{"id":"https://openalex.org/W2147276836","doi":null,"title":"Bone Tissue Engineering Using Colloidal Gels and Native Extracellular Matrix Biomaterials","display_name":"Bone Tissue Engineering Using Colloidal Gels and Native Extracellular Matrix Biomaterials","publication_year":2015,"publication_date":"2015-05-31","ids":{"openalex":"https://openalex.org/W2147276836","mag":"2147276836"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/18395","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/18395","pdf_url":"http://hdl.handle.net/1808/18395","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1808/18395","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014950680","display_name":"S. Connor Dennis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S. Connor Dennis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014950680"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.9789999723434448},{"id":"https://openalex.org/keywords/colloidal-gels","display_name":"colloidal gels","score":0.8960000276565552},{"id":"https://openalex.org/keywords/injectable-scaffolds","display_name":"injectable scaffolds","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hydroxyapatite","display_name":"hydroxyapatite","score":1.0},{"id":"https://openalex.org/keywords/extracellular-matrix-biomaterials","display_name":"extracellular matrix biomaterials","score":0.8920000195503235},{"id":"https://openalex.org/keywords/decellularized-cartilage","display_name":"decellularized cartilage","score":0.8730000257492065},{"id":"https://openalex.org/keywords/demineralized-bone-matrix","display_name":"demineralized bone matrix","score":1.0},{"id":"https://openalex.org/keywords/rheology","display_name":"rheology","score":0.6399999856948853},{"id":"https://openalex.org/keywords/viscoelasticity","display_name":"viscoelasticity","score":0.9139999747276306},{"id":"https://openalex.org/keywords/swelling-power","display_name":"swelling power","score":0.6420000195503235},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.9160000085830688},{"id":"https://openalex.org/keywords/critical-sized-calvarial-defect","display_name":"critical-size calvarial defect","score":0.8289999961853027},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.7705111503601074},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7168862819671631},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.640880823135376},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6360681653022766},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.631248950958252},{"id":"https://openalex.org/C2779869580","wikidata":"https://www.wikidata.org/wiki/Q5255359","display_name":"Demineralized bone matrix","level":5,"score":0.5448089838027954},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5424152612686157},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.5334720015525818},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5271517634391785},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.46731823682785034},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45869582891464233},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4441797733306885},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43379759788513184},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.43344438076019287},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.4219937324523926},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4193704128265381},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36299967765808105},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19764792919158936},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13039231300354004},{"id":"https://openalex.org/C94105702","wikidata":"https://www.wikidata.org/wiki/Q777017","display_name":"dBm","level":4,"score":0.12725934386253357},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.10074305534362793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09623309969902039},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.07220634818077087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C194257627","wikidata":"https://www.wikidata.org/wiki/Q211554","display_name":"Amplifier","level":3,"score":0.0},{"id":"https://openalex.org/C46362747","wikidata":"https://www.wikidata.org/wiki/Q173431","display_name":"CMOS","level":2,"score":0.0},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/18395","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/18395","pdf_url":"http://hdl.handle.net/1808/18395","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.933.789","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.933.789","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://kuscholarworks.ku.edu/bitstream/handle/1808/18395/Dennis_ku_0099D_13837_DATA_1.pdf%3Bjsessionid%3DCBBEC967071FF9E1694D1E9C8D042158?sequence%3D1","raw_type":"text"},{"id":"mag:2147276836","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/handle/1808/18395","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/18395","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/18395","pdf_url":"http://hdl.handle.net/1808/18395","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147276836.pdf","grobid_xml":"https://content.openalex.org/works/W2147276836.grobid-xml"},"referenced_works_count":188,"referenced_works":["https://openalex.org/W30014773","https://openalex.org/W38879183","https://openalex.org/W68704341","https://openalex.org/W990936862","https://openalex.org/W1496564805","https://openalex.org/W1504463291","https://openalex.org/W1521430351","https://openalex.org/W1524725220","https://openalex.org/W1531198701","https://openalex.org/W1566227297","https://openalex.org/W1797652360","https://openalex.org/W1806851239","https://openalex.org/W1846706585","https://openalex.org/W1944287377","https://openalex.org/W1964610568","https://openalex.org/W1968069093","https://openalex.org/W1968084778","https://openalex.org/W1968217647","https://openalex.org/W1968817520","https://openalex.org/W1971552204","https://openalex.org/W1972723830","https://openalex.org/W1972906016","https://openalex.org/W1974565328","https://openalex.org/W1975980065","https://openalex.org/W1976113824","https://openalex.org/W1978864310","https://openalex.org/W1979519394","https://openalex.org/W1979608886","https://openalex.org/W1980650004","https://openalex.org/W1981011460","https://openalex.org/W1982028780","https://openalex.org/W1982094025","https://openalex.org/W1982491228","https://openalex.org/W1983894674","https://openalex.org/W1984685797","https://openalex.org/W1986138379","https://openalex.org/W1987465286","https://openalex.org/W1987476673","https://openalex.org/W1987602789","https://openalex.org/W1991842246","https://openalex.org/W1992112921","https://openalex.org/W1992407852","https://openalex.org/W1994253527","https://openalex.org/W1996626693","https://openalex.org/W1997376006","https://openalex.org/W1997526887","https://openalex.org/W1998489952","https://openalex.org/W2000335115","https://openalex.org/W2002230244","https://openalex.org/W2003777772","https://openalex.org/W2003988556","https://openalex.org/W2004006890","https://openalex.org/W2005417829","https://openalex.org/W2006335494","https://openalex.org/W2008342341","https://openalex.org/W2014680491","https://openalex.org/W2014733123","https://openalex.org/W2015926432","https://openalex.org/W2017517555","https://openalex.org/W2018145050","https://openalex.org/W2019592328","https://openalex.org/W2020614754","https://openalex.org/W2020645925","https://openalex.org/W2021420116","https://openalex.org/W2022848314","https://openalex.org/W2024056569","https://openalex.org/W2024261809","https://openalex.org/W2024358771","https://openalex.org/W2025002691","https://openalex.org/W2030154898","https://openalex.org/W2030961193","https://openalex.org/W2033378260","https://openalex.org/W2034500595","https://openalex.org/W2035209595","https://openalex.org/W2035368770","https://openalex.org/W2035759260","https://openalex.org/W2036177694","https://openalex.org/W2036774174","https://openalex.org/W2039033164","https://openalex.org/W2041636168","https://openalex.org/W2042303079","https://openalex.org/W2044494246","https://openalex.org/W2045117011","https://openalex.org/W2045896691","https://openalex.org/W2045917740","https://openalex.org/W2046457747","https://openalex.org/W2048626490","https://openalex.org/W2049791410","https://openalex.org/W2049906701","https://openalex.org/W2050506514","https://openalex.org/W2050507929","https://openalex.org/W2051400613","https://openalex.org/W2052875771","https://openalex.org/W2053016699","https://openalex.org/W2053350695","https://openalex.org/W2054141235","https://openalex.org/W2054859965","https://openalex.org/W2058191567","https://openalex.org/W2058452918","https://openalex.org/W2058628090","https://openalex.org/W2059486645","https://openalex.org/W2060657670","https://openalex.org/W2061245480","https://openalex.org/W2062224667","https://openalex.org/W2062317324","https://openalex.org/W2062978994","https://openalex.org/W2063666536","https://openalex.org/W2066518402","https://openalex.org/W2066549760","https://openalex.org/W2066668792","https://openalex.org/W2066816373","https://openalex.org/W2067716147","https://openalex.org/W2068149454","https://openalex.org/W2068271233","https://openalex.org/W2068885595","https://openalex.org/W2069142829","https://openalex.org/W2069810199","https://openalex.org/W2070197586","https://openalex.org/W2070746774","https://openalex.org/W2071359561","https://openalex.org/W2071573102","https://openalex.org/W2071708686","https://openalex.org/W2071741465","https://openalex.org/W2071986963","https://openalex.org/W2072100512","https://openalex.org/W2073857965","https://openalex.org/W2074528940","https://openalex.org/W2075682493","https://openalex.org/W2076092305","https://openalex.org/W2076529839","https://openalex.org/W2077309660","https://openalex.org/W2077648724","https://openalex.org/W2080790182","https://openalex.org/W2085038604","https://openalex.org/W2086438691","https://openalex.org/W2087125520","https://openalex.org/W2092315508","https://openalex.org/W2092904432","https://openalex.org/W2093063838","https://openalex.org/W2093353711","https://openalex.org/W2096272151","https://openalex.org/W2096467350","https://openalex.org/W2101947377","https://openalex.org/W2103338895","https://openalex.org/W2104263631","https://openalex.org/W2109293470","https://openalex.org/W2111242220","https://openalex.org/W2114529565","https://openalex.org/W2122667215","https://openalex.org/W2123419409","https://openalex.org/W2126200687","https://openalex.org/W2130033521","https://openalex.org/W2131229281","https://openalex.org/W2131978756","https://openalex.org/W2136172298","https://openalex.org/W2138149517","https://openalex.org/W2139502965","https://openalex.org/W2140877396","https://openalex.org/W2141541885","https://openalex.org/W2143476062","https://openalex.org/W2143612388","https://openalex.org/W2147815156","https://openalex.org/W2149501637","https://openalex.org/W2154773597","https://openalex.org/W2155983200","https://openalex.org/W2157152728","https://openalex.org/W2157664121","https://openalex.org/W2160698351","https://openalex.org/W2161561471","https://openalex.org/W2163565101","https://openalex.org/W2163580553","https://openalex.org/W2163768016","https://openalex.org/W2164112925","https://openalex.org/W2165673443","https://openalex.org/W2165780899","https://openalex.org/W2166550189","https://openalex.org/W2167667624","https://openalex.org/W2168420558","https://openalex.org/W2169318502","https://openalex.org/W2170363905","https://openalex.org/W2171918057","https://openalex.org/W2263451416","https://openalex.org/W2323112818","https://openalex.org/W2334200488","https://openalex.org/W2339677954","https://openalex.org/W2412653856","https://openalex.org/W2465950763","https://openalex.org/W2506800878"],"related_works":["https://openalex.org/W2553880787","https://openalex.org/W2320694928","https://openalex.org/W1987476673","https://openalex.org/W2522522258","https://openalex.org/W1944719098","https://openalex.org/W2323112818","https://openalex.org/W2580253338","https://openalex.org/W4311270792","https://openalex.org/W2622300755","https://openalex.org/W4405368902"],"abstract_inverted_index":{"Self-assembling":[0],"and":[1,7,13,68,82,97,103,122,171,195,231,273,330],"shear-responsive":[2],"biomaterials":[3,52],"possess":[4],"favorable":[5],"rheological":[6],"viscoelastic":[8],"properties":[9,99],"to":[10,47,153,177,189,203,216,257,317,334,340],"be":[11],"injectable":[12,88],"facilitate":[14],"minimally":[15],"invasive":[16],"surgery.":[17],"The":[18],"current":[19,76],"thesis":[20,77],"work":[21],"describes":[22],"the":[23,32,44,55,75,155,184,229,260,295,306,323,342],"evaluation":[24],"of":[25,34,57,86,112,158,167,186,233,262,280,294,308,325,337],"malleable":[26],"colloidal":[27,148,160,180,200,234,254,282],"gel":[28,283],"scaffolding":[29],"technology":[30,284],"for":[31,100,322],"regeneration":[33],"bone":[35,59,67,124,197,222,247,302,328],"tissue":[36,303,310],"in":[37,54,74,80,83,135,139,175,179,211,220,236,245,250,271,287],"non-load":[38,326],"bearing":[39,327],"critical-sized":[40,237],"defects.":[41,240,276],"This":[42],"represents":[43],"first":[45],"attempt":[46],"form":[48],"colloids":[49,92],"exclusively":[50],"from":[51,109,315],"found":[53],"microenvironment":[56],"healing":[58],"fractures":[60],"including":[61],"hyaluronic":[62],"acid":[63],"(HA),":[64],"hydroxyapatite":[65],"(HAP),":[66],"cartilage":[69,120],"extracellular":[70],"matrix":[71,125,198],"(ECM).":[72],"Work":[73],"evaluated":[78],"preliminary":[79,289],"vitro":[81,163],"vivo":[84,226],"efficacy":[85,232],"several":[87],"colloids.":[89],"Specifically,":[90],"HA-HAP":[91,129,159,272],"exhibiting":[93],"desirable":[94],"rheological,":[95],"viscoelastic,":[96],"swelling":[98],"surgical":[101],"placement":[102],"defect":[104],"site":[105],"retention":[106],"were":[107,248,268,285],"identified":[108],"an":[110,208],"array":[111],"formulations.":[113,161],"Subsequent":[114],"formulation":[115,297],"refinement":[116],"incorporated":[117],"micronized":[118],"decellularized":[119],"(DCC)":[121],"demineralized":[123,196],"(DBM)":[126],"particles":[127],"into":[128],"colloids,":[130],"which":[131],"did":[132],"not":[133],"result":[134],"any":[136],"significant":[137,243],"decreases":[138],"measured":[140],"fluid":[141,149],"properties.":[142],"Coupling":[143],"ECM":[144],"microparticles":[145],"within":[146],"a":[147,212],"carrier":[150],"was":[151],"hypothesized":[152],"enhance":[154],"regenerative":[156],"capacity":[157],"In":[162,225],"studies":[164,227],"demonstrated":[165,228],"evidence":[166],"temporal":[168,213],"chondrogenic,":[169],"hypertrophic,":[170],"osteogenic":[172,209],"gene":[173],"expression":[174,217],"response":[176],"changes":[178],"composition.":[181],"More":[182],"specifically,":[183],"inclusion":[185],"DCC":[187],"led":[188],"hypertrophic":[190],"chondrogenesis":[191],"while":[192],"both":[193],"HAP":[194],"DBM":[199],"formulations":[201,255],"appeared":[202],"direct":[204],"cell":[205],"lineage":[206],"down":[207],"pathway":[210],"manner":[214],"similar":[215],"profiles":[218],"observed":[219,249,270,286],"native":[221],"fracture":[223],"healing.":[224],"feasibility":[230],"scaffolds":[235],"rat":[238],"calvarial":[239],"Although":[241],"no":[242],"differences":[244],"regenerated":[246],"defects":[251],"treated":[252,275],"with":[253],"compared":[256],"negative":[258],"control,":[259],"presence":[261],"endochondral":[263],"(EC)":[264],"derived":[265],"ossification":[266],"foci":[267],"only":[269],"HA-HAP-ECM":[274],"Thus,":[277],"definite":[278],"advantages":[279],"using":[281],"these":[288],"studies,":[290],"but":[291],"future":[292],"iterations":[293],"implant":[296],"design":[298],"may":[299],"yield":[300],"enhanced":[301],"regeneration.":[304],"Ultimately,":[305],"idea":[307],"colloidal-based":[309],"implants":[311],"has":[312,331],"been":[313],"taken":[314],"concept":[316],"practice,":[318],"produced":[319],"promising":[320],"results":[321],"treatment":[324],"defects,":[329],"given":[332],"rise":[333],"numerous":[335],"areas":[336],"tangential":[338],"research":[339],"refine":[341],"technology.":[343]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}