{"id":"https://openalex.org/W2147235183","doi":"https://doi.org/10.1152/japplphysiol.00590.2005","title":"Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle","display_name":"Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle","publication_year":2005,"publication_date":"2005-08-12","ids":{"openalex":"https://openalex.org/W2147235183","doi":"https://doi.org/10.1152/japplphysiol.00590.2005","mag":"2147235183","pmid":"https://pubmed.ncbi.nlm.nih.gov/16099893"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.00590.2005","doi":"https://doi.org/10.1152/japplphysiol.00590.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00590.2005","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110407707","display_name":"Charlotte Keller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I4405272138","display_name":"Copenhagen Muscle Research Centre","ror":"https://ror.org/03mq5zt44","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4405272138"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Charlotte Keller","raw_affiliation_strings":["Department of Infectious Disease, Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark. ckeller@inflammation-metabolism.dk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark. ckeller@inflammation-metabolism.dk","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434","https://openalex.org/I4405272138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008622478","display_name":"Adam Steensberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Steensberg","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081275713","display_name":"Anne K. Hansen","orcid":"https://orcid.org/0000-0003-2095-3100","observed_orcids":["https://orcid.org/0000-0003-2095-3100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne K. Hansen","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054417922","display_name":"Christian Philip Fischer","orcid":"https://orcid.org/0000-0002-0657-9143","observed_orcids":["https://orcid.org/0000-0002-0657-9143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian P. Fischer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021551158","display_name":"Peter Plomgaard","orcid":"https://orcid.org/0000-0002-2404-2702","observed_orcids":["https://orcid.org/0000-0002-2404-2702"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Plomgaard","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074362044","display_name":"Bente Klarlund Pedersen","orcid":"https://orcid.org/0000-0001-6508-6288","observed_orcids":["https://orcid.org/0000-0001-6508-6288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bente Klarlund Pedersen","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9245,"has_fulltext":false,"cited_by_count":180,"citation_normalized_percentile":{"value":0.90331023,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"99","issue":"6","first_page":"2075","last_page":"2079"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-6-receptor","display_name":"IL-6 receptor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9139999747276306},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.5320000052452087},{"id":"https://openalex.org/keywords/training","display_name":"training","score":0.527999997138977},{"id":"https://openalex.org/keywords/acute-exercise","display_name":"acute exercise","score":0.5630000233650208},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6190000176429749},{"id":"https://openalex.org/keywords/gp130","display_name":"gp130","score":0.9509999752044678},{"id":"https://openalex.org/keywords/energy-availability","display_name":"energy availability","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7920910120010376},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.7325218915939331},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.731397807598114},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7112728357315063},{"id":"https://openalex.org/C133165541","wikidata":"https://www.wikidata.org/wiki/Q472094","display_name":"Exercise physiology","level":2,"score":0.5367661118507385},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5119048357009888},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.494340181350708},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4641355872154236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42066770792007446},{"id":"https://openalex.org/C99830354","wikidata":"https://www.wikidata.org/wiki/Q362854","display_name":"Endurance training","level":2,"score":0.4166969656944275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3665304183959961},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14621031284332275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06739071011543274}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005082","descriptor_name":"Physical Exertion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1152/japplphysiol.00590.2005","doi":"https://doi.org/10.1152/japplphysiol.00590.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00590.2005","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:16099893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16099893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.326.1154","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.1154","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jap.physiology.org/content/99/6/2075.full.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/9a2c1dc8-747c-451f-90c5-67850e57764f","doi":null,"is_oa":false,"landing_page_url":"https://www.scopus.com/pages/publications/28044442051","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Keller, C, Steensberg, A, Hansen, A K, Fischer, C P, Plomgaard, P & Pedersen, B K 2005, 'Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle', Journal of Applied Physiology, vol. 99, no. 6, pp. 2075-2079. https://doi.org/10.1152/japplphysiol.00590.2005","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310077","display_name":"National Research Centre","ror":"https://ror.org/02n85j827"},{"id":"https://openalex.org/F4320320943","display_name":"Danmarks Grundforskningsfond","ror":"https://ror.org/00znyv691"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W107919769","https://openalex.org/W196618629","https://openalex.org/W1486822318","https://openalex.org/W1779691448","https://openalex.org/W1800084700","https://openalex.org/W1874865406","https://openalex.org/W1931408530","https://openalex.org/W1978291164","https://openalex.org/W1988501271","https://openalex.org/W1999725325","https://openalex.org/W2006332285","https://openalex.org/W2036423156","https://openalex.org/W2043113475","https://openalex.org/W2045498864","https://openalex.org/W2053431552","https://openalex.org/W2083816898","https://openalex.org/W2086840459","https://openalex.org/W2088094751","https://openalex.org/W2091510385","https://openalex.org/W2093845352","https://openalex.org/W2098882931","https://openalex.org/W2099823442","https://openalex.org/W2112857693","https://openalex.org/W2121051855","https://openalex.org/W2127647469","https://openalex.org/W2128088040","https://openalex.org/W2130248772","https://openalex.org/W2152174497","https://openalex.org/W2167880402","https://openalex.org/W2168755719","https://openalex.org/W2169292567","https://openalex.org/W2169826533"],"related_works":["https://openalex.org/W7095427606","https://openalex.org/W2121051855","https://openalex.org/W2088094751","https://openalex.org/W1443802491","https://openalex.org/W1979269683","https://openalex.org/W2132607881","https://openalex.org/W7099584248","https://openalex.org/W1580091943","https://openalex.org/W2360560118","https://openalex.org/W2205871813"],"abstract_inverted_index":{"The":[0,124,182],"cytokine":[1],"interleukin-6":[2],"(IL-6)":[3],"exerts":[4],"it":[5],"actions":[6],"via":[7],"the":[8,15,44,57,60,64,71,85,91,113,156,168,187,225],"IL-6":[9,20,45,243],"receptor":[10],"(IL-6R)":[11],"in":[12,24,93,130,140,192,197,233],"conjunction":[13],"with":[14,105,179],"ubiquitously":[16],"expressed":[17,171],"gp130":[18],"receptor.":[19],"is":[21,54,205],"tightly":[22],"regulated":[23],"response":[25,46,127,134,159,198,203],"to":[26,47,69,81,135,160,199,221,242],"exercise,":[27,74,137,201],"being":[28,209],"affected":[29,210],"by":[30,211],"factors":[31,79],"such":[32],"as":[33,38,40,219],"exercise":[34,48,108,122],"intensity":[35],"and":[36,76,111],"duration,":[37],"well":[39,207],"energy":[41],"availability.":[42],"Although":[43],"has":[49],"been":[50],"extensively":[51],"studied,":[52],"little":[53],"known":[55,80],"about":[56],"regulation":[58,86],"of":[59,73,87,90,103,166,176,239],"IL-6R":[61,92,125,141,157,177,188,228],"response.":[62],"In":[63,133],"present":[65,183],"study,":[66],"we":[67],"aimed":[68],"investigate":[70],"effect":[72,154],"training,":[75,167],"glycogen":[77,150,217],"availability,":[78],"affect":[82],"IL-6,":[83],"on":[84,155],"gene":[88,189],"expression":[89,190],"human":[94],"skeletal":[95,169,193,234,240],"muscle.":[96],"Human":[97],"subjects":[98],"performed":[99],"either":[100],"10":[101,164],"wk":[102,165],"training":[104,114,147,213,226],"an":[106,138,153],"acute":[107,121,136,200],"bout":[109],"before":[110,180],"after":[112,163,224],"period,":[115,227],"or":[116],"a":[117,172,202,237],"low-glycogen":[118],"vs.":[119],"normal-glycogen":[120],"trial.":[123],"mRNA":[126,142,158,174,229],"was":[128,144,231],"evaluated":[129],"both":[131],"trials.":[132],"increase":[139],"levels":[143,151,191],"observed.":[145],"Neither":[146],"nor":[148,215],"intramuscular":[149,216],"had":[152],"exercise.":[161],"However,":[162,223],"muscle":[170,194,241],"higher":[173],"level":[175],"compared":[178],"training.":[181],"study":[184],"demonstrated":[185],"that":[186,204],"are":[195],"increased":[196,232],"very":[206],"conserved,":[208],"neither":[212],"status":[214],"levels,":[218],"opposed":[220],"IL-6.":[222],"production":[230],"muscle,":[235],"suggesting":[236],"sensitization":[238],"at":[244],"rest.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}