{"id":"https://openalex.org/W2147339089","doi":"https://doi.org/10.1128/jb.187.11.3894-3897.2005","title":"The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes","display_name":"The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes","publication_year":2005,"publication_date":"2005-05-18","ids":{"openalex":"https://openalex.org/W2147339089","doi":"https://doi.org/10.1128/jb.187.11.3894-3897.2005","mag":"2147339089","pmid":"https://pubmed.ncbi.nlm.nih.gov/15901719","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1112065"},"language":"en","primary_location":{"id":"doi:10.1128/jb.187.11.3894-3897.2005","doi":"https://doi.org/10.1128/jb.187.11.3894-3897.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.187.11.3894-3897.2005","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1112065","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075462672","display_name":"Muriel Masi","orcid":"https://orcid.org/0000-0002-1444-7511","observed_orcids":["https://orcid.org/0000-0002-1444-7511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muriel Masi","raw_affiliation_strings":["Enveloppe bacte\u0301rienne, Perme\u0301abilite\u0301 et Antibiotiques, EA2197, IFR 48, Faculte\u0301 de Me\u0301decine, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enveloppe bacte\u0301rienne, Perme\u0301abilite\u0301 et Antibiotiques, EA2197, IFR 48, Faculte\u0301 de Me\u0301decine, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090499815","display_name":"Jean\u2010Marie Pag\u00e8s","orcid":"https://orcid.org/0000-0001-7092-7977","observed_orcids":["https://orcid.org/0000-0001-7092-7977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Marie Page\u0300s","raw_affiliation_strings":["Enveloppe bacte\u0301rienne, Perme\u0301abilite\u0301 et Antibiotiques, EA2197, IFR 48, Faculte\u0301 de Me\u0301decine, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enveloppe bacte\u0301rienne, Perme\u0301abilite\u0301 et Antibiotiques, EA2197, IFR 48, Faculte\u0301 de Me\u0301decine, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071001458","display_name":"Claude Villard","orcid":"https://orcid.org/0000-0002-6600-0762","observed_orcids":["https://orcid.org/0000-0002-6600-0762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claude Villard","raw_affiliation_strings":["Plate-forme Prote\u0301omique, Faculte\u0301 de Pharmacie, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plate-forme Prote\u0301omique, Faculte\u0301 de Pharmacie, Marseille, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084659595","display_name":"Elizabeth Pradel","orcid":"https://orcid.org/0000-0003-3563-9325","observed_orcids":["https://orcid.org/0000-0003-3563-9325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Pradel","raw_affiliation_strings":["Enveloppe bacte\u0301rienne, Perme\u0301abilite\u0301 et Antibiotiques, EA2197, IFR 48, Faculte\u0301 de Me\u0301decine, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enveloppe bacte\u0301rienne, Perme\u0301abilite\u0301 et Antibiotiques, EA2197, IFR 48, Faculte\u0301 de Me\u0301decine, Marseille, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6366,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.79550225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"187","issue":"11","first_page":"3894","last_page":"3897"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-efflux-pumps","display_name":"multidrug efflux pumps","score":0.9539999961853027},{"id":"https://openalex.org/keywords/h-ns","display_name":"H-NS","score":0.8169999718666077},{"id":"https://openalex.org/keywords/enterobacter-aerogenes","display_name":"Enterobacter aerogenes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gene-repression","display_name":"gene repression","score":0.6510000228881836},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/acra","display_name":"AcrA","score":0.5899999737739563},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.7710000276565552},{"id":"https://openalex.org/keywords/lacz-fusion","display_name":"lacZ fusions","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2776265613","wikidata":"https://www.wikidata.org/wiki/Q644487","display_name":"Enterobacter aerogenes","level":4,"score":0.9843767881393433},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.8535629510879517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8395182490348816},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.818211555480957},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.7532125115394592},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7244172096252441},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6716049909591675},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5531550049781799},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4726140797138214},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.44871264696121216},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4423593580722809},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3688969016075134},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18028584122657776},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019450","descriptor_name":"Genes, MDR","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021902","descriptor_name":"Enterobacter aerogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jb.187.11.3894-3897.2005","doi":"https://doi.org/10.1128/jb.187.11.3894-3897.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.187.11.3894-3897.2005","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:135096","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1112065","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:15901719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15901719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1112065","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1112065/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:135096","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1112065","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W193267154","https://openalex.org/W1546783991","https://openalex.org/W1551176833","https://openalex.org/W1570356933","https://openalex.org/W1574886161","https://openalex.org/W1579756873","https://openalex.org/W1644443740","https://openalex.org/W1810878477","https://openalex.org/W1836616222","https://openalex.org/W1839245887","https://openalex.org/W1892148740","https://openalex.org/W1927502485","https://openalex.org/W1970632274","https://openalex.org/W1976095793","https://openalex.org/W1996066959","https://openalex.org/W1999884441","https://openalex.org/W2034650928","https://openalex.org/W2047908973","https://openalex.org/W2050266703","https://openalex.org/W2070196678","https://openalex.org/W2077538666","https://openalex.org/W2078594804","https://openalex.org/W2078785671","https://openalex.org/W2097798630","https://openalex.org/W2099095400","https://openalex.org/W2108847607","https://openalex.org/W2120559051","https://openalex.org/W2121303975","https://openalex.org/W2130443164","https://openalex.org/W2136541185","https://openalex.org/W2150013876","https://openalex.org/W2156712092","https://openalex.org/W2157664391","https://openalex.org/W2159861657","https://openalex.org/W2170187097","https://openalex.org/W2181329160","https://openalex.org/W6685646256"],"related_works":["https://openalex.org/W2098137569","https://openalex.org/W2095325503","https://openalex.org/W4388552634","https://openalex.org/W2108847607","https://openalex.org/W3023077948","https://openalex.org/W4404374555","https://openalex.org/W4407221847","https://openalex.org/W2099095400","https://openalex.org/W2296723658","https://openalex.org/W4414614391"],"abstract_inverted_index":{"The":[0],"Enterobacter":[1],"aerogenes":[2,22,71],"eefABC":[3,41],"locus,":[4],"which":[5],"encodes":[6],"a":[7,30,73],"tripartite":[8],"efflux":[9],"pump,":[10],"was":[11,42,56,67],"cloned":[12],"by":[13],"complementation":[14],"of":[15,33],"an":[16,59],"Escherichia":[17],"coli":[18,61,77],"tolC":[19],"mutant.":[20,63],"E.":[21,60,70,76],"deltaacrA":[23],"expressing":[24,72],"EefABC":[25],"became":[26],"less":[27],"susceptible":[28],"to":[29],"wide":[31],"range":[32],"antibiotics.":[34],"Data":[35],"from":[36,54],"eef::lacZ":[37],"fusions":[38],"showed":[39],"that":[40],"not":[43],"transcribed":[44],"in":[45,58,69],"the":[46],"various":[47],"laboratory":[48],"conditions":[49],"tested.":[50],"However,":[51],"increased":[52],"transcription":[53],"Peef":[55],"observed":[57],"hns":[62,78],"In":[64],"addition,":[65],"EefA":[66],"detected":[68],"dominant":[74],"negative":[75],"allele.":[79]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
