{"id":"https://openalex.org/W2147305376","doi":null,"title":"Quantification of angiogenesis in breast cancer by automated vessel identification in CD34 immunohistochemical sections.","display_name":"Quantification of angiogenesis in breast cancer by automated vessel identification in CD34 immunohistochemical sections.","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2147305376","mag":"2147305376","pmid":"https://pubmed.ncbi.nlm.nih.gov/22199261"},"language":"en","primary_location":{"id":"pmid:22199261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22199261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040190048","display_name":"Lars Tore Gyland Mikalsen","orcid":"https://orcid.org/0000-0001-9836-8468","observed_orcids":["https://orcid.org/0000-0001-9836-8468"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Lars Tore Gyland Mikalsen","raw_affiliation_strings":["Department of Physics, University of Oslo, Postboks 1048 Blindern, N-0316, Oslo, Norway. l.t.g.mikalsen@fys.uio.no"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Oslo, Postboks 1048 Blindern, N-0316, Oslo, Norway. l.t.g.mikalsen@fys.uio.no","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055344473","display_name":"Hari Prasad Dhakal","orcid":"https://orcid.org/0009-0007-7776-3101","observed_orcids":["https://orcid.org/0009-0007-7776-3101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hari Prasad Dhakal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035939033","display_name":"\u00d8yvind Sverre Bruland","orcid":"https://orcid.org/0000-0003-1631-3733","observed_orcids":["https://orcid.org/0000-0003-1631-3733","https://orcid.org/0009-0006-7985-9919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oyvind S Bruland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109081203","display_name":"Jahn M. Nesland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jahn M Nesland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109109266","display_name":"Dag Rune Olsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dag Rune Olsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8356,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.86545911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"12","first_page":"4053","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.05570000037550926,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.8190000057220459},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.9049999713897705},{"id":"https://openalex.org/keywords/image-analysis","display_name":"image analysis","score":0.5979999899864197},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.8240000009536743},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tumor-vascularity","display_name":"tumor vascularity","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.7966528534889221},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7144871950149536},{"id":"https://openalex.org/C104709138","wikidata":"https://www.wikidata.org/wiki/Q1671540","display_name":"Intraclass correlation","level":3,"score":0.6495017409324646},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.6186220645904541},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6110860109329224},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5945298671722412},{"id":"https://openalex.org/C178596483","wikidata":"https://www.wikidata.org/wiki/Q7916472","display_name":"Vascularity","level":2,"score":0.5579748749732971},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5107142925262451},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4980618953704834},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4325275123119354},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.4125061333179474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22473928332328796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19076889753341675},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13142317533493042},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.06149682402610779},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22199261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22199261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2147305376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22199261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W5657494","https://openalex.org/W1487682175","https://openalex.org/W1526854257","https://openalex.org/W1568917520","https://openalex.org/W1921822648","https://openalex.org/W1978014005","https://openalex.org/W1983015953","https://openalex.org/W1995499810","https://openalex.org/W1998839569","https://openalex.org/W1998842935","https://openalex.org/W2003032376","https://openalex.org/W2004769542","https://openalex.org/W2005498517","https://openalex.org/W2010943731","https://openalex.org/W2015795623","https://openalex.org/W2027091505","https://openalex.org/W2033168226","https://openalex.org/W2037761545","https://openalex.org/W2047112531","https://openalex.org/W2048597171","https://openalex.org/W2063204257","https://openalex.org/W2064297621","https://openalex.org/W2070080933","https://openalex.org/W2070947530","https://openalex.org/W2073364858","https://openalex.org/W2075723168","https://openalex.org/W2082206724","https://openalex.org/W2086073957","https://openalex.org/W2091733153","https://openalex.org/W2100608628","https://openalex.org/W2100812787","https://openalex.org/W2107493872","https://openalex.org/W2107880104","https://openalex.org/W2110327625","https://openalex.org/W2114371641","https://openalex.org/W2119480061","https://openalex.org/W2127367027","https://openalex.org/W2127833285","https://openalex.org/W2133059825","https://openalex.org/W2133693112","https://openalex.org/W2136320367","https://openalex.org/W2141403362","https://openalex.org/W2155522996","https://openalex.org/W2158743409","https://openalex.org/W2159789252","https://openalex.org/W2283630805","https://openalex.org/W2319962899","https://openalex.org/W3005347330"],"related_works":["https://openalex.org/W2900775600","https://openalex.org/W2003032376","https://openalex.org/W2412085322","https://openalex.org/W2398684601","https://openalex.org/W1976539995","https://openalex.org/W1972051241","https://openalex.org/W1986944960","https://openalex.org/W2516878976","https://openalex.org/W4383472796","https://openalex.org/W2070080933"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"Tumor":[1,7],"growth":[2],"is":[3],"dependent":[4],"upon":[5],"angiogenesis.":[6,150],"vascularity,":[8],"as":[9],"measured":[10],"by":[11],"microvessel":[12],"density":[13],"or":[14],"Chalkley":[15],"counts,":[16],"has":[17],"been":[18],"shown":[19],"to":[20,28,46,62,68,121,128,148],"predict":[21],"treatment":[22],"outcome.":[23],"However,":[24],"many":[25],"issues":[26],"related":[27],"reproducibility":[29],"and":[30,74,87,107],"methodology":[31],"have":[32,129],"prevented":[33],"its":[34],"clinical":[35],"application.":[36],"We":[37],"present":[38],"a":[39,108,130],"method":[40,99,124,136],"of":[41,72,105,144],"automatic":[42,86],"vessel":[43,89],"identification":[44],"applied":[45],"CD34":[47,64,147],"immunohistochemical":[48],"sections":[49],"which":[50],"facilitates":[51],"increased":[52],"reproducibility.":[53],"MATERIALS":[54],"AND":[55],"METHODS:":[56],"Pixel":[57],"colour":[58,142],"information":[59],"was":[60,125],"used":[61,140],"identify":[63],"stain.":[65],"In":[66],"order":[67],"reduce":[69],"the":[70,98,113,117],"effects":[71],"noise":[73],"background,":[75],"stained":[76],"areas":[77],"smaller":[78],"than":[79],"3.5":[80],"\u03bcm":[81],"were":[82],"ignored.":[83],"RESULTS:":[84],"Comparing":[85],"manual":[88],"counts":[90,118],"in":[91],"50":[92],"randomly":[93],"selected":[94],"breast":[95],"cancer":[96],"cases,":[97],"achieved":[100],"an":[101],"intraclass":[102],"correlation":[103],"coefficient":[104],"r(a)(2)=0.96":[106],"95%":[109],"confidence":[110],"interval":[111],"for":[112,146],"percentage":[114],"difference":[115],"between":[116],"from":[119],"-26.1%":[120],"10.8%.":[122],"The":[123,135],"also":[126],"found":[127],"sensitivity":[131],"approaching":[132],"100%.":[133],"CONCLUSION:":[134],"can":[137],"reliably":[138],"be":[139],"on":[141],"photographs":[143],"staining":[145],"quantify":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
