{"id":"https://openalex.org/W2147336895","doi":"https://doi.org/10.1086/524074","title":"Chronic Hepatitis B in Italy: New Features of an Old Disease--Approaching the Universal Prevalence of Hepatitis B e Antigen--Negative Cases and the Eradication of Hepatitis D Infection","display_name":"Chronic Hepatitis B in Italy: New Features of an Old Disease--Approaching the Universal Prevalence of Hepatitis B e Antigen--Negative Cases and the Eradication of Hepatitis D Infection","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2147336895","doi":"https://doi.org/10.1086/524074","mag":"2147336895","pmid":"https://pubmed.ncbi.nlm.nih.gov/18171224"},"language":"en","primary_location":{"id":"doi:10.1086/524074","doi":"https://doi.org/10.1086/524074","is_oa":false,"landing_page_url":"https://doi.org/10.1086/524074","pdf_url":null,"source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061888532","display_name":"Evangelista Sagnelli","orcid":"https://orcid.org/0000-0003-2817-8436","observed_orcids":["https://orcid.org/0000-0003-2817-8436"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"E. Sagnelli","raw_affiliation_strings":["Infectious Disease Unit, Second University of Naples, Naples, Italy. evangelista.sagnelli@unina2.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Unit, Second University of Naples, Naples, Italy. evangelista.sagnelli@unina2.it","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083170580","display_name":"Tommaso Stroffolini","orcid":"https://orcid.org/0000-0001-6285-0412","observed_orcids":["https://orcid.org/0000-0001-6285-0412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Stroffolini","raw_affiliation_strings":["Gastroenterology Unit, S. Giacomo Hospital, Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Unit, S. Giacomo Hospital, Rome","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069561561","display_name":"Andrea Mele","orcid":"https://orcid.org/0000-0002-0351-0538","observed_orcids":["https://orcid.org/0000-0002-0351-0538"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Mele","raw_affiliation_strings":["Laboratory of Epidemiology, Clinical Epidemiology Unit, Istituto Superiore di Sanit\u00e0, Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Epidemiology, Clinical Epidemiology Unit, Istituto Superiore di Sanit\u00e0, Rome","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018036828","display_name":"Michele Imparato","orcid":"https://orcid.org/0000-0002-3774-5079","observed_orcids":["https://orcid.org/0000-0002-3774-5079"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Imparato","raw_affiliation_strings":["Infectious Disease Unit, Second University of Naples, Naples"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Unit, Second University of Naples, Naples","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109132944","display_name":"P.L. Almasio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. L. Almasio","raw_affiliation_strings":["Gastroenterology Unit, University of Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Unit, University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061888532"],"corresponding_institution_ids":["https://openalex.org/I197809005"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":1.761,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.82497672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"46","issue":"1","first_page":"110","last_page":"113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatitis-c-coinfection","display_name":"hepatitis C coinfection","score":0.9850000143051147},{"id":"https://openalex.org/keywords/liver-cirrhosis-progression","display_name":"liver cirrhosis progression","score":0.9049999713897705},{"id":"https://openalex.org/keywords/alcohol-abuse","display_name":"alcohol abuse","score":0.7990000247955322},{"id":"https://openalex.org/keywords/age-as-risk-factor","display_name":"age as risk factor","score":0.6919999718666077},{"id":"https://openalex.org/keywords/anti-hdv-antibodies","display_name":"anti-HDV antibodies","score":0.6629999876022339},{"id":"https://openalex.org/keywords/anti-hcv-antibodies","display_name":"anti-HCV antibodies","score":0.9549999833106995},{"id":"https://openalex.org/keywords/italy","display_name":"Italy","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.884119987487793},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6214278340339661},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5653530955314636},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5398606061935425},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.5336331725120544},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.5330283641815186},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45999443531036377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4590209424495697},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.453535795211792},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.4385099709033966},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.43487539887428284},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.43328115344047546},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39970341324806213},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3760848045349121}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006513","descriptor_name":"Hepatitis B e Antigens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016036","descriptor_name":"Seroepidemiologic Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019701","descriptor_name":"Hepatitis D, Chronic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D019701","descriptor_name":"Hepatitis D, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1086/524074","doi":"https://doi.org/10.1086/524074","is_oa":false,"landing_page_url":"https://doi.org/10.1086/524074","pdf_url":null,"source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:18171224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18171224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/631993","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/631993","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unicampania.it:11591/187806","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/187806","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unicampania.it:11591/366531","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/366531","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unipa.it:10447/22537","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10447/22537","pdf_url":null,"source":{"id":"https://openalex.org/S4306401065","display_name":"Nova Science Publishers (Nova Science Publishers, Inc.)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/462041","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/462041","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1967017906","https://openalex.org/W1970468418","https://openalex.org/W1974511288","https://openalex.org/W1979160377","https://openalex.org/W2017347114","https://openalex.org/W2020215421","https://openalex.org/W2020572739","https://openalex.org/W2022072975","https://openalex.org/W2099502756","https://openalex.org/W2106016785","https://openalex.org/W2129793275","https://openalex.org/W2132254613","https://openalex.org/W2133291642","https://openalex.org/W2139222466","https://openalex.org/W2146574134","https://openalex.org/W2160036457"],"related_works":["https://openalex.org/W6999276257","https://openalex.org/W4255158953","https://openalex.org/W7217325112","https://openalex.org/W2094191337","https://openalex.org/W1993473861","https://openalex.org/W4320487106","https://openalex.org/W2090680151","https://openalex.org/W2892543517","https://openalex.org/W7099716349","https://openalex.org/W2004299193"],"abstract_inverted_index":{"We":[0],"evaluated":[1],"1336":[2],"hepatitis":[3,21,33,45],"B":[4,22],"surface":[5],"antigen-positive":[6],"subjects":[7],"consecutively":[8],"observed":[9],"in":[10],"79":[11],"Italian":[12],"hospitals":[13],"over":[14],"a":[15],"6-month":[16],"period.":[17],"The":[18],"proportion":[19],"of":[20,29,41,73],"e":[23],"antigen-negative":[24],"cases":[25],"was":[26,36,48],"86.4%,":[27],"that":[28,55],"patients":[30,42],"coinfected":[31,43],"with":[32,44],"D":[34,63],"virus":[35,47,64,68],"9.7%,":[37],"and":[38,61,65],"the":[39],"rate":[40],"C":[46,67],"16.8%.":[49],"Multiple":[50],"logistic":[51],"regression":[52],"analysis":[53],"showed":[54],"age":[56],">49":[57],"years,":[58],"alcohol":[59],"abuse,":[60],"anti-hepatitis":[62,66],"positivity":[69],"were":[70],"independent":[71],"predictors":[72],"progression":[74],"to":[75],"liver":[76],"cirrhosis.":[77]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
