8],"tumor":[9,45,67,73,145,190],"antigen-specific":[10,146],"T-cell":[11,25],"responses":[12,148],"against":[13,199,205],"frequently":[14],"found":[15],"cancers.":[16],"Previous":[17],"work":[18],"has":[19],"shown":[20],"generate":[23],"effective":[24,91],"responses,":[26,196],"peptides":[27,207],"have":[28],"be":[30,156,169,223],"administered":[31,157],"in":[32,60,92,131,229],"combination":[33,132],"with":[34,115,133,171,179],"strong":[35],"adjuvants":[36],"such":[37],"as":[38],"Toll-like":[39,135],"receptor":[40,136],"agonists.":[41],"However,":[42],"most":[43],"animal":[44],"model":[46],"systems":[47],"used":[48,65,76],"study":[50],"were":[53,113,177,185],"not":[54,197],"truly":[55],"representative":[56],"of":[57,71,98,162],"malignant":[58],"diseases":[59],"humans":[61],"because":[62],"they":[63,75],"solely":[64],"transplantable":[66],"lines,":[68],"and":[69,149,192],"instead":[70],"true":[72],"antigens,":[74],"highly":[77,90],"immunogenic":[78],"foreign":[79],"proteins.":[80],"Here,":[81],"we":[82],"describe":[83],"a":[84,116,134],"vaccination":[86],"strategy,":[87],"which":[88,125],"delaying":[93],"or":[94,159,184],"preventing":[95],"the":[96,108,120,152,160,200],"occurrence":[97],"spontaneous":[99,189],"breast":[100],"tumors.":[101],"Transgenic":[102],"female":[103],"BALB-neuT":[104],"mice":[105],"carry":[107],"activated":[109],"rat":[110,121,210],"HER-2/neu":[111,122,211],"oncogene":[112],"vaccinated":[114,178],"synthetic":[117],"from":[119,209],"gene":[123],"product,":[124],"represents":[126],"an":[127],"epitope":[128,214],"for":[129,225],"CTLs":[130],"agonist":[137],"adjuvant.":[138],"results":[140,217],"show":[141],"obtain":[144],"CTL":[147,195],"antitumor":[150],"effects,":[151],"vaccine":[153],"had":[154,167],"repetitively,":[158],"function":[161],"CD4/CD25":[163],"T":[164],"regulatory":[165],"cells":[166],"blocked":[170],"anti-CD25":[172],"antibody":[173],"therapy.":[174],"Mice":[175],"this":[180],"approach":[181],"remained":[182],"tumor-free":[183],"able":[186],"control":[188],"growth":[191],"exhibited":[193],"long-lasting":[194],"only":[198],"immunizing":[201],"but":[203],"also":[204],"other":[206],"derived":[208],"product":[212],"(i.e.,":[213],"spreading).":[215],"These":[216],"suggest":[218],"similar":[220],"strategies":[221],"should":[222],"followed":[224],"conducting":[226],"clinical":[227],"studies":[228],"patients.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}