{"id":"https://openalex.org/W2147290688","doi":"https://doi.org/10.1084/jem.185.1.141","title":"Downregulation of CD1 Marks Acquisition of Functional Maturation of Human Thymocytes and Defines a Control Point in Late Stages of Human T Cell Development","display_name":"Downregulation of CD1 Marks Acquisition of Functional Maturation of Human Thymocytes and Defines a Control Point in Late Stages of Human T Cell Development","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2147290688","doi":"https://doi.org/10.1084/jem.185.1.141","mag":"2147290688","pmid":"https://pubmed.ncbi.nlm.nih.gov/8996250","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2196108"},"language":"en","primary_location":{"id":"doi:10.1084/jem.185.1.141","doi":"https://doi.org/10.1084/jem.185.1.141","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.185.1.141","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2196108/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110181587","display_name":"Pieter C.M. Res","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["JP","NL"],"is_corresponding":false,"raw_author_name":"Pieter Res","raw_affiliation_strings":["From the *Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands; and \u2021Laboratory of AIDS Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan","From the Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands; and \u2021Laboratory of AIDS Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"From the Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032186327","display_name":"Bianca Blom","orcid":"https://orcid.org/0000-0002-8401-5319","observed_orcids":["https://orcid.org/0000-0002-8401-5319"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["JP","NL"],"is_corresponding":false,"raw_author_name":"Bianca Blom","raw_affiliation_strings":["From the *Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands; and \u2021Laboratory of AIDS Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan","From the Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands; and \u2021Laboratory of AIDS Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"From the Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101561152","display_name":"Toshiyuki Hori","orcid":"https://orcid.org/0000-0002-4339-1406","observed_orcids":["https://orcid.org/0000-0002-4339-1406"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["JP","NL"],"is_corresponding":false,"raw_author_name":"Toshiyuki Hori","raw_affiliation_strings":["From the *Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands; and \u2021Laboratory of AIDS Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan","From the Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands; and \u2021Laboratory of AIDS Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"From the Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013085782","display_name":"Kees C. Weijer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["JP","NL"],"is_corresponding":false,"raw_author_name":"Kees Weijer","raw_affiliation_strings":["From the *Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands; and \u2021Laboratory of AIDS Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan","From the Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands; and \u2021Laboratory of AIDS Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"From the Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089955013","display_name":"Hergen Spits","orcid":"https://orcid.org/0000-0003-3269-8338","observed_orcids":["https://orcid.org/0000-0003-3269-8338"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["JP","NL"],"is_corresponding":true,"raw_author_name":"Hergen Spits","raw_affiliation_strings":["From the *Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands; and \u2021Laboratory of AIDS Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan","From the Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands; and \u2021Laboratory of AIDS Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"From the Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089955013"],"corresponding_institution_ids":["https://openalex.org/I22299242","https://openalex.org/I2898336195"],"apc_list":null,"apc_paid":null,"fwci":2.3521,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.8866989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"185","issue":"1","first_page":"141","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd1a","display_name":"CD1a","score":0.7929999828338623},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.746999979019165},{"id":"https://openalex.org/keywords/cd4-cd8-double-positive-thymocytes","display_name":"double-positive thymocytes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/single-positive-thymocytes","display_name":"single positive thymocytes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.7860000133514404},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.9670000076293945},{"id":"https://openalex.org/keywords/thymic-microenvironment","display_name":"thymic microenvironment","score":0.722000002861023},{"id":"https://openalex.org/keywords/thymic-organ-culture","display_name":"thymic organ culture","score":0.6610000133514404},{"id":"https://openalex.org/keywords/neonatal-cord-blood","display_name":"neonatal cord blood","score":0.7540000081062317},{"id":"https://openalex.org/keywords/thymic-stromal-cells","display_name":"thymic stromal cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7602333426475525},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6615685224533081},{"id":"https://openalex.org/C2778954852","wikidata":"https://www.wikidata.org/wiki/Q7799635","display_name":"Thymocyte","level":4,"score":0.560973584651947},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5544219017028809},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5489611029624939},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5124917030334473},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5093683004379272},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4632488489151001},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.45452582836151123},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.45021799206733704},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44528454542160034},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.43476641178131104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4323854446411133},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41117575764656067},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4094589948654175},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2832430601119995},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19133862853050232},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.13560888171195984},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0960114598274231},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018949","descriptor_name":"Antigens, CD1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1084/jem.185.1.141","doi":"https://doi.org/10.1084/jem.185.1.141","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.185.1.141","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2196108","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2196108/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2196108/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:8996250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8996250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.7081","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.7081","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/51/58/J_Exp_Med_1997_Jan_6_185(1)_141-152.tar.gz","raw_type":"text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/8a5a4834-c21f-4f43-9313-cd38cde5226e","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/downregulation-of-cd1-marks-acquisition-of-functional-maturation-of-human-thymocytes-and-defines-a-control-point-in-late-stages-of-human-t-cell-development(8a5a4834-c21f-4f43-9313-cd38cde5226e).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of experimental medicine, 185(1), 141 - 151. Rockefeller University Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/e08a03a8-5233-433e-9c43-5cf65e3bc395","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/e08a03a8-5233-433e-9c43-5cf65e3bc395","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Res, P, Blom, B, Hori, T, Weijer, K & Spits, H 1997, 'Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development', Journal of experimental medicine, vol. 185, no. 1, pp. 141-151. https://doi.org/10.1084/jem.185.1.141","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2196108","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2196108/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2196108/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147290688.pdf","grobid_xml":"https://content.openalex.org/works/W2147290688.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1499978984","https://openalex.org/W1533178083","https://openalex.org/W1535603654","https://openalex.org/W1548353348","https://openalex.org/W1581150959","https://openalex.org/W1583964613","https://openalex.org/W1597009847","https://openalex.org/W1613492859","https://openalex.org/W1622259699","https://openalex.org/W1649510769","https://openalex.org/W1907586712","https://openalex.org/W1913179054","https://openalex.org/W1940095235","https://openalex.org/W1945938648","https://openalex.org/W1981032081","https://openalex.org/W1983687074","https://openalex.org/W1983865595","https://openalex.org/W1985300016","https://openalex.org/W1995179449","https://openalex.org/W1996420070","https://openalex.org/W1998651301","https://openalex.org/W2001300923","https://openalex.org/W2009654152","https://openalex.org/W2017584066","https://openalex.org/W2022978700","https://openalex.org/W2047797295","https://openalex.org/W2050515006","https://openalex.org/W2050990545","https://openalex.org/W2052115135","https://openalex.org/W2057259026","https://openalex.org/W2061797668","https://openalex.org/W2063096720","https://openalex.org/W2064336505","https://openalex.org/W2078957773","https://openalex.org/W2093143038","https://openalex.org/W2118466356","https://openalex.org/W2122956735","https://openalex.org/W2123727988","https://openalex.org/W2134812217","https://openalex.org/W2139987022","https://openalex.org/W2144437446","https://openalex.org/W2146734212","https://openalex.org/W2150590994","https://openalex.org/W2156008881","https://openalex.org/W2160789639","https://openalex.org/W2322548232","https://openalex.org/W2402443265"],"related_works":["https://openalex.org/W1982219626","https://openalex.org/W2096485594","https://openalex.org/W2395691512","https://openalex.org/W2026518726","https://openalex.org/W1486013549","https://openalex.org/W2153630331","https://openalex.org/W1537122411","https://openalex.org/W1978757502","https://openalex.org/W1535603654","https://openalex.org/W2326623647"],"abstract_inverted_index":{"We":[0],"have":[1],"investigated":[2,105],"whether":[3],"in":[4,38,40,78,106,157,166],"the":[5,32,95,158],"human":[6,128,150,195],"thymus":[7],"transition":[8],"of":[9,26,34,57,66,88,127,230],"CD4+CD8+":[10],"double":[11],"positive":[12,19],"(DP)":[13],"to":[14,36,42,188,232],"CD4+":[15],"or":[16],"CD8+":[17],"single":[18],"(SP)":[20],"cells":[21,69,91,103,191,212,215],"is":[22,226],"sufficient":[23],"for":[24,49,99,228],"generation":[25],"functional":[27,50,55,101,234],"immunocompetent":[28],"T":[29,102],"cells.":[30,151,198,240],"Using":[31],"capacity":[33],"thymocytes":[35,62,174,186],"expand":[37],"vitro":[39,167],"response":[41],"PHA":[43,169],"and":[44,60,161,170],"IL-2":[45],"as":[46],"a":[47,71,86,107],"criterion":[48],"maturity,":[51],"we":[52],"found":[53,77],"that":[54,83,137,204,220],"maturity":[56],"both":[58],"SP":[59,134,149,154,173,185],"DP":[61,73,90,207],"correlates":[63],"with":[64,70,168,194,217],"downregulation":[65,229],"CD1a.":[67],"CD1a-":[68,190],"persistent":[72],"phenotype":[74],"were":[75,104],"also":[76],"neonatal":[79],"cord":[80],"blood,":[81],"suggesting":[82],"at":[84],"least":[85],"proportion":[87],"mature":[89,235],"can":[92,142],"emigrate":[93],"from":[94],"thymus.":[96],"The":[97],"requirements":[98],"generating":[100],"hybrid":[108],"human/mouse":[109],"fetal":[110],"thymic":[111,123,196],"organ":[112],"culture.":[113],"MHC":[114,119,139],"class":[115,120,140],"II-positive,":[116],"but":[117,219],"not":[118,163,176],"II-negative,":[121],"mouse":[122,138],"microenvironments":[124],"support":[125],"differentiation":[126],"progenitors":[129],"into":[130],"TCR":[131,145,208,236],"alpha":[132,146,209,237],"beta+CD4+":[133],"cells,":[135],"indicating":[136],"II":[141],"positively":[143],"select":[144],"beta":[147,210,238],"+CD4+":[148],"Strikingly,":[152],"these":[153,201,214],"are":[155],"arrested":[156],"CD1a+":[159,206],"stage":[160,180],"could":[162],"be":[164],"expanded":[165],"IL-2.":[171],"CD1a+CD4+":[172,184],"do":[175],"represent":[177],"an":[178,221],"end":[179],"population":[181],"because":[182],"purified":[183],"differentiate":[187],"expandable":[189],"upon":[192],"cocultivation":[193],"stromal":[197],"Taken":[199],"together":[200],"data":[202],"indicate":[203],"when":[205],"low":[211],"mature,":[213],"interact":[216],"MHC,":[218],"additional,":[222],"apparently":[223],"species-specific,":[224],"signal":[225],"required":[227],"CD1a":[231],"generate":[233],"+":[239]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
