{"id":"https://openalex.org/W2147169832","doi":"https://doi.org/10.1128/mcb.01139-07","title":"Localization to the Cortical Cytoskeleton Is Necessary for Nf2/Merlin-Dependent Epidermal Growth Factor Receptor Silencing","display_name":"Localization to the Cortical Cytoskeleton Is Necessary for Nf2/Merlin-Dependent Epidermal Growth Factor Receptor Silencing","publication_year":2007,"publication_date":"2007-12-17","ids":{"openalex":"https://openalex.org/W2147169832","doi":"https://doi.org/10.1128/mcb.01139-07","mag":"2147169832","pmid":"https://pubmed.ncbi.nlm.nih.gov/18086884","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2258752"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.01139-07","doi":"https://doi.org/10.1128/mcb.01139-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.01139-07","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2258752","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063582275","display_name":"Banumathi K. Cole","orcid":"https://orcid.org/0000-0003-0976-2610","observed_orcids":["https://orcid.org/0000-0003-0976-2610"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Banumathi K. Cole","raw_affiliation_strings":["MGH Center for Cancer Research and Harvard Medical School, Department of Pathology, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGH Center for Cancer Research and Harvard Medical School, Department of Pathology, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110089552","display_name":"Marcello Curto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcello Curto","raw_affiliation_strings":["MGH Center for Cancer Research and Harvard Medical School, Department of Pathology, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGH Center for Cancer Research and Harvard Medical School, Department of Pathology, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053515304","display_name":"Annie W. Chan","orcid":"https://orcid.org/0009-0005-3157-647X","observed_orcids":["https://orcid.org/0009-0005-3157-647X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annie W. Chan","raw_affiliation_strings":["MGH Center for Cancer Research and Harvard Medical School, Department of Pathology, Charlestown, Massachusetts 02129","MGH Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts 02114","2 MGH Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGH Center for Cancer Research and Harvard Medical School, Department of Pathology, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"MGH Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"2 MGH Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064644062","display_name":"Andrea I. McClatchey","orcid":"https://orcid.org/0000-0002-6150-3619","observed_orcids":["https://orcid.org/0000-0002-6150-3619"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea I. McClatchey","raw_affiliation_strings":["MGH Center for Cancer Research and Harvard Medical School, Department of Pathology, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGH Center for Cancer Research and Harvard Medical School, Department of Pathology, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064644062"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":4.6044,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.94429333,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"28","issue":"4","first_page":"1274","last_page":"1284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.07180000096559525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/merlin","display_name":"Merlin","score":0.734000027179718},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cortical-actin-cytoskeleton","display_name":"cortical actin cytoskeleton","score":0.843999981880188},{"id":"https://openalex.org/keywords/erm-proteins","display_name":"ERM proteins","score":0.9049999713897705},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.6449999809265137},{"id":"https://openalex.org/keywords/receptor-signaling","display_name":"receptor signaling","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C178628643","wikidata":"https://www.wikidata.org/wiki/Q410233","display_name":"Merlin (protein)","level":4,"score":0.9622118473052979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7545615434646606},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7445827126502991},{"id":"https://openalex.org/C196509110","wikidata":"https://www.wikidata.org/wiki/Q18031082","display_name":"Radixin","level":5,"score":0.6832772493362427},{"id":"https://openalex.org/C2776292417","wikidata":"https://www.wikidata.org/wiki/Q18029442","display_name":"Moesin","level":5,"score":0.6766853928565979},{"id":"https://openalex.org/C2780246058","wikidata":"https://www.wikidata.org/wiki/Q18032329","display_name":"Ezrin","level":4,"score":0.6569674015045166},{"id":"https://openalex.org/C200342125","wikidata":"https://www.wikidata.org/wiki/Q24726381","display_name":"FERM domain","level":5,"score":0.5726611614227295},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.5489773750305176},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.49801039695739746},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4541383385658264},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.3741450905799866},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3398342728614807},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26168715953826904},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.1953245997428894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.137897789478302},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.09894010424613953},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.07586175203323364},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07368156313896179}],"mesh":[{"descriptor_ui":"D000099149","descriptor_name":"Ezrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025581","descriptor_name":"Neurofibromin 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025581","descriptor_name":"Neurofibromin 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/mcb.01139-07","doi":"https://doi.org/10.1128/mcb.01139-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.01139-07","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2258752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2258752","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:18086884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18086884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2258752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2258752","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306305","display_name":"Dana Foundation","ror":"https://ror.org/01wt3vs82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W99955887","https://openalex.org/W1505477266","https://openalex.org/W1912436781","https://openalex.org/W1963768207","https://openalex.org/W1966704740","https://openalex.org/W1984338129","https://openalex.org/W1984732869","https://openalex.org/W1989780904","https://openalex.org/W1995267967","https://openalex.org/W2001073149","https://openalex.org/W2003366955","https://openalex.org/W2005252392","https://openalex.org/W2012819315","https://openalex.org/W2016569169","https://openalex.org/W2029976610","https://openalex.org/W2032062053","https://openalex.org/W2050152356","https://openalex.org/W2053547776","https://openalex.org/W2056736540","https://openalex.org/W2070967930","https://openalex.org/W2072770131","https://openalex.org/W2075670599","https://openalex.org/W2076430025","https://openalex.org/W2086750244","https://openalex.org/W2091559752","https://openalex.org/W2097930500","https://openalex.org/W2111529846","https://openalex.org/W2111622605","https://openalex.org/W2112387151","https://openalex.org/W2113588085","https://openalex.org/W2114550587","https://openalex.org/W2123593982","https://openalex.org/W2128021675","https://openalex.org/W2130515511","https://openalex.org/W2135432931","https://openalex.org/W2143286984","https://openalex.org/W2149956571","https://openalex.org/W2150706412","https://openalex.org/W2152927359","https://openalex.org/W2157450466","https://openalex.org/W2158950529","https://openalex.org/W2159383827","https://openalex.org/W2161655320","https://openalex.org/W2161807488","https://openalex.org/W2164565944","https://openalex.org/W2167593330","https://openalex.org/W2169831961","https://openalex.org/W2170103257","https://openalex.org/W2314452554","https://openalex.org/W2339310168","https://openalex.org/W2403618778"],"related_works":["https://openalex.org/W1852638080","https://openalex.org/W2104286888","https://openalex.org/W2127411947","https://openalex.org/W2000522885","https://openalex.org/W2128021675","https://openalex.org/W2147469756","https://openalex.org/W2888076703","https://openalex.org/W7100128318","https://openalex.org/W2114550587","https://openalex.org/W2053547776"],"abstract_inverted_index":{"Merlin,":[0],"the":[1,4,13,26,36,43,52,68,86,102,119,126,153,158,162,168],"product":[2],"of":[3,35,49,64,122,129,171],"NF2":[5],"tumor":[6],"suppressor":[7],"gene,":[8],"is":[9,116],"closely":[10],"related":[11],"to":[12,94,101,157],"ERM":[14,53],"(ezrin,":[15],"radixin,":[16],"moesin)":[17],"proteins,":[18],"which":[19],"provide":[20],"anchorage":[21],"between":[22],"membrane":[23,80,97,135,147,176],"proteins":[24,32,54],"and":[25,46,51,65,99,124,133,172],"underlying":[27],"cortical":[28,103,154,163],"cytoskeleton;":[29],"all":[30],"four":[31],"are":[33,55],"members":[34],"band":[37],"4.1":[38],"superfamily.":[39],"Despite":[40],"their":[41],"similarity,":[42],"subcellular":[44],"distributions":[45],"functional":[47,127],"properties":[48],"merlin":[50,61,92,123,130,145],"largely":[56],"distinct.":[57],"Upon":[58],"cell-cell":[59,111],"contact":[60],"prevents":[62],"internalization":[63],"signaling":[66,173],"from":[67,174],"epidermal":[69],"growth":[70],"factor":[71],"receptor":[72],"(EGFR)":[73],"by":[74],"sequestering":[75],"it":[76],"into":[77],"an":[78,95],"insoluble":[79,96],"compartment.":[81],"Here":[82],"we":[83],"show":[84],"that":[85,161],"extreme":[87],"amino":[88],"(N)":[89],"terminus":[90],"directs":[91],"biochemically":[93],"compartment":[98],"physically":[100],"actin":[104,164],"network,":[105,155],"with":[106,131],"a":[107,140],"marked":[108],"concentration":[109],"along":[110],"boundaries.":[112],"This":[113],"insoluble-membrane":[114],"distribution":[115],"required":[117],"for":[118,125],"growth-suppressing":[120],"function":[121],"association":[128],"EGFR":[132,151],"other":[134],"receptors.":[136,177],"Our":[137],"data":[138],"support":[139],"model":[141],"whereby":[142],"locally":[143],"activated":[144],"sequesters":[146],"receptors":[148],"such":[149],"as":[150],"at":[152],"contributing":[156],"long-held":[159],"observation":[160],"cytoskeleton":[165],"can":[166],"control":[167],"lateral":[169],"mobility":[170],"certain":[175]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
