{"id":"https://openalex.org/W2147254207","doi":"https://doi.org/10.1016/s0140-6736(99)07330-4","title":"Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials","display_name":"Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2147254207","doi":"https://doi.org/10.1016/s0140-6736(99)07330-4","mag":"2147254207","pmid":"https://pubmed.ncbi.nlm.nih.gov/10752701"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(99)07330-4","doi":"https://doi.org/10.1016/s0140-6736(99)07330-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(99)07330-4","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2147254207"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043512811","display_name":"Jan A. Staessen","orcid":"https://orcid.org/0000-0002-3026-1637","observed_orcids":["https://orcid.org/0000-0002-3026-1637"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan A Staessen","raw_affiliation_strings":["Department of Molecular and Cardiovasuclar Research, Univeristy of Leuven, Belgium. jan.staessen@med.kuleuven.ac.be","Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cardiovasuclar Research, Univeristy of Leuven, Belgium. jan.staessen@med.kuleuven.ac.be","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084088459","display_name":"Jerzy G\u0105sowski","orcid":"https://orcid.org/0000-0002-8025-5323","observed_orcids":["https://orcid.org/0000-0002-8025-5323"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","PL"],"is_corresponding":false,"raw_author_name":"Jerzy Gasowski","raw_affiliation_strings":["Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium","Jagiellonian University School of Medicine, Department of Gerontology and Family Medicine, Cracow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Jagiellonian University School of Medicine, Department of Gerontology and Family Medicine, Cracow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027477818","display_name":"Ji G. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","CN"],"is_corresponding":false,"raw_author_name":"Ji G Wang","raw_affiliation_strings":["Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China","Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]},{"raw_affiliation_string":"Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071616414","display_name":"Lutgarde Thijs","orcid":"https://orcid.org/0000-0002-8108-2356","observed_orcids":["https://orcid.org/0000-0002-8108-2356"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lutgarde Thijs","raw_affiliation_strings":["Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111759708","display_name":"Elly Den Hond","orcid":"https://orcid.org/0000-0002-3909-6877","observed_orcids":["https://orcid.org/0000-0002-3909-6877"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Elly Den Hond","raw_affiliation_strings":["Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107837524","display_name":"Jean\u2010Pierre Boissel","orcid":"https://orcid.org/0000-0001-8938-2284","observed_orcids":["https://orcid.org/0000-0001-8938-2284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Pierre Boissel","raw_affiliation_strings":["Department of Clinical Pharmacology, Claude Bernard University, Lyon Hospitals, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Claude Bernard University, Lyon Hospitals, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010194384","display_name":"John Coope","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103439","display_name":"East Cheshire NHS Trust","ror":"https://ror.org/01j64ar73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210103439"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Coope","raw_affiliation_strings":["Bollington Medical Centre, Maccesfield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bollington Medical Centre, Maccesfield, UK","institution_ids":["https://openalex.org/I4210103439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111959934","display_name":"Tork Ekbom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tork Ekbom","raw_affiliation_strings":["Lund University, Department of Community Medicine, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lund University, Department of Community Medicine, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091690444","display_name":"Fran\u00e7ois Gueyffier","orcid":"https://orcid.org/0000-0002-9921-0977","observed_orcids":["https://orcid.org/0000-0002-9921-0977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Gueyffier","raw_affiliation_strings":["Department of Clinical Pharmacology, Claude Bernard University, Lyon Hospitals, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Claude Bernard University, Lyon Hospitals, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021591848","display_name":"Lisheng Liu","orcid":"https://orcid.org/0000-0002-8254-8031","observed_orcids":["https://orcid.org/0000-0002-8254-8031"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lisheng Liu","raw_affiliation_strings":["Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085257013","display_name":"Karla M. Kerlikowske","orcid":"https://orcid.org/0000-0001-8793-8779","observed_orcids":["https://orcid.org/0000-0001-8793-8779"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karla Kerlikowske","raw_affiliation_strings":["Department of Veterans Affairs Medical Center, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, San Francisco, California, USA","institution_ids":["https://openalex.org/I1315708478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023436129","display_name":"Stuart Pocock","orcid":"https://orcid.org/0000-0003-2212-4007","observed_orcids":["https://orcid.org/0000-0003-2212-4007"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stuart Pocock","raw_affiliation_strings":[", London School of Hygiene and Tropical Medicine, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", London School of Hygiene and Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111569665","display_name":"Robert H. Fagard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Robert H Fagard","raw_affiliation_strings":["Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":16.6726,"has_fulltext":false,"cited_by_count":1158,"citation_normalized_percentile":{"value":0.99906542,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"355","issue":"9207","first_page":"865","last_page":"872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isolated-systolic-hypertension","display_name":"isolated systolic hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5860000252723694},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.9610000252723694},{"id":"https://openalex.org/keywords/diastolic-blood-pressure","display_name":"diastolic blood pressure","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pulse-pressure","display_name":"pulse pressure","score":0.9860000014305115},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.5870000123977661},{"id":"https://openalex.org/keywords/coronary-events","display_name":"coronary events","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.8209999799728394},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.7829999923706055},{"id":"https://openalex.org/keywords/regression-dilution-bias","display_name":"regression dilution bias","score":0.8420000076293945},{"id":"https://openalex.org/keywords/number-needed-to-treat","display_name":"number needed to treat","score":0.6980000138282776},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7450000047683716},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.828000009059906},{"id":"https://openalex.org/keywords/cardiovascular-complications","display_name":"cardiovascular complications","score":0.6539999842643738},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.4620000123977661},{"id":"https://openalex.org/keywords/cardiovascular-complications-prevention","display_name":"cardiovascular complications prevention","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.8780434131622314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8499963283538818},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6987208724021912},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6899712085723877},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.628739595413208},{"id":"https://openalex.org/C17140001","wikidata":"https://www.wikidata.org/wiki/Q1759415","display_name":"Pulse pressure","level":3,"score":0.6277551054954529},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5754184126853943},{"id":"https://openalex.org/C118190526","wikidata":"https://www.wikidata.org/wiki/Q7239981","display_name":"Prehypertension","level":3,"score":0.5432331562042236},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5139174461364746},{"id":"https://openalex.org/C2777193177","wikidata":"https://www.wikidata.org/wiki/Q7663896","display_name":"Systolic hypertension","level":3,"score":0.4816835820674896},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4784122407436371},{"id":"https://openalex.org/C124936440","wikidata":"https://www.wikidata.org/wiki/Q6822263","display_name":"Meta-regression","level":3,"score":0.44347262382507324},{"id":"https://openalex.org/C169554166","wikidata":"https://www.wikidata.org/wiki/Q496359","display_name":"Systole","level":4,"score":0.43986859917640686},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4211321473121643},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.33471494913101196},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.27323299646377563},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0140-6736(99)07330-4","doi":"https://doi.org/10.1016/s0140-6736(99)07330-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(99)07330-4","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:10752701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10752701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W52607851","https://openalex.org/W107895376","https://openalex.org/W116339080","https://openalex.org/W207080712","https://openalex.org/W367900235","https://openalex.org/W438375824","https://openalex.org/W629637854","https://openalex.org/W1932020037","https://openalex.org/W1963536646","https://openalex.org/W1971031187","https://openalex.org/W1971681111","https://openalex.org/W1972565234","https://openalex.org/W1973948212","https://openalex.org/W1974386138","https://openalex.org/W2004873902","https://openalex.org/W2013822143","https://openalex.org/W2019722720","https://openalex.org/W2027805815","https://openalex.org/W2028067695","https://openalex.org/W2040888535","https://openalex.org/W2084003875","https://openalex.org/W2088581697","https://openalex.org/W2091468497","https://openalex.org/W2092244434","https://openalex.org/W2110283911","https://openalex.org/W2112846582","https://openalex.org/W2114634962","https://openalex.org/W2119369921","https://openalex.org/W2125883254","https://openalex.org/W2132613663","https://openalex.org/W2137408480","https://openalex.org/W2139480984","https://openalex.org/W2141659719","https://openalex.org/W2145089653","https://openalex.org/W2145144040","https://openalex.org/W2150290224","https://openalex.org/W2318579539","https://openalex.org/W2329648467","https://openalex.org/W2334941116","https://openalex.org/W2469840549","https://openalex.org/W2520693628","https://openalex.org/W3080346889","https://openalex.org/W3110805540","https://openalex.org/W4232706911","https://openalex.org/W4233812751","https://openalex.org/W4235625929","https://openalex.org/W4236191630","https://openalex.org/W4238414359","https://openalex.org/W4238900290","https://openalex.org/W4242869084","https://openalex.org/W4245326396","https://openalex.org/W4300718545"],"related_works":["https://openalex.org/W2110736765","https://openalex.org/W2060973079","https://openalex.org/W1974740367","https://openalex.org/W4212917075","https://openalex.org/W2412859516","https://openalex.org/W2022606812","https://openalex.org/W2149200043","https://openalex.org/W2036850433","https://openalex.org/W2143236425","https://openalex.org/W2038719826"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":36},{"year":2015,"cited_by_count":43},{"year":2014,"cited_by_count":40},{"year":2013,"cited_by_count":51},{"year":2012,"cited_by_count":45}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
