{"id":"https://openalex.org/W2147166999","doi":"https://doi.org/10.1517/17425247.2015.1014034","title":"In vivobrain electrophoresis \u2013 a novel method for chemotherapy of CNS diseases","display_name":"In vivobrain electrophoresis \u2013 a novel method for chemotherapy of CNS diseases","publication_year":2015,"publication_date":"2015-02-10","ids":{"openalex":"https://openalex.org/W2147166999","doi":"https://doi.org/10.1517/17425247.2015.1014034","mag":"2147166999","pmid":"https://pubmed.ncbi.nlm.nih.gov/25666687"},"language":"en","primary_location":{"id":"doi:10.1517/17425247.2015.1014034","doi":"https://doi.org/10.1517/17425247.2015.1014034","is_oa":false,"landing_page_url":"https://doi.org/10.1517/17425247.2015.1014034","pdf_url":null,"source":{"id":"https://openalex.org/S51663496","display_name":"Expert Opinion on Drug Delivery","issn_l":"1742-5247","issn":["1742-5247","1744-7593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012316455","display_name":"Mario Ammirati","orcid":"https://orcid.org/0000-0001-9057-0696","observed_orcids":["https://orcid.org/0000-0001-9057-0696"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario Ammirati","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Department of Neurological Surgery , N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210 , USA +1 614 293 1970 ; +1 614 293 4024 ; Mario.ammirati@osumc.edu","+1 614 293 4024","The Ohio State University Wexner Medical Center, Department of Neurological Surgery, N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210, USA +1 614 293 1970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Department of Neurological Surgery , N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210 , USA +1 614 293 1970 ; +1 614 293 4024 ; Mario.ammirati@osumc.edu","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"+1 614 293 4024","institution_ids":[]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Department of Neurological Surgery, N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210, USA +1 614 293 1970","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041457208","display_name":"Tariq Lamki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tariq Lamki","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Department of Neurological Surgery, N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210, USA +1 614 293 1970; +1 614 293 4024; Mario.ammirati@osumc.edu","+1 614 293 4024","The Ohio State University Wexner Medical Center, Department of Neurological Surgery, N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210, USA +1 614 293 1970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Department of Neurological Surgery, N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210, USA +1 614 293 1970; +1 614 293 4024; Mario.ammirati@osumc.edu","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"+1 614 293 4024","institution_ids":[]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Department of Neurological Surgery, N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210, USA +1 614 293 1970","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021374311","display_name":"Girish D. Chitnis","orcid":"https://orcid.org/0000-0001-7737-7912","observed_orcids":["https://orcid.org/0000-0001-7737-7912"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Girish Chitnis","raw_affiliation_strings":["Purdue University, Birck Nanotechnology Center, 1205 west State st, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Purdue University, Birck Nanotechnology Center, 1205 west State st, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100651646","display_name":"Xiangyu Yang","orcid":"https://orcid.org/0000-0002-1541-667X","observed_orcids":["https://orcid.org/0000-0002-1541-667X"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangyu Yang","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Division of Imaging Science, Room 430, 395 west 12th ave, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Division of Imaging Science, Room 430, 395 west 12th ave, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112471131","display_name":"Duncan Russell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duncan Russell","raw_affiliation_strings":["The Ohio State University, Department of Veterinary Biosciences, 201 Goss Laboratory, 1925 Coffey rd, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Department of Veterinary Biosciences, 201 Goss Laboratory, 1925 Coffey rd, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025213667","display_name":"Dondrae J Coble","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dondrae Coble","raw_affiliation_strings":["The Ohio State University, University Laboratory Animal Resources, Department of Veterinary Preventive Medicine, 111 Wiseman Hall, 400 west 12th ave, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, University Laboratory Animal Resources, Department of Veterinary Preventive Medicine, 111 Wiseman Hall, 400 west 12th ave, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041131555","display_name":"Balveen Kaur","orcid":"https://orcid.org/0000-0001-7738-0804","observed_orcids":["https://orcid.org/0000-0001-7738-0804"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Balveen Kaur","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Department of Neurological Surgery, N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210, USA +1 614 293 1970; +1 614 293 4024; Mario.ammirati@osumc.edu","+1 614 293 4024","The Ohio State University Wexner Medical Center, Department of Neurological Surgery, N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210, USA +1 614 293 1970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Department of Neurological Surgery, N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210, USA +1 614 293 1970; +1 614 293 4024; Mario.ammirati@osumc.edu","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"+1 614 293 4024","institution_ids":[]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Department of Neurological Surgery, N-1025 Doan Hall, 410 west 10th ave, Columbus, OH 43210, USA +1 614 293 1970","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016175407","display_name":"Michael Vinzenz Knopp","orcid":"https://orcid.org/0000-0001-9543-2962","observed_orcids":["https://orcid.org/0000-0001-9543-2962"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Knopp","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Division of Imaging Science, Room 430, 395 west 12th ave, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Division of Imaging Science, Room 430, 395 west 12th ave, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030698818","display_name":"Sarah A. Moore","orcid":"https://orcid.org/0000-0002-4311-6199","observed_orcids":["https://orcid.org/0000-0002-4311-6199"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Moore","raw_affiliation_strings":["The Ohio State University, Veterinary Medical Center, Department of Veterinary Clinical Sciences, 601 Vernon Tharp Street, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Veterinary Medical Center, Department of Veterinary Clinical Sciences, 601 Vernon Tharp Street, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023612792","display_name":"Babak Ziaie","orcid":"https://orcid.org/0000-0002-3557-267X","observed_orcids":["https://orcid.org/0000-0002-3557-267X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Babak Ziaie","raw_affiliation_strings":["Purdue University, Birck Nanotechnology Center, 1205 west State st, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Purdue University, Birck Nanotechnology Center, 1205 west State st, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3276,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60358237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"5","first_page":"727","last_page":"734"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.6190999746322632,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.6190999746322632,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.06909999996423721,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8429999947547913},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.6499999761581421},{"id":"https://openalex.org/keywords/gadolinium","display_name":"gadolinium","score":0.6729999780654907},{"id":"https://openalex.org/keywords/intracerebral-injection","display_name":"intracerebral injection","score":0.7609999775886536},{"id":"https://openalex.org/keywords/implantable-electrodes","display_name":"implanted electrodes","score":0.7559999823570251},{"id":"https://openalex.org/keywords/central-nervous-system-diseases","display_name":"central nervous system disorders","score":0.5460000038146973},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7392596006393433},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.46981221437454224},{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.45454853773117065},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.43451988697052},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.42135441303253174},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4103519320487976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.394198477268219},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3064565062522888},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27732139825820923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18218779563903809},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1517/17425247.2015.1014034","doi":"https://doi.org/10.1517/17425247.2015.1014034","is_oa":false,"landing_page_url":"https://doi.org/10.1517/17425247.2015.1014034","pdf_url":null,"source":{"id":"https://openalex.org/S51663496","display_name":"Expert Opinion on Drug Delivery","issn_l":"1742-5247","issn":["1742-5247","1744-7593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Delivery","raw_type":"journal-article"},{"id":"pmid:25666687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25666687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug delivery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W100162714","https://openalex.org/W1966033721","https://openalex.org/W1968770683","https://openalex.org/W1998962655","https://openalex.org/W2016386915","https://openalex.org/W2020890137","https://openalex.org/W2027284802","https://openalex.org/W2027568813","https://openalex.org/W2044419292","https://openalex.org/W2055249927","https://openalex.org/W2056024740","https://openalex.org/W2062689759","https://openalex.org/W2063816661","https://openalex.org/W2073351219","https://openalex.org/W2077128382","https://openalex.org/W2077343267","https://openalex.org/W2085072793","https://openalex.org/W2101099825","https://openalex.org/W2134807618","https://openalex.org/W2141513261","https://openalex.org/W2142146640","https://openalex.org/W2151264866","https://openalex.org/W2162592548","https://openalex.org/W2164322384","https://openalex.org/W2165114272","https://openalex.org/W2331750420"],"related_works":["https://openalex.org/W2809831094","https://openalex.org/W4411449211","https://openalex.org/W2622214766","https://openalex.org/W2413904105","https://openalex.org/W2219739244","https://openalex.org/W3040137836","https://openalex.org/W4294686058","https://openalex.org/W2346909059","https://openalex.org/W2011367738","https://openalex.org/W1975610778"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,120,164,186],"blood-brain":[2],"barrier":[3],"(BBB)":[4],"is":[5],"a":[6,47,114,135,140,211],"protective":[7],"mechanism":[8],"that":[9,17],"does":[10],"its":[11],"job":[12],"superbly.":[13],"So":[14],"much":[15],"so,":[16],"hitherto,":[18],"brain":[19,34,75,202],"chemotherapy":[20],"has":[21],"been":[22],"limited":[23],"by":[24,80,233],"it.":[25],"In":[26],"fact,":[27],"very":[28],"few":[29],"agents":[30],"are":[31],"effective":[32],"against":[33],"disease":[35],"due":[36],"to":[37,55,66,87,125,143,228,230],"the":[38,43,67,71,145,157,161,179,193,221,234],"inherent":[39],"difficulties":[40],"of":[41,74,84,122,192,201,246],"penetrating":[42],"BBB.":[44,72],"We":[45],"describe":[46],"novel,":[48],"extremely":[49],"focused":[50],"method":[51,61,94],"for":[52],"delivering":[53],"drugs":[54],"specific":[56],"diseased":[57,88],"areas.":[58,90],"This":[59,103,195],"innovative":[60],"directly":[62],"delivers":[63],"putative":[64],"substances":[65,86,124],"pathological":[68],"area,":[69],"bypassing":[70],"Treatment":[73],"diseases":[76,203],"could":[77],"be":[78,208],"improved":[79],"targeted,":[81],"controlled":[82,190],"delivery":[83,121],"therapeutic":[85,218],"cerebral":[89],"Our":[91],"described":[92],"novel":[93],"-":[95,99,215],"in":[96,107,210],"vivo":[97],"electrophoresis":[98],"achieves":[100],"this.":[101],"METHODS:":[102],"technique":[104,196],"was":[105,111,132,147,154,169,175],"evaluated":[106,170],"beagles":[108],"after":[109],"craniotomy":[110],"performed":[112],"and":[113,223],"custom-designed":[115],"plate":[116],"with":[117,128,220],"electrodes":[118,159],"inserted.":[119],"charged":[123],"selected":[126],"areas":[127],"predictably":[129,177],"guided":[130],"movement":[131,168,191],"achieved":[133],"via":[134],"created":[136,155,180],"electrical":[137,152,165,181],"field.":[138],"Gadolinium,":[139],"compound":[141],"unable":[142],"cross":[144],"BBB,":[146],"injected":[148],"intracerebrally":[149],"whereas":[150],"an":[151],"field":[153,182],"using":[156,171,178],"implanted":[158],"surrounding":[160],"injection":[162],"area.":[163],"field-guided":[166],"Gadolinium":[167,174],"MRI.":[172],"RESULTS:":[173],"moved":[176,209],"without":[183],"complications.":[184],"CONCLUSIONS:":[185],"experiment":[187],"successfully":[188],"demonstrated":[189],"substance.":[194],"can":[197],"significantly":[198],"change":[199],"treatment":[200],"because":[204],"substances:":[205],"i)":[206],"may":[207],"controlled,":[212],"predictable":[213],"way":[214],"exponentially":[216],"increasing":[217,243],"interactions":[219],"target;":[222],"ii)":[224],"no":[225],"longer":[226],"need":[227],"conform":[229],"constraints":[231],"dictated":[232],"BBB":[235],"(molecular":[236],"mass":[237],"<":[238],"500":[239],"d;":[240],"lipophilic),":[241],"thereby":[242],"potential":[244],"number":[245],"usable":[247],"substances.":[248]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}