{"id":"https://openalex.org/W2147207459","doi":"https://doi.org/10.1039/c4cc09921d","title":"Exploring hydrogen peroxide responsive thiazolidinone-based prodrugs","display_name":"Exploring hydrogen peroxide responsive thiazolidinone-based prodrugs","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2147207459","doi":"https://doi.org/10.1039/c4cc09921d","mag":"2147207459","pmid":"https://pubmed.ncbi.nlm.nih.gov/25811298","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4659858"},"language":"en","primary_location":{"id":"doi:10.1039/c4cc09921d","doi":"https://doi.org/10.1039/c4cc09921d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c4cc09921d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2015/cc/c4cc09921d","source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2015/cc/c4cc09921d","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074759786","display_name":"Christian Perez","orcid":"https://orcid.org/0000-0002-0905-5820","observed_orcids":["https://orcid.org/0000-0002-0905-5820"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Perez","raw_affiliation_strings":["Department of Chemistry & Biochemistry","La Jolla","USA","University of California, San Diego","Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry","institution_ids":[]},{"raw_affiliation_string":"La Jolla","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111708692","display_name":"Jean\u2010Philippe Monserrat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Monserrat","raw_affiliation_strings":["Department of Chemistry & Biochemistry","La Jolla","USA","University of California, San Diego","Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive,La Jolla,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry","institution_ids":[]},{"raw_affiliation_string":"La Jolla","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive,La Jolla,USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394247","display_name":"Yao Chen","orcid":"https://orcid.org/0000-0002-3465-7380","observed_orcids":["https://orcid.org/0000-0002-3465-7380"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yao Chen","raw_affiliation_strings":["Department of Chemistry & Biochemistry","La Jolla","USA","University of California, San Diego","Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive,La Jolla,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry","institution_ids":[]},{"raw_affiliation_string":"La Jolla","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive,La Jolla,USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028132671","display_name":"Seth M. Cohen","orcid":"https://orcid.org/0000-0002-5233-2280","observed_orcids":["https://orcid.org/0000-0002-5233-2280","https://orcid.org/0000-0002-4247-8008"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seth M. Cohen","raw_affiliation_strings":["Department of Chemistry & Biochemistry","La Jolla","USA","University of California, San Diego","Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive,La Jolla,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry","institution_ids":[]},{"raw_affiliation_string":"La Jolla","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive,La Jolla,USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028132671"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":1.5882,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.82439656,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"51","issue":"33","first_page":"7116","last_page":"7119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.1476999968290329,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hydrogen-peroxide-activation","display_name":"hydrogen peroxide activation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8349999785423279},{"id":"https://openalex.org/keywords/thiazolidinones","display_name":"thiazolidinones","score":0.4620000123977661},{"id":"https://openalex.org/keywords/prodrug-activation","display_name":"prodrug activation","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.926889181137085},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.9117005467414856},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.8305051326751709},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8003597259521484},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6692554950714111},{"id":"https://openalex.org/C2781048764","wikidata":"https://www.wikidata.org/wiki/Q107429","display_name":"Peroxide","level":2,"score":0.46239173412323},{"id":"https://openalex.org/C2779074116","wikidata":"https://www.wikidata.org/wiki/Q134856","display_name":"Carboxylic acid","level":2,"score":0.4553951621055603},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.33195310831069946},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1926194429397583}],"mesh":[{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053778","descriptor_name":"Thiazolidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1039/c4cc09921d","doi":"https://doi.org/10.1039/c4cc09921d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c4cc09921d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2015/cc/c4cc09921d","source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},{"id":"pmid:25811298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25811298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical communications (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3810793","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4659858","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4659858","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4659858/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Commun (Camb)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1039/c4cc09921d","doi":"https://doi.org/10.1039/c4cc09921d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c4cc09921d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2015/cc/c4cc09921d","source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5560124085","display_name":"Insight and Optimization of Metalloprotein Inhibitors","funder_award_id":"R01GM098435","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147207459.pdf","grobid_xml":"https://content.openalex.org/works/W2147207459.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1809723326","https://openalex.org/W1921965616","https://openalex.org/W1968142217","https://openalex.org/W1968436252","https://openalex.org/W1969014625","https://openalex.org/W1977320698","https://openalex.org/W1989987141","https://openalex.org/W1991952977","https://openalex.org/W1997296674","https://openalex.org/W2005122786","https://openalex.org/W2006651770","https://openalex.org/W2013018625","https://openalex.org/W2016180217","https://openalex.org/W2017722427","https://openalex.org/W2027443731","https://openalex.org/W2030817463","https://openalex.org/W2037586146","https://openalex.org/W2040699335","https://openalex.org/W2042677606","https://openalex.org/W2044627978","https://openalex.org/W2055538544","https://openalex.org/W2059142487","https://openalex.org/W2059183805","https://openalex.org/W2064245442","https://openalex.org/W2065294001","https://openalex.org/W2067593902","https://openalex.org/W2098076093","https://openalex.org/W2099484653","https://openalex.org/W2100722865","https://openalex.org/W2103697408","https://openalex.org/W2128569634","https://openalex.org/W2131693985","https://openalex.org/W2138369210","https://openalex.org/W2141723108","https://openalex.org/W2149374690","https://openalex.org/W2166967403","https://openalex.org/W2313101637","https://openalex.org/W2314017959","https://openalex.org/W2949766799","https://openalex.org/W2950008399","https://openalex.org/W2951106423","https://openalex.org/W4255412941"],"related_works":["https://openalex.org/W7014201981","https://openalex.org/W7136630292","https://openalex.org/W6903883346","https://openalex.org/W1969560293","https://openalex.org/W4403142685","https://openalex.org/W2019644211","https://openalex.org/W4401589893","https://openalex.org/W2904117168","https://openalex.org/W4379134782","https://openalex.org/W2404342554"],"abstract_inverted_index":{"A":[0],"novel":[1],"approach":[2],"for":[3],"developing":[4],"prodrugs":[5],"based":[6],"on":[7,49],"masked":[8],"carboxylic":[9,28],"acids":[10],"is":[11],"described.":[12],"Rather":[13],"than":[14],"using":[15],"conventional":[16],"esterase-based":[17],"activation,":[18],"thiazolidinone":[19],"protecting":[20],"groups":[21,30],"have":[22],"been":[23],"identified":[24],"that":[25,47],"can":[26],"reveal":[27],"acid":[29],"upon":[31],"activation":[32],"by":[33],"hydrogen":[34],"peroxide.":[35],"This":[36],"may":[37],"prove":[38],"valuable":[39],"in":[40],"the":[41],"continuing":[42],"development":[43],"of":[44],"prodrug":[45],"strategies":[46],"rely":[48],"reactive":[50],"oxygen":[51],"species":[52],"(ROS)":[53],"as":[54],"a":[55],"trigger.":[56]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
