{"id":"https://openalex.org/W2147274635","doi":"https://doi.org/10.1093/nar/gkm034","title":"Translational repression of mouse mu opioid receptor expression via leaky scanning","display_name":"Translational repression of mouse mu opioid receptor expression via leaky scanning","publication_year":2007,"publication_date":"2007-01-30","ids":{"openalex":"https://openalex.org/W2147274635","doi":"https://doi.org/10.1093/nar/gkm034","mag":"2147274635","pmid":"https://pubmed.ncbi.nlm.nih.gov/17284463","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865057"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkm034","doi":"https://doi.org/10.1093/nar/gkm034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkm034","pdf_url":"https://academic.oup.com/nar/article-pdf/35/5/1501/4093519/gkm034.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/35/5/1501/4093519/gkm034.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034337397","display_name":"Kyu Young Song","orcid":"https://orcid.org/0000-0001-7313-514X","observed_orcids":["https://orcid.org/0000-0001-7313-514X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Y. Song","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. songx047@umn.edu","Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. songx047@umn.edu","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. K. Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. K. Hwang","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062077581","display_name":"C. S. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. S. Kim","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102717994","display_name":"Hoon Sang Choi","orcid":"https://orcid.org/0000-0002-2791-3788","observed_orcids":["https://orcid.org/0000-0002-2791-3788"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. S. Choi","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042950704","display_name":"Ping\u2010Yee Law","orcid":"https://orcid.org/0000-0002-5364-1093","observed_orcids":["https://orcid.org/0000-0002-5364-1093"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.-Y. Law","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034365665","display_name":"Li\u2010Na Wei","orcid":"https://orcid.org/0000-0002-6376-8506","observed_orcids":["https://orcid.org/0000-0002-6376-8506"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.-N. Wei","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014354004","display_name":"Horace H. Loh","orcid":"https://orcid.org/0000-0002-3409-4100","observed_orcids":["https://orcid.org/0000-0002-3409-4100"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. H. Loh","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034337397"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":2.7845,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.91091247,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"5","first_page":"1501","last_page":"1513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.8119999766349792},{"id":"https://openalex.org/keywords/leaky-scanning","display_name":"leaky scanning","score":0.8560000061988831},{"id":"https://openalex.org/keywords/upstream-open-reading-frames","display_name":"upstream open reading frames","score":0.9639999866485596},{"id":"https://openalex.org/keywords/upstream-augs","display_name":"upstream AUGs","score":0.8769999742507935},{"id":"https://openalex.org/keywords/5-untranslated-region","display_name":"5' untranslated region","score":0.9629999995231628},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/negative-regulation-of-gene-expression","display_name":"negative regulation of gene expression","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8096171021461487},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.6307170987129211},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6229215860366821},{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.5931483507156372},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.585892915725708},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.543196976184845},{"id":"https://openalex.org/C166258313","wikidata":"https://www.wikidata.org/wiki/Q7899328","display_name":"Upstream open reading frame","level":5,"score":0.5350186824798584},{"id":"https://openalex.org/C12464233","wikidata":"https://www.wikidata.org/wiki/Q937624","display_name":"Five prime untranslated region","level":5,"score":0.5295529961585999},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5087459683418274},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.4300971031188965},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4225679337978363},{"id":"https://openalex.org/C4718897","wikidata":"https://www.wikidata.org/wiki/Q5408698","display_name":"Eukaryotic translation","level":5,"score":0.41010597348213196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40479302406311035},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3888396620750427},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.37550070881843567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.296269953250885},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.1316351294517517}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018387","descriptor_name":"Codon, Initiator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018387","descriptor_name":"Codon, Initiator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018387","descriptor_name":"Codon, Initiator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018387","descriptor_name":"Codon, Initiator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkm034","doi":"https://doi.org/10.1093/nar/gkm034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkm034","pdf_url":"https://academic.oup.com/nar/article-pdf/35/5/1501/4093519/gkm034.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1350844","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1865057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865057","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:17284463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17284463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkm034","doi":"https://doi.org/10.1093/nar/gkm034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkm034","pdf_url":"https://academic.oup.com/nar/article-pdf/35/5/1501/4093519/gkm034.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G146407700","display_name":null,"funder_award_id":"DA 001583","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G1997679578","display_name":null,"funder_award_id":"DA-011806","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2064480274","display_name":null,"funder_award_id":"DA 000564","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2877801392","display_name":"NEUROCHEMICAL MECHANISM OF NARCOTIC ACTION","funder_award_id":"K05DA070554","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3039475230","display_name":"Basic Research Center on Molecular and Cell Biology of Drug Abuse","funder_award_id":"P50DA011806","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4110999814","display_name":"Structural and Functions Studies of Mu Opiate Receptors: Regulation of its Gene","funder_award_id":"R01DA001583","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5859051125","display_name":"Neurochemical Basis of Opiate Addiction","funder_award_id":"R56DA000564","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6431938048","display_name":null,"funder_award_id":"DA013926","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7528625023","display_name":"Studies of Mouse Kappa Opioid Receptor Gene Regulation","funder_award_id":"R01DA011190","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7930446050","display_name":"Neurochemical Basis of Opiate Addiction","funder_award_id":"R01DA000564","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8255552217","display_name":null,"funder_award_id":"DA011190","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000026570","display_name":null,"funder_award_id":"DA000564","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000058278","display_name":null,"funder_award_id":"DA011806","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000199512","display_name":null,"funder_award_id":"DA013926","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000333663","display_name":null,"funder_award_id":"DA001583","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G901866320","display_name":"Studies of the Mouse Kappa Opioid Receptor Gene","funder_award_id":"K02DA013926","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147274635.pdf","grobid_xml":"https://content.openalex.org/works/W2147274635.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1506019467","https://openalex.org/W1566430503","https://openalex.org/W1598665107","https://openalex.org/W1602721983","https://openalex.org/W1653006923","https://openalex.org/W1654622166","https://openalex.org/W1827821010","https://openalex.org/W1849730822","https://openalex.org/W1920555941","https://openalex.org/W1964606534","https://openalex.org/W1964813963","https://openalex.org/W1968879325","https://openalex.org/W1982980697","https://openalex.org/W1991514368","https://openalex.org/W1995207106","https://openalex.org/W1995732158","https://openalex.org/W2005633684","https://openalex.org/W2018610067","https://openalex.org/W2018859562","https://openalex.org/W2020850864","https://openalex.org/W2026671662","https://openalex.org/W2027195993","https://openalex.org/W2028199453","https://openalex.org/W2030104393","https://openalex.org/W2034914156","https://openalex.org/W2038305786","https://openalex.org/W2038585580","https://openalex.org/W2044641140","https://openalex.org/W2045348184","https://openalex.org/W2045839437","https://openalex.org/W2049528674","https://openalex.org/W2049661143","https://openalex.org/W2051304325","https://openalex.org/W2057913182","https://openalex.org/W2058426472","https://openalex.org/W2068954505","https://openalex.org/W2071253111","https://openalex.org/W2072419382","https://openalex.org/W2073497770","https://openalex.org/W2078933408","https://openalex.org/W2079959402","https://openalex.org/W2102350597","https://openalex.org/W2103791221","https://openalex.org/W2105080299","https://openalex.org/W2109941922","https://openalex.org/W2113286169","https://openalex.org/W2120235608","https://openalex.org/W2127848114","https://openalex.org/W2140257707","https://openalex.org/W2144548050","https://openalex.org/W2149960535","https://openalex.org/W2153521373","https://openalex.org/W2168847939","https://openalex.org/W4244614471","https://openalex.org/W6607556645"],"related_works":["https://openalex.org/W2170048138","https://openalex.org/W2049528674","https://openalex.org/W2107891892","https://openalex.org/W2153521373","https://openalex.org/W2282312702","https://openalex.org/W4383956555","https://openalex.org/W205506410","https://openalex.org/W3091759281","https://openalex.org/W2157112612","https://openalex.org/W4293767712"],"abstract_inverted_index":{"Mu":[0],"opioid":[1],"receptor":[2],"(MOR)":[3],"expression":[4,12,88],"is":[5],"under":[6,195],"temporal":[7],"and":[8,31,44,92,118],"spatial":[9],"controls,":[10],"but":[11],"levels":[13,48,108],"of":[14,40,56,97,130,192],"the":[15,38,41,46,64,106,111,116,156,160,167,190],"MOR":[16,58,65,73,85,173,194],"gene":[17],"are":[18],"relatively":[19],"low":[20],"in":[21,49,82,89,139,171,189],"vivo.":[22],"In":[23,69],"addition":[24],"to":[25,102],"transcriptional":[26],"regulations,":[27],"upstream":[28],"AUGs":[29,120],"(uAUGs)":[30],"open":[32],"reading":[33],"frames":[34],"(uORFs)":[35],"profoundly":[36],"affect":[37],"translation":[39,162],"primary":[42],"ORF":[43],"thus":[45],"protein":[47,146],"several":[50],"genes.":[51],"The":[52],"5'-untranslated":[53],"region":[54],"(UTR)":[55],"mouse":[57,172,193],"mRNA":[59,107,174],"contains":[60],"three":[61],"uORFs":[62,170],"preceding":[63],"main":[66],"initiation":[67,153],"codon.":[68],"MOR-fused":[70],"EGFP":[71],"or":[72,81,114],"promoter/luciferase":[74],"reporter":[75],"constructs,":[76],"mutating":[77],"each":[78,140],"uAUG":[79,113,152,158],"individually":[80],"combinations":[83],"increased":[84,100],"transient":[86],"heterologous":[87],"neuroblastoma":[90],"NMB":[91],"HEK293":[93],"cells":[94],"significantly.":[95],"Translation":[96],"such":[98],"constructs":[99],"up":[101],"3-fold":[103],"without":[104],"altering":[105],"if":[109],"either":[110],"third":[112,119,157],"both":[115],"second":[117],"were":[121,128,148],"mutated.":[122],"Additionally,":[123],"these":[124,151],"uAUG-mediated":[125],"translational":[126],"inhibitions":[127],"independent":[129],"their":[131],"peptide":[132],"as":[133,176],"confirmed":[134],"by":[135],"internal":[136],"mutation":[137],"analyses":[138],"uORF.":[141],"Translational":[142],"studies":[143],"indicated":[144],"that":[145,169],"syntheses":[147],"initiated":[149],"at":[150],"sites,":[154],"with":[155],"initiating":[159],"highest":[161],"level.":[163],"These":[164],"results":[165],"support":[166],"hypothesis":[168],"act":[175],"negative":[177],"regulators":[178],"through":[179],"a":[180],"ribosome":[181],"leaky":[182,186],"scanning":[183,187],"mechanism.":[184],"Such":[185],"resulted":[188],"suppression":[191],"normal":[196],"conditions.":[197]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}