{"id":"https://openalex.org/W2147208546","doi":"https://doi.org/10.1099/mic.0.049759-0","title":"The vapA co-expressed virulence plasmid gene vcgB (orf10) of the intracellular actinomycete Rhodococcus equi","display_name":"The vapA co-expressed virulence plasmid gene vcgB (orf10) of the intracellular actinomycete Rhodococcus equi","publication_year":2011,"publication_date":"2011-05-13","ids":{"openalex":"https://openalex.org/W2147208546","doi":"https://doi.org/10.1099/mic.0.049759-0","mag":"2147208546","pmid":"https://pubmed.ncbi.nlm.nih.gov/21565932"},"language":"en","primary_location":{"id":"doi:10.1099/mic.0.049759-0","doi":"https://doi.org/10.1099/mic.0.049759-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/mic.0.049759-0","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059818024","display_name":"Ra\u00fal Miranda-CasoLuengo","orcid":"https://orcid.org/0000-0002-9294-6578","observed_orcids":["https://orcid.org/0000-0002-9294-6578"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Ra\u00fal Miranda-CasoLuengo","raw_affiliation_strings":["UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084039745","display_name":"Aleksandra A. Miranda-CasoLuengo","orcid":"https://orcid.org/0000-0001-7794-7698","observed_orcids":["https://orcid.org/0000-0001-7794-7698"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Aleksandra A. Miranda-CasoLuengo","raw_affiliation_strings":["UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070372117","display_name":"Enda O\u2019Connell","orcid":"https://orcid.org/0000-0001-7441-0262","observed_orcids":["https://orcid.org/0000-0001-7441-0262"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Enda P. O\u2019Connell","raw_affiliation_strings":["UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002763185","display_name":"Ruth J. Fahey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Ruth J. Fahey","raw_affiliation_strings":["UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079154959","display_name":"Clara A. Boland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Clara A. Boland","raw_affiliation_strings":["UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047955027","display_name":"Jos\u00e9 A. V\u00e1zquez\u2010Boland","orcid":"https://orcid.org/0000-0003-4521-5972","observed_orcids":["https://orcid.org/0000-0003-4521-5972"]},"institutions":[{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Jose A. V\u00e1zquez-Boland","raw_affiliation_strings":["Grupo de Patogen\u00f3mica Bacteriana, Facultad de Veterinaria e Instituto de Biolog\u00eda Molecular y Gen\u00f3mica, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain","Microbial Pathogenesis Unit, Centre for Infectious Diseases, Ashworth Laboratories, King\u2019s Buildings, University of Edinburgh, Edinburgh EH9 3JT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Patogen\u00f3mica Bacteriana, Facultad de Veterinaria e Instituto de Biolog\u00eda Molecular y Gen\u00f3mica, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]},{"raw_affiliation_string":"Microbial Pathogenesis Unit, Centre for Infectious Diseases, Ashworth Laboratories, King\u2019s Buildings, University of Edinburgh, Edinburgh EH9 3JT, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014791006","display_name":"Wim G. Meijer","orcid":"https://orcid.org/0000-0003-1302-4338","observed_orcids":["https://orcid.org/0000-0003-1302-4338"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Wim G. Meijer","raw_affiliation_strings":["UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1029,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.77806416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"157","issue":"8","first_page":"2357","last_page":"2368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12914","display_name":"Infectious Disease Case Reports and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12914","display_name":"Infectious Disease Case Reports and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhodococcus-equi","display_name":"Rhodococcus equi","score":1.0},{"id":"https://openalex.org/keywords/virulence-plasmid","display_name":"virulence plasmid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vapa","display_name":"VAPA","score":0.6830000281333923},{"id":"https://openalex.org/keywords/virulence-proteins","display_name":"virulence proteins","score":0.7789999842643738},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5460000038146973},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/macrophage-infection","display_name":"macrophage infection","score":0.6700000166893005},{"id":"https://openalex.org/keywords/pathogenicity-islands","display_name":"pathogenicity islands","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.8940147757530212},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.8866569995880127},{"id":"https://openalex.org/C2777581609","wikidata":"https://www.wikidata.org/wiki/Q293148","display_name":"Rhodococcus equi","level":4,"score":0.8601354956626892},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.78824782371521},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.7438958287239075},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.641139805316925},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6225691437721252},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5574368834495544},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4615817666053772},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3722001016139984},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2398701012134552},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0773341953754425},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016929","descriptor_name":"Rhodococcus equi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016929","descriptor_name":"Rhodococcus equi","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D016929","descriptor_name":"Rhodococcus equi","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024363","descriptor_name":"Transcription Initiation Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D044404","descriptor_name":"Genomic Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1099/mic.0.049759-0","doi":"https://doi.org/10.1099/mic.0.049759-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/mic.0.049759-0","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},{"id":"pmid:21565932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21565932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology (Reading, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8573905934","display_name":"A Novel Virulence Mechanism of the Intracellular Pathogen Rhodococcus Equi: Protein Networks Their Role in Virulence and Impact on Macrophage Physiology","funder_award_id":"02/IN.1/B203","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"},{"id":"https://openalex.org/F4320324670","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1688045665","https://openalex.org/W1838606285","https://openalex.org/W1904141847","https://openalex.org/W1916929424","https://openalex.org/W1970277500","https://openalex.org/W1983001845","https://openalex.org/W1988049462","https://openalex.org/W2000179109","https://openalex.org/W2001312439","https://openalex.org/W2005763938","https://openalex.org/W2011261850","https://openalex.org/W2016101323","https://openalex.org/W2016506595","https://openalex.org/W2017519756","https://openalex.org/W2034166604","https://openalex.org/W2036316917","https://openalex.org/W2048674864","https://openalex.org/W2059025151","https://openalex.org/W2060900485","https://openalex.org/W2078178166","https://openalex.org/W2090197974","https://openalex.org/W2099098590","https://openalex.org/W2099808084","https://openalex.org/W2110135644","https://openalex.org/W2114196811","https://openalex.org/W2117875503","https://openalex.org/W2121526389","https://openalex.org/W2123927310","https://openalex.org/W2124552187","https://openalex.org/W2129627219","https://openalex.org/W2137015675","https://openalex.org/W2138762386","https://openalex.org/W2144634347","https://openalex.org/W2152042796","https://openalex.org/W2157690938","https://openalex.org/W2158023121","https://openalex.org/W2159392515","https://openalex.org/W2159604303","https://openalex.org/W2159740473","https://openalex.org/W2159761795","https://openalex.org/W2160993408","https://openalex.org/W2191004726","https://openalex.org/W2402030017","https://openalex.org/W2403878052","https://openalex.org/W2613703036","https://openalex.org/W2804007336","https://openalex.org/W3190155767","https://openalex.org/W3199943451","https://openalex.org/W4241322650","https://openalex.org/W6713305683","https://openalex.org/W6800717233"],"related_works":["https://openalex.org/W4406051949","https://openalex.org/W7006687196","https://openalex.org/W2157690938","https://openalex.org/W1894356512","https://openalex.org/W2020146058","https://openalex.org/W2152042796","https://openalex.org/W2163792806","https://openalex.org/W2115870737","https://openalex.org/W1868335667","https://openalex.org/W2121526389"],"abstract_inverted_index":{"The":[0,23,115,131,199],"virulence":[1,42,77,229],"plasmid":[2,28,78],"of":[3,13,21,26,32,37,55,60,113,150,202,207,213,230],"the":[4,19,47,56,61,89,99,145,151,157,169,183,189,224,228],"pathogenic":[5,197,216],"actinomycete":[6],"Rhodococcus":[7],"equi":[8],"is":[9,40,106,144,186],"essential":[10],"for":[11,75,221],"proliferation":[12],"this":[14,27],"pathogen":[15],"in":[16,127,188,196,215,227],"macrophages":[17],"and":[18,92,117,125,160,181,204,211,223],"development":[20],"disease.":[22],"pathogenicity":[24],"island":[25],"encodes":[29],"a":[30,41,69,85,110,128,219],"family":[31],"virulence-associated":[33],"proteins":[34],"(Vap),":[35],"one":[36],"which":[38],"(VapA)":[39],"factor.":[43],"This":[44],"paper":[45],"describes":[46],"vcgAB":[48,62,116,152],"operon":[49,63,153],"(vapA":[50],"co-expressed":[51],"gene),":[52],"located":[53],"upstream":[54],"vapA":[57,90,118],"operon.":[58],"Transcription":[59,82,149,164],"gave":[64],"rise":[65],"to":[66,72,88,179],"transcripts":[67],"with":[68],"half-life":[70],"similar":[71,87],"those":[73],"determined":[74],"other":[76],"genes":[79,226],"(1.8":[80],"min).":[81],"started":[83],"at":[84,137],"promoter":[86,111],"promoter,":[91],"proceeded":[93],"through":[94],"an":[95],"inefficient":[96],"terminator":[97],"into":[98],"downstream":[100,112],"vcgC":[101,105],"gene.":[102],"In":[103,177],"addition,":[104],"also":[107,166],"transcribed":[108],"from":[109],"vcgB.":[114],"operons":[119],"were":[120],"coordinately":[121],"regulated":[122],"by":[123,174],"temperature":[124,143],"pH":[126],"synergistic":[129],"manner.":[130],"latter":[132],"parameter":[133],"only":[134],"affected":[135],"transcription":[136,206],"higher":[138],"growth":[139,162],"temperatures,":[140],"indicating":[141],"that":[142],"dominant":[146],"regulatory":[147],"signal.":[148],"increased":[154],"10-fold":[155],"during":[156,168],"late":[158],"exponential":[159],"stationary":[161],"phases.":[163],"was":[165],"upregulated":[167],"initial":[170],"hours":[171],"following":[172,209],"phagocytosis":[173,210],"phagocytic":[175],"cells.":[176],"contrast":[178],"vcgA":[180],"vcgC,":[182],"vcgB":[184,203,208,214,222],"gene":[185],"conserved":[187],"porcine":[190],"VapB-encoding":[191],"plasmid,":[192],"as":[193,195],"well":[194],"mycobacteria.":[198],"coordinated":[200],"regulation":[201],"vapA,":[205],"conservation":[212],"mycobacteria":[217],"indicate":[218],"role":[220],"vcg":[225],"R.":[231],"equi.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}