{"id":"https://openalex.org/W2147249379","doi":"https://doi.org/10.1002/phy2.233","title":"The cerebrovascular response to graded Valsalva maneuvers while standing","display_name":"The cerebrovascular response to graded Valsalva maneuvers while standing","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W2147249379","doi":"https://doi.org/10.1002/phy2.233","mag":"2147249379","pmid":"https://pubmed.ncbi.nlm.nih.gov/24744902","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3966248"},"language":"en","primary_location":{"id":"doi:10.1002/phy2.233","doi":"https://doi.org/10.1002/phy2.233","is_oa":true,"landing_page_url":"https://doi.org/10.1002/phy2.233","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/phy2.233","source":{"id":"https://openalex.org/S91696817","display_name":"Physiological Reports","issn_l":"2051-817X","issn":["2051-817X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/phy2.233","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059435889","display_name":"Blake G. Perry","orcid":"https://orcid.org/0000-0003-4197-519X","observed_orcids":["https://orcid.org/0000-0003-4197-519X"]},"institutions":[{"id":"https://openalex.org/I51158804","display_name":"Massey University","ror":"https://ror.org/052czxv31","country_code":"NZ","type":"education","lineage":["https://openalex.org/I51158804"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Blake G. Perry","raw_affiliation_strings":["School of Sport and Exercise, Massey University, Palmerston North, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Sport and Exercise, Massey University, Palmerston North, New Zealand","institution_ids":["https://openalex.org/I51158804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077474283","display_name":"Toby M\u00fcndel","orcid":"https://orcid.org/0000-0002-4214-8543","observed_orcids":["https://orcid.org/0000-0002-4214-8543"]},"institutions":[{"id":"https://openalex.org/I51158804","display_name":"Massey University","ror":"https://ror.org/052czxv31","country_code":"NZ","type":"education","lineage":["https://openalex.org/I51158804"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Toby M\u00fcndel","raw_affiliation_strings":["School of Sport and Exercise, Massey University, Palmerston North, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Sport and Exercise, Massey University, Palmerston North, New Zealand","institution_ids":["https://openalex.org/I51158804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052093082","display_name":"Darryl James Cochrane","orcid":"https://orcid.org/0000-0003-0273-1926","observed_orcids":["https://orcid.org/0000-0003-0273-1926"]},"institutions":[{"id":"https://openalex.org/I51158804","display_name":"Massey University","ror":"https://ror.org/052czxv31","country_code":"NZ","type":"education","lineage":["https://openalex.org/I51158804"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Darryl J. Cochrane","raw_affiliation_strings":["School of Sport and Exercise, Massey University, Palmerston North, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Sport and Exercise, Massey University, Palmerston North, New Zealand","institution_ids":["https://openalex.org/I51158804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113957238","display_name":"James David Cotter","orcid":"https://orcid.org/0000-0002-6014-9865","observed_orcids":["https://orcid.org/0000-0002-6014-9865"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"James D. Cotter","raw_affiliation_strings":["School of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084812288","display_name":"Samuel J. E. Lucas","orcid":"https://orcid.org/0000-0002-8713-2457","observed_orcids":["https://orcid.org/0000-0002-8713-2457"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]},{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["GB","NZ"],"is_corresponding":false,"raw_author_name":"Samuel J. E. Lucas","raw_affiliation_strings":["Department of Physiology, University of Otago, Dunedin, New Zealand","School of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin, New Zealand","School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]},{"raw_affiliation_string":"School of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]},{"raw_affiliation_string":"School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059435889"],"corresponding_institution_ids":["https://openalex.org/I51158804"],"apc_list":{"value":2050,"currency":"USD","value_usd":2050},"apc_paid":{"value":2050,"currency":"USD","value_usd":2050},"fwci":1.9856,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.87904343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2","issue":"2","first_page":"e00233","last_page":"e00233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valsalva-maneuver","display_name":"Valsalva maneuver","score":1.0},{"id":"https://openalex.org/keywords/middle-cerebral-artery-blood-flow-velocity","display_name":"middle cerebral artery blood flow velocity","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cerebrovascular-response","display_name":"cerebrovascular response","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.550000011920929},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.7120000123977661},{"id":"https://openalex.org/keywords/syncope","display_name":"syncope","score":0.7099999785423279},{"id":"https://openalex.org/keywords/intrathoracic-pressure","display_name":"intrathoracic pressure","score":0.8769999742507935},{"id":"https://openalex.org/keywords/intracranial-pressure","display_name":"intracranial pressure","score":0.9409999847412109},{"id":"https://openalex.org/keywords/standing-posture","display_name":"standing posture","score":0.4729999899864197},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cerebral-perfusion","display_name":"cerebral perfusion","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6159601211547852},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5469905138015747},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.5151523351669312},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.46049052476882935},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4512183666229248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43900737166404724},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.43221622705459595},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3428134322166443},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.25273674726486206},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.11828330159187317}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/phy2.233","doi":"https://doi.org/10.1002/phy2.233","is_oa":true,"landing_page_url":"https://doi.org/10.1002/phy2.233","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/phy2.233","source":{"id":"https://openalex.org/S91696817","display_name":"Physiological Reports","issn_l":"2051-817X","issn":["2051-817X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2952959","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3966248","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3966248","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3966248","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiol Rep","raw_type":"Text"},{"id":"pmid:24744902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24744902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/phy2.233","doi":"https://doi.org/10.1002/phy2.233","is_oa":true,"landing_page_url":"https://doi.org/10.1002/phy2.233","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/phy2.233","source":{"id":"https://openalex.org/S91696817","display_name":"Physiological Reports","issn_l":"2051-817X","issn":["2051-817X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320816","display_name":"Massey University","ror":"https://ror.org/052czxv31"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147249379.pdf","grobid_xml":"https://content.openalex.org/works/W2147249379.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1562502808","https://openalex.org/W1565894869","https://openalex.org/W1582532974","https://openalex.org/W1852307386","https://openalex.org/W1966071826","https://openalex.org/W1966355383","https://openalex.org/W1967961674","https://openalex.org/W1984509277","https://openalex.org/W1986772215","https://openalex.org/W1987990823","https://openalex.org/W1993057582","https://openalex.org/W2004149336","https://openalex.org/W2006840981","https://openalex.org/W2028869710","https://openalex.org/W2032656032","https://openalex.org/W2040679672","https://openalex.org/W2042622458","https://openalex.org/W2043938462","https://openalex.org/W2044310549","https://openalex.org/W2047431474","https://openalex.org/W2096365100","https://openalex.org/W2099592577","https://openalex.org/W2101077152","https://openalex.org/W2102282914","https://openalex.org/W2107075065","https://openalex.org/W2108394284","https://openalex.org/W2114919659","https://openalex.org/W2121903024","https://openalex.org/W2121934251","https://openalex.org/W2135541716","https://openalex.org/W2136078346","https://openalex.org/W2144553814","https://openalex.org/W2156579478","https://openalex.org/W2159631883","https://openalex.org/W2161790639","https://openalex.org/W2163498887","https://openalex.org/W2166769055","https://openalex.org/W2175159617","https://openalex.org/W2260591796","https://openalex.org/W2337655483","https://openalex.org/W2341223505","https://openalex.org/W2344925548"],"related_works":["https://openalex.org/W7100860187","https://openalex.org/W1971047380","https://openalex.org/W2260591796","https://openalex.org/W2999307625","https://openalex.org/W1966071826","https://openalex.org/W2107075065","https://openalex.org/W2015764574","https://openalex.org/W1984509277","https://openalex.org/W4237521861","https://openalex.org/W1532681685"],"abstract_inverted_index":{"The":[0,220],"Valsalva":[1],"maneuver":[2],"(VM)":[3],"produces":[4],"large":[5],"and":[6,40,64,74,83,93,143,158,177,184,200,266],"abrupt":[7,254],"increases":[8,125,233,239],"in":[9,126,193,234,240,249],"mean":[10,54],"arterial":[11],"pressure":[12,227],"(MAP)":[13],"at":[14,89],"the":[15,35,98,150,165,170,212,218,224,247,256,264,269],"onset":[16],"of":[17,37,66,215,223,258,268],"strain":[18],"(Phase":[19],"I),":[20],"however,":[21,243],"hypotension,":[22,255],"sufficient":[23],"to":[24,211],"induce":[25],"syncope,":[26],"occurs":[27],"upon":[28,262],"VM":[29,38,69,172],"release":[30],"(phase":[31,91],"III).":[32],"We":[33],"examined":[34],"effect":[36],"intensity":[39,159,267],"duration":[41,265],"on":[42],"middle":[43],"cerebral":[44,235],"artery":[45],"blood":[46],"velocity":[47],"(MCAv)":[48],"responses.":[49],"Healthy":[50],"men":[51],"(n":[52],"=10;":[53],"\u00b1":[55,58,109,132,137,175,179,198,202],"SD:":[56],"26":[57],"4":[59],"years)":[60],"completed":[61],"30%,":[62],"60%,":[63],"90%":[65,144,171],"their":[67],"maximal":[68],"mouth":[70],"pressure,":[71],"for":[72,139,182],"5":[73,140,183],"10":[75,185],"sec":[76,141,186],"(order":[77],"randomized)":[78],"while":[79],"standing.":[80],"Beat-to-beat":[81],"MCAv":[82,106,151,216,250],"MAP":[84,127,194],"during":[85,228,244],"phase":[86,104,229,245],"I":[87,230],"(peak),":[88],"nadir":[90],"III),":[92],"recovery":[94],"are":[95],"reported":[96],"as":[97],"change":[99],"from":[100,252],"standing":[101],"baseline.":[102],"During":[103,147],"I,":[105],"rose":[107],"15":[108],"6":[110],"cm\u00b7s(-1)":[111,181],"(P":[112,121,128,155,161,195],"<0.001),":[113],"which":[114,259],"was":[115,153],"not":[116],"reliably":[117],"different":[118],"between":[119],"intensities":[120],"=0.11),":[122],"despite":[123],"graded":[124],"<0.001;":[129],"e.g.,":[130],"+12":[131],"9":[133,203],"mmHg":[134],"vs.":[135],"+35":[136],"14":[138],"30%":[142],"VM,":[145,187],"respectively).":[146],"Phase":[148],"III,":[149],"response":[152,207],"duration-":[154],"=":[156],"0.045)":[157],"dependent":[160,261],"<":[162],"0.001),":[163],"with":[164,189],"largest":[166],"decrease":[167,192,248],"observed":[168],"following":[169],"(e.g.,":[173],"-19":[174],"13":[176],"-15":[178],"11":[180,199],"respectively)":[188],"a":[190],"concomitant":[191],"<0.001,":[196],"-23":[197,201],"mmHg).":[204],"This":[205],"asymmetric":[206],"may":[208,231],"be":[209],"attributable":[210],"differential":[213],"modulators":[214],"throughout":[217],"VM.":[219,270],"mechanical":[221],"effects":[222],"elevated":[225],"intrathoracic":[226],"restrain":[232],"perfusion":[236],"via":[237],"related":[238],"intracranial":[241],"pressure;":[242],"III":[246],"arises":[251],"an":[253],"extent":[257],"is":[260],"both":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}