{"id":"https://openalex.org/W2147272291","doi":"https://doi.org/10.1093/bja/80.6.800","title":"Synergistic antinociceptive interaction between sevoflurane and intrathecal fentanyl in dogs","display_name":"Synergistic antinociceptive interaction between sevoflurane and intrathecal fentanyl in dogs","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2147272291","doi":"https://doi.org/10.1093/bja/80.6.800","mag":"2147272291","pmid":"https://pubmed.ncbi.nlm.nih.gov/9771311"},"language":"en","primary_location":{"id":"doi:10.1093/bja/80.6.800","doi":"https://doi.org/10.1093/bja/80.6.800","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bja/80.6.800","pdf_url":null,"source":{"id":"https://openalex.org/S33418846","display_name":"British Journal of Anaesthesia","issn_l":"0007-0912","issn":["0007-0912","1471-6771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Anaesthesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1093/bja/80.6.800","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100707338","display_name":"Daqing Ma","orcid":"https://orcid.org/0000-0003-1235-0537","observed_orcids":["https://orcid.org/0000-0003-1235-0537","https://orcid.org/0000-0002-0688-2097"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Ma","raw_affiliation_strings":["Department of Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110203322","display_name":"S M Sapsed-Byrne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S M Sapsed-Byrne","raw_affiliation_strings":["Department of Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113693002","display_name":"M.K. CHAKRABARTI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M K Chakrabarti","raw_affiliation_strings":["Department of Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033079308","display_name":"JAMES GORDON WHITWAM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J G Whitwam","raw_affiliation_strings":["Department of Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4450,"currency":"USD","value_usd":4450},"apc_paid":null,"fwci":1.4867,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.81482696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"80","issue":"6","first_page":"800","last_page":"806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.18199999630451202,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.14030000567436218,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sevoflurane","display_name":"sevoflurane","score":1.0},{"id":"https://openalex.org/keywords/intrathecal-fentanyl","display_name":"intrathecal fentanyl","score":0.9929999709129333},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8399999737739563},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/somatosympathetic-reflex","display_name":"somatosympathetic reflex","score":0.9779999852180481},{"id":"https://openalex.org/keywords/renal-sympathetic-nerves","display_name":"renal sympathetic nerves","score":0.8429999947547913},{"id":"https://openalex.org/keywords/a-delta-fibers","display_name":"A-delta fibers","score":0.8579999804496765},{"id":"https://openalex.org/keywords/c-fibers","display_name":"C-fibers","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tibial-nerve-stimulation","display_name":"tibial nerve stimulation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/opioid-analgesia","display_name":"opioid analgesia","score":0.550000011920929},{"id":"https://openalex.org/keywords/inhalational-anesthetics","display_name":"inhalational anesthetics","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.912662148475647},{"id":"https://openalex.org/C2781453256","wikidata":"https://www.wikidata.org/wiki/Q419394","display_name":"Sevoflurane","level":2,"score":0.8916974067687988},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.727303147315979},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7072737812995911},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.6195299625396729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5546433925628662},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5233094692230225},{"id":"https://openalex.org/C157820659","wikidata":"https://www.wikidata.org/wiki/Q1320251","display_name":"Intrathecal","level":2,"score":0.4738212823867798},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33048808574676514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12329959869384766},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.049992382526397705}],"mesh":[{"descriptor_ui":"D000077149","descriptor_name":"Sevoflurane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008738","descriptor_name":"Methyl Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bja/80.6.800","doi":"https://doi.org/10.1093/bja/80.6.800","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bja/80.6.800","pdf_url":null,"source":{"id":"https://openalex.org/S33418846","display_name":"British Journal of Anaesthesia","issn_l":"0007-0912","issn":["0007-0912","1471-6771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Anaesthesia","raw_type":"journal-article"},{"id":"pmid:9771311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9771311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of anaesthesia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bja/80.6.800","doi":"https://doi.org/10.1093/bja/80.6.800","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bja/80.6.800","pdf_url":null,"source":{"id":"https://openalex.org/S33418846","display_name":"British Journal of Anaesthesia","issn_l":"0007-0912","issn":["0007-0912","1471-6771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Anaesthesia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W88073431","https://openalex.org/W1762877386","https://openalex.org/W1970855672","https://openalex.org/W1989423171","https://openalex.org/W1989718404","https://openalex.org/W1993752270","https://openalex.org/W2006133901","https://openalex.org/W2007028896","https://openalex.org/W2009915058","https://openalex.org/W2014716635","https://openalex.org/W2019250342","https://openalex.org/W2021908531","https://openalex.org/W2023444285","https://openalex.org/W2024060499","https://openalex.org/W2025456760","https://openalex.org/W2031173944","https://openalex.org/W2036756639","https://openalex.org/W2039296581","https://openalex.org/W2051323806","https://openalex.org/W2067883679","https://openalex.org/W2069054355","https://openalex.org/W2074900009","https://openalex.org/W2083900498","https://openalex.org/W2088213907","https://openalex.org/W2091245412","https://openalex.org/W2094568924","https://openalex.org/W2101261772","https://openalex.org/W2101986800","https://openalex.org/W2104494035","https://openalex.org/W2105961368","https://openalex.org/W2106513136","https://openalex.org/W2158101800","https://openalex.org/W2167614359"],"related_works":["https://openalex.org/W2047204977","https://openalex.org/W1984313166","https://openalex.org/W2085870199","https://openalex.org/W2051323806","https://openalex.org/W2047703760","https://openalex.org/W1990085301","https://openalex.org/W2071183022","https://openalex.org/W2565559942","https://openalex.org/W1553895279","https://openalex.org/W1510167944"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}