{"id":"https://openalex.org/W2147257015","doi":"https://doi.org/10.1186/s12977-015-0197-x","title":"Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production","display_name":"Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production","publication_year":2015,"publication_date":"2015-08-13","ids":{"openalex":"https://openalex.org/W2147257015","doi":"https://doi.org/10.1186/s12977-015-0197-x","mag":"2147257015","pmid":"https://pubmed.ncbi.nlm.nih.gov/26268989","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4535389"},"language":"en","primary_location":{"id":"doi:10.1186/s12977-015-0197-x","doi":"https://doi.org/10.1186/s12977-015-0197-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12977-015-0197-x","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/s12977-015-0197-x","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/s12977-015-0197-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101818024","display_name":"Bo Meng","orcid":"https://orcid.org/0000-0001-5668-2221","observed_orcids":["https://orcid.org/0000-0001-5668-2221"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bo Meng","raw_affiliation_strings":["Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. bm432@cam.ac.uk","Department of Medicine, University of Cambridge Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. bm432@cam.ac.uk","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]},{"raw_affiliation_string":"Department of Medicine, University of Cambridge Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090578255","display_name":"Natasha C.Y. Ip","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Natasha C Y Ip","raw_affiliation_strings":["Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. natasha.ip@cantab.net","Department of Medicine, University of Cambridge Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. natasha.ip@cantab.net","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]},{"raw_affiliation_string":"Department of Medicine, University of Cambridge Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106859242","display_name":"Liam J. Prestwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Liam J Prestwood","raw_affiliation_strings":["Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. l.j.p21@hotmail.com","Department of Medicine, University of Cambridge Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. l.j.p21@hotmail.com","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]},{"raw_affiliation_string":"Department of Medicine, University of Cambridge Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090253321","display_name":"Truus E. M. Abbink","orcid":"https://orcid.org/0000-0001-6932-0449","observed_orcids":["https://orcid.org/0000-0001-6932-0449"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Truus E M Abbink","raw_affiliation_strings":["Centre for Childhood White Matter Disorders, VU University Medical Centre, Amsterdam, The Netherlands. g.abbink@vumc.nl","Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. g.abbink@vumc.nl","Centre for Childhood White Matter Disorders, VU University Medical Centre, Amsterdam, The Netherlands","Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Childhood White Matter Disorders, VU University Medical Centre, Amsterdam, The Netherlands. g.abbink@vumc.nl","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. g.abbink@vumc.nl","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]},{"raw_affiliation_string":"Centre for Childhood White Matter Disorders, VU University Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038420346","display_name":"Andrew M. L. Lever","orcid":"https://orcid.org/0000-0001-9819-4453","observed_orcids":["https://orcid.org/0000-0001-9819-4453"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew M L Lever","raw_affiliation_strings":["Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. amll1@medschl.cam.ac.uk","Department of Medicine, University of Cambridge Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. amll1@medschl.cam.ac.uk","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]},{"raw_affiliation_string":"Department of Medicine, University of Cambridge Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038420346"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":3.4531,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.93599615,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"72","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.24549999833106995,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escrt-ii","display_name":"ESCRT-II","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/virus-budding","display_name":"viral budding","score":0.7549999952316284},{"id":"https://openalex.org/keywords/late-domain","display_name":"late domain","score":0.5630000233650208},{"id":"https://openalex.org/keywords/gag-processing","display_name":"Gag processing","score":0.6579999923706055},{"id":"https://openalex.org/keywords/alix","display_name":"Alix","score":0.6489999890327454},{"id":"https://openalex.org/keywords/escrt-i","display_name":"ESCRT-I","score":0.6830000281333923},{"id":"https://openalex.org/keywords/escrt-iii","display_name":"ESCRT-III","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C143876685","wikidata":"https://www.wikidata.org/wiki/Q22327705","display_name":"ESCRT","level":4,"score":0.9941390752792358},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.7146762609481812},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5940840244293213},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5594357848167419},{"id":"https://openalex.org/C2778283623","wikidata":"https://www.wikidata.org/wiki/Q18032200","display_name":"TSG101","level":5,"score":0.49152883887290955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48545700311660767},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.4289088249206543},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.42391350865364075},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40157800912857056},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3765738606452942},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2537441551685333},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.21451109647750854},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.18157395720481873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12885522842407227},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12865763902664185},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12255385518074036},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.0},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056827","descriptor_name":"Endosomal Sorting Complexes Required for Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056827","descriptor_name":"Endosomal Sorting Complexes Required for Transport","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057074","descriptor_name":"Virus Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1186/s12977-015-0197-x","doi":"https://doi.org/10.1186/s12977-015-0197-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12977-015-0197-x","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/s12977-015-0197-x","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3512035","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4535389","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4535389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4535389","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Text"},{"id":"pmid:26268989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26268989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/34251e06-3c25-4ad6-a541-376e5045d0cf","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/34251e06-3c25-4ad6-a541-376e5045d0cf","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Meng, B, Ip, N C, Prestwood, L J, Abbink, G E M & Lever, A M L 2015, 'Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production', Retrovirology, vol. 12, 72. https://doi.org/10.1186/s12977-015-0197-x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/3c310ebc-3b9d-46cc-9035-b3cafc491967","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/3c310ebc-3b9d-46cc-9035-b3cafc491967","pdf_url":null,"source":{"id":"https://openalex.org/S7407055350","display_name":"Amsterdam UMC (VU Amsterdam) - Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Meng, B, Ip, N C, Prestwood, L J, Abbink, G E M & Lever, A M L 2015, 'Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production', Retrovirology, vol. 12, 72. https://doi.org/10.1186/s12977-015-0197-x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.789.5957","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.789.5957","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8d/84/12977_2015_Article_197.PMC4535389.pdf","raw_type":"text"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/180900","doi":null,"is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/180900","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Unpaywall 20201031","raw_type":"Article"},{"id":"pmh:oai:research.vu.nl:openaire/d63630b7-f29c-447e-b2a7-c444081b602e","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1871.1/d63630b7-f29c-447e-b2a7-c444081b602e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Meng, B, Ip, N C, Prestwood, L J, Abbink, G E M & Lever, A M L 2015, 'Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production', Retrovirology, vol. 12, 72. https://doi.org/10.1186/s12977-015-0197-x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu:oai:research.vu.nl:publications/d63630b7-f29c-447e-b2a7-c444081b602e","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/d63630b7-f29c-447e-b2a7-c444081b602e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Retrovirology, 12:72. BioMed Central","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/3c310ebc-3b9d-46cc-9035-b3cafc491967","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/3c310ebc-3b9d-46cc-9035-b3cafc491967","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Retrovirology, 12:72. BioMed Central","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12977-015-0197-x","doi":"https://doi.org/10.1186/s12977-015-0197-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12977-015-0197-x","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/s12977-015-0197-x","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8083256915","display_name":null,"funder_award_id":"RCAG/269","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320323260","display_name":"Universitetet i Oslo","ror":"https://ror.org/01xtthb56"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334635","display_name":"Cambridge Institute for Medical Research, University of Cambridge","ror":null},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147257015.pdf","grobid_xml":"https://content.openalex.org/works/W2147257015.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1523314824","https://openalex.org/W1826848447","https://openalex.org/W1964951207","https://openalex.org/W1970564514","https://openalex.org/W1974729150","https://openalex.org/W1980798766","https://openalex.org/W1987462880","https://openalex.org/W1988418980","https://openalex.org/W1992752531","https://openalex.org/W1993232578","https://openalex.org/W1993877052","https://openalex.org/W2007311551","https://openalex.org/W2010542476","https://openalex.org/W2012070412","https://openalex.org/W2022634370","https://openalex.org/W2023420720","https://openalex.org/W2028972269","https://openalex.org/W2030994365","https://openalex.org/W2036202997","https://openalex.org/W2041321679","https://openalex.org/W2042722403","https://openalex.org/W2046580082","https://openalex.org/W2050887754","https://openalex.org/W2054888430","https://openalex.org/W2056548409","https://openalex.org/W2059841928","https://openalex.org/W2063531346","https://openalex.org/W2075027086","https://openalex.org/W2078188527","https://openalex.org/W2082565834","https://openalex.org/W2083858193","https://openalex.org/W2093145534","https://openalex.org/W2104100666","https://openalex.org/W2105254705","https://openalex.org/W2107079905","https://openalex.org/W2109455280","https://openalex.org/W2126255146","https://openalex.org/W2128892763","https://openalex.org/W2130845654","https://openalex.org/W2132762716","https://openalex.org/W2136605585","https://openalex.org/W2138054112","https://openalex.org/W2140430371","https://openalex.org/W2144976687","https://openalex.org/W2145732342","https://openalex.org/W2146478787","https://openalex.org/W2147157181","https://openalex.org/W2149579871","https://openalex.org/W2152689946","https://openalex.org/W2156696460","https://openalex.org/W2167476707","https://openalex.org/W2168941502"],"related_works":["https://openalex.org/W7210375926","https://openalex.org/W2999665125","https://openalex.org/W1968419204","https://openalex.org/W2128892763","https://openalex.org/W7153970882","https://openalex.org/W2050887754","https://openalex.org/W2007311551","https://openalex.org/W2888914380","https://openalex.org/W2089532319","https://openalex.org/W2183897006"],"abstract_inverted_index":{"BACKGROUND:":[0],"Egress":[1],"of":[2,5,15,55,68,93,108,118,125,142,157,188,226,235,242],"a":[3,83,115,143,153,161,196,276],"number":[4],"different":[6],"virus":[7,168,181,198,211,227,253,287],"species":[8],"from":[9,35,96,289],"infected":[10,99],"cells":[11],"depends":[12],"on":[13],"proteins":[14],"the":[16,36,53,66,189,202,208,231,252,290],"endosomal":[17],"sorting":[18],"complexes":[19],"required":[20,238],"for":[21,52,239],"transport":[22],"(ESCRT)":[23],"pathway.":[24],"HIV":[25,98,264],"has":[26],"also":[27,283],"hijacked":[28],"this":[29,44,59],"system":[30],"to":[31,114,131,147,223,256,262],"bud":[32],"viruses":[33],"outward":[34],"cell":[37,87,100,291],"surface.":[38],"How":[39],"ESCRT-I":[40,135,175],"activates":[41],"ESCRT-III":[42],"in":[43,61,155,164,167,191,210],"process":[45],"remains":[46],"unclear":[47],"with":[48,152,174,177,294],"conflicting":[49],"published":[50],"evidence":[51],"requirement":[54],"ESCRT-II":[56,69,94,126,178,215,218,236,260],"which":[57,78,199],"fulfils":[58],"role":[60,67,234],"other":[62,295],"systems.":[63],"We":[64],"investigated":[65],"using":[70],"knockdown":[71,219],"mediated":[72,204],"by":[73,269,275,284],"siRNA":[74],"and":[75,82,136,160,267,282],"shRNA,":[76],"mutants":[77],"prevent":[79],"ESCRT-I/ESCRT-II":[80],"interaction":[81],"CRISPR/Cas9":[84],"EAP45":[85],"knockout":[86],"line.":[88],"RESULTS:":[89],"Depletion":[90],"or":[91,278],"elimination":[92,225],"components":[95,138],"an":[97,128],"produces":[101,127],"two":[102],"distinct":[103],"effects.":[104],"The":[105,183],"overall":[106,192],"production":[107,266],"HIV-1":[109],"Gag":[110,145,193],"is":[111,186,216,237],"reduced":[112],"leading":[113],"diminished":[116],"amount":[117],"intracellular":[119],"virion":[120,158,265],"protein.":[121],"In":[122],"addition":[123],"depletion":[124],"effect":[129],"similar":[130],"that":[132,141,172,230,246,251],"seen":[133,213],"when":[134,214],"-III":[137],"are":[139,248],"depleted,":[140],"delayed":[144],"p26":[146],"p24":[148],"+p2":[149],"cleavage":[150],"associated":[151],"reduction":[154,163],"export":[156,184,205,212,268,288],"particles":[159],"visible":[162],"budding":[165,244],"efficiency":[166,241],"producing":[169],"cells.":[170],"Mutants":[171],"interfere":[173],"interacting":[176],"similarly":[179],"reduce":[180],"export.":[182],"defect":[185],"independent":[187],"decrease":[190,209],"production.":[194],"Using":[195],"mutant":[197],"cannot":[200],"use":[201],"ALIX":[203],"pathway":[206],"exacerbates":[207],"depleted.":[217],"does":[220],"not":[221],"lead":[222],"complete":[224],"release":[228],"suggesting":[229],"late":[232],"domain":[233],"optimal":[240],"viral":[243],"but":[245],"there":[247],"additional":[249],"pathways":[250],"can":[254],"employ":[255],"facilitate":[257],"this.":[258],"CONCLUSION:":[259],"contributes":[261],"efficient":[263,286],"more":[270],"than":[271],"one":[272],"pathway;":[273],"both":[274],"transcriptional":[277,280],"post":[279],"mechanism":[281],"facilitating":[285],"through":[292],"interactions":[293],"ESCRT":[296],"components.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}