{"id":"https://openalex.org/W2147262390","doi":"https://doi.org/10.1186/scrt380","title":"Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening","display_name":"Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2147262390","doi":"https://doi.org/10.1186/scrt380","mag":"2147262390","pmid":"https://pubmed.ncbi.nlm.nih.gov/24476344","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4056681"},"language":"en","primary_location":{"id":"doi:10.1186/scrt380","doi":"https://doi.org/10.1186/scrt380","is_oa":true,"landing_page_url":"https://doi.org/10.1186/scrt380","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/scrt380","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/scrt380","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070508954","display_name":"Arun Sharma","orcid":"https://orcid.org/0000-0002-0607-5455","observed_orcids":["https://orcid.org/0000-0002-0607-5455","https://orcid.org/0000-0003-3472-3859"]},"institutions":[{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun Sharma","raw_affiliation_strings":["Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA","Department of Biology, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047561254","display_name":"Joseph C. Wu","orcid":"https://orcid.org/0000-0002-6068-8041","observed_orcids":["https://orcid.org/0000-0002-6068-8041","https://orcid.org/0000-0003-4274-0413"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C Wu","raw_affiliation_strings":["Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA","Department of Radiology, Stanford University School of Medicine, Stanford, CA, 94305, USA","Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Radiology, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071721806","display_name":"Sean M. Wu","orcid":"https://orcid.org/0000-0002-0000-3821","observed_orcids":["https://orcid.org/0000-0002-0000-3821"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean M Wu","raw_affiliation_strings":["Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA","Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071721806"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":0.7829,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.61894568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"4","issue":"6","first_page":"150","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cardiovascular-disease-modeling","display_name":"cardiovascular disease modeling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.949999988079071},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6679999828338623},{"id":"https://openalex.org/keywords/patient-derived-cells","display_name":"patient-derived cells","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.42800000309944153},{"id":"https://openalex.org/keywords/cell-replacement-therapy","display_name":"cell replacement therapy","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8497342467308044},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6750252842903137},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6481899619102478},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.6306000351905823},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5907769203186035},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5572848916053772},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5313630104064941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5255507230758667},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5219316482543945},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.45476725697517395},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42341774702072144},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4174679219722748},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3466378450393677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2974109649658203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15834054350852966},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15820369124412537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09367090463638306},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/scrt380","doi":"https://doi.org/10.1186/scrt380","is_oa":true,"landing_page_url":"https://doi.org/10.1186/scrt380","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/scrt380","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3239657","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4056681","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4056681","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4056681","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmid:24476344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24476344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/scrt380","doi":"https://doi.org/10.1186/scrt380","is_oa":true,"landing_page_url":"https://doi.org/10.1186/scrt380","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/scrt380","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G13731040","display_name":"Induced pluripotent stem cells in the understanding and treatment of heart disease","funder_award_id":"U01HL099776","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4714389115","display_name":"Generation of functional organs via developmental chimerism","funder_award_id":"DP2OD004411","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6262610701","display_name":"Elucidating Molecular Basis of Hypertrophic Cardiomyopathy with Human Induced Pluripotent Stem Cells","funder_award_id":"RB3-05129","funder_id":"https://openalex.org/F4320306171","funder_display_name":"California Institute for Regenerative Medicine"}],"funders":[{"id":"https://openalex.org/F4320306171","display_name":"California Institute for Regenerative Medicine","ror":"https://ror.org/033m8b439"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147262390.pdf","grobid_xml":"https://content.openalex.org/works/W2147262390.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1596115288","https://openalex.org/W1971590660","https://openalex.org/W1972662556","https://openalex.org/W1972774086","https://openalex.org/W1977025496","https://openalex.org/W1993138656","https://openalex.org/W1999251970","https://openalex.org/W2009682316","https://openalex.org/W2010420011","https://openalex.org/W2011844821","https://openalex.org/W2019136342","https://openalex.org/W2021710989","https://openalex.org/W2022229270","https://openalex.org/W2023315677","https://openalex.org/W2026404421","https://openalex.org/W2028036560","https://openalex.org/W2029904491","https://openalex.org/W2030290211","https://openalex.org/W2034862301","https://openalex.org/W2050856345","https://openalex.org/W2051272245","https://openalex.org/W2061547804","https://openalex.org/W2061778565","https://openalex.org/W2066767635","https://openalex.org/W2070251374","https://openalex.org/W2070587587","https://openalex.org/W2071833353","https://openalex.org/W2073202258","https://openalex.org/W2077806591","https://openalex.org/W2080549930","https://openalex.org/W2081524260","https://openalex.org/W2085050235","https://openalex.org/W2088152986","https://openalex.org/W2088483457","https://openalex.org/W2093888082","https://openalex.org/W2094097843","https://openalex.org/W2094892482","https://openalex.org/W2095059099","https://openalex.org/W2098466621","https://openalex.org/W2100092472","https://openalex.org/W2101986300","https://openalex.org/W2104790299","https://openalex.org/W2104996733","https://openalex.org/W2106394784","https://openalex.org/W2106854002","https://openalex.org/W2108903695","https://openalex.org/W2109111859","https://openalex.org/W2111947054","https://openalex.org/W2115644752","https://openalex.org/W2124929662","https://openalex.org/W2125987139","https://openalex.org/W2133808555","https://openalex.org/W2134662886","https://openalex.org/W2138773108","https://openalex.org/W2143747124","https://openalex.org/W2144859693","https://openalex.org/W2152635048","https://openalex.org/W2152793450","https://openalex.org/W2153314615","https://openalex.org/W2155235762","https://openalex.org/W2157741370","https://openalex.org/W2165179483","https://openalex.org/W2165872135","https://openalex.org/W2166305181","https://openalex.org/W2171310378","https://openalex.org/W4211016865","https://openalex.org/W4211191293","https://openalex.org/W4250649831"],"related_works":["https://openalex.org/W4415237215","https://openalex.org/W3107757056","https://openalex.org/W4415217282","https://openalex.org/W3130522032","https://openalex.org/W4200536277","https://openalex.org/W3085926273","https://openalex.org/W310828878","https://openalex.org/W2025187846","https://openalex.org/W4254133297","https://openalex.org/W3137968416"],"abstract_inverted_index":{"Human":[0],"induced":[1],"pluripotent":[2],"stem":[3,27],"cells":[4,28],"(hiPSCs)":[5],"have":[6,59,125],"emerged":[7],"as":[8,68,80,167,187],"a":[9,69,168],"novel":[10],"tool":[11],"for":[12,73,160,170,180],"drug":[13,147,171,181],"discovery":[14],"and":[15,30,65,88,149,166,175],"therapy":[16],"in":[17,114,157,164],"cardiovascular":[18,112,136],"medicine.":[19],"hiPSCs":[20,57,106],"are":[21,141],"functionally":[22],"similar":[23],"to":[24,93,107,118,128],"human":[25,49,97],"embryonic":[26],"(hESCs)":[29],"can":[31,100],"be":[32,94,119,185],"derived":[33,55],"autologously":[34],"without":[35],"the":[36,43,48,103],"ethical":[37],"challenges":[38],"associated":[39],"with":[40,134],"hESCs.":[41],"Given":[42],"limited":[44],"regenerative":[45],"capacity":[46],"of":[47,84,105,111,177],"heart":[50],"following":[51],"myocardial":[52],"injury,":[53],"cardiomyocytes":[54],"from":[56,63,132],"(hiPSC-CMs)":[58],"garnered":[60],"significant":[61],"attention":[62],"basic":[64],"translational":[66],"scientists":[67],"promising":[70],"cell":[71,81,89],"source":[72],"replacement":[74],"therapy.":[75],"However,":[76],"ongoing":[77],"issues":[78],"such":[79],"immaturity,":[82],"scale":[83],"production,":[85],"inter-line":[86],"variability,":[87],"purity":[90],"will":[91,153,184],"need":[92],"resolved":[95],"before":[96],"clinical":[98],"trials":[99],"begin.":[101],"Meanwhile,":[102],"use":[104],"explore":[108],"cellular":[109],"mechanisms":[110],"diseases":[113],"vitro":[115,165],"has":[116],"proven":[117],"extremely":[120],"valuable.":[121],"For":[122],"example,":[123],"hiPSC-CMs":[124,140,159,179],"been":[126],"shown":[127],"recapitulate":[129],"disease":[130,162],"phenotypes":[131],"patients":[133],"monogenic":[135],"disorders.":[137],"Furthermore,":[138],"patient-derived":[139],"now":[142],"providing":[143],"new":[144],"insights":[145],"regarding":[146],"efficacy":[148],"toxicity.":[150],"This":[151],"review":[152],"highlight":[154],"recent":[155],"advances":[156],"utilizing":[158],"cardiac":[161],"modeling":[163],"platform":[169],"validation.":[172],"The":[173],"advantages":[174],"disadvantages":[176],"using":[178],"screening":[182],"purposes":[183],"explored":[186],"well.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}