{"id":"https://openalex.org/W2147275382","doi":"https://doi.org/10.1016/j.ebiom.2015.08.022","title":"Neural Stem Cell Carriers for the Treatment of Glioblastoma Multiforme","display_name":"Neural Stem Cell Carriers for the Treatment of Glioblastoma Multiforme","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2147275382","doi":"https://doi.org/10.1016/j.ebiom.2015.08.022","mag":"2147275382","pmid":"https://pubmed.ncbi.nlm.nih.gov/26425671","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4563132"},"language":"en","primary_location":{"id":"doi:10.1016/j.ebiom.2015.08.022","doi":"https://doi.org/10.1016/j.ebiom.2015.08.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2015.08.022","pdf_url":"http://www.thelancet.com/article/S2352396415001383/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.thelancet.com/article/S2352396415001383/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074786388","display_name":"Jason M. Miska","orcid":"https://orcid.org/0000-0001-9608-2810","observed_orcids":["https://orcid.org/0000-0001-9608-2810"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Miska","raw_affiliation_strings":["The Brain Tumor Center, Department of Neurosurgery, The University of Chicago, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Brain Tumor Center, Department of Neurosurgery, The University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053972433","display_name":"Maciej S. Lesniak","orcid":"https://orcid.org/0000-0002-0096-5107","observed_orcids":["https://orcid.org/0000-0002-0096-5107","https://orcid.org/0000-0002-6282-6583"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maciej S. Lesniak","raw_affiliation_strings":["The Brain Tumor Center, Department of Neurosurgery, The University of Chicago, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Brain Tumor Center, Department of Neurosurgery, The University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053972433"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":5780,"currency":"USD","value_usd":5780},"apc_paid":{"value":5780,"currency":"USD","value_usd":5780},"fwci":0.524,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.66007564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2","issue":"8","first_page":"774","last_page":"775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.13259999454021454,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/stem-cell-carriers","display_name":"stem cell carriers","score":0.7279999852180481},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.972000002861023},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.6370000243186951},{"id":"https://openalex.org/keywords/biodegradable-polymers","display_name":"biodegradable polymers","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7829999923706055},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.714094877243042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6349631547927856},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.555168628692627},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5522291660308838},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5266513824462891},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44108396768569946},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.44032520055770874},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.43765684962272644},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4206988513469696},{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.41943567991256714},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.41644108295440674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3570544123649597},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30684521794319153},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.19894102215766907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15482747554779053},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018914","descriptor_name":"Cells, Immobilized","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018914","descriptor_name":"Cells, Immobilized","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ebiom.2015.08.022","doi":"https://doi.org/10.1016/j.ebiom.2015.08.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2015.08.022","pdf_url":"http://www.thelancet.com/article/S2352396415001383/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4563132","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4563132","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Text"},{"id":"pmid:26425671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26425671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a5627d18ac3f4dd2910b7c1f7199de08","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a5627d18ac3f4dd2910b7c1f7199de08","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EBioMedicine, Vol 2, Iss 8, Pp 774-775 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ebiom.2015.08.022","doi":"https://doi.org/10.1016/j.ebiom.2015.08.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2015.08.022","pdf_url":"http://www.thelancet.com/article/S2352396415001383/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147275382.pdf","grobid_xml":"https://content.openalex.org/works/W2147275382.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1972923489","https://openalex.org/W1980441719","https://openalex.org/W2003327408","https://openalex.org/W2037805669","https://openalex.org/W2043106681","https://openalex.org/W2066122640","https://openalex.org/W2096338956","https://openalex.org/W2143041108","https://openalex.org/W2152815924","https://openalex.org/W2326516929"],"related_works":["https://openalex.org/W2275318246","https://openalex.org/W4405873649","https://openalex.org/W2997887722","https://openalex.org/W2804854412","https://openalex.org/W3177151739","https://openalex.org/W2566644721","https://openalex.org/W3120170115","https://openalex.org/W4304127734","https://openalex.org/W2616549771","https://openalex.org/W2905994681"],"abstract_inverted_index":{"Grade":[0],"IV":[1],"astrocytoma,":[2],"termed":[3],"glioblastoma":[4],"multiforme":[5],"(GBM)":[6],"is":[7,37,45],"one":[8],"the":[9,19,28,32,38,62,65,69,94,97],"most":[10],"aggressive":[11],"malignancies":[12,36],"known":[13],"to":[14,31,47,56,77],"man.":[15],"Despite":[16],"intensive":[17],"therapies,":[18],"median":[20],"survival":[21],"has":[22],"remained":[23],"approximately":[24],"15months.":[25],"One":[26],"of":[27,34,64,96],"major":[29],"challenges":[30],"treatment":[33],"CNS":[35],"blood":[39,73],"brain":[40],"barrier":[41,44],"(BBB).":[42],"The":[43],"designed":[46],"be":[48],"incredibly":[49],"selective,":[50],"which":[51],"means":[52],"few":[53],"therapeutics":[54,92],"given":[55],"patients":[57],"will":[58],"reliably":[59],"arrive":[60],"at":[61,93],"site":[63,95],"malignancy.":[66],"To":[67],"overcome":[68],"BBB":[70],"and":[71,86],"low":[72],"flow":[74],"that":[75,88],"tends":[76],"occur":[78],"within":[79],"these":[80],"tumors,":[81],"various":[82],"biodegradable":[83],"materials,":[84],"polymers":[85],"nanoparticles":[87],"can":[89],"slowly":[90],"release":[91],"tumor":[98],"have":[99],"been":[100],"developed.":[101]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
