{"id":"https://openalex.org/W2147341744","doi":null,"title":"Relationship between CD4+CD25+ Treg and expression of HIF-1\u03b1 and Ki-67 in NSCLC patients.","display_name":"Relationship between CD4+CD25+ Treg and expression of HIF-1\u03b1 and Ki-67 in NSCLC patients.","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2147341744","mag":"2147341744","pmid":"https://pubmed.ncbi.nlm.nih.gov/25967708"},"language":"en","primary_location":{"id":"pmid:25967708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25967708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072735225","display_name":"L-Y He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L-Y He","raw_affiliation_strings":["People's Hospital of Hebei Province, Shijiazhuang, Hebei Province, China. hongzhenzhang456@sohu.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"People's Hospital of Hebei Province, Shijiazhuang, Hebei Province, China. hongzhenzhang456@sohu.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435304","display_name":"Ling Li","orcid":"https://orcid.org/0000-0001-5358-4968","observed_orcids":["https://orcid.org/0000-0001-5358-4968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M-L Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M-L Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100354659","display_name":"Yang Zhang","orcid":"https://orcid.org/0000-0002-2739-1916","observed_orcids":["https://orcid.org/0000-0002-2739-1916","https://orcid.org/0000-0002-0789-4938","https://orcid.org/0000-0003-1405-0212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039086111","display_name":"Zhang Hz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H-Z Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5807,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.65217696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"19","issue":"8","first_page":"1351","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-cd25-regulatory-t-cells","display_name":"CD4+CD25+ T cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-immune-status","display_name":"tumor immune status","score":0.8100000023841858},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.5730000138282776},{"id":"https://openalex.org/keywords/clinical-stage","display_name":"clinical stage","score":0.8769999742507935},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.7234949469566345},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.692044734954834},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6585974097251892},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6314034461975098},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.580746591091156},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5597941875457764},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4469984471797943},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.43518996238708496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4267585277557373},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4175031781196594},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38032373785972595},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3799208104610443},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.333121120929718},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32856354117393494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2022700309753418},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25967708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25967708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2147341744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25967708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2020277906","https://openalex.org/W2024283645","https://openalex.org/W2182821464","https://openalex.org/W2184726369"],"related_works":["https://openalex.org/W2024283645","https://openalex.org/W2362536498","https://openalex.org/W2929084077","https://openalex.org/W1966489062","https://openalex.org/W2917234605","https://openalex.org/W2600212560","https://openalex.org/W2391717883","https://openalex.org/W1982989360","https://openalex.org/W2342970657","https://openalex.org/W3032469326"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,6,12,16,41,55,127,165],"relationship":[4],"between":[5],"CD4+CD25+":[7,42,75,120,147],"Treg":[8,43,76,121,148],"cell":[9,21,44,77,122,149],"proportion":[10],"in":[11,46,62,78],"peripheral":[13,47,79],"blood":[14,48,80],"and":[15,26,49,59,92,109,137,159,164,169],"clinicopathologic":[17],"features":[18],"of":[19,57,65,67,74,102,105,112,119,129,156,161,167,177],"non-small":[20],"lung":[22],"cancer":[23,63],"(NSCLC)":[24],"patients":[25,163],"hypoxia-inducible":[27],"factor-1\u03b1":[28],"(HIF-1\u03b1),":[29],"Ki-67":[30,60,138,170],"expression.":[31],"PATIENTS":[32],"AND":[33],"METHODS:":[34],"Flow":[35],"cytometry":[36],"was":[37,81,123],"used":[38,52,152],"to":[39,53,83,106,175],"measure":[40],"level":[45,73,118],"immunohistochemical":[50],"staining":[51],"detect":[54],"expression":[56,128,172],"HIF-1\u03b1":[58,130,168],"protein":[61,171],"tissue":[64],"each":[66],"50":[68],"NSCLC":[69,103,162],"patients.":[70],"RESULTS:":[71],"The":[72,117],"related":[82],"pathologic":[84,110],"grades":[85],"(t":[86,95],"=":[87,90,96,99,132,135,140,143],"3.265,":[88],"p":[89,98,134,142],"0.006)":[91],"clinical":[93],"stage":[94],"4.417,":[97],"0.":[100],"001)":[101],"instead":[104],"patient's":[107],"gender":[108],"type":[111],"tumor":[113],"(p":[114],">":[115],"0.05).":[116],"positively":[124],"correlated":[125],"with":[126],"(r":[131,139],"0.711,":[133],"0.003)":[136],"0.517,":[141],"0.04),":[144],"respectively.":[145],"CONCLUSIONS:":[146],"can":[150],"be":[151],"as":[153],"a":[154],"predictor":[155],"immune":[157,178],"status":[158],"prognosis":[160],"levels":[166],"may":[173],"relate":[174],"inhibition":[176],"cells.":[179]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}