{"id":"https://openalex.org/W2147303181","doi":"https://doi.org/10.1152/ajpgi.2001.280.3.g400","title":"Characterization of apical membrane Cl-dependent Na/H exchange in crypt cells of rat distal colon","display_name":"Characterization of apical membrane Cl-dependent Na/H exchange in crypt cells of rat distal colon","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2147303181","doi":"https://doi.org/10.1152/ajpgi.2001.280.3.g400","mag":"2147303181","pmid":"https://pubmed.ncbi.nlm.nih.gov/11171622"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.2001.280.3.g400","doi":"https://doi.org/10.1152/ajpgi.2001.280.3.g400","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.2001.280.3.g400","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056444185","display_name":"Vazhaikkurichi M. Rajendran","orcid":"https://orcid.org/0000-0002-8999-8721","observed_orcids":["https://orcid.org/0000-0002-8999-8721"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vazhaikkurichi M. Rajendran","raw_affiliation_strings":["Departments of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065040724","display_name":"John Peter Geibel","orcid":"https://orcid.org/0000-0003-1147-7501","observed_orcids":["https://orcid.org/0000-0003-1147-7501"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Geibel","raw_affiliation_strings":["Surgery, Yale University, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Yale University, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112387166","display_name":"Henry J. Binder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry J. Binder","raw_affiliation_strings":["Departments of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0473,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.74889317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"280","issue":"3","first_page":"G400","last_page":"G405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crypt-cells","display_name":"crypt cells","score":0.671999990940094},{"id":"https://openalex.org/keywords/distal-colon","display_name":"distal colon","score":0.9710000157356262},{"id":"https://openalex.org/keywords/apical-membrane-vesicles","display_name":"apical membrane vesicles","score":0.8069999814033508},{"id":"https://openalex.org/keywords/intracellular-ph-recovery","display_name":"intracellular pH recovery","score":0.968999981880188},{"id":"https://openalex.org/keywords/amiloride","display_name":"amiloride","score":0.7440000176429749},{"id":"https://openalex.org/keywords/ethylisopropylamiloride","display_name":"ethylisopropylamiloride","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hoe-694","display_name":"HOE 694","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dids","display_name":"DIDS","score":0.8629999756813049},{"id":"https://openalex.org/keywords/plasma-aldosterone-concentration","display_name":"plasma aldosterone","score":0.8859999775886536},{"id":"https://openalex.org/keywords/colonic-epithelium","display_name":"colonic epithelium","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.7299069166183472},{"id":"https://openalex.org/C3018436504","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Apical membrane","level":3,"score":0.6914999485015869},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.676688551902771},{"id":"https://openalex.org/C188053792","wikidata":"https://www.wikidata.org/wiki/Q3640664","display_name":"Cotransporter","level":3,"score":0.6720958948135376},{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.6336547136306763},{"id":"https://openalex.org/C120405084","wikidata":"https://www.wikidata.org/wiki/Q285307","display_name":"Symporter","level":4,"score":0.5321637392044067},{"id":"https://openalex.org/C114574056","wikidata":"https://www.wikidata.org/wiki/Q7553395","display_name":"Sodium\u2013hydrogen antiporter","level":3,"score":0.5260457992553711},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.49214881658554077},{"id":"https://openalex.org/C90424259","wikidata":"https://www.wikidata.org/wiki/Q211026","display_name":"Electrochemical gradient","level":3,"score":0.48717233538627625},{"id":"https://openalex.org/C39587587","wikidata":"https://www.wikidata.org/wiki/Q5383698","display_name":"Epithelial polarity","level":3,"score":0.48654499650001526},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47371476888656616},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.42747583985328674},{"id":"https://openalex.org/C2778844314","wikidata":"https://www.wikidata.org/wiki/Q191700","display_name":"Benzoic acid","level":2,"score":0.4239342510700226},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.41288405656814575},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.364987313747406},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3566271662712097},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26849523186683655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18690460920333862},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.15531966090202332},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004039","descriptor_name":"Diet, Sodium-Restricted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009579","descriptor_name":"Nitrobenzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017878","descriptor_name":"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.2001.280.3.g400","doi":"https://doi.org/10.1152/ajpgi.2001.280.3.g400","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.2001.280.3.g400","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:11171622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11171622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G273881035","display_name":null,"funder_award_id":"DK 14669","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5041993942","display_name":"COLONIC CRYPT CELL FUNCTION","funder_award_id":"5r01dk014669-26","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1494032084","https://openalex.org/W1547581450","https://openalex.org/W1565223184","https://openalex.org/W1567364863","https://openalex.org/W1580672895","https://openalex.org/W1775749144","https://openalex.org/W1900598585","https://openalex.org/W1967989557","https://openalex.org/W1989519336","https://openalex.org/W1991660853","https://openalex.org/W1994379611","https://openalex.org/W2017249356","https://openalex.org/W2048771801","https://openalex.org/W2057595921","https://openalex.org/W2122862287","https://openalex.org/W2132947258","https://openalex.org/W2174970607","https://openalex.org/W2186437658","https://openalex.org/W2256895485","https://openalex.org/W2314840148","https://openalex.org/W2346732241","https://openalex.org/W2396092200","https://openalex.org/W2396875274","https://openalex.org/W2413207073","https://openalex.org/W2414241074","https://openalex.org/W2415496155","https://openalex.org/W4230105298"],"related_works":["https://openalex.org/W1994379611","https://openalex.org/W2132947258","https://openalex.org/W1971991422","https://openalex.org/W2026799941","https://openalex.org/W2008899035","https://openalex.org/W7101075533","https://openalex.org/W1985475545","https://openalex.org/W2159415844","https://openalex.org/W1580672895","https://openalex.org/W2133394134"],"abstract_inverted_index":{"A":[0],"novel":[1,221],"Cl-dependent":[2,55],"Na/H":[3,107],"exchange":[4,108,136],"(Cl-NHE)":[5],"has":[6],"been":[7],"identified":[8],"in":[9,32,46,184,205],"apical":[10,33],"membranes":[11],"of":[12,15,21,76,98,120,160,190,196],"crypt":[13,48,216],"cells":[14],"rat":[16],"distal":[17],"colon.":[18],"The":[19,50],"presence":[20],"Cl":[22,143,154],"is":[23,62,81,103,129,219],"required":[24],"for":[25,74,96],"both":[26],"outward":[27,56,85],"proton":[28,57],"gradient-driven":[29,58],"Na":[30,67,75,175],"uptake":[31,60],"membrane":[34],"vesicles":[35],"(AMV)":[36],"and":[37,93,113,124,141,149,163,167,181,199],"Na-dependent":[38],"intracellular":[39],"pH":[40],"recovery":[41],"from":[42,194],"an":[43,116,134],"acid":[44],"load":[45],"the":[47,106,214],"gland.":[49],"present":[51,204],"study":[52],"establishes":[53],"that":[54,202,213],"(22)Na":[59],"1)":[61],"saturated":[63,82],"with":[64,69,83,89,115,157],"increasing":[65,84],"extravesicular":[66],"concentration":[68,87,140],"a":[70,90,94,142,153,158,220],"Michaelis":[71],"constant":[72,118],"(K(m))":[73],"approximately":[77,99,121,161],"24.2":[78],"mM;":[79],"2)":[80],"H":[86,97],"gradient":[88],"hyperbolic":[91],"curve":[92],"K(m)":[95],"1.5":[100],"microM;":[101],"3)":[102],"inhibited":[104,130],"by":[105,131,150,173],"(NHE)":[109],"inhibitors":[110],"amiloride,":[111],"ethylisopropylamiloride,":[112],"HOE-694":[114],"inhibitory":[117],"(K(i))":[119],"480.2,":[122],"1.1,":[123],"9.5":[125],"microM,":[126,165],"respectively;":[127,166],"4)":[128],"4,4'-diisothiocyanostilbene-2,2'-disulfonic":[132],"acid,":[133,152],"anion":[135],"inhibitor":[137],"at":[138,146],"low":[139],"channel":[144,155],"blocker":[145],"high":[147],"dose,":[148],"5-nitro-2(3-phenylpropylamino)benzoic":[151],"blocker,":[156],"K(i)":[159],"280.6":[162],"18.3":[164],"5)":[168],"substantially":[169],"stimulated":[170],"Cl-NHE":[171,191,218],"activity":[172],"dietary":[174],"depletion,":[176],"which":[177],"increases":[178],"plasma":[179],"aldosterone":[180],"inhibits":[182],"NHE":[183,222],"surface":[185],"cell":[186,217],"AMV.":[187],"These":[188],"properties":[189],"are":[192,203],"distinct":[193],"those":[195],"NHE1,":[197],"NHE2,":[198],"NHE3":[200],"isoforms":[201],"colonic":[206,215],"epithelial":[207],"cells;":[208],"thus":[209],"these":[210],"results":[211],"suggest":[212],"isoform.":[223]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}